Results for technologies (139)
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A Novel Platform for Rapid Generation of Covalent Biotherapeutics (No. T4-2282)
Covalent drugs have emerged as a groundbreaking modality for improving the affinity, potency, and duration of action of molecularly targeted inhibitors. Prof.
It is difficult to target certain therapeutic targets, such as transcription factors and protein-protein interaction inter...
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18694
Sustainable Utilization of Ethane (No. T4-2279)
Aerobic oxidation is a chemical reaction in which hydrocarbons such as alkanes or alkenes are oxidized using oxygen as the oxidizing agent.
Saturated and unsaturated hydrocarbons, alkanes and alkenes, respectively, are primary chemicals found in natural gas and formed in petroleum...
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18592
Stirring-Free Scalable Electrosynthesis Enabled by Alternating Current (No. T4-2268)
Electrochemical transformations are unfavorable while using conventional direct current (DC) electrosynthesis. The main reason is the interelectrode mass transfer, which serves as a major limiting factor for the overall efficiency and the process’s selectivity.
The vast majority...
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18649
Sparsity Based Non-Contact Vital Signs Monitoring of Multiple People Via Radar (No. T4-2257)
The rise in chronic health conditions, alongside the increase in the elderly population, emphasizes the importance of long-term monitoring in addition to urgent intervention.
Monitoring human vital signs entails numerous difficulties. First, current monitoring devices are typicall...
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18610
Nonlinear Waveform Inversion for Quantitative Ultrasound (No. T4-2254)
Conventional ultrasound brightness-mode images do not provide sufficient contrast for certain anatomical structures and have a poor physical interpretation. This can highly affect the medical diagnosis reliability.
Due to its non-invasive and non-radiating nature, along with its l...
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18751
Transparent Electrodes Based on Carbon Nanotubes (No. T4-2235)
The electrical, optical, and mechanical qualities of transparent conductive electrodes (TCEs) make them ideal for electro-optic applications. However, existing TCEs are costly, inflexible, and their performance is inadequate.
Carbon nanotubes (CNTs) are utilized to produce high-qu...
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18754
Adapters for Targeted Viral Vector-Based Therapies (No. T4-2229)
A major challenge in developing viral-based therapies, such as gene therapies, CAR-T cell immunotherapy, and oncolytic virotherapy, is that the most efficient vectors and viruses are not specific, preventing their direct administration to the patient. Prof.
VSV-G-pseudotyped lenti...
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18691
Catalytic Synthesis of Salbutamol Intermediate (No. T4-2226)
Salbutamol, also known as Ventolin, is a generic drug used for asthma treatments. It is one of the most common medications in the world as millions are using it daily. The mass production of Salbutamol usually consumes expensive reagents and generates a large amount of chemical waste.
...
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18508
Electrospining of Epoxy Fibers for Filters and Composites (No. T4-2224)
Electrospinning is a common technique for producing ultrafine polymer fibers (of a few microns). However, it is almost exclusively used for thermoplastic polymers.
Fibrous materials tend to exhibit superior properties compared to their bulks. One of the methods to fabricate materi...
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18143
Anti importin beta1 monoclonal antibody (No. M7-2223)
A highly specific and sensitive anti-Importin b1 (KPNB1) monoclonal antibody. The mAb recognizes an epitope comprising residues 301-320 of human KPBN1 and is highly specific for cytoplasmic KPNB1 in diverse applications.
Importin b1 (KPNB1) is a nucleocytoplasmic transport factor...
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17648
A Novel Treatment for Cancer-Associated Cachexia (No. T4-2221)
Cancer-associated cachexia (CAC) is a late-stage metabolic syndrome characterized by massive weight loss that occurs in 80% of cancer patients and is responsible for 20% of cancer deaths. It does not respond to dietary changes, and there is currently no effective biomarker or treatment for C...
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18685
An Improved Single-Cell RNA-Sequencing Method (No. T4-2217)
Single-cell RNA sequencing (scRNA-seq) enables the analysis of gene expression in individual cells, unveiling new subsets of cells in different states or diseases through statistical analysis.
scRNA-seq enables the detection of gene expression in individual cells, uncovering disti...
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18646
Hyperstable Serum Albumin Variants for Microbial Mass Production (No. T4-2216)
Serum albumins are essential in a wide variety of molecular and cellular applications, including in the medical, biotechnological and cultivated meat industries.
Albumins derived from animal or human plasma present ethical and reproducibility challenges (e.g., contamination risks,...
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18682
Radiation Curing Enhancement by Semiconducting Nanoparticles (No. T4-2215)
The curing of polymers by UV light is of great technological importance in, for example, dentistry, advanced manufacturing (3D printing), and various applications such as manufacturing of optical media, biotechnology, and more.
Cationic photo-cured thermosetting polymers, like epo...
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17678
High Throughput Screening Platform For Inhibitors of Viral Membrane Fusion (No. T4-2213)
Enveloped viruses pose significant health risks and lack effective treatments. Inhibiting viral membrane fusion, a crucial step in infection, holds promise for antiviral drug development. Dr.
Enveloped viruses, including SARS-CoV-2, influenza, Nipah virus, Hendra virus, HIV, and E...
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18679
GFP variants (No. M7-2209)
A collection of GFP variants with improved/unique properties, such as increased thermostability, photostability, quantum yield, altered fluorescence lifetime, pH sensitivity, and excitation spectra.
The team led by Prof. Fleishman developed a machine-learning-based approach calle...
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18032
AS-22 cell line (high grade serous ovarian carcinoma) (No. M7-2204)
A cell line originated from a patient diagnosed with high-grade serous ovarian carcinoma (HGSOC). Derived from tumor cells in ascites fluids (metastatic site) originating in a chemonaive 73-year-old caucasian female diagnosed with stage IIIc high-grade serous ovarian carcinoma (HGSOC).
