EP156 cells were derived from a radical prostatectomy specimen of a 66-year-old patient. Pathologic tumor stage was pT3a, Gleason score 7 (4 + 3). The specimen had a positive margin, meaning that the tumor extended the prostate capsule. Seminal vesicles were tumor-free.

The cells provide an authentic prostate microenvironment. They may serve as a suitable experimental platform to study the transformation of prostate cells and the stem cell origins of prostate cancer. Furthermore, they could be used as a model for prostate differentiation and cell-cell interactions

Relevant disease: Prostate cancer

Parental Line: Primary human prostate fibroblasts (PFs) (designated PF179; 179, patient number) were isolated from a prostatectomy specimen, marginal to the prostate tumor.

Host: human

Tissue: Prostate

Production details: Primary human prostate epithelial (hPEC) cultures were infected with a recombinant retrovirus encoding hTERT. Details can be found in the publication.