Therapeutics(25)
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Synthetic Antimicrobial Peptides for Selective and Potent Malaria Treatment (No. T4-2408)
Malaria remains a major global health challenge, with increasing resistance to current drugs and limited treatment options that selectively target infected red blood cells. ... Read more19146 -
Adapters for Targeted Viral Vector-Based Therapies (No. T4-2229)
A major challenge in developing viral-based therapies, such as gene therapies, CAR-T cell immunotherapy, and oncolytic virotherapy, is that the most efficient vectors and viruses are not specific, preventing their direct administration to the patient. Prof. ... Read more18691 -
Hyperstable Serum Albumin Variants for Microbial Mass Production (No. T4-2216)
Serum albumins are widely used in medicine, biotechnology, and cultivated meat production. However, they are mostly extracted from animal sources, raising ethical, reproducibility, and scalability concerns. ... Read more18682 -
High Throughput Screening Platform For Inhibitors of Viral Membrane Fusion (No. T4-2213)
Enveloped viruses pose significant health risks and lack effective treatments. Inhibiting viral membrane fusion, a crucial step in infection, holds promise for antiviral drug development. Dr. ... Read more18679 -
Bispecific Immune Synapse Engagers as Immunotherapy for Oncology and Autoimmunity (No. T4-2176)
Dysfunctional immune circuits underlie many diseases, including cancer and autoimmunity. Current immunotherapies often target a single pathway or cell type, limiting their efficacy. ... Read more19180 -
Novel Antibody Therapeutics Targeting Senescent Cells for Cancer and Fibrotic Disease Treatment (No. T4-2158)
Senescent cells play a dual role in cancer and fibrosis, where their persistent presence can drive chronic inflammation, tissue remodeling, and disease progression. ... Read more19186 -
MMP14 targeting natural antibodies to treat ovarian cancer (No. T4-2152)
MMP14 is a major antibody target on the tumor cell surface as it is highly expressed on tumor cells and plays a key role in cancer progression and metastasis. Natural occurring autoantibodies targeting MMP14 were isolated from ovarian cancer patients. ... Read more17825 -
Novel Combination Therapy For Improved Management of Depression (No. T4-2129)
Psychiatric disorders, especially major depressive disorder (MDD), are leading causes of disability and premature death across the globe, with patients showing a heightened risk of self-harm and suicidal ideation. Prof. ... Read more6097 -
Modulating Weight Gain and Loss by Understanding the Mechanism of Smoking Related Weight Changes (No. T4-2078)
A new approach to prevent weight gain during smoking cessation (SCWG) focuses on the gut microbiome and metabolites like dimethylglycine (DMG) and acetylglycine (ACG). ... Read more17357 -
Enhanced Anti-PD-L1 Immunotherapy (No. T4-2059)
A novel approach for enhancing the efficacy of PD-L1 targeting antibodies by harnessing beneficial FcγR signaling pathways. Strategy involves either (1) Co-administration of PD-L1 targeting antibodies with an FcγRIIB-blocking antibody or ... Read more17039
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