...
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18320
PT-16 cell line (high grade serous ovarian carcinoma) (No. M7-2203)
A cell line originated from a patient diagnosed with high-grade serous ovarian carcinoma (HGSOC). The cell line was derived from a primary adnexal tumor originating in a chemonaive 74-year-old caucasian female diagnosed with stage IIIc high-grade serous ovarian carcinoma (HGSOC).
...
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18317
OM-17 cell line (high grade serous ovarian carcinoma) (No. M7-2202)
A cell line originated from a patient diagnosed with high-grade serous ovarian carcinoma (HGSOC).
...
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18314
Green Synthesis of Biocompatible Porous Nanostructured Silica-Composite (No. T4-2201)
Nanostructured silica is a promising material with remarkable properties, such as high porosity, biocompatibility, and stability.
Nanostructured silica is a group of materials composed of silica with a controllable, homogeneous, and functionalized nanosurface.
It was di...
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18137
Super Resolution Vascular Ultrasound Imaging for Clinical Diagnostics (No. T4-2194)
Alterations in the microvasculature characterize various pathologies, including cancers and inflammatory diseases (i.e., Crohn's disease). Therefore, precise in vivo microvascular imaging at the capillary level could be a valuable tool for early diagnosis and clinical management.
...
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16721
Splicing ViT Features for Semantic Appearance Transfer (No. T4-2192)
Artificial intelligence (AI) solutions are vastly available for applications such as object segmentation, image detection, visual creation, writing assistance, and many more. There is a continuous quest to improve photograph editing software and existing AI systems.
The demand for...
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18637
Diagnosis and Prognosis of Inflammatory Bowel Diseases Using Host RNA Sequencing of Fecal Samples (No. T4-2175)
Inflammatory bowel disease (IBD) patients suffer from chronic inflammation of the gastrointestinal (GI) tract. The disease course varies, and patients often experience relapses and remission, despite the availability of several medications types.
IBD (Crohn’s and ulcerative coli...
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12511
Innovative Immunotherapy for Cardiac Regeneration after Myocardial Infarction (No. T4-2166)
Myocardial infarction (MI), commonly known as a heart attack, is a leading cause of death worldwide, with no available therapies for restoring heart function post-MI. Prof.
Cardiovascular diseases claim millions of lives annually, with MI and strokes accounting for the majority of...
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18664
Fungicidal RNAi for Stopping Grey Mold on Produce (No. T4-2162)
Pathogenic fungi that cause postharvest decay of fruits and vegetables result in massive yield loss. The gray-mold disease affects various plant species, and the current treatments of non-specific fungicides are not eco-friendly and may impact human health.
More than 40% of the gl...
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18457
Measuring Carbon Fixation of Individual Trees (No. T4-2161)
A method to better calculate carbon uptake by trees. Considering not only biomass but also measured by use of presently available sensors other aspects and factors of the trees, to get a more accurate picture of tree carbon uptake. More information available under NDA
...
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17552
Natural Human Antibodies to Treat Cancer (No. T4-2152)
Ovarian cancer is the fifth leading cause of cancer-related death in women. Due to a lack of early detection methods, it is often diagnosed at a late stage, resulting in negligible changes to cure.
Ovarian carcinoma is the most lethal gynecological malignancy and the fifth leading...
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17825
Treating myeloid malignancies with Rock inhibitors (No. T4-2147)
Acute myeloid leukemia (AML) incidents increases with age and mortality exceeds 90% when it is diagnosed after the age of 65. Specific mutations were shown to exist in pre-leukemic subjects years before the disease breaks.
Once acute myeloid leukemia (AML) is diagnosed, up to 80...
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18409
Diagnosis and Treatment of Breast Cancer based on Extracellular Vesicles (No. T4-2145)
Early detection of breast cancer (BC) and monitoring its progression, treatment response, and recurrence are crucial for survival.
Early detection of BC is crucial for successful therapy and survival. Currently, screening commonly relies on mammography, ultrasound, and magnetic re...
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16676
Biodegradable "Fiberglass" for Packing Industry (No. T4-2137)
Conventional plastics are materials with attractive properties but with low recyclability. They also persist in the environment. Furthermore, the plastic waste decomposes into microplastic, which pollutes the soil, the sea, and the air. Therefore new regulations restrict its use.
...
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14756
Design of a Multivalent mRNA Vaccine to Protect Against Multiple Variants (No. T4-2136)
The constant emergence of new variants threatens the success of the mRNA vaccines developed against SARS-CoV-2. Therefore, there is an urgent need to develop a vaccine that will provide immunity against multiple variants – both existing and potential. Prof.
Vaccines can elicit a...
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14762
Novel Combination Therapy For Improved Management of Depression (No. T4-2129)
Psychiatric disorders, especially major depressive disorder (MDD), are leading causes of disability and premature death across the globe, with patients showing a heightened risk of self-harm and suicidal ideation. Prof.
Major depressive disorder (MDD) is the third-leading cause of...
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6097
Reusable Gold Nanostars Substrates for Signal Amplification for Diagnostics (No. T4-2127)
Numerous spectroscopic techniques utilize signal enhancement from surfaces of nanoparticles linked to analyte molecules. However, existing surface-enhanced spectroscopies (SES) are based on solution-based nanoparticles dispersion and are unsuitable for solid substrates. Dr.
Surfac...
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12950
WISER – A Holistic Analysis Of Large Scale Electronics Health Records (No. T4-2113)
In the current era of big-data medicine, the Electronic Health Records (EHR) analysis is limited due to its disease-oriented approach.
