Results for technologies (144)
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Diagnosis and prognosis of inflammatory bowel diseases using host RNA sequencing of fecal samples (No. T4-2175)
Inflammatory bowel disease (IBD) patients suffer from chronic inflammation of the gastrointestinal (GI) tract. The disease course varies, and patients often experience relapses and remission, despite the availability of several medications types.
IBD (Crohn’s and ulcerative coli...
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12511
Electrocatalytic Reduction of Carbon Dioxide (CO2) (No. T4-2133)
Carbon dioxide (CO2) is the main greenhouse gas that is produced by human activity and has brought the atmospheric CO2 concentration level over the normal outdoor ambient threshold of 400 ppm.
Fixation and further utilization of gaseous carbon dioxide are some of the most importan...
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6100
Repurposed Drug for Amplifying the Anti-Depressant Effects of Ketamine (No. T4-2129)
Psychiatric disorders, with emphasis on major depressive disorder (MDD), are leading causes of disability and premature death across the globe, with patients showing a heightened risk of self-harm and suicidal ideation.
Major depressive disorder (MDD) is the third-leading cause of...
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6097
Artificial Womb Device for Extended Mammalian Embryogenesis (No. T4-2128)
Mammalian embryos develop inside the uterine environment, making them inaccessible for direct monitoring and perturbations. Therefore, the full in-depth understanding of the developmental process that occurs post embryo implantation in the uterus remains limited. The lab of Prof.
...
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6023
Reusable Gold Nanostars Substrates for Signal Amplification for Diagnostics (No. T4-2127)
Numerous spectroscopic techniques utilize signal enhancement from surfaces of nanoparticles linked to analyte molecules. However, existing surface-enhanced spectroscopies (SES) are based on solution-based nanoparticles dispersion and are unsuitable for solid substrates. Dr.
Surfac...
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12950
WISER – A Holistic Analysis Of Large Scale Electronics Health Records (No. T4-2113)
In the current era of big-data medicine, the Electronic Health Records (EHR) analysis is limited due to its disease-oriented approach.
Current EHR analysis systems have many drawbacks: The raw data is treated ad-hoc, the infrastructure is “endpoint-driven” although the problem...
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6145
Search Engine for New Anti-Cancer Targets (No. T4-2090)
Many newly developed anti-cancer treatments rely on identifying cancer unique signatures that can be used to harness the immune system against the tumor.
The internal state of cells is represented on their surfaces by Human Leukocyte Antigen (HLA), molecules that bind and display ...
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6011
Sensitizing Non-Small Cell Lung Cancer (NSCLC) to Immunotherapy (No. T4-2082)
non-small cell lung cancer (NSCLC) has a poor prognosis and low survival rates. Recently developed immunotherapy has revolutionized the therapy for NSCLC, significantly prolonging the overall survival of advanced‑stage patients.
NSCLC comprises approximately 85-90% of all known ...
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7108
Predicting Childhood Obesity (No. T4-2076)
Childhood obesity is a global health crisis, which holds extended complex health and psychological problems. Although an early diagnosis of children at risk for obesity could allow intervention and prevention, healthcare professionals have little guidance to identify individuals at risk.
...
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6961
Single-Cell Analysis to Enhance Multiple Myeloma Prognostics (No. T4-2075)
Multiple myeloma (MM) is an incurable malignancy, and despite novel anti-myeloma drugs that increased survival, up to 30% of patients develop primary resistance, and many patients experience early relapse.
Multiple myeloma (MM) is a malignancy characterized by expansion of plasma ...
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6019
Treatment for Acute liver failure (ALF) (No. T4-2071)
Acute liver failure (ALF) is a rapid deterioration of liver function, resulting in a high mortality rate in the absence of liver transplantation. ALF treatment remains highly limited and mostly supportive due to a lack of a comprehensive understanding of the molecular base of ALF.
...
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6091
Treatment for Ewing Sarcoma Using ETS Proteins (No. T4-2068)
Ewing sarcoma (ES) is a common bone malignancy in children and young adolescents which is usually treated by systemic chemotherapy. In about 25% of the cases, cancer has already spread to other parts of the body at the time of diagnosis.
Ewing sarcoma is the second most common ped...
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6154
Inhibitory Proteins for 20S Proteasome Regulation as Cancer Treatment (No. T4-2065)
Proteasomal protein degradation is crucial in maintaining cellular integrity and in regulating key cellular processes including cell cycle, proliferation and cell death.
The protein degradation machinery plays a critical role in the maintenance of cellular homeostasis, preventing ...
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6139
Peptides for Treating Alzheimer's Disease (No. T4-2057)
Alzheimer's Disease (AD) is an age-associated neurodegenerative disorder characterized clinically by a decline in cognitive function. It is the most common type of dementia, with 5.8 million Americans living with AS in 2020.
Alzheimer's disease (AD) is an age-associated, irreversi...
