Diagnostics
Software & Algorithms
MedTech & Digital Health
Nonlinear Waveform Inversion for Quantitative Ultrasound (No. T4-2254)

18751
Overview

A Nonlinear Waveform Inversion (NWI) algorithm enhances ultrasound imaging by using Recurrent Neural Networks (RNNs) to reconstruct material properties from acquired signals. Unlike traditional methods, it captures nonlinear acoustic behavior, improving resolution, contrast, and anatomical interpretation for greater diagnostic precision.

Applications
  • Discerning between benign and malignant breast tumors
  • Identifying muscle loss and fatty muscular degeneration
  • Differentiating healthy and diseased tissues (e.g., in livers affected by NAFLD)
  • Quantifying fat levels in the liver (critical for monitoring NAFLD and NASH)
Differentiation
  • Increases diagnostic reliability
  • Non-invasive and non-ionizing
  • Reduced processing time and costs
  • Easily integrated into existing medical ultrasound equipment
  • Adaptable to other imaging techniques (photoacoustic, seismology)

Reconstruction of simulated medium properties (headers), using the NWI algorithm compared to the FWI. The left and right objects are fat and liver, respectively.

Development Stage

Algorithm development and validation completed, with superior performance demonstrated versus standard methods. Clinical translation currently in progress.

Patent Status: 
European Patent Office Published: Publication Number: 4522032
Full Professor Yonina Eldar

Yonina Eldar

Faculty of Mathematics and Computer Science
Computer Science and Applied Mathematics
All projects (5)
Contact for more information

Nir Stein

Director of Business Development, Exact Sciences

+972-8-9345164 Linkedin