Current EHR analysis systems have many drawbacks: The raw data is treated ad-hoc, the infrastructure is “endpoint-driven” although the problem...
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6145
A Method for Vitamin D Production (No. T4-2086)
Vitamin D is essential for health including the growth of bones, mental health, and functioning immune system, with vitamin D deficiency is associated with a number of health conditions.
Vitamin D is a group of essential fat-soluble molecules important for the absorption and metab...
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18442
Modulating Weight Gain and Loss by Understanding the Mechanism of Smoking Related Weight Changes (No. T4-2078)
Of the approximately 30 million adult smokers in the U.S, more than half report attempting to quit smoking every year. However, smoking cessation-associated weight gain (SCWG) constitutes a major obstacle to smoking withdrawal.
Nearly 13 of every 100 U.S. adults (12.5%) were repor...
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17357
Predicting Childhood Obesity (No. T4-2076)
Childhood obesity is a global health crisis, which holds extended complex health and psychological problems. Although an early diagnosis of children at risk for obesity could allow intervention and prevention, healthcare professionals have little guidance to identify individuals at risk.
...
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6961
Treatment for Ewing Sarcoma Using ETS Proteins (No. T4-2068)
Ewing sarcoma (ES) is a common bone malignancy in children and young adolescents which is usually treated by systemic chemotherapy. In about 25% of the cases, cancer has already spread to other parts of the body at the time of diagnosis.
Ewing sarcoma is the second most common ped...
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6154
Inhibitory Proteins for 20S Proteasome Regulation as Cancer Treatment (No. T4-2065)
Proteasomal protein degradation is crucial in maintaining cellular integrity and in regulating key cellular processes including cell cycle, proliferation and cell death.
The protein degradation machinery plays a critical role in the maintenance of cellular homeostasis, preventing ...
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6139
Increasing Immunotherapy Efficacy of Anti PD-L1 (No. T4-2059)
Immunotherapy has revolutionized cancer treatment by activating the immune system to attack tumor cells. However, notable limitations remain, including differential responses between individuals and cancer types. Dr.
Checkpoint inhibitors are drugs used to activate the immune syst...
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17039
Peptides for Treating Alzheimer's Disease (No. T4-2057)
Alzheimer's Disease (AD) is an age-associated neurodegenerative disorder characterized clinically by a decline in cognitive function. It is the most common type of dementia, with 5.8 million Americans living with AS in 2020.
Alzheimer's disease (AD) is an age-associated, irreversi...
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Ruth Arnon
Faculty of Biology
6160
Spin Current and Magnetoresistance from the Orbital Hall Effect (No. T4-2053)
The Spin Hall Effect (SHE) generates spin current, spin torque, and magnetoresistance and is extensively used in spintronic devices, such as memory devices, magnetic sensors, and data storage media. However, strong SHE behavior mainly exists in heavy and expensive metals.
The Spin...
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18700
Coupling of Alternating Current to Transition – Metal Catalysis (No. T4-2050)
The coupling of transition-metal to photoredox catalytic cycles through single-electron transfer steps has become a powerful tool in the development of catalytic processes.
Transition-metal catalysis is one of the most common forms of catalysis. However, the number of possible tra...
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18308
Protein coupling using cystein-free inteins (No. T4-2039)
Traceless covalent modification of proteins, including joining peptides or adding chemical groups, is extremely useful for numerous applications in chemical biology, protein chemistry, and biotechnology.
Modifying or joining proteins with other proteins/ peptides/chemical groups i...
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6862
Cell-free microRNA as a Prognostic Biomarker for Amyotrophic Lateral Sclerosis (ALS) (No. T4-2038)
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder of the human motor neuron system, for which no effective treatment exists.
ALS is a relentless neurodegenerative syndrome of the human motor neuron system, for which no curative treatment exists. It is...
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6115
Frontotemporal Dementia Diagnosis Using Circulating microRNA Biomarkers (No. T4-2037)
Frontotemporal dementia (FTD) is a heterogeneous neurodegenerative disorder characterized by frontal and temporal lobe atrophy, typically manifesting with behavioral or language impairment.
FTD is the second most common form of dementia, after Alzheimer’s disease below the age o...
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6082
Scarless CRISPR-mediated Genome Editing (No. T4-2036)
CRISPR-Cas9 is a widely-used tool for genome editing; however, it is very inefficient and often requires the addition of selection markers, forcing the introduction of foreign DNA elements.
CRISPR-Cas9 method, while promising, is currently inherently inefficient and requires selec...
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6112
Safer CAR-T Cell Platform (No. T4-2033)
Chimeric Antigen Receptor (CAR)-T Cell Therapy is a personalized treatment for cancer in which the patient's T cells are genetically engineered to express a synthetic receptor that binds a tumor antigen.
CAR-T Cell Therapy is a cutting-edge immunotherapy modality with a global mar...
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6124
Biologic Drug for Prevention and Treatment of COVID-19 (No. T4-2024)
Combat against COVID-19 is still ongoing worldwide.
Combating the COVID-19 pandemic focuses on two main therapeutic strategies: developing efficient vaccines and identifying potent drugs.
To attenuate SARS-CoV-2 infection, the groups of Profs. Schreiber and Rudich const...
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6027
Predicting Gestational Diabetes Mellitus (No. T4-1962)
diabetes mellitus (GDM) is one of the most common complications of pregnancy, increasing the risk for short and long-term adverse events for both mother and offspring. Early intervention can reduce future complications, however, GDM is currently diagnosed only at late pregnancy stages.
...
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5998
Cell Surface Modification with Synthetic Receptors (No. T4-1961)
Technologies that target cells or modify their behavior are of great interest to improve diagnostic, therapeutic, and imaging platforms.
Cell surface proteins are key mediators of cell responses to changing environments. They are naturally regulated by dynamic structure, expressio...
