Therapeutics(31)
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New Antiviral Drugs from Bacterial Natural Products (No. T4-1934)
There is a growing need for effective antiviral therapies, particularly for viruses that currently lack approved treatments. ... Read more12514 -
Novel TCRs against mutated KRAS, NRAS, and androgen receptor, and neoantigens identification platform (No. T4-1926)
Immunotherapy can induce durable tumor regression in patients with metastatic cancer, largely driven by the immune system’s recognition of tumor-specific neoantigens. ... Read more19192 -
Anti-LOX for the Treatment of Duchenne, Fibrosis and Cancer (No. T4-1913)
LOX is a key driver of fibrosis and tumor progression through its role in extracellular matrix remodeling. We developed a set of LOX inhibitors based on LOX’s natural prodomain (LPD) to treat fibrosis, Duchenne Muscular Dystrophy (DMD), and cancer. ... Read more6026 -
Universal CAR-Ts for Treating Cancer (No. T4-1884)
Chimeric Antigen Receptor T-Cells (CAR-Ts) are one of the revolutionary technologies of the twenty-first century, invented by Prof. Zelig Eshhar at the Weizmann Institute of Science. ... Read more
Zelig Eshhar
Biology5722 -
Synthetic Immune Niche for Enhanced T Cell Expansion and Function (No. T4-1810)
Efficient generation of large quantities of functional T cells is a major bottleneck in the development of T cell-based immunotherapies. Conventional ex-vivo culturing methods often lead to cell death or functional loss. ... Read more
Nir Friedman
Biology5665 -
Microbiome-Based Prediction, Diagnosis, and Treatment of Relapsing Obesity (No. T4-1805)
A novel gut microbiome-based method has been developed to predict and prevent weight regain after weight loss. ... Read more5659 -
Structure-Guided Antibiotic Discovery Platform for MRSA (No. T4-1760)
Antibiotic-resistant bacteria such as Staphylococcus aureus (MRSA) are a growing threat, causing severe infections that are increasingly untreatable by existing drugs. This technology provides a high-resolution crystal structure of the large ribosomal subunit (50S) from pathogenic S. ... Read more19255 -
Preventing Infections Using Lipid Based Molecules (No. T4-1673)
Chronic lung infections, especially in cystic fibrosis (CF) patients, are increasingly difficult to manage due to rising antibiotic resistance. ... Read more5584 -
Optimized MAGE-A1 targeting TCR for T-cell Therapy (No. T4-1662)
TCR gene therapies show promise in cancer treatment but are hindered by the low natural avidity of TCRs against tumor-associated antigens. MAGE-A1 is a germline antigen expressed in many tumor types, making it a compelling target for TCR-based immunotherapy. ... Read more5572 -
Repurposing Enoxacin: A Novel Therapeutic Strategy Targeting miRNA Biogenesis in ALS (No. T4-1632)
A novel therapeutic strategy for Amyotrophic Lateral Sclerosis (ALS) targets impaired microRNA (miRNA) biogenesis—a key molecular defect found in both sporadic and familial ALS. ... Read more18887
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