Terpenes represent the largest class of secondary plant metabolites. Their oxyfunctionalized derivatives, terpenoids, are widely used in the pharmaceutical, flavor, and fragrance industries due to their aromatic properties. ... Read more

A novel modality for selectively inactivating homomeric proteins, common in disease-driving pathways, by inducing their polymerization. ... Read more

Emerging and re-emerging enveloped viruses, such as SARS-CoV-2, influenza, Nipah, and Ebola, continue to pose serious global health threats, with limited treatment options. ... Read more

CoLDR (Covalent Ligand-Directed Release) chemistry enables site-specific covalent labeling and activation of endogenous proteins using small-molecule covalent ligands. ... Read more

A platform for engineering CAR-T cells with enhanced cancer-killing ability and reduced toxicity. By redesigning the transmembrane domain of the CAR using a computational protein design platform, researchers created synthetic receptors that form stable, specific oligomeric structures. ... Read more

MAPP (Mass Spectrometry Analysis of Proteolytic Peptides) is a groundbreaking technology that isolates and identifies proteins actively degraded by the proteasome, offering an unparalleled and direct view of the "active degradome." This innovative approach provides a sensitive an ... Read more

Bacterial defense systems often block plasmid delivery, limiting strain engineering and biomanufacturing. ... Read more