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7150
A Marker for Consciousness State Following Brain Injury (No. T4-1959)
Improvements in emergency medicine have increased survival rates after brain injury but, paradoxically, have resulted in an increasing number of survivors living with disorders of consciousness.
Disorders of consciousness (DOC) resulting from a severe brain injury can range from n...
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13571
Unique Fingerprinting Using Strain in Nanodiamonds (No. T4-1957)
Fluorescent nanodiamonds are nanoparticles (less than 100 nanometers) made of diamonds that have been engineered to emit fluorescent light. They are used in various applications, including biological imaging and sensing.
Fluorescent markers are site-labeled markers in nanotechnolo...
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18706
Small Molecules for Treatment of Huntington's Disease and Related Disorders (No. T4-1947)
Trinucleotide repeats expansion disorders (TREDs) are a set of diseases in which repetitions of short DNA segments (three nucleotides) occur and accumulate in the genome.
TREDs are a group of human diseases in which repeats of three nucleotides accumulate in the genome.
...
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6193
Treatment for Drug-Resistant Non-Small Cell Lung Cancer (No. T4-1944)
Non-Small Cell Lung Cancer (NSCLC) is a very common type of cancer, and despite currently available therapies, is one of the deadliest due to the emergence of drug resistance, which results in tumor recurrence.
Lung cancer is one of the most deadly and common types of cancer in th...
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6025
Artificial Pancreas (No. T4-1942)
The alarmingly sharp increase in type 1 diabetes mellitus incidence in recent years has been coupled with a marked rise in the development of closed-loop systems aimed at continuously monitoring blood glucose levels, predicting glucose behavior and delivering adjusted insulin doses.
...
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5752
New Antiviral Drugs from Bacterial Natural Products (No. T4-1934)
The increasing incidence of viral infections across the globe is driving the demand for antiviral drugs. Prof. Rotem Sorek and his team identified a new family of bacterial enzymes that produce various nucleotide analogs with antiviral properties (Bernheim, Nature 2021).
The incre...
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12514
Higher Efficiency of CRISPR Gene Editing Using Chimeric Cas9 (No. T4-1930)
CRISPR-Cas9 is a powerful tool for genome editing, widely used for basic research and the development of treatments for genetic diseases. However, its efficiency is currently limited.
CRISPR-Cas9 is a powerful tool for genome editing that allows researchers to modify genomes easil...
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6024
Reversible Operation of Molecular Switches on Solid Surfaces (No. T4-1927)
Molecular photoswitches are light-responsive molecules with potential applications in a broad range of systems with on-demand functionalities.
Molecular photoswitches are photoactive molecules that can be shifted to a new state by irradiation with light of a specific wavelength, a...
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5749
Modulating Protein Degradation through COP9 Signalosome regulation (No. T4-1923)
A potentially therapeutic method to interfere with CSNAP activity, a key negative regulator of protein degradation.
Protein degradation is one of the most essential mechanisms regulating the proteome and its responses to stimuli. The process is largely mediated by E3 ligases, whi...
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18406
Protein Based Treatment for Duchene Muscular Dystrophy and Cancer (No. T4-1913)
Duchenne muscular dystrophy (DMD) is a disease that affects approximately 1 in 3,500 boys with a life expectancy of ~26 years.
Duchenne muscular dystrophy (DMD) is a disease that causes progressive muscle weakness, loss of skeletal and heart muscle tissue, degeneration, and eventu...
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6026
Extraction of Gold from Electronic Waste and Ores (No. T4-1910)
A method for selective extraction of gold has been developed at the Weizmann Institute.
Gold is playing an important role in many industrial applications such as jewelry and ornaments, electronics, telephone circuits, dental alloys, etc.
Prof. Igor Lubomirsky and his gr...
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5743
Continuous Biooptical Monitoring of Microalgae Crops (No. T4-1908)
Current microalgae farming methods are challenged by biotic and abiotic stresses, which often induce irreversible damage, including sudden batch collapse. Available stress monitoring techniques suffer from low-resolution, high costs, and intermittence.
Thanks to their high area pr...
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14678
Iron Catalyzed Ring-Opening Metathesis Polymerization (ROMP) (No. T4-1905)
The olefin metathesis reaction is among the most important catalytic carbon-carbon double bond formation reactions. The most widely used catalysts for this reaction are Mo- and Ru- carbene complexes which are expensive and toxic 1.
Mo- and Ru-carbene catalysts are the most common ...
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6199
Inorganic Nanotubes/Polymer Composites for 3D Printing (No. T4-1900)
Biocompatible polymers commonly used in the orthopedic and cosmetic prosthetics, cardiovascular and dental implants and food packaging industries often suffer from poor mechanical properties and thermal stability, limited dimensionality and short shelf-life as compared to their metal compara...
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5737
GreenTap - A Method for Stimulating Production and Extraction of Metabolites in Plants (No. T4-1894)
Numerous plant-originated compounds with unique properties are widely used for diverse applications in the drugs, food, and cosmetics industries.
Numerous plant-originated compounds with unique properties are widely used for diverse applications ranging from therapeutics, fungicid...
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6029
Preventing Biofilm Formation by Enzyme Inhibitors (No. T4-1893)
Biofilm is a complex colony of bacteria, which are attached together by extracellular polymeric substance. This setting provides the bacteria protection against environmental factors, improves their surface attachment, and plays a major role in resistance to treatment.
The present...
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5731
A Sustainable Process for Phenol Production (No. T4-1892)
Phenol is an important industrial commodity used as a precursor to many useful compounds.
The cumene hydroperoxide process, which is the most commonly used phenol production process nowadays, is both complicated, with low per pass cumene conversion and is producing acetone as a by...
