Results for technologies (139)
Advanced filter
Cyclic Capture of Atmospheric CO2 (No. T4-2433)
Reducing greenhouse gas emissions alone will not be enough to limit the impacts of climate change - active removal of CO₂ from the atmosphere is essential. CycCap addresses this need with a cyclic process in which a salt solution is electrochemically split into alkaline and acidic streams....
Read more
19247
RF Resonators for Strong Driving of Nuclear Spins (No. T4-2431)
An RF resonator designed for strong and fast driving of nuclear spins with applications in quantum sensing and microscopy. The resonator is a spiral structure composed of two metallic layers separated by an insulating material.
Integration in quantum sensing toolboxes for addressi...
Read more
19127
DYNAMIC VR-BASED MOTION BIO-FEEDBACK ALGORITHM FOR ACTIVE CLP EXPOSURE (No. T4-2420)
Current exposure-based therapies for PTSD, phobias, and ADHD lack personalization, real-time safety monitoring, and patient agency.
Treating ADHD with biofeedback during gamified training sessions
Treating PTSD with AI-assisted triggering environments that recreate the specific tr...
Read more
19198
Synthetic Antimicrobial Peptides for Selective and Potent Malaria Treatment (No. T4-2408)
Malaria remains a major global health challenge, with increasing resistance to current drugs and limited treatment options that selectively target infected red blood cells.
Applications
Selectively targets infected red blood cells while sparing naïve RBCs
Minimal hemol...
Read more
19146
Computationally Designed Peroxygenases for Selective Terpene Oxyfunctionalization (No. T4-2403)
Terpenes represent the largest class of secondary plant metabolites. Their oxyfunctionalized derivatives, terpenoids, are widely used in the pharmaceutical, flavor, and fragrance industries due to their aromatic properties.
Applications
High diversity: All 50 designed e...
Read more
19149
Early Detection of Liver Cirrhosis via Algorithmic Screening of EHR Data (No. T4-2392)
Liver cirrhosis often goes undiagnosed until advanced stages, despite being a major global health burden. This technology introduces a machine learning–based algorithm that analyzes routine blood tests from electronic health records (EHR) to predict cirrhosis risk up to five years in advan...
Read more
19219
mAb mouse anti-Amphiregulin clone AR37 (No. M7-2388)
The AR37 monoclonal antibody recognizes human and mouse amphiregulin (AREG), a member of the epidermal growth factor (EGF) family.
in vivo blocking of amphiregulin (AREG)in vitro blocking of amphiregulin (AREG)
Immunofluorescence
Western blot
ELISA
Lindzen et al, Oncog...
Read more
19341
Proteasome-Derived Defense Peptides (PDDPs) for Antimicrobial Therapy and Applications (No. T4-2372)
Proteasome-derived defense peptides (PDDPs) represent a novel class of antimicrobial peptides (AMPs) generated through proteasomal degradation. These peptides disrupt bacterial membranes and provide a cell-autonomous defense mechanism against infections.
Sepsis treatment – PDDPs...
Read more
19213
Modulo-Based High Dynamic Range ADC (No. T4-2371)
A novel analog-to-digital conversion pre-processor uses a modulo-based signal folding method to overcome the limited dynamic range of conventional ADCs. The folded signal is reconstructed using a dedicated unfolding algorithm, enabling precise signal recovery across a wide amplitude spectrum...
Read more
19237
High-Resolution Microbial Profiling Across Unexplored Niches Using CoSMIC (No. T4-2368)
Microbial profiling methods based on 16S rRNA sequencing are limited by primer bias, short-read coverage, and databases dominated by human-associated microbes. These limitations reduce phylogenetic resolution and hinder accurate species detection in underexplored environments.
Mic...
Read more
19210
A Multistate Memory Cell Based on Electrochromic Metallo-Organic Assemblies (No. T4-2360)
The pressing and ongoing demand to boost chip capacity while simultaneously reducing its size underscores the crucial importance of enhancing memory cell technology. In response to this need, we have innovated a conceptually new memory cell.
The drive towards miniaturization and e...
Read more
18973
Colloidal Synthesis of Micron-Scale Organic Crystalline Spherulites (No. T4-2334)
A controllable method for synthesizing organic, crystalline spherulites from compounds with guanine-based structures.
Paints and coatings
Food coloring
Cosmetics
Plastics
Ink and tattoo pigments
Supplements
Medicine
Toothpaste
Non-toxic
Biocompatible
Can be applied to ...
Read more
19076
Superconducting Quantum Memory with Tens of Milliseconds Coherence Time (No. T4-2333)
Quantum computing platforms based on superconducting qubits suffer from high error rates and short storage time of only a few milliseconds, limiting scalable computations.
Quantum memory modules in superconducting quantum computers based on Transmon, SNAIL, or Fluxonium qubits.
Pr...
Read more
Serge ROSENBLUM
Physics
19339
Polymerization-Inducing Chimeras (PINCH) for Selective Target Inactivation (No. T4-2323)
A novel modality for selectively inactivating homomeric proteins, common in disease-driving pathways, by inducing their polymerization.
Functional inactivation of disease-driving homomeric proteins (e.g., transcription factors, metabolic enzymes, scaffold-like proteins etc.)
Poten...
Read more
19253
Flexible Soft-Printed Synthetic and Bio-Polymer Films with Gold Nanoparticles (No. T4-2318)
A novel soft-printing method enables the precise deposition of gold nano-islands (AuNIs) onto flexible synthetic and bio-polymer films.
Cosmetic applications - illuminating masks, under-eye brighteners, blemish covers, and smart patches that visually signal treatment time or expos...
Read more
19243
Smart Energy Storage Devices with Visual Charge Monitoring (No. T4-2316)
The growing demand for energy devices that store and deliver power and offer additional functionalities, like instant performance monitoring, is evident.
Electrochromic (EC) materials change their optical transparency when voltage is applied. A particularly promising category of E...
Read more
18931
Sustainable Utilization of Ethane (No. T4-2279)
Aerobic oxidation is a chemical reaction in which hydrocarbons such as alkanes or alkenes are oxidized using oxygen as the oxidizing agent.