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Ruth Arnon
Faculty of Biology
6160
One Step Synthesis of L-DOPA (No. T4-2048)
Current synthetic pathways of the standard Parkinson’s disease treatment, L-DOPA (levodopa), are complicated, requiring multiple steps, and depend upon the use of either hazardous starting compounds or producing toxic side products.
The use of L-DOPA by itself and in combination...
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6085
Covalent Chemistry Platform for Diagnostics and Drug Discovery (No. T4-2045)
delivery and activation of drugs or probes is of great importance in therapeutics, diagnostics, and research. For instance, selective delivery/activation of anti-cancer drugs to tumor cells is crucial for their efficacy and reduced side effects.
Targeted delivery and/or activation...
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6106
Treating Chronic Pain by Inhibiting Importin Alpha 3 (No. T4-2040)
Pain, particularly in cases of chronic nerve injury and disease, is a critical element of numerous medical conditions and procedures, which is generally managed with opioid analgesics.
Neuropathic pain is the pain sensed following injury or chronic progressive nerve disease and ar...
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6118
Protein coupling using cystein-free inteins (No. T4-2039)
Traceless covalent modification of proteins, including joining peptides or adding chemical groups, is extremely useful for numerous applications in chemical biology, protein chemistry, and biotechnology.
Modifying or joining proteins with other proteins/ peptides/chemical groups i...
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6862
Cell-free microRNA as a prognostic biomarker for amyotrophic lateral sclerosis (ALS) (No. T4-2038)
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder of the human motor neuron system, for which no effective treatment exists.
ALS is a relentless neurodegenerative syndrome of the human motor neuron system, for which no curative treatment exists. It is...
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6115
Frontotemporal Dementia Diagnosis Using Circulating microRNA Biomarkers (No. T4-2037)
Frontotemporal dementia (FTD) is a heterogeneous neurodegenerative disorder characterized by frontal and temporal lobe atrophy, typically manifesting with behavioral or language impairment.
FTD is the second most common form of dementia, after Alzheimer’s disease below the age o...
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6082
Scarless CRISPR-mediated Genome Editing (No. T4-2036)
CRISPR-Cas9 is a widely-used tool for genome editing; however, it is very inefficient and often requires the addition of selection markers, forcing the introduction of foreign DNA elements.
CRISPR-Cas9 method, while promising, is currently inherently inefficient and requires selec...
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6112
Safer CAR-T cell platform (No. T4-2033)
Chimeric Antigen Receptor (CAR)-T Cell Therapy is a personalized treatment for cancer in which the patient's T cells are genetically engineered to express a synthetic receptor that binds a tumor antigen.
CAR-T Cell Therapy is a cutting-edge immunotherapy modality with a global mar...
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6124
A Platform for Boosting Efficiency of Therapeutic RNA Editing (No. T4-2028)
Single-point mutations can give rise to a wide spectrum of genetic diseases. Recent therapeutic approaches aim at editing the mutated mRNA, providing a safe, reversible and tunable treatment.
Single-point nonsense or missense mutations are responsible for several diseases, includi...
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6016
Biologic Drug for prevention and treatment of COVID-19 (No. T4-2024)
Combat against COVID-19 is still ongoing worldwide.
Combating the COVID-19 pandemic focuses on two main therapeutic strategies: developing efficient vaccines and identifying potent drugs.
To attenuate SARS-CoV-2 infection, the groups of Profs. Schreiber and Rudich const...
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6027
Quantum Simulation with Trapped Ions in a Gradient Field (No. T4-1965)
Progress in a broad range of scientific and technological fields is hampered by the difficulty of understanding and predicting the behavior of highly complex systems.
Quantum simulators are highly controlled quantum machines with which it is possible to engineer and study complex ...
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6151
Predicting Gestational Diabetes Mellitus (No. T4-1962)
diabetes mellitus (GDM) is one of the most common complications of pregnancy, increasing the risk for short and long-term adverse events for both mother and offspring. Early intervention can reduce future complications, however, GDM is currently diagnosed only at late pregnancy stages.
...
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5998
Cell Surface Modification with Synthetic Receptors (No. T4-1961)
Technologies that target cells or modify their behavior are of great interest to improve diagnostic, therapeutic, and imaging platforms.
Cell surface proteins are key mediators of cell responses to changing environments. They are naturally regulated by dynamic structure, expressio...
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7150
A Marker for Consciousness State Following Brain Injury (No. T4-1959)
Improvements in emergency medicine have increased survival rates after brain injury but, paradoxically, have resulted in an increasing number of survivors living with disorders of consciousness.
Disorders of consciousness (DOC) resulting from a severe brain injury can range from n...
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13571
Small Molecules for Treatment of Huntington's Disease and Related Disorders (No. T4-1947)
Trinucleotide repeats expansion disorders (TREDs) are a set of diseases in which repetitions of short DNA segments (three nucleotides) occur and accumulate in the genome.