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5728
Universal CAR-Ts for Treating Cancer (No. T4-1884)
Chimeric Antigen Receptor T-Cells (CAR-Ts) are one of the revolutionary technologies of the twenty-first century, invented by Prof. Zelig Eshhar at the Weizmann Institute of Science.
The group of Prof. Eshhar has developed a method for an adoptive cell therapy, such that cells fro...
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Zelig Eshhar
Faculty of Biology
5722
A Platform for Identifying Specific Autophagy Inhibitors for Cancer (No. T4-1883)
Autophagy plays a vital role in the survival of many solid tumors, often leading to drug resistance in chemotherapy and targeted treatments. Prof.
Tumors often rely on high levels of autophagy, a process known as "autophagy addiction," for survival.
Prof. Adi Kimchi and...
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18497
Covalent Inhibitors for Treatment of Inflammation and Neurodegeneration (No. T4-1880)
C-Jun NH2-terminal kinase (JNK) plays an integral role in many cellular processes and is associated with the pathophysiology of a number of neurological, inflammatory, and autoimmune diseases.
The JNK signaling cascade plays an integral role in the pathology of several neurodegene...
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6109
Targeting Novel Regulator for Improved Hematopoietic Stem Cells Generation (No. T4-1874)
A potential method of generating hematopoietic stem cells for transplantation by inhibiting CD74.
Hematopoietic stem cells (HSCs) originate in the bone marrow and are the progenitors of all hematopoietic cells. HSCs have the capacity to both self-renew and to differentiate, and t...
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5716
Optical Bus for a Multi-Core Processor (No. T4-1863)
Over the last decades, the exponential increase in computational power is running into a bottleneck, as integrating multiple cores is currently the most efficient way to get more computing power per chip.
Chipmakers are constantly seeking innovative ways to reduce power consumptio...
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5704
Prosody Based Speech Analysis (No. T4-1856)
A major part of human communication is conveyed through intonation, or prosody – the music of speech.
The study of prosody is largely absent from the rapidly-evolving field of automatic speech processing applications. Current approaches to computerized analysis of spoken text ar...
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Tirza Biron
Physics
14060
Super-Resolution Using Unsupervised Deep Internal Network (No. T4-1850)
Optical and dimensional limitations of images can be partially overcome today using signal enhancement technologies which typically rely on supervised, deep-learning methods.
Signal enhancement of corrupted input collected under suboptimal conditions, poses multiple challenges, in...
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5701
A Novel Synthetic Biology Platform for Controlling Gene Expression (No. T4-1847)
A method for controlling gene expression using a novel phage-based transcription factor-peptide system.
A fundamental challenge of synthetic biology and its clinical applications is the capability to control gene expression.
The team of Prof. Sorek at the Weizmann Inst...
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5695
Composite Functional Metasurfaces for Multispectral Achromatic Optics (No. T4-1845)
A new technology for producing flat optical components based on optical metasurfaces. These components can potentially serve high resolution imaging, spectrometry, light processing and beam shaping devices.
The proposed technology can be used to generate a wide variety of novel ...
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5689
Secure Search of Encrypted Cloud Data (No. T4-1840)
Searchable symmetric encryption with practical big-data performance and strong security
Highlights
...
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5683
Highly Selective Fluorescent Biosensor for Labeling His-Tagged Proteins in a Specific Conformation (No. T4-1834)
A rapid, label-free biosensor for detecting specific conformation of His-tag labeled proteins, accessible for use in both academic- and commercial-R&D was invented at the Weizmann Institute of Science.
The biosensor presented here is comprised from three main molecular-compone...
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5677
A Method to Identify Actively Degraded Proteins (No. T4-1832)
This technology provides a method to identify the full landscape of proteins that are actively being degraded by the proteasome, offering a way to identify novel targets in various biological conditions and contexts.
The cell's proteome (protein profile) is constantly changing du...
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6030
Inertial NEMS for Nanosensor Applications Based on Inorganic Nanotubes (No. T4-1828)
Inertial sensors for motion detection are being incorporated into an increasing number of portable devices, including diverse IoT applications, mobile phones, wearable electronics, automotive systems and medical diagnostic sensors.
Current microelectromechanical system (MEMS) fabr...
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5674
Nanoscale Electronic Spin Polarizer and Enhanced Magnetoresistance for Memory Applications (No. T4-1816)
Spintronics has a large impact on daily life, being the backbone of computing and electronic applications. The reduction in the size of spintronic elements is of central importance for efficient information processing.
While conventional electronics is based on the charge of elect...
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6205
Homogeneous Dispersion of CNT Composites for Improved Conductivity, Bucky Papers (No. T4-1809)
Battery and capacitor electrode technologies available in the industry today, are struggling to keep up with rapidly advancing applications that require high power and energy density such as electric vehicles, solar cells and telecommunications systems.
The growing need to provide...
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5662
Microbiome-Based Prediction, Diagnosis, and Treatment of Relapsing Obesity (No. T4-1805)
A novel method for analyzing the likelihood of weight regain following a weight loss program and maintaining target body weight, based on gut microbiome analysis.
The past century has seen an overwhelming increase in the prevalence of overweight and obese individuals, effecting o...
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5659
Antibody for Preventing/Treating Secondary Respiratory Infections (No. T4-1790)
A novel method of preventing secondary infections, by inhibition of membrane type I matrix-metalloproteinase-1, which reduces degradation of the extra cellular matrix.
Pathogens that infect the respiratory system are the cause of some of the most dangerous infections, especially ...
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5647
Treating Drug-Resistant Lung Cancer Using a Combination of Antibodies (No. T4-1774)
A novel method to treat tyrosine kinase inhibitor (TKI) resistant cancer by using a combination of three antibodies that target EGFR (ERBB1), HER2 (ERBB2), and HER3 (ERBB3) receptors.
