A novel modality for selectively inactivating homomeric proteins, common in disease-driving pathways, by inducing their polymerization. Functional inactivation of disease-driving homomeric proteins (e.g., transcription factors, metabolic enzymes, scaffold-like proteins etc.) Poten... Read more

CoLDR (Covalent Ligand-Directed Release) chemistry enables site-specific covalent labeling and activation of endogenous proteins using small-molecule covalent ligands. Targeted prodrug activation in cancer and inflammatory diseases Drug and probe delivery with selective activation... Read more