Therapeutics(24)

  • Preventing Infections Using Lipid Based Molecules (No. T4-1673)

    Sphingosine (SPH), a natural bactericidal agent which acts as a part of the human innate immune system in the skin, was found to be an effective treatment and prophylaxis for bacterial lung infections in cystic fibrosis (CF) mice. ... Read more
    Full Professor Anthony H. Futerman

    Anthony H. Futerman

    Faculty of Biochemistry

    5584

  • Optimized MAGE-A1 targeting TCR for T-cell Therapy (No. T4-1662)

    TCR gene therapies show promise in cancer treatment but are hindered by the low natural avidity of TCRs against tumor-associated antigens. MAGE-A1 is a germline antigen expressed in many tumor types, making it a compelling target for TCR-based immunotherapy. ... Read more
    Emeritus Rachel Lea Eisenbach

    Rachel Lea Eisenbach

    Faculty of Biology

    5572

  • Repurposing Enoxacin: A Novel Therapeutic Strategy Targeting miRNA Biogenesis in ALS (No. T4-1632)

    Amyotrophic Lateral Sclerosis (ALS) remains an incurable neurodegenerative disease, in need of innovative treatment options. Prof. Eran Hornstein and his team identified microRNAs (miRNA) as pivotal regulators of ALS progression. ... Read more
    Associate Professor Eran Hornstein

    Eran Hornstein

    Faculty of Biochemistry

    18887

  • Targeted Inhibition of ADAM17 for the Treatment of Inflammatory Diseases and Cancer (No. T4-1628)

    ADAM17 is a metalloprotease that regulates shedding of membrane-bound proteins, including IL-6, TNF-α, and others. ADAM17 is implicated in inflammatory diseases, fibrosis, cancer, and autoimmune conditions, making it a compelling target. ... Read more
    Full Professor Irit Sagi

    Irit Sagi

    Faculty of Biology

    5551

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