The ErbB/HER family of receptor tyrosine kinases includes epidermal growth factor receptor (EGFR...
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5635
Multimodel Transcranial Optical Vascular Assessment (No. T4-1769)
Subdural hematoma (SDH) is a collection of blood between the inner layer of the dura and the brain that occurs mostly as a result of trauma. It is one of the most common neurosurgical conditions in the United States today.
The incidence of subdural hematoma (SDH) is on a constant ...
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Alon Harmelin
Office of the Vice President for Administration and Finance
5629
Treatment of Heart Failure by Inducing Cardiomyocyte Proliferation (No. T4-1752)
Regulating ErbB2 signaling in cardiomyocytes (CM) as novel treatment for heart diseases by inducing regeneration of cardiac tissue.
Ischemic heart disease and heart failure are the leading causes of death in the western world. Although improved medical care reduced early mortalit...
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5623
Carbon fixing bacteria (No. T4-1736)
The two most pressing challenges facing humanity are the need to feed the growing population with restricted land and water sources and global warming caused due to high atmospheric CO2 levels.
The two most pressing ecological challenges of our time are reducing CO2 levels in the ...
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5608
Green Chemistry for Ketones and Aldehydes Production (No. T4-1722)
Our technology provides a new type of oxidative cleavage reaction of organic compounds with highly selective product formation.
The realization that many processes practiced on a large scale were detrimental to the environment led to a movement of reshaping the science of organic ...
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5596
Highly Selective Optical Biosensors for Proteins in Biological Samples, with Excellent Signal-to-Noise Ratio (No. T4-1689)
Sensing the levels of protein-based biomarkers in biological samples is crucial for diagnosis of various diseases including cancer.
Applications
Detection of proteins in biological samples for medical diagnostics
Fluorescent detection of His-tag or GST labeled proteins for imaging...
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5587
Preventing Infections Using Lipid Based Molecules (No. T4-1673)
Sphingosine (SPH), a natural bactericidal agent which acts as a part of the human innate immune system in the skin, was found to be an effective treatment and prophylaxis for bacterial lung infections in cystic fibrosis (CF) mice.
Cystic fibrosis (CF) is caused by mutations in the...
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5584
Recycling of Precious Metals via an Efficient Process with no Toxic Byproduct (No. T4-1670)
Platinum group metals (PGM) are well-known precious metals that play an important role in many industrial applications as catalysts. Current methods for their recycling are not efficient, require extreme conditions, and involve toxic reagents or byproducts. Prof.
PGM, e.g., platin...
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13574
Magnetic resonance imaging (MRI) Of Tissue Fibrosis without Contrast Agent (No. T4-1665)
Cardiac fibrosis is a scarring event in the cardiac muscle that causes abnormalities in cardiac function and significantly increases the risk of sudden cardiac death.
Myocardial fibrosis is associated with worsening ventricular systolic function, abnormal cardiac remodeling, and i...
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5575
Optimizing T Cell Receptor Avidity for Adoptive T Cell Therapies (No. T4-1662)
Using affinity maturated TCRs to generate reactive T cells
Immunotherapy, that is the use of the immune system to treat cancer, is currently a leading candidate in the combat against cancer.
This technology presents a new method of increasing the affinity of a TCR to i...
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5572
An Off-Line Image Search Engine (No. T4-1647)
Although images search engines are available online, offline networks and databases (in governmental offices, banks, etc.) require an efficient and reliable image search engine.
Nowadays, image searching and image classification are available to everyone online (e.g., Google image...
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5566
Anti-QSOX1 Antibody for Treating Cancer and Metastasis (No. T4-1642)
Cancer, and especially cancer metastasis, is a leading cause of death worldwide. Research in recent years highlighted the importance of the extracellular matrix (ECM) surrounding the tumor in cancer progression metastasis formation.
Cancer is a leading cause of death worldwide, ac...
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5560
Antibody Based Therapy to Treat Cancer and GI Related Diseases (No. T4-1640)
A novel therapeutic antibody against MMP-7, with exceptional specificity, for the treatment of aggressive cancers.
Matrix metalloproteins (MMPs), a family of zinc-dependent endopeptidases, are key enzymes participating in remodeling of the extracellular matrix (ECM), and are thus ...
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5557
Novel MRI Contrast Agent (No. T4-1604)
Novel reporter gene for magnetic resonance imaging applications.The ability to image the duration and location of gene expression in vivo and noninvasively is imperative for the future of biology and clinical medicine.
Non-invasive imaging of gene expression in transgenic mice mod...
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5545
A Novel Database to Reduce Unsuccessful Cloning in E. Coli by Detection of Toxic Genes (No. M7-1576)
Synthetic genes are commonly used in academic and industrial applications, however in many cases these said genes can be toxic when inserted into the ubiquitously used E. coli. This is problematic as time and money is wasted on attempts to generate genes that will not function in E. coli.
...
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5530
Inorganic Fullerene Coating For Medical Devices (No. T4-1566)
Implantable or insertable medical devices must be made of materials with unique properties in addition to biocompatibility to address potential damage from the physiological environment and to maintain their effectiveness over time.
Implantable or insertable medical devices must b...
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5521
Synthetic Carbon Fixation Pathways For Superior Biomass Generation (No. T4-1556)
Modern agriculture faces limited arable land and climate changes. Carbon fixation under these conditions will become a significant growth-limiting factor. Synthetic carbon fixation pathways can allow plants to produce more biomass using the same amount of energy from sunlight.
Car...