TREDs are a group of human diseases in which repeats of three nucleotides accumulate in the genome.
...
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6193
A high-throughput method for detecting allergens and viral infections (No. T4-1946)
Allergies affect a large portion of the population, affecting life quality and can impose life-threatening conditions in some cases. The diagnosis of allergies is currently limited by expensive low throughput methods, presenting a need for high‑throughput methods for allergen detection.
...
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6187
Novel Methods of Treating Bacterial Vaginosis (No. T4-1945)
Treating bacterial vaginosis by performing vaginal microbial transplants (VMT).
Bacterial Vaginosis (BV) is considered the most prevalent form of vaginal infection in women of reproductive age, affecting from one-quarter to one-third of women.
The group of Prof. Eran E...
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6088
Treatment for Drug-Resistant Non-Small Cell Lung Cancer (No. T4-1944)
Non-Small Cell Lung Cancer (NSCLC) is a very common type of cancer, and despite currently available therapies, is one of the deadliest due to the emergence of drug resistance, which results in tumor recurrence.
Lung cancer is one of the most deadly and common types of cancer in th...
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6025
Artificial Pancreas (No. T4-1942)
The alarmingly sharp increase in type 1 diabetes mellitus incidence in recent years has been coupled with a marked rise in the development of closed-loop systems aimed at continuously monitoring blood glucose levels, predicting glucose behavior and delivering adjusted insulin doses.
...
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5752
Predicting Blood Metabolites (No. T4-1941)
The serum metabolome contains a plethora of biomarkers and causative agents of various diseases. They are known to be modulated by various genetic and environmental factors such as the gut microbiome, nutrition, and lifestyle.
The blood contains many small molecules called the ser...
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6220
New Antiviral Drugs from Bacterial Natural Products (No. T4-1934)
The increasing incidence of viral infections across the globe is driving the demand for antiviral drugs. Prof. Rotem Sorek and his team identified a new family of bacterial enzymes that produce various nucleotide analogs with antiviral properties (Bernheim, Nature 2021).
The incre...
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12514
Higher Efficiency of CRISPR Gene Editing Using Chimeric Cas9 (No. T4-1930)
CRISPR-Cas9 is a powerful tool for genome editing, widely used for basic research and the development of treatments for genetic diseases. However, its efficiency is currently limited.
CRISPR-Cas9 is a powerful tool for genome editing that allows researchers to modify genomes easil...
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6024
Atomic Magnetometer with Increased Coherence Time for Improved Magnetic Fields Measurements (No. T4-1928)
Atomic magnetometers are the most precise magnetometers to date and are often used in applications ranging from medical to military uses. The use of atomic magnetometers is often limited in resolution when measuring low frequency signals due to short coherence time (mSec time scale).
...
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6208
Reversible Operation of Molecular Switches on Solid Surfaces (No. T4-1927)
Molecular photoswitches are light-responsive molecules with potential applications in a broad range of systems with on-demand functionalities.
Molecular photoswitches are photoactive molecules that can be shifted to a new state by irradiation with light of a specific wavelength, a...
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5749
Imaging Platform for IBD Drug Discovery (No. T4-1925)
Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the gastrointestinal (GI) tract, resulting in its damage and gut barrier dysfunction.
Inflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis (UC), is characterized by ch...
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5746
Protein Based Treatment for Duchene Muscular Dystrophy and Cancer (No. T4-1913)
Duchenne muscular dystrophy (DMD) is a disease that affects approximately 1 in 3,500 boys with a life expectancy of ~26 years.
Duchenne muscular dystrophy (DMD) is a disease that causes progressive muscle weakness, loss of skeletal and heart muscle tissue, degeneration, and eventu...
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6026
Extraction of Gold from Electronic Waste and Ores (No. T4-1910)
A method for selective extraction of gold has been developed at the Weizmann Institute.
Gold is playing an important role in many industrial applications such as jewelry and ornaments, electronics, telephone circuits, dental alloys, etc.
Prof. Igor Lubomirsky and his gr...
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5743
Photovoltaic Devices Based on Guided Nanowire Arrays (No. T4-1906)
Nanowires are being produced and integrated into various systems today, including solar cells, nano-sensors, nano-electrodes, transparent touch-screen coatings, and LED replacements.
Most nanowire-based photovoltaic cells and photodetectors are based on vertical arrays, which can ...
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5740
Inorganic Nanotubes/Polymer Composites for 3D Printing (No. T4-1900)
Biocompatible polymers commonly used in the orthopedic and cosmetic prosthetics, cardiovascular and dental implants and food packaging industries often suffer from poor mechanical properties and thermal stability, limited dimensionality and short shelf-life as compared to their metal compara...
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5737
Early Detection and Treatment of Myeloid Leukemia (No. T4-1896)
malignancies such as AML and MDS are usually aggressive and have a low overall survival rate. Recent studies demonstrated that specific mutations in hematopoietic stem cells occur years before the disease is diagnosed in individuals at high risk of developing myeloid malignancies.
