Malaria remains a major global health challenge, with increasing resistance to current drugs and limited treatment options that selectively target infected red blood cells. ... Read more

Proteasome-derived defense peptides (PDDPs) represent a novel class of antimicrobial peptides (AMPs) generated through proteasomal degradation. These peptides disrupt bacterial membranes and provide a cell-autonomous defense mechanism against infections. ... Read more

A novel modality for selectively inactivating homomeric proteins, common in disease-driving pathways, by inducing their polymerization. ... Read more

Malaria, caused by Plasmodium falciparum, remains a leading global health burden with growing drug resistance threatening current therapies. ... Read more

Serum albumins are widely used in medicine, biotechnology, and cultivated meat production. However, they are mostly extracted from animal sources, raising ethical, reproducibility, and scalability concerns. ... Read more

Emerging and re-emerging enveloped viruses, such as SARS-CoV-2, influenza, Nipah, and Ebola, continue to pose serious global health threats, with limited treatment options. ... Read more

Bacterial and plant immune systems rely on Toll/Interleukin-1 receptor (TIR) domains to detect pathogens and initiate defense responses through immune signals comprising isomers of cyclic ADP-ribose. ... Read more

Dysfunctional immune circuits underlie many diseases, including cancer and autoimmunity. Current immunotherapies often target a single pathway or cell type, limiting their efficacy. ... Read more

Senescent cells play a dual role in cancer and fibrosis, where their persistent presence can drive chronic inflammation, tissue remodeling, and disease progression. ... Read more

MMP14 is a major antibody target on the tumor cell surface as it is highly expressed on tumor cells and plays a key role in cancer progression and metastasis. Natural occurring autoantibodies targeting MMP14 were isolated from ovarian cancer patients. ... Read more