The Anti-JUNV GP1 monoclonal antibody specifically recognizes the receptor-binding domain (GP1) of the Junín virus glycoprotein complex (GPC). Developed in mice immunized with recombinant JUNV GP1, this antibody exhibits high affinity (KD ≈ 42 nM) and potent neutralizing activity (IC₅₀ = 11 ng/ml) by targeting the transferrin receptor-1 (TfR1) binding site on GP1.
Applications: ELISA; FACS, Immunoprecipitation, Immunohistochemistry, neutralization
Antigen/Gene or Protein Targets: GP1 from JUNV
Reactivity: Human
Host: Chimera: constant domains – Human, Variable domains – Mouse
Immunogen: portions of GP1 from JUNV (amino acids 77 to 246 of GPC) (see publication for details).
Subclass: IgG1
Molecular weight (in kDa): ~150kDa
Borenstein-Katz A, Shulman A, Hamawi H, Leitner O, Diskin R. Differential Antibody-Based Immune Response against Isolated GP1 Receptor-Binding Domains from Lassa and Junín Viruses. Dutch RE, ed. J Virol. 2019;93(8). doi:10.1128/JVI.00090-19