...
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6166
Person-specific Assessment of Probiotics Responsiveness (No. T4-1895)
Probiotics are a widely consumed dietary supplement, however, their efficacy is controversial and not all individuals benefit from their use. Therefore, a predictive tool that distinguishes between probiotic-permissive and resistant individuals is needed.
Probiotics are the third ...
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5734
GreenTap - A Method for Stimulating Production and Extraction of Metabolites in Plantss (No. T4-1894)
Numerous plant-originated compounds with unique properties are widely used for diverse applications in the drugs, food, and cosmetics industries.
Numerous plant-originated compounds with unique properties are widely used for diverse applications ranging from therapeutics, fungicid...
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6029
Preventing Biofilm Formation by Enzyme Inhibitors (No. T4-1893)
Biofilm is a complex colony of bacteria, which are attached together by extracellular polymeric substance. This setting provides the bacteria protection against environmental factors, improves their surface attachment, and plays a major role in resistance to treatment.
The present...
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5731
A Sustainable Process for Phenol Production (No. T4-1892)
Phenol is an important industrial commodity used as a precursor to many useful compounds.
The cumene hydroperoxide process, which is the most commonly used phenol production process nowadays, is both complicated, with low per pass cumene conversion and is producing acetone as a by...
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5728
Universal CAR-Ts for Treating Cancer (No. T4-1884)
Chimeric Antigen Receptor T-Cells (CAR-Ts) are one of the revolutionary technologies of the twenty-first century, invented by Prof. Zelig Eshhar at the Weizmann Institute of Science.
The group of Prof. Eshhar has developed a method for an adoptive cell therapy, such that cells fro...
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Zelig Eshhar
Faculty of Biology
5722
Covalent Inhibitors for Treatment of Inflammation and Neurodegeneration (No. T4-1880)
C-Jun NH2-terminal kinase (JNK) plays an integral role in many cellular processes and is associated with the pathophysiology of a number of neurological, inflammatory, and autoimmune diseases.
The JNK signaling cascade plays an integral role in the pathology of several neurodegene...
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6109
Ultra-Rapid Structure Reconstruction Using an All-optical Digital Technology (No. T4-1879)
Reconstruction of structures from their scattered intensity distributions is heavily exploited in a range of disciplines, with common methods limited when phase information is lost.
Reconstruction of objects from their scattered intensity distributions stands at the basis of numer...
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6130
Treatment of Psychiatric Disorders by Inhibiting Importin Alpha 5 (No. T4-1875)
Anxiety and stress-related conditions pose a significant health burden on modern healthcare systems. While currently, available anxiolytic drugs can be highly effective for some patients, their long-term use is limited by their potentially severe and debilitating side effects. The group of P...
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5719
Targeting Novel Regulator for Improved Hematopoietic Stem Cells Generation (No. T4-1874)
A potential method of generating hematopoietic stem cells for transplantation by inhibiting CD74.
Hematopoietic stem cells (HSCs) originate in the bone marrow and are the progenitors of all hematopoietic cells. HSCs have the capacity to both self-renew and to differentiate, and t...
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5716
Cancer Diagnostics by Analyzing Urea Cycle Enzymes (No. T4-1872)
An innovative method to diagnose and potentially treat various cancers by analyzing the urea cycle metabolites.
Early stage diagnosis and treatment of cancer is essential, especially for highly malignant or metastatic tumors.
The research team of Dr. Ayelet Erez discov...
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5713
Allogeneic Cell Transplantation for Treatment for Lung Diseases (No. T4-1868)
The treatment of respiratory conditions is currently one of the major challenges to health care systems all over the world. The problem is that most therapeutics currently available for treating pulmonary indications are non-curative, and simply improve symptoms.
? Treatment of ...
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Yair Reisner
Faculty of Biology
5707
Optical Bus for a Multi-Core Processor (No. T4-1863)
The exponential increase in computational power over the last decades is running into a bottle-neck – the only way of getting more computing power per chip is to integrate multiple-cores, but the problem with multiple-cores is the complex wiring system, used for inter-core communication. ...
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5704
Prosody Based Speech Analysis (No. T4-1856)
A major part of human communication is conveyed through intonation, or prosody – the music of speech.
The study of prosody is largely absent from the rapidly-evolving field of automatic speech processing applications. Current approaches to computerized analysis of spoken text ar...
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Tirza Biron
Physics
14060
Super-Resolution Using Unsupervised Deep Internal Network (No. T4-1850)
Optical and dimensional limitations of images can be partially overcome today using signal enhancement technologies which typically rely on supervised, deep-learning methods.
Signal enhancement of corrupted input collected under suboptimal conditions, poses multiple challenges, in...
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5701
A Novel Synthetic Biology Platform for Controlling Gene Expression (No. T4-1847)
A method for controlling gene expression using a novel phage-based transcription factor-peptide system.
