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Anti-IgE monoclonal antibody (No. M7-185)

5365
Summary

Monoclonal antibodies to IgE Description: Rat monoclonal anti-IgE antibodies that was generated by fusion of plasmacytoma (84.1C) or myeloma (EM953) cells with splenocytes of rat immunized with purified murine IgE mAb. The antibodies react with various IgE mAb of different specificities and not with immunoglobulins of other classes, and recognize an epitope on the murine Fc epsilon region. Were shown to block IgE interactions and inhibit passive cutaneous anaphylaxis.  Clone 84.1c recognizes a site on IgE, which is identical or very close to the binding site. May be used for detection and manipulation of the IgE response in mice.

Reference:  Schwarzbaum S, Nissim A, Alkalay I, Ghozi MC, Schindler DG, Bergman Y, Eshhar Z. 1989. Mapping of murine IgE epitopes involved in IgE-Fc epsilon receptor interactions. Eur J Immunol 19(6):1015-23.

Dr Michal Baniash

Michal Baniash

All projects (1)
Emeritus Zelig Eshhar

Zelig Eshhar

Faculty of Biology
Department of Immunology
All projects (4)
 Tova Waks

Tova Waks

Faculty of Biology
All projects (1)
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Dr. Yael Klionsky

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