Saturated and unsaturated hydrocarbons, alkanes and alkenes, respectively, are primary chemicals found in natural gas and formed in petroleum...
Read more
18592
Stirring-Free Scalable Electrosynthesis Enabled by Alternating Current (No. T4-2268)
Electrochemical transformations are unfavorable while using conventional direct current (DC) electrosynthesis. The main reason is the interelectrode mass transfer, which serves as a major limiting factor for the overall efficiency and the process’s selectivity.
The vast majority...
Read more
18649
Pmel-1 TCR transduced cells (No. M7-2265)
This T-cell line, derived from the BWZ.36/CD8a thymoma of murine origin, was genetically engineered to express CD3 and a codon-optimized Pmel-1 T-cell receptor (TCR) through sequential retroviral transductions.
Bassan et al., Int J Cancer, 2019.
...
Read more
19345
Time-Encoding Sub-Nyquist ADC (No. T4-2258)
Modern ADCs must reduce cost and power consumption without compromising signal quality, particularly in power-sensitive systems such as wearables, IoT, and security devices. This technology introduces the first sub-Nyquist ADC based on an integrate-and-fire time encoding machine (IF-TEM).
...
Read more
19235
Sparsity Based Non-Contact Vital Signs Monitoring of Multiple People Via Radar (No. T4-2257)
Current contact-based monitoring devices cause patient discomfort, increase infection risks, and demand significant medical staff time.
Medical Monitoring: Heart rate, respiration, sleep apnea detection, lung function, cardiac diagnostics in hospitals, clinics, and homes.
Workplac...
Read more
18610
Nonlinear Waveform Inversion for Quantitative Ultrasound (No. T4-2254)
A Nonlinear Waveform Inversion (NWI) algorithm enhances ultrasound imaging by using Recurrent Neural Networks (RNNs) to reconstruct material properties from acquired signals.
Discerning between benign and malignant breast tumors
Identifying muscle loss and fatty muscular degenerat...
Read more
18751
Cell line mutant in the R2-box region of the R2 gene (No. M7-2251)
A CRISPR-Cas9–engineered cell line carrying a mutation in the R2-box region of the R2 gene (within the ERE-homologous 5′UTR) exhibits markedly reduced R2 transcript and protein levels.
...
Read more
19271
Nephrostomy Tube – A New Design to Decrease Dislodgement (No. T4-2230)
The existing nephrostomy tube design, widely used for kidney drainage, presents challenges related to accidental premature extraction, necessitating resource-intensive replacement.
Nephrostomy tubes are vital in managing short- and long-term medical conditions, including ureteral ...
Read more
Yaniv Shilo
18868
Anti importin beta1 monoclonal antibody (No. M7-2223)
A highly specific and sensitive anti-Importin b1 (KPNB1) monoclonal antibody. The mAb recognizes an epitope comprising residues 301-320 of human KPBN1 and is highly specific for cytoplasmic KPNB1 in diverse applications.
Importin b1 (KPNB1) is a nucleocytoplasmic transport factor...
Read more
17648
An Improved Single-Cell RNA-Sequencing Method (No. T4-2217)
Single-cell RNA sequencing (scRNA-seq) methods enable the detection of only 10%-15% of the cellular transcriptome, rendering low-expressing genes in the dark.
Applications
WRAP-seq is fully developed
TRAP-seq has a POC of several target genes, and is in validation stage...
Read more
18646
Hyperstable Serum Albumin Variants for Microbial Mass Production (No. T4-2216)
Serum albumins are widely used in medicine, biotechnology, and cultivated meat production. However, they are mostly extracted from animal sources, raising ethical, reproducibility, and scalability concerns.
Applications
Fast and economical
Large-scale production in E. c...
Read more
18682
Radiation Curing Enhancement by Semiconducting Nanoparticles (No. T4-2215)
The curing of polymers by UV light is of great technological importance in, for example, dentistry, advanced manufacturing (3D printing), and various applications such as manufacturing of optical media, biotechnology, and more.
Cationic photo-cured thermosetting polymers, like epo...
Read more
17678
High Throughput Screening Platform For Inhibitors of Viral Membrane Fusion (No. T4-2213)
Emerging and re-emerging enveloped viruses, such as SARS-CoV-2, influenza, Nipah, and Ebola, continue to pose serious global health threats, with limited treatment options.
High-throughput screening for viral membrane fusion inhibitors
Discovery of novel antivirals targeting SARS-...
Read more
18679
GFP variants (No. M7-2209)
A collection of GFP variants with improved/unique properties, such as increased thermostability, photostability, quantum yield, altered fluorescence lifetime, pH sensitivity, and excitation spectra.
The team led by Prof. Fleishman developed a machine-learning-based approach calle...
Read more
18032
OM-17 cell line (high grade serous ovarian carcinoma) (No. M7-2202)
A cell line originated from a patient diagnosed with high-grade serous ovarian carcinoma (HGSOC).
...
Read more
18314
Green Synthesis of Biocompatible Porous Nanostructured Silica-Composite (No. T4-2201)
Nanostructured silica is a promising material with remarkable properties, such as high porosity, biocompatibility, and stability.
Nanostructured silica is a group of materials composed of silica with a controllable, homogeneous, and functionalized nanosurface.
It was di...
Read more
18137
Enhancing Biofuel Production through Engineered Versatile Peroxidases (No. T4-2197)
The growing need for sustainable biofuel alternatives is challenged by the difficulty of breaking down lignin, a major component of plant biomass.
Applications
High expression yields in yeast
Enhanced enzyme stability under industrial conditions
Broad substrate specific...
Read more
18667
Super Resolution Vascular Ultrasound Imaging for Clinical Diagnostics (No. T4-2194)
An advanced deep-learning method for analyzing super-resolution Ultrasound Localization Microscopy (ULM) data to quickly and accurately reconstruct microvasculature structures, without needing prior knowledge of the system's characteristics.
Microvascular imaging using super-resol...
