TCR gene therapies show promise in cancer treatment but are hindered by the low natural avidity of TCRs against tumor-associated antigens. MAGE-A1 is a germline antigen expressed in many tumor types, making it a compelling target for TCR-based immunotherapy. ... Read more

A novel therapeutic strategy for Amyotrophic Lateral Sclerosis (ALS) targets impaired microRNA (miRNA) biogenesis—a key molecular defect found in both sporadic and familial ALS. ... Read more

ADAM17 is a metalloprotease that regulates shedding of membrane-bound proteins, including IL-6, TNF-α, and others. ADAM17 is implicated in inflammatory diseases, fibrosis, cancer, and autoimmune conditions, making it a compelling target. ... Read more

Lung cancer patients treated with the blockbuster drug Osimertinib (Tagrisso) eventually develop resistance. We identified a novel MERTK-dependent escape mechanism, that occurs even in the absence of new mutations and is estimated to account for more than 60% of resistance cases. ... Read more