A fundamental challenge of synthetic biology and its clinical applications is the capability to control gene expression.
team of Prof. Sorek at the Weizmann Institut...
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5695
Composite Functional Metasurfaces for Multispectral Achromatic Optics (No. T4-1845)
A new technology for producing flat optical components based on optical metasurfaces. These components can potentially serve high resolution imaging, spectrometry, light processing and beam shaping devices.
The proposed technology can be used to generate a wide variety of novel ...
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5689
Secure Search of Encrypted Cloud Data (No. T4-1840)
Searchable symmetric encryption with practical big-data performance and strong security
Highlights
...
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5683
Detecting Necroptosis Activation via Exosome Analysis (No. T4-1839)
Numerous medical conditions are related to inflammation, such as pancreatitis, psoriasis, inflammatory bowel disease, atherosclerosis, neurodegeneration, and more. However, determination of inflammation in the body, especially at early stages of a pathology is difficult to assess.
...
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5680
Highly Selective Fluorescent Biosensor for Labeling His-Tagged Proteins in a Specific Conformation (No. T4-1834)
A rapid, label-free biosensor for detecting specific conformation of His-tag labeled proteins, accessible for use in both academic- and commercial-R&D was invented at the Weizmann Institute of Science.
The biosensor presented here is comprised from three main molecular-compone...
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5677
A method to identify actively degraded proteins (No. T4-1832)
This technology provides a method to identify the full landscape of proteins that are actively being degraded by the proteasome, offering a way to identify novel targets in various biological conditions and contexts.
The cell's proteome (protein profile) is constantly changing du...
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6030
Inertial NEMS for Nanosensor Applications Based on Inorganic Nanotubes (No. T4-1828)
Inertial sensors for motion detection are being incorporated into an increasing number of portable devices, including diverse IoT applications, mobile phones, wearable electronics, automotive systems and medical diagnostic sensors.
Current microelectromechanical system (MEMS) fabr...
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5674
Nanoscale Electronic Spin Polarizer and Enhanced Magnetoresistance for Memory Applications (No. T4-1816)
Spintronics has a large impact on daily life, being the backbone of computing and electronic applications. The reduction in the size of spintronic elements is of central importance for efficient information processing.
While conventional electronics is based on the charge of elect...
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6205
Platform for Boosting Yield and Activity of Therapeutic T Cells (No. T4-1810)
Production of large quantities of T cells is an essential demand for the development of immunotherapies. However, ex-vivo culturing of T-cells is very inefficient, resulting in high cell death rates.
Culturing and expanding T cells ex-vivo while retaining their functionality is an...
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Nir Friedman
Biology
5665
Homogeneous Dispersion of CNT Composites for Improved Conductivity (No. T4-1809)
Battery and capacitor electrode technologies available in the industry today, are struggling to keep up with rapidly advancing applications that require high power and energy density such as electric vehicles, solar cells and telecommunications systems.
The growing need to provide...
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5662
Method for Microbiome-Based Prediction, Diagnosis, and Treatment of Relapsing Obesity (No. T4-1805)
A novel method for analyzing the likelihood of weight regain following a weight loss program and maintaining target body weight, based on gut microbiome analysis.
The past century has seen an overwhelming increase in the prevalence of overweight and obese individuals, effecting o...
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5659
Antibody for Preventing/Treating Secondary Respiratory Infections (No. T4-1790)
A novel method of preventing secondary infections, by inhibition of membrane type I matrix-metalloproteinase-1, which reduces degradation of the extra cellular matrix.
Pathogens that infect the respiratory system are the cause of some of the most dangerous infections, especially ...
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5647
Treating Drug-Resistant Lung Cancer Using a Combination of Antibodies (No. T4-1774)
A novel method to treat tyrosine kinase inhibitor (TKI) resistant cancer by using a combination of three antibodies that target EGFR (ERBB1), HER2 (ERBB2), and HER3 (ERBB3) receptors.
The ErbB/HER family of receptor tyrosine kinases includes epidermal growth factor receptor (EGFR...
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5635
Multimodel Transcranial Optical Vascular Assessment (No. T4-1769)
Subdural hematoma (SDH) is a collection of blood between the inner layer of the dura and the brain that occurs mostly as a result of trauma. It is one of the most common neurosurgical conditions in the United States today.
The incidence of subdural hematoma (SDH) is on a constant ...
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Alon Harmelin
Office of the Vice President for Administration and Finance
5629
Spin Controlled Water Electrolysis for Efficient Production of Hydrogen (No. T4-1753)
The chiral-induced spin selectivity (CISS) effect, discovered in recent years by Prof.
Hydrogen is the most efficient and environmentally friendly fuel; it possesses the highest energy capacity per unit mass and produces water upon combustion.
Here we present spin-selec...