Read more
16721
Splicing ViT Features for Semantic Appearance Transfer (No. T4-2192)
Artificial intelligence (AI) solutions are vastly available for applications such as object segmentation, image detection, visual creation, writing assistance, and many more. There is a continuous quest to improve photograph editing software and existing AI systems.
The demand for...
Read more
18637
Ab289 (No. M7-2188)
The Anti-JUNV GP1 monoclonal antibody specifically recognizes the receptor-binding domain (GP1) of the Junín virus glycoprotein complex (GPC).
Borenstein-Katz A, Shulman A, Hamawi H, Leitner O, Diskin R. Differential Antibody-Based Immune Response against Isolated GP1 Receptor-Bi...
Read more
Aliza Borenstein Katz
Chemistry
19335
Zirconium Doped Ceria Electroceramic with a High Electrostriction Coefficient (No. T4-2180)
Electrostrictive materials can generate large movement under voltage, making them attractive for numerous applications.
Electrostrictors are applicable in every device where voltage-controlled movement is required.
Doping ceria with Zr can increase the electrostriction ...
Read more
18925
B16F10.9 Cell Line (No. M7-2179)
Spontaneous metastatic spread of melanoma after surgery of the primary tumor. immunization against melanoma metastasis
Relevance: A model to study melanoma metastasis in mice.
Melanoma metastatic spread, immunization against melanoma metastasis
Relevant disease: melanoma
Porgador ...
Read more
19329
Bispecific Immune Synapse Engagers as Immunotherapy for Oncology and Autoimmunity (No. T4-2176)
Dysfunctional immune circuits underlie many diseases, including cancer and autoimmunity. Current immunotherapies often target a single pathway or cell type, limiting their efficacy.
Treatment of anti-PD-1 refractory solid tumors, including breast, colorectal, lung, and melanoma ca...
Read more
19180
Novel Antibody Therapeutics Targeting Senescent Cells for Cancer and Fibrotic Disease Treatment (No. T4-2158)
Senescent cells play a dual role in cancer and fibrosis, where their persistent presence can drive chronic inflammation, tissue remodeling, and disease progression.
Development as ADCs, BiTEs, or bispecifics for targeted senescent cell elimination
Anti-cancer therapy targeting res...
Read more
19186
MMP14 targeting natural antibodies to treat ovarian cancer (No. T4-2152)
MMP14 is a major antibody target on the tumor cell surface as it is highly expressed on tumor cells and plays a key role in cancer progression and metastasis. Natural occurring autoantibodies targeting MMP14 were isolated from ovarian cancer patients.
Monoclonal antibody therapy...
Read more
17825
Diagnosis and Treatment of Breast Cancer based on Extracellular Vesicles (No. T4-2145)
Early detection of breast cancer (BC) and monitoring its progression, treatment response, and recurrence are crucial for survival.
Early detection of BC is crucial for successful therapy and survival. Currently, screening commonly relies on mammography, ultrasound, and magnetic re...
Read more
16676
Novel Combination Therapy For Improved Management of Depression (No. T4-2129)
A novel combination therapy pairing ketamine with retigabine, an FDA-approved KCNQ channel activator, offers a promising strategy for mood-related disorders.
Potential to expand treatment opportunities for patients with treatment-resistant depression (TRD) unresponsive to existing...
Read more
6097
Reusable Gold Nanostars Substrates for Signal Amplification for Diagnostics (No. T4-2127)
Numerous spectroscopic techniques rely on signal enhancement from nanoparticles linked to analyte molecules. However, existing surface-enhanced spectroscopies (SES) typically use nanoparticles dispersed in solution, making them unsuitable for solid substrates.
Signal amplification...
Read more
12950
A Method for Vitamin D Production (No. T4-2086)
A sustainable method to produce vegan Vitamin D using the microalga Emiliania huxleyi. This approach enables efficient production of both Vitamin D2 and Vitamin D3, along with additional nutritional values, in a dry biomass form suitable for nutritional supplements.
Nutritional Su...
Read more
18442
Modulating Weight Gain and Loss by Understanding the Mechanism of Smoking Related Weight Changes (No. T4-2078)
A new approach to prevent weight gain during smoking cessation (SCWG) focuses on the gut microbiome and metabolites like dimethylglycine (DMG) and acetylglycine (ACG).
Modalities for Weight Management: Development of treatments targeting these metabolites to aid in weight loss.
...
Read more
17357
Enhanced Anti-PD-L1 Immunotherapy (No. T4-2059)
A novel approach for enhancing the efficacy of PD-L1 targeting antibodies by harnessing beneficial FcγR signaling pathways.
Strategy involves either
(1) Co-administration of PD-L1 targeting antibodies with an FcγRIIB-blocking antibody or
Enhanced anti-PD-L1 therapy for cancer tr...
Read more
17039
Peptides for Treating Alzheimer's Disease (No. T4-2057)
Alzheimer's Disease (AD) is an age-associated neurodegenerative disorder characterized clinically by a decline in cognitive function. It is the most common type of dementia, with 5.8 million Americans living with AS in 2020.
Alzheimer's disease (AD) is an age-associated, irreversi...
Read more
6160
Spin Current and Magnetoresistance from the Orbital Hall Effect (No. T4-2053)
An innovative method to generate spin current and magnetoresistance by leveraging the Orbital Hall Effect (OHE). This approach utilizes ordinary metals like Aluminum and Copper, combined with a thin layer of heavy metal to convert orbital currents into spin currents.
Magnetic fiel...
Read more
18700
YotiCurl Ureteral Stent (No. T4-2052)
Ureteral/kidney stones are a very common disease, affecting millions. In some cases, the stones may cause an obstruction that requires inserting a single-use ureteral stent to maintain urine flow.
Ureteral/kidney stones are a frequent disease estimated to affect between 10-15% of ...
Read more
18871
Coupling of Alternating Current to Transition – Metal Catalysis (No. T4-2050)
The coupling of transition-metal to photoredox catalytic cycles through single-electron transfer steps has become a powerful tool in the development of catalytic processes.
Transition-metal catalysis is one of the most common forms of catalysis. However, the number of possible tra...
