Transgenic “HyBNAR” mice express humanized type I interferon receptors (IFNARs), enabling in vivo studies of human type I interferons (Hu-IFN-Is) in a murine model. These mice carry chimeric IFNAR1 and IFNAR2 receptors, in which the human extracellular domains are fused to mouse transmembrane and cytoplasmic regions.

By accounting for interspecies algometric differences, HyBNAR mice offer a non-primate, preclinical platform for evaluating human IFN-I biology and therapeutics.