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5515
Green Catalytic Formation of Alcohols, Amines, Amides, Imines and Esters under Mild Conditions (No. T4-1551)
In recent years, complexes based on cooperating ligands have exhibited remarkable catalytic activity. These ligands can cooperate with the metal center by undergoing reversible structural
changes in the processes of substrate activation and product formation.
Amines, alcohols, am...
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5512
Optical Conversion of Ultra-Fast Laser Pulses (No. T4-1529)
Ultra-fast lasers are highly used in both academia (to monitor chemical & biological reactions) and industry (for submicron resolution products).
Femto-lasers are highly important devices in both academia and industry. In academia, these lasers are mainly used for reaction stu...
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Yaron (deceased) Silberberg
Physics
5503
Super Resolution from a Single Visual Source (No. T4-1522)
Many imaging devices produce signals of unsatisfactory resolution (e.g. a photo from a cell-phone camera may have low spatial resolution or a video from a web camera may have both spatial and temporal low resolution).
Ever taken a digital photograph and then found out you had miss...
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5500
Conductive Inorganic Fullerenes and Nanotubes (No. T4-1482)
Modification of the electronic properties of layered-type semiconductors can be accomplished by doping/alloying of the semiconductor.
Catalytic processes for energy storage and sulfur free gasoline.Polymer nanocomposites for packaging Electromagnetic shielding.Conductive glues/adh...
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5485
Highly Sensitive Nanoscale Scanning Magnetic and Thermal Sensor (No. T4-1481)
A new technology developed by a group of researchers from the Weizmann Institute is a nanoscale sensor-on-tip for local magnetic signals and thermal dissipation with state-of-the-art sensitivity and spatial resolution.
In light of the rapidly developing scanning-probe based techno...
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5482
Smart Resize of Images & Videos (No. T4-1461)
Data storage of images and videos became a real issue in the last years when pictures and videos are taken and shared more often, and the memory devices aren’t being minimized fast enough.
Camera phones and social media made images and videos more accessible and widespread than ...
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5479
Automatic Photo Animation in Video and Still Images (No. T4-1423)
Many currently marketed animation tools enable users to define objects and provide them with motion, yet none enable the fast and automatic, animation of a full body captured in a single still photo.
The live animation tool was constructed by a successful combination between “of...
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5467
Software for Detecting Irregularities in Visual Data (No. T4-1381)
While image & video processing are rapidly developing fields, most of the recent algorithms must be trained on large and sorted databases to gain adequate performance. Detecting irregularities in previously unknown images or videos is still an unsolved problem. Prof.
Detecting...
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5461
High-Performance Electrochromic Devices (No. T4-1380)
High-performance electrochromic materials that exhibit a practical combination of low-voltage operation and efficient color-switching, as well as long-term stability have been developed by the group of Prof. van der Boom.
The trends towards energy efficiency, comfort and privacy a...
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5458
Mouse IgE and Anti-Mouse IgE Monoclonal Antibodies (No. M7-1270)
Monoclonal antibodies to IgE Description: Rat monoclonal anti-IgE antibodies that was generated by fusion of plasmacytoma (84.1C) or myeloma (EM953) cells with splenocytes of rat immunized with purified murine IgE mAb.
...
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Zelig Eshhar
Faculty of Biology
5452
Cholesterol Antibodies (No. T4-1267)
Description: Monoclonal antibodies specific for cholesterol/ceramide-rich domains (clones 405F, 14F, 499F) and cholesterol micro-domains (clones 36A1, 5881) in cell membranes. Originally raised against an artificial monolayer of lipid mixtures in, and were shown to specifically label the ab...
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5449
Blood Test to Identify People at High Risk for Lung Cancer (No. T4-1033)
A novel diagnostic test to identify individuals with increased risk of lung cancer
Lung cancer is the number one killer among cancers, with 160,000 deaths/year in the USA and 1.6 million/year worldwide. Early detection of lung cancer increases 5-year survival rate from 4% to 54%....
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5428
Escherichia coli UTL2 (No. M7-358)
Escherichia coli UTL2 Description: A "leaky" strain of E. coli, which is significantly more susceptible to cytotoxic agents. UTL2 holds a mutation in the galU gene causing an impaired outer membrane.
...
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5425
Anti-Mast cell Function-associated Antigen (MAFA) monoclonal antibody (No. M7-320)
320 - Monoclonal antibody G63 Description: Monoclonal antibodies to MAFA (Mast cell Function-associated Antigen), originally raised against intact rat RBL-2H3 cells.
...
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5422
Anti-Runx-3 monoclonal antibody (No. M7-306)
Monoclonal antibody to Runx-3 Description: Monoclonal antibody to Runx-3 raised against the Runx3 peptide TPSTPSPRGSLSTTSHF. Available clones: 62, H8.
...
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5416
Anti-Estrone-3-Glucuronide monoclonal antibody (clones: 155B3, 8A3) (No. M7-276)
Monoclonal antibodies raised against estrone-3-glucuronide-BSA. Available clones: 8A3 (Rat, IgG2a), 155B3. Estrone-glucuronide is the dominant metabolite of estradiol. Used as one reference method for determining ovulation.
Monitoring ovarian function by the simultaneous t...
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5413
Anti-Estrone-3-Glucuronide monoclonal antibody (No. M7-275)
Monoclonal antibodies raised against estrone-3-glucuronide-BSA. Available clones: 8A3 (Rat, IgG2a). Estrone-glucuronide is the dominant metabolite of estradiol. Used as one reference method for determining ovulation.
Monitoring ovarian function by the simultaneous time-resolved fl...
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5410
Anti- estrone-3- glucuronide monoclonal antibody (No. M7-273)
Betatypic anti-idiotypic antibody raised against anti- estrone-3- glucuronide (clone 8A3). Available clone: 7C1.