Read more
18308
Covalent Chemistry Platform for Diagnostics and Drug Discovery (No. T4-2045)
CoLDR (Covalent Ligand-Directed Release) chemistry enables site-specific covalent labeling and activation of endogenous proteins using small-molecule covalent ligands.
Targeted prodrug activation in cancer and inflammatory diseases
Drug and probe delivery with selective activation...
Read more
6106
Protein coupling using cystein-free inteins (No. T4-2039)
Traceless covalent modification of proteins, including joining peptides or adding chemical groups, is extremely useful for numerous applications in chemical biology, protein chemistry, and biotechnology.
Modifying or joining proteins with other proteins/ peptides/chemical groups i...
Read more
6862
Cell-free microRNA as a Prognostic Biomarker for Amyotrophic Lateral Sclerosis (ALS) (No. T4-2038)
ALS is a severe neurodegenerative disorder with no cure and highly variable disease progression, which complicates clinical trial design and therapeutic development.
Prognostic tool – Predicts disease progression in ALS patients
Clinical trial optimization by patient stratificat...
Read more
6115
Frontotemporal Dementia Diagnosis Using Circulating microRNA Biomarkers (No. T4-2037)
Frontotemporal dementia (FTD) is difficult to diagnose due to overlapping symptoms with other neurodegenerative disorders, often leading to delays in treatment and clinical trial enrollment.
Early and accurate FTD diagnosis – Reduces misdiagnosis and diagnostic delays
Clinical t...
Read more
6082
Scarless CRISPR-mediated Genome Editing (No. T4-2036)
CRISPR-Cas9 is a widely-used tool for genome editing; however, it is very inefficient and often requires the addition of selection markers, forcing the introduction of foreign DNA elements.
CRISPR-Cas9 method, while promising, is currently inherently inefficient and requires selec...
Read more
6112
Safer CAR-T Cell Platform (No. T4-2033)
Chimeric Antigen Receptor (CAR)-T Cell Therapy is a personalized treatment for cancer in which the patient's T cells are genetically engineered to express a synthetic receptor that binds a tumor antigen.
CAR-T Cell Therapy is a cutting-edge immunotherapy modality with a global mar...
Read more
6124
Cell Surface Modification with Synthetic Receptors (No. T4-1961)
Technologies that target cells or modify their behavior are of great interest to improve diagnostic, therapeutic, and imaging platforms.
Cell surface proteins are key mediators of cell responses to changing environments. They are naturally regulated by dynamic structure, expressio...
Read more
7150
Carbon Nanotubes - Polymer Composites for Improved Mechanical and Electrical Properties (No. T4-1953)
The superior mechanical and electrical properties of carbon nanotubes (CNTs) are uniquely advantageous for enhancing polymer composites' mechanical and electrical properties. However, CNTs usually heavily bundle.
Markets continuously search for stronger, more durable, lightweight,...
Read more
18922
Small Molecules for Treatment of Huntington's Disease and Related Disorders (No. T4-1947)
A new class of small molecules offers a targeted strategy for treating Huntington’s disease (HD) and related trinucleotide repeat expansion disorders (TREDs).
Treatment of Huntington’s Disease (HD)
Potential treatment of other TREDs, including: Spinocerebellar Ataxias 1, 2, 3 ...
Read more
6193
Treatment for Drug-Resistant Non-Small Cell Lung Cancer (No. T4-1944)
Non-Small Cell Lung Cancer (NSCLC) is a very common type of cancer, and despite currently available therapies, is one of the deadliest due to the emergence of drug resistance, which results in tumor recurrence.
Lung cancer is one of the most deadly and common types of cancer in th...
Read more
6025
Artificial Pancreas (No. T4-1942)
The alarmingly sharp increase in type 1 diabetes mellitus incidence in recent years has been coupled with a marked rise in the development of closed-loop systems aimed at continuously monitoring blood glucose levels, predicting glucose behavior and delivering adjusted insulin doses.
...
Read more
5752
New Antiviral Drugs from Bacterial Natural Products (No. T4-1934)
There is a growing need for effective antiviral therapies, particularly for viruses that currently lack approved treatments.
Treatment of viral infections with no currently approved antiviral therapies
Development of broad-spectrum antiviral drugs
Nucleotide chain term...
Read more
12514
Higher Efficiency of CRISPR Gene Editing Using Chimeric Cas9 (No. T4-1930)
CRISPR-Cas9 is a powerful tool for genome editing, widely used for basic research and the development of treatments for genetic diseases. However, its efficiency is currently limited.
Gene therapy applications
Basic science research
Simple implementation – requires o...
Read more
6024
Novel TCRs against mutated KRAS, NRAS, and androgen receptor, and neoantigens identification platform (No. T4-1926)
Immunotherapy can induce durable tumor regression in patients with metastatic cancer, largely driven by the immune system’s recognition of tumor-specific neoantigens.
Discovery and validation of TCRs against common immunogenic neoantigens
Off-the-shelf TCR cell therapy for cance...
Read more
19192
Anti-LOX for the Treatment of Duchenne, Fibrosis and Cancer (No. T4-1913)
LOX is a key driver of fibrosis and tumor progression through its role in extracellular matrix remodeling. We developed a set of LOX inhibitors based on LOX’s natural prodomain (LPD) to treat fibrosis, Duchenne Muscular Dystrophy (DMD), and cancer.
Treatment of fibrotic disease...
Read more
6026
Iron Catalyzed Ring-Opening Metathesis Polymerization (ROMP) (No. T4-1905)
The olefin metathesis reaction is among the most important catalytic carbon-carbon double bond formation reactions. The most widely used catalysts for this reaction are Mo- and Ru- carbene complexes which are expensive and toxic 1.
Mo- and Ru-carbene catalysts are the most common ...
Read more
6199
Inorganic Nanotubes/Polymer Composites for 3D Printing (No. T4-1900)
Biocompatible polymers commonly used in the orthopedic and cosmetic prosthetics, cardiovascular and dental implants and food packaging industries often suffer from poor mechanical properties and thermal stability, limited dimensionality and short shelf-life as compared to their metal compara...
Read more
5737
GreenTap - A Method for Stimulating Production and Extraction of Metabolites in Plants (No. T4-1894)
A method for inducing and extracting valuable plant metabolites without damaging the plant or interfereing with compound formation.
Production of Bioactive Compounds: Increases yield of plant metabolites used in pharmaceuticals, food, and cosmetics.
Novel Metabolite Discovery: Pro...
Read more
6029
A Sustainable Process for Phenol Production (No. T4-1892)
Phenol is an important industrial commodity used as a precursor to many useful compounds.
The cumene hydroperoxide process, which is the most commonly used phenol production process nowadays, is both complicated, with low per pass cumene conversion and is producing acetone as a by...
Read more
5728
Universal CAR-Ts for Treating Cancer (No. T4-1884)
Chimeric Antigen Receptor T-Cells (CAR-Ts) are one of the revolutionary technologies of the twenty-first century, invented by Prof. Zelig Eshhar at the Weizmann Institute of Science.
The group of Prof. Eshhar has developed a method for an adoptive cell therapy, such that cells fro...
Read more
Zelig Eshhar
Biology
5722
Optical Bus for a Multi-Core Processor (No. T4-1863)
A compact on-chip optical layer that replaces traditional wiring in multi-core processors using silicon photonics. This innovative approach significantly reduces power consumption, heat generation, and space requirements, enabling higher core densities and improved inter-core communication.
...
Read more
5704
Super-Resolution Using Unsupervised Deep Internal Network (No. T4-1850)
Optical and dimensional limitations of images can be partially overcome today using signal enhancement technologies which typically rely on supervised, deep-learning methods.
Signal enhancement of corrupted input collected under suboptimal conditions, poses multiple challenges, in...
Read more
5701
Composite Functional Metasurfaces for Multispectral Achromatic Optics (No. T4-1845)
A new technology for producing flat optical components based on optical metasurfaces. These components can potentially serve high resolution imaging, spectrometry, light processing and beam shaping devices.
The proposed technology can be used to generate a wide variety of novel ...
Read more
5689
Secure Search of Encrypted Cloud Data (No. T4-1840)
Searchable symmetric encryption with practical big-data performance and strong security
Highlights
...
Read more
5683
Highly Selective Fluorescent Biosensor for Labeling His-Tagged Proteins in a Specific Conformation (No. T4-1834)
A rapid, label-free biosensor for detecting specific conformation of His-tag labeled proteins, accessible for use in both academic- and commercial-R&D was invented at the Weizmann Institute of Science.
The biosensor presented here is comprised from three main molecular-compone...
Read more
5677
A Method to Identify Actively Degraded Proteins (No. T4-1832)
MAPP (Mass Spectrometry Analysis of Proteolytic Peptides) is a groundbreaking technology that isolates and identifies proteins actively degraded by the proteasome, offering an unparalleled and direct view of the "active degradome." This innovative approach provides a sensitive an
...
Read more
6030
Inertial NEMS for Nanosensor Applications Based on Inorganic Nanotubes (No. T4-1828)
Inertial sensors for motion detection are being incorporated into an increasing number of portable devices, including diverse IoT applications, mobile phones, wearable electronics, automotive systems and medical diagnostic sensors.
Current microelectromechanical system (MEMS) fabr...
Read more
5674
Homogeneous Dispersion of CNT Composites for Improved Conductivity, Bucky Papers (No. T4-1809)
Battery and capacitor electrode technologies available in the industry today, are struggling to keep up with rapidly advancing applications that require high power and energy density such as electric vehicles, solar cells and telecommunications systems.
The growing need to provide...
Read more
5662
Microbiome-Based Prediction, Diagnosis, and Treatment of Relapsing Obesity (No. T4-1805)
A novel gut microbiome-based method has been developed to predict and prevent weight regain after weight loss.
Predictive Diagnostic Tool: Provides a microbiome-based test to identify individuals at high risk of post-diet weight regain.
Personalized Approach: Uses a mac...
Read more
5659
Treating Drug-Resistant Lung Cancer Using a Combination of Antibodies (No. T4-1774)
A novel method to treat tyrosine kinase inhibitor (TKI) resistant cancer by using a combination of three antibodies that target EGFR (ERBB1), HER2 (ERBB2), and HER3 (ERBB3) receptors.
The ErbB/HER family of receptor tyrosine kinases includes epidermal growth factor receptor (EGFR...
Read more
5635
Multimodel Transcranial Optical Vascular Assessment (No. T4-1769)
Subdural hematoma (SDH) is a common neurosurgical condition that requires continuous monitoring, which current imaging methods fail to provide.
Continuous monitoring of SDH during hospital stays and post-discharge
SDH detection and monitoring in ambulances and urgent care settings...
Read more
Alon Harmelin
Office of the President
5629
Structure-Guided Antibiotic Discovery Platform for MRSA (No. T4-1760)
Antibiotic-resistant bacteria such as Staphylococcus aureus (MRSA) are a growing threat, causing severe infections that are increasingly untreatable by existing drugs. This technology provides a high-resolution crystal structure of the large ribosomal subunit (50S) from pathogenic S.
...
Read more
19255
Carbon fixing bacteria (No. T4-1736)
A bacteria (E. coli) engineered to fix atmospheric CO₂, converting it into organic biomass.
Potential Precision Fermentation Platform: A modular platform for producing various chemicals with net negative CO₂ emissions by integrating synthetic metabolic pathways.
Sus...
Read more
5608
Green Chemistry for Ketones and Aldehydes Production (No. T4-1722)
Our technology provides a new type of oxidative cleavage reaction of organic compounds with highly selective product formation.
The realization that many processes practiced on a large scale were detrimental to the environment led to a movement of reshaping the science of organic ...
Read more
5596
Highly Selective Optical Biosensors for Proteins in Biological Samples, with Excellent Signal-to-Noise Ratio (No. T4-1689)
Sensing the levels of protein-based biomarkers in biological samples is crucial for diagnosis of various diseases including cancer.
Applications
Detection of proteins in biological samples for medical diagnostics
Fluorescent detection of His-tag or GST labeled proteins for imaging...
