Recent studies have established the notion that fibroblasts are prominent modifiers of cancer progression, with a specific subpopulation designated as cancer-associated fibroblasts (CAFs) that play a key role in promoting tumor initiation and progression. This cell line provides an in vitro system to study prostate cancer-associated fibroblast cells and their effect on the neighboring epithelia.

Relevant disease: Prostate cancer

Parental Line: Primary human prostate fibroblasts (PFs) (designated PF179; 179, patient number) were isolated from a prostatectomy specimen, marginal to the prostate tumor.

Host: human

Tissue: Prostate

Production details: Primary human PFs (designated PF179) were isolated from a prostatectomy specimen, marginal to the prostate tumor. Cell cultures were immortalized by infection with a retroviral vector encoding for the human telomerase catalytic subunit, hTERT. Details can be found in the publication.