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5626
Treatment of Heart Failure by Inducing Cardiomyocyte Proliferation (No. T4-1752)
Regulating ErbB2 signaling in cardiomyocytes (CM) as novel treatment for heart diseases by inducing regeneration of cardiac tissue.
Ischemic heart disease and heart failure are the leading causes of death in the western world. Although improved medical care reduced early mortalit...
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5623
rPTE with Potent Organophosphate (OPH) Activities (No. T4-1750)
Organophosphates are toxic compounds found in chemical warfare agents, such as nerve gases, and insect pesticides.Use of volatile nerve gas agents by terrorist organizations is a key concern of governments around the world. V-type nerve agents (e.g.
Researc...
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5620
Treating Cancer and Collagen-Associated Diseases by Using Anti-LOXL-2 Antibody (No. T4-1743)
An innovative method for treating diseases associated with dysregulation of collagen fibers in the extracellular matrix (ECM), such as cancer and fibrosis, by targeting LOXL-2.
ECM disruption is associated with many pathological conditions, such as various cancer types and tissue...
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5611
Carbon fixing bacteria (No. T4-1736)
The two most pressing challenges facing humanity are the need to feed the growing population with restricted land and water sources and global warming caused due to high atmospheric CO2 levels.
The two most pressing ecological challenges of our time are reducing CO2 levels in the ...
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5608
Treatment for Inflammatory Diseases and Cancer (No. T4-1733)
The development of kinase inhibitors to treat inflammatory diseases was proved beneficial, however, designing specific inhibitors with minimal side effects and prolonged efficacy is challenging as drug resistance often develops.
Inflammatory diseases include a wide variety of cond...
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5605
CNT-Based Structure for High-Resolution Semiconductor Process Control (No. T4-1730)
With the continuous trend of electronic component miniaturization, process control technologies must keep up with component size reduction. Defects that were so far negligible, are now posing critical operation obstacles, and are more difficult to identify as scales are reduced to <10 nm....
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Avishai Benyamini
Physics
5602
Green Chemistry for Ketones and Aldehydes Production (No. T4-1722)
Our technology provides a new type of oxidative cleavage reaction of organic compounds with highly selective product formation.
The realization that many processes practiced on a large scale were detrimental to the environment led to a movement of reshaping the science of organic ...
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5596
Highly Selective Optical Biosensors for Proteins in Biological Samples, with Excellent Signal-to-Noise Ratio (No. T4-1689)
Sensing the levels of protein-based biomarkers in biological samples is crucial for diagnosis of various diseases including cancer.
· Detection of proteins in biological samples for medical diagnostics
· Fluorescent detection of His-tag or GST lab...
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5587
Preventing Infections Using Lipid Based Molecules (No. T4-1673)
Sphingosine (SPH), a natural bactericidal agent which acts as a part of the human innate immune system in the skin, was found to be an effective treatment and prophylaxis for bacterial lung infections in cystic fibrosis (CF) mice.
Cystic fibrosis (CF) is caused by mutations in the...
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5584
Recycling of Platinum Group Metals (No. T4-1670)
A method for selective extraction of precious and rare metals has been developed at the Weizmann Institute.
Platinum group metals (PGM), e.g., platinum (Pt), palladium (Pd) and rhodium (Rh), are well-known precious metals playing an important role in many industrial applications s...
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13574
Magnetic resonance imaging (MRI) Of Tissue Fibrosis Without Contrast Agent (No. T4-1665)
Cardiac fibrosis is a scarring event in the cardiac muscle that causes abnormalities in cardiac function and significantly increases the risk of sudden cardiac death.
Myocardial fibrosis is associated with worsening ventricular systolic function, abnormal cardiac remodeling, and i...
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5575
Optimizing T Cell Receptor Avidity for Adoptive T Cell Therapies (No. T4-1662)
Using affinity maturated TCRs to generate reactive T cells
Immunotherapy, that is the use of the immune system to treat cancer, is currently a leading candidate in the combat against cancer.
This technology presents a new method of increasing the affinity of a TCR to i...
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5572
An Off-Line Image Search Engine (No. T4-1647)
Although images search engines are available online, offline networks and databases (in governmental offices, banks, etc.) require an efficient and reliable image search engine.
Nowadays, image searching and image classification are available to everyone online (e.g., Google image...
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5566
Anti-QSOX1 Antibody for Treating Cancer and Metastasis (No. T4-1642)
Cancer, and especially cancer metastasis, is a leading cause of death worldwide. Research in recent years highlighted the importance of the extracellular matrix (ECM) surrounding the tumor in cancer progression metastasis formation.
Cancer is a leading cause of death worldwide, ac...
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5560
Antibody Based Therapy to Treat Cancer and GI Related Diseases (No. T4-1640)
A novel therapeutic antibody against MMP-7, with exceptional specificity, for the treatment of aggressive cancers.
Matrix metalloproteins (MMPs), a family of zinc-dependent endopeptidases, are key enzymes participating in remodeling of the extracellular matrix (ECM), and are thus ...