Read more
5587
Preventing Infections Using Lipid Based Molecules (No. T4-1673)
Sphingosine (SPH), a natural bactericidal agent which acts as a part of the human innate immune system in the skin, was found to be an effective treatment and prophylaxis for bacterial lung infections in cystic fibrosis (CF) mice.
Cystic fibrosis (CF) is caused by mutations in the...
Read more
5584
Magnetic resonance imaging (MRI) Of Tissue Fibrosis without Contrast Agent (No. T4-1665)
Cardiac fibrosis, a scarring process that impairs cardiac function and increases the risk of sudden death, remains difficult to detect at early stages with current imaging tools.
Early and non-invasive detection of myocardial fibrosis in hypertensive, diabetic, or post-infarction ...
Read more
5575
Optimized MAGE-A1 targeting TCR for T-cell Therapy (No. T4-1662)
TCR gene therapies show promise in cancer treatment but are hindered by the low natural avidity of TCRs against tumor-associated antigens. MAGE-A1 is a germline antigen expressed in many tumor types, making it a compelling target for TCR-based immunotherapy.
Cell therapy for MAGE-...
Read more
5572
Repurposing Enoxacin: A Novel Therapeutic Strategy Targeting miRNA Biogenesis in ALS (No. T4-1632)
A novel therapeutic strategy for Amyotrophic Lateral Sclerosis (ALS) targets impaired microRNA (miRNA) biogenesis—a key molecular defect found in both sporadic and familial ALS.
Treatment of ALS
Repurposes an FDA-approved drug, reducing development time and regulato...
Read more
18887
Targeted Inhibition of ADAM17 for the Treatment of Inflammatory Diseases and Cancer (No. T4-1628)
ADAM17 is a metalloprotease that regulates shedding of membrane-bound proteins, including IL-6, TNF-α, and others. ADAM17 is implicated in inflammatory diseases, fibrosis, cancer, and autoimmune conditions, making it a compelling target.
Treatment of autoimmune, inflammatory and ...
Read more
5551
Novel MRI Contrast Agent (No. T4-1604)
Novel reporter gene for magnetic resonance imaging applications.The ability to image the duration and location of gene expression in vivo and noninvasively is imperative for the future of biology and clinical medicine.
Non-invasive imaging of gene expression in transgenic mice mod...
Read more
5545
A Novel Database to Reduce Unsuccessful Cloning in E. Coli by Detection of Toxic Genes (No. M7-1576)
Synthetic genes are commonly used in academic and industrial applications, however in many cases these said genes can be toxic when inserted into the ubiquitously used E. coli. This is problematic as time and money is wasted on attempts to generate genes that will not function in E. coli.
...
Read more
5530
Inorganic Fullerene Coating For Medical Devices (No. T4-1566)
Implantable or insertable medical devices must be made of materials with unique properties in addition to biocompatibility to address potential damage from the physiological environment and to maintain their effectiveness over time.
Implantable or insertable medical devices must b...
Read more
5521
Green Catalytic Formation of Alcohols, Amines, Amides, Imines and Esters under Mild Conditions (No. T4-1551)
In recent years, complexes based on cooperating ligands have exhibited remarkable catalytic activity. These ligands can cooperate with the metal center by undergoing reversible structural
changes in the processes of substrate activation and product formation.
Amines, alcohols, am...
Read more
5512
Production of Amines from Alcohol and Ammonia (No. T4-1507)
Current methods for synthesizing primary amines require high energy input, toxic reagents, and result in undesired byproducts. This technology offers a direct, single-step catalytic process using alcohols and ammonia under mild conditions.
Industrial synthesis of primary amines fo...
Read more
5494
Highly Sensitive Nanoscale Scanning Magnetic and Thermal Sensor (No. T4-1481)
A nanoscale Superconducting Quantum Interference Device (SQUID) on Tip (SOT) that enables high spatial, magnetic, and thermal resolution for local imaging.
Scanning Probe Microscope
Cryogenic Thermal Imaging (mK Temperatures)
Metrology Tools for Quantum Circuits
Imaging of Electri...
Read more
5482
High-Performance Electrochromic Devices (No. T4-1380)
High-performance electrochromic materials that exhibit a practical combination of low-voltage operation and efficient color-switching, as well as long-term stability have been developed by the group of Prof. van der Boom.
The trends towards energy efficiency, comfort and privacy a...
Read more
5458
Mouse IgE and Anti-Mouse IgE Monoclonal Antibodies (No. M7-1270)
Monoclonal antibodies to IgE Description: Rat monoclonal anti-IgE antibodies that was generated by fusion of plasmacytoma (84.1C) or myeloma (EM953) cells with splenocytes of rat immunized with purified murine IgE mAb.
...
Read more
Zelig Eshhar
Biology
5452
Cholesterol Antibodies (No. T4-1267)
Description: Monoclonal antibodies specific for cholesterol/ceramide-rich domains (clones 405F, 14F, 499F) and cholesterol micro-domains (clones 36A1, 5881) in cell membranes. Originally raised against an artificial monolayer of lipid mixtures in, and were shown to specifically label the ab...
Read more
5449
Blood Test to Identify People at High Risk for Lung Cancer (No. T4-1033)
A novel diagnostic test to identify individuals with increased risk of lung cancer
Lung cancer is the number one killer among cancers, with 160,000 deaths/year in the USA and 1.6 million/year worldwide. Early detection of lung cancer increases 5-year survival rate from 4% to 54%....
Read more
5428
Polyclonal anti human MUC2-D3 (No. M7-442)
A rabbit polyclonal antibody that detects D3 domain of Mucin-2. It targets an epitope within D3
domain from the N-terminal half, which is localized in amino acids 858-1259.
Javitt, G., et. al. (2020). Cell.183(3): 717-729).
...
Read more
Tal Ilani
Faculty of Chemistry
19323
Anti - gp100 T - cell Secreting Hybridoma [BUSA14 cell line] (No. M7-397)
Hybridoma cell line [clone BUSA14] which generates lacZ inducible CD8+ T -cells capable of recognizing both human and mouse gp100(25-33) melanoma antigens presented on dendritic and tumor cell lines.