Monitoring ovarian function by the simultaneous time-resolved fluorescence immunoassay of two urinary steroid metabolites.
Barnard G, Kohen F.Clin Chem. 1998 J...
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5404
Monoclonal Antibodies Specific to Cholesterol/Ceramide Mixture Clone (No. M7-263)
Originally raised against an artificial monolayer of lipid mixtures in, and were shown to specifically label the above domains in different cell membranes. Reference: Scheffer L, Futerman AH, Addadi L. 2007. Antibody labeling of cholesterol/ceramide ordered domains in cell membranes.
...
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Luana Scheffer
Chemistry
5398
Monoclonal Anti-Caspr Antibody (Mab#275) (No. M7-259)
259 - Monoclonal antibody to Caspr Description: Monoclonal antibody to Caspr (Mab275), raised against the extracellular domain of Caspr.
...
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5392
Monoclonal Anti-Ermin Antibody (Mab#160) (No. M7-258)
258 - Monoclonal antibody to Ermin Description: Monoclonal antibody to Ermin (MAb160) raised against purified GST–Ermin (residues 1–261).
...
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Damian Brockschnieder
5389
Monoclonal Anti-Gliomedin Antibody (Mab#94) (No. M7-257)
257 - Monoclonal antibody to Gliomedin Description: Monoclonal antibody to Gliomedin (MAb 94) raised against a synthetic peptide corresponding to amino acid residues 273–287 (CVIPNDDTLVGRA), present in the extra cellular region of Rat Gliomedin.
...
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5386
Anti-IgE monoclonal antibody (No. M7-185)
Monoclonal antibodies to IgE Description: Rat monoclonal anti-IgE antibodies that was generated by fusion of plasmacytoma (84.1C) or myeloma (EM953) cells with splenocytes of rat immunized with purified murine IgE mAb.
...
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Michal Baniash
Zelig Eshhar
Faculty of Biology
Tova Waks
Faculty of Biology
5365
Anti-Phospho-ERK (PY193 or PT115) Monoclonal Antibodies (No. M7-176)
176-177 - Monoclonal antibodies to phospho-ERK/Map Kinase Description: Monoclonal antibodies raised against peptides containing the 11 amino acids, HTGFLTEYVAT, corresponding to the ERK activation loop either Tyr -phosphorylated (ERK-PY193), or Thr-phos
...
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5356
Clone - 1E11 (No. M7-148)
Monoclonal antibodies for peptide and steroid hormones Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics.
...
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5350
Anti-Human chorionic gonadotropin (hCG) monoclonal antibody (No. M7-147)
Monoclonal antibodies raised against bhCG. Available clones: 1D5 (IgG1) .Human chorionic gonadotropin (hCG) is a hormone produced by the syncytiotrophoblast, a component of the fertilized egg, after conception.
...
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5347
Clone 1E11 Progesterone (No. M7-146)
Anti-progesterone. Monoclonal antibody raised against position 11 of progesterone (Clone 1E11). It is very specific for progesterone.Progesterone is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
...
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9580
Anti-oestradiol-6-carboxymethyl oxime monoclonal antibody (No. M7-141)
Monoclonal antibodies to estradiol Description: Monoclonal antibodies raised against oestradiol-6-carboxymethyl oxime-BSA. Available clones: 2F9 (Rat, IgG2a), 15 (IgG2b), 8D9 (IgG2a).
Direct chemiluminescence immunoassay for estradiol in serum. De Boever J, Kohen F, Usanachitt C, ...
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5335
Anti-progesterone-7 monoclonal antibody (No. M7-138)
Monoclonal antibodies raised against position 7 of progesterone (clone 2H4), Rat IgG1. Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food produc...
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5332
Human T3N1M1 prostatic adenocarcinoma tissue for xenograft (No. M7-132)
WISH-PC frozen tissue samples
...
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Zelig Eshhar
Faculty of Biology
5329
Anti-idiotypic antibody against anti-Sulfamethazine (12E12) (No. M7-130)
Betatypic anti-idiotypic antibody raised against anti Sulfamethazine –KLH (clone 21C7). Available clone: 12E12.
Generation of an anti-idiotypic antibody as a surrogate ligand for sulfamethazine in immunoassay procedures/
...
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5326
Anti-testosterone 3-(0- carboxymethyl)oxime-BSA monoclonal antibody (No. M7-119)
Rat monoclonal antibodies raised against testosterone 3-(0- carboxymethyl)oxime-BSA. Available clones: 5F2, 5A4.Testosterone is the principal male sex hormone and an anabolic steroid.
Preparation of monoclonal antibodies able to discriminate between testosterone and 5 alpha-dihydr...
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5317
Anti-Biotin Antibody (No. M7-116)
Monoclonal anti-biotin antibody (clone F1). Very specific for biotin.
Preparation and properties of anti-biotin antibodies.
...
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5308
Anti-Sulfamethazine monoclonal antibody (No. M7-115)
Monoclonal antibody to Sulfamethazine (SMZ) Description: Rat monoclonal antibodies raised against Sulfamethazine-BSA. Available clone: 21C7, IgG1. Sulfamethazine is an antibacterial agents commonly given to food animals (swine, fishetc.) to prevent disease and maximize production.
...
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5305
An endothelial-adipose cell line derived from a murine bone marrow stroma (14F1.1) (No. M7-103)
103 - Bone marrow derived stroma cell line 14F1.1
Description: An endothelial-adipose cell line derived from a murine bone marrow stroma.
...
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5302
LTC4 (6E7) (No. M7-101)
Rat monoclonal antibodies raised against Leukotriene C4-KLH. Available clone: 6E7 (IgG1). Cysteinyl leukotrienes are potent lipid mediators in inflammation, inducing smooth muscle contractions and increased capillary permeability.
...
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5299