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5557
Novel MRI Contrast Agent (No. T4-1604)
Novel reporter gene for magnetic resonance imaging applications.The ability to image the duration and location of gene expression in vivo and noninvasively is imperative for the future of biology and clinical medicine.
Non-invasive imaging of gene expression in transgenic mice mod...
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5545
A Novel Technique of Thermoelectric Conversion (No. T4-1583)
The thermoelectric effect is the direct conversion of temperature differences to electric voltage and vice versa. Thermoelectric effects are used in various applications, where heat energy is saved, that would be otherwise lost.
Various TE devices will benefit from better TE effic...
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Yoseph Imry
Physics
5536
Desulfurization of Flue-Gasses (No. T4-1577)
A novel flue gas desulfurization (FGD) system achieves removal of sulfur dioxide (SO2) from industrial exhaust streams at efficiencies that can greatly supersede technologies currently in use.
Existing SO2 scrubbing technologies generate significant amounts of hazardous waste by-p...
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5533
A Novel Database to Reduce Unsuccessful Cloning in E. Coli by Detection of Toxic Genes (No. M7-1576)
Synthetic genes are commonly used in academic and industrial applications, however in many cases these said genes can be toxic when inserted into the ubiquitously used E. coli. This is problematic as time and money is wasted on attempts to generate genes that will not function in E. coli.
...
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5530
Inorganic Fullerene Coating For Medical Devices (No. T4-1566)
Various dental applications suffer from excessive friction, which severely compromises their function. For orthodontic procedures, friction significantly reduces effectiveness and thereby leads to prolonged treatments.
Friction among appliances used for orthodontic correction of t...
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5521
Synthetic Carbon Fixation Pathways For Superior Biomass Generation (No. T4-1556)
Modern agriculture faces limited arable land and climate changes. Carbon fixation under these conditions will become a significant growth-limiting factor. Synthetic carbon fixation pathways can allow plants to produce more biomass using the same amount of energy from sunlight.
Car...
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5515
Green Catalytic Formation of Alcohols, Amines, Amides, Imines and Esters under Mild Conditions (No. T4-1551)
A team of researchers headed by Prof. David Milstein at the Weizmann Institute of Science (WIS), have developed a novel set of manganese, ruthenium, and related borohydride complexes (Pincer-type).
Amines, alcohols, amides, imines, and esters, are essential for industries such as ...
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5512
Optical Conversion of Ultra-Fast Laser Pulses (No. T4-1529)
Ultra-fast lasers are highly used in both academia (to monitor chemical & biological reactions) and industry (for submicron resolution products).
Femto-lasers are highly important devices in both academia and industry. In academia, these lasers are mainly used for reaction stu...
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Yaron (deceased) Silberberg
Physics
5503
Super resolution from a single visual source (No. T4-1522)
Many imaging devices produce signals of unsatisfactory resolution (e.g. a photo from a cell-phone camera may have low spatial resolution or a video from a web camera may have both spatial and temporal low resolution).
Ever taken a digital photograph and then found out you had miss...
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5500
Production of Amines from Alcohol and Ammonia (No. T4-1507)
A novel, selective, and direct synthesis of primary amines from alcohols and ammonia catalyzed by novel Pincer-type Ruthenium complexes.
Present production methods of amines require harsh conditions such as high reaction temperatures (over 300oC) and pressures (over 15 atm). These...
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5494
Conductive Inorganic Fullerenes and Nanotubes (No. T4-1482)
Modification of the electronic properties of layered-type semiconductors can be accomplished by doping/alloying of the semiconductor.
Catalytic processes for energy storage and sulfur free gasoline.Polymer nanocomposites for packaging Electromagnetic shielding.Conductive glues/adh...
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5485
Highly Sensitive Nanoscale Scanning Magnetic and Thermal Sensor (No. T4-1481)
A new technology developed by a group of researchers from the Weizmann Institute is a nanoscale sensor-on-tip for local magnetic signals and thermal dissipation with state-of-the-art sensitivity and spatial resolution.
In light of the rapidly developing scanning-probe based techno...
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5482
Smart Resize of Images & Videos (No. T4-1461)
Data storage of images and videos became a real issue in the last years when pictures and videos are taken and shared more often, and the memory devices aren’t being minimized fast enough.
Camera phones and social media made images and videos more accessible and widespread than ...
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5479
Treating Cancer by Inhibiting Nuclear Entry of MAPK Cascade Proteins (No. T4-1446)
Inhibition of Nuclear Entry of MAPK Cascade Proteins as a Novel Mechanism for Treating Cancer
ERK is a major signaling molecule, which plays a driving role in various pathologies, particularly cancer. When not activated ERK is localized to the cytoplasm.
The peptide in...