Cafri G, Sharbi-Yunger A, Tzehoval E, Eisenbach L. Production of LacZ Inducible T...
Read more
Adi Sharbi-Yunger
Biology
Gal Cafri
Esther Tzehoval
Faculty of Biology
19317
Cntnap2 Tlacz/Tlacz Mice (No. M7-394)
Jax Strain #:028635
Cntnap2tlacz/tlacz knockin/knockout mice have a tau-LacZ gene and a neo cassette replacing exon 1 of the Cntnap2 gene. These mice may be useful for studying neuronal circuitry involved in some neurological disorders.
Gordon A , et al. Mol Cell Neurosci, 2016
...
Read more
19301
Immortalized Prostate Cell Cultures PF179T-Prostate Fibroblasts h-TERT Immortalized Cells (No. M7-375)
Recent studies have established the notion that fibroblasts are prominent modifiers of cancer progression, with a specific subpopulation designated as cancer-associated fibroblasts (CAFs) that play a key role in promoting tumor initiation and progression.
Madar S, Bro...
Read more
19319
Immortalized Prostate Cell Cultures EP156T-Epithelial Prostate h-TERT Immortalized Cells (No. M7-373)
EP156 cells were derived from a radical prostatectomy specimen of a 66-year-old patient. Pathologic tumor stage was pT3a, Gleason score 7 (4 + 3). The specimen had a positive margin, meaning that the tumor extended the prostate capsule. Seminal vesicles were tumor-free.
...
Read more
19309
Escherichia coli UTL2 (No. M7-358)
Escherichia coli UTL2 Description: A "leaky" strain of E. coli, which is significantly more susceptible to cytotoxic agents. UTL2 holds a mutation in the galU gene causing an impaired outer membrane.
...
Read more
5425
CNTNAP2 Knock Out Mouse Model for Human Diseases (No. M7-330)
Jax Stock # 017482
Cntnap2 (contactin-associated protein-like 2) knockout mice lack detectable mRNA or protein expression in brain tissue and serve as a robust model for Cortical Dysplasia-Focal Epilepsy Syndrome and autism spectrum disorders (ASD).
Poliak S , et al. 2003, J Cell...
Read more
19273
Anti-Mast cell Function-associated Antigen (MAFA) monoclonal antibody (No. M7-320)
320 - Monoclonal antibody G63 Description: Monoclonal antibodies to MAFA (Mast cell Function-associated Antigen), originally raised against intact rat RBL-2H3 cells.
...
Read more
5422
Anti-Runx-3 monoclonal antibody (No. M7-306)
Monoclonal antibody to Runx-3 Description: Monoclonal antibody to Runx-3 raised against the Runx3 peptide TPSTPSPRGSLSTTSHF. Available clones: 62, H8.
...
Read more
5416
HyBNAR Mice: A Humanized Model for Studying Type I Interferons (No. M7-297)
Transgenic “HyBNAR” mice express humanized type I interferon receptors (IFNARs), enabling in vivo studies of human type I interferons (Hu-IFN-Is) in a murine model.
Harari et al, PLOS ONE, 2014
...
Read more
19229
CX3CR1-Cre ER Mice (No. M7-293)
Cx3cr1CreER knock-in/knock-out mice express tamoxifen-inducible Cre recombinase under the direction of the Cx3cr1 promoter in the mononuclear phagocyte system, making them useful for fate-mapping studies of the monocyte and macrophage compartment, as well as microglia.
Yona S , et...
Read more
19265
CX3CR1-Cre Mice (No. M7-292)
Cx3cr1-Cre mice express Cre recombinase under the direction of the Cx3cr1 promoter in the mononuclear phagocyte system, making them useful for fate-mapping studies of the monocyte and macrophage compartments, as well as microglia. These mice do not express endogenous Cx3cr1.
Yona ...
Read more
19263
Anti-Estrone-3-Glucuronide monoclonal antibody (clones: 155B3, 8A3) (No. M7-276)
Monoclonal antibodies raised against estrone-3-glucuronide-BSA. Available clones: 8A3 (Rat, IgG2a), 155B3. Estrone-glucuronide is the dominant metabolite of estradiol. Used as one reference method for determining ovulation.
Monitoring ovarian function by the simultaneous t...
Read more
5413
Anti-Estrone-3-Glucuronide monoclonal antibody (No. M7-275)
Monoclonal antibodies raised against estrone-3-glucuronide-BSA. Available clones: 8A3 (Rat, IgG2a). Estrone-glucuronide is the dominant metabolite of estradiol. Used as one reference method for determining ovulation.
Monitoring ovarian function by the simultaneous time-resolved fl...
Read more
5410
Anti- estrone-3- glucuronide monoclonal antibody (No. M7-273)
Betatypic anti-idiotypic antibody raised against anti- estrone-3- glucuronide (clone 8A3). Available clone: 7C1.
Monitoring ovarian function by the simultaneous time-resolved fluorescence immunoassay of two urinary steroid metabolites.
Barnard G, Kohen F.Clin Chem. 1998 J...
Read more
5404
499F (No. M7-265)
Monoclonal antibodies specific to cholesterol/ceramide mixture
Description: Monoclonal antibodies specific for cholesterol/ceramide-rich domains (clones 405F, 14F, 499F) and cholesterol micro-domains (clones 36A1, 5881) in cell membranes.
...
Read more
Luana Scheffer
Chemistry
5401
Monoclonal Antibodies Specific to Cholesterol/Ceramide Mixture Clone (No. M7-263)
Originally raised against an artificial monolayer of lipid mixtures in, and were shown to specifically label the above domains in different cell membranes. Reference: Scheffer L, Futerman AH, Addadi L. 2007. Antibody labeling of cholesterol/ceramide ordered domains in cell membranes.
...
Read more
Luana Scheffer
Chemistry
5398
Monoclonal Anti-Caspr Antibody (Mab#275) (No. M7-259)
259 - Monoclonal antibody to Caspr Description: Monoclonal antibody to Caspr (Mab275), raised against the extracellular domain of Caspr.
...
Read more
5392
Monoclonal Anti-Ermin Antibody (Mab#160) (No. M7-258)
258 - Monoclonal antibody to Ermin Description: Monoclonal antibody to Ermin (MAb160) raised against purified GST–Ermin (residues 1–261).
...
Read more
Damian Brockschnieder
5389
Monoclonal Anti-Gliomedin Antibody (Mab#94) (No. M7-257)
257 - Monoclonal antibody to Gliomedin Description: Monoclonal antibody to Gliomedin (MAb 94) raised against a synthetic peptide corresponding to amino acid residues 273–287 (CVIPNDDTLVGRA), present in the extra cellular region of Rat Gliomedin.
...
Read more
5386
Anti-IgE monoclonal antibody (No. M7-185)
Monoclonal antibodies to IgE Description: Rat monoclonal anti-IgE antibodies that was generated by fusion of plasmacytoma (84.1C) or myeloma (EM953) cells with splenocytes of rat immunized with purified murine IgE mAb.
...
Read more
Michal Baniash
Zelig Eshhar
Biology
Tova Waks
Faculty of Biology
5365
Anti-Phospho-ERK (PY193 or PT115) Monoclonal Antibodies (No. M7-176)
176-177 - Monoclonal antibodies to phospho-ERK/Map Kinase Description: Monoclonal antibodies raised against peptides containing the 11 amino acids, HTGFLTEYVAT, corresponding to the ERK activation loop either Tyr -phosphorylated (ERK-PY193), or Thr-phos
...
Read more
5356
Clone - 1E11 (No. M7-148)
Monoclonal antibodies for peptide and steroid hormones Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics.
...
Read more
5350
Anti-Human chorionic gonadotropin (hCG) monoclonal antibody (No. M7-147)
Monoclonal antibodies raised against bhCG. Available clones: 1D5 (IgG1) .Human chorionic gonadotropin (hCG) is a hormone produced by the syncytiotrophoblast, a component of the fertilized egg, after conception.
...
Read more
5347
Clone 1E11 Progesterone (No. M7-146)
Anti-progesterone. Monoclonal antibody raised against position 11 of progesterone (Clone 1E11). It is very specific for progesterone.Progesterone is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
...
Read more
9580
Anti-oestradiol-6-carboxymethyl oxime monoclonal antibody (No. M7-141)
Monoclonal antibodies to estradiol Description: Monoclonal antibodies raised against oestradiol-6-carboxymethyl oxime-BSA. Available clones: 2F9 (Rat, IgG2a), 15 (IgG2b), 8D9 (IgG2a).
Direct chemiluminescence immunoassay for estradiol in serum. De Boever J, Kohen F, Usanachitt C, ...
Read more
5335
Anti-progesterone-7 monoclonal antibody (No. M7-138)
Monoclonal antibodies raised against position 7 of progesterone (clone 2H4), Rat IgG1. Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food produc...
Read more
5332
Human T3N1M1 prostatic adenocarcinoma tissue for xenograft (No. M7-132)
WISH-PC frozen tissue samples
...
Read more
Zelig Eshhar
Biology
5329
Anti-idiotypic antibody against anti-Sulfamethazine (12E12) (No. M7-130)
Betatypic anti-idiotypic antibody raised against anti Sulfamethazine –KLH (clone 21C7). Available clone: 12E12.
Generation of an anti-idiotypic antibody as a surrogate ligand for sulfamethazine in immunoassay procedures/
...
Read more
5326
Anti-testosterone 3-(0- carboxymethyl)oxime-BSA monoclonal antibody (No. M7-119)
Rat monoclonal antibodies raised against testosterone 3-(0- carboxymethyl)oxime-BSA. Available clones: 5F2, 5A4.Testosterone is the principal male sex hormone and an anabolic steroid.
Preparation of monoclonal antibodies able to discriminate between testosterone and 5 alpha-dihydr...
Read more
5317
Anti-Biotin Antibody (No. M7-116)
Monoclonal anti-biotin antibody (clone F1). Very specific for biotin.
Preparation and properties of anti-biotin antibodies.
...
Read more
5308
Anti-Sulfamethazine monoclonal antibody (No. M7-115)
Monoclonal antibody to Sulfamethazine (SMZ) Description: Rat monoclonal antibodies raised against Sulfamethazine-BSA. Available clone: 21C7, IgG1. Sulfamethazine is an antibacterial agents commonly given to food animals (swine, fishetc.) to prevent disease and maximize production.
...
Read more
5305
An endothelial-adipose cell line derived from a murine bone marrow stroma (14F1.1) (No. M7-103)
103 - Bone marrow derived stroma cell line 14F1.1
Description: An endothelial-adipose cell line derived from a murine bone marrow stroma.
...
Read more
5302
LTC4 (6E7) (No. M7-101)
Rat monoclonal antibodies raised against Leukotriene C4-KLH. Available clone: 6E7 (IgG1). Cysteinyl leukotrienes are potent lipid mediators in inflammation, inducing smooth muscle contractions and increased capillary permeability.
...
Read more
5299
Innovative Pulsed Magnetic Field Gradient Technique for Enhanced Nanoscale MRI (No. T4-2452)
A switchable magnetic field gradient on a tip designed to significantly enhance nanoscale MRI resolution and sensitivity achieved in modern nanoMRI sensors, which use permanent magnets.
Applications
Simple and robust fabrication
Short measurement time and enhanced effic...
Read more
19163
Baffinity B-probe: Cell-Surface-Biomarkers Detection Platform (No. T4-2487)
Accurate detection of minimal residual disease (MRD) is critical for predicting relapse in hematological cancers. However, current diagnostic tools often fail when therapeutic antibodies mask target markers, leading to false negatives.
Detection of MRD markers in blood samples fro...
Read more
19239
360° Rotating Field Transcranial Magnetic Stimulation (rfTMS) (No. T4-2472)
Transcranial magnetic stimulation (TMS) is an FDA-approved, non-invasive treatment for depression, OCD, and migraines. However, its efficacy is limited by the fixed directional orientation of standard TMS, which only stimulates axons aligned with the field.
Treatment-resistant dep...
Read more
19251