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5473
Treatment of Autoimmune Diseases by Modulating Bregs (No. T4-1441)
Chronic lymphocytic leukemia (CLL), a malignant disease characterized by the accumulation of B lymphocytes in the blood, lymphoid organs, and bone marrow, is the second most common type of leukemia in adults, accounting for about 7,000 new cases of leukemia each year.
• Diagnos...
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5470
Improved Treatment for Glaucoma (No. T4-1433)
Glaucoma is one of the leading causes of irreversible blindness worldwide, affecting over 60 million people. It is usually caused due to raised intraocular pressure (IOP).
Glaucoma is a common eye condition in which the optic nerve that connects the eye to the brain is damaged, us...
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6232
Automatic Photo Animation in Video and Still Images (No. T4-1423)
Many currently marketed animation tools enable users to define objects and provide them with motion, yet none enable the fast and automatic, animation of a full body captured in a single still photo.
The live animation tool was constructed by a successful combination between “of...
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5467
Software for Detecting Irregularities in Visual Data (No. T4-1381)
While image & video processing are rapidly developing fields, most of the recent algorithms must be trained on large and sorted databases to gain adequate performance. Detecting irregularities in previously unknown images or videos is still an unsolved problem. Prof.
Detecting...
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5461
High-Performance Electrochromic Devices (No. T4-1380)
High-performance electrochromic materials that exhibit a practical combination of low-voltage operation and efficient color-switching, as well as long-term stability have been developed by the group of Prof. van der Boom.
The trends towards energy efficiency, comfort and privacy a...
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5458
On-Chip Synthetic Biology Platform for Diagnostics and Therapeutics (No. T4-1369)
Cell-free synthetic platforms that enable complex biological activities such as synthesis and self-assembly of biomolecules, can be employed for various applications, including drug discovery and diagnostics.
The development of artificial cells capable of executing DNA programs ha...
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5455
Mouse IgE and Anti-Mouse IgE Monoclonal Antibodies (No. M7-1270)
Monoclonal antibodies to IgE Description: Rat monoclonal anti-IgE antibodies that was generated by fusion of plasmacytoma (84.1C) or myeloma (EM953) cells with splenocytes of rat immunized with purified murine IgE mAb.
...
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Zelig Eshhar
Faculty of Biology
5452
Cholesterol Antibodies (No. T4-1267)
Description: Monoclonal antibodies specific for cholesterol/ceramide-rich domains (clones 405F, 14F, 499F) and cholesterol micro-domains (clones 36A1, 5881) in cell membranes. Originally raised against an artificial monolayer of lipid mixtures in, and were shown to specifically label the ab...
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5449
Optical Cross-Sectioning Multiphoton Microscopy Without Scanning (No. T4-1266)
Fast cross-sectioning using multiphoton microscope. The conventionally used laser-scanning microscopy, confocal and multiphoton microscopy, although being capable of performing optical sectioning, requires a long image acquisition time, tens of milliseconds per section in current commercia...
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Yaron (deceased) Silberberg
Physics
5446
Acquisition of Multidimensional NMR Spectra in a Single Scan (No. T4-1151)
Multidimensional nuclear magnetic resonance (NMR) is used nowadays in many applications (e.g., discovering new pharmaceutical drugs, characterization of new catalysts, and investigation of the structure and dynamics of proteins).
NMR and MRI are costly devices due to t...
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5434
Blood Test to Identify People at High Risk for Lung Cancer (No. T4-1033)
A novel diagnostic test to identify individuals with increased risk of lung cancer
Lung cancer is the number one killer among cancers, with 160,000 deaths/year in the USA and 1.6 million/year worldwide. Early detection of lung cancer increases 5-year survival rate from 4% to 54%....
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5428
Escherichia coli UTL2 (No. M7-358)
Escherichia coli UTL2 Description: A "leaky" strain of E. coli, which is significantly more susceptible to cytotoxic agents. UTL2 holds a mutation in the galU gene causing an impaired outer membrane.
...
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5425
Anti-Mast cell Function-associated Antigen (MAFA) monoclonal antibody (No. M7-320)
320 - Monoclonal antibody G63 Description: Monoclonal antibodies to MAFA (Mast cell Function-associated Antigen), originally raised against intact rat RBL-2H3 cells.
...
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5422
Chromogenic substrate for serum paraoxonase (PONs) activity (No. M7-315)
315 - TBBL (5-thiobutyl butyrolactone) Description: TBBL (5-thiobutyl butyrolactone) is a chromogenic lipo-lactone substrate for Serum paraoxonases (PONs), used for sera tests of PONs activity, based on their lactonase activity. The primary enzymatic r
...
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Olga Khersonsky
Faculty of Biochemistry
5419
Anti-Runx-3 monoclonal antibody (No. M7-306)
Monoclonal antibody to Runx-3 Description: Monoclonal antibody to Runx-3 raised against the Runx3 peptide TPSTPSPRGSLSTTSHF. Available clones: 62, H8.
...
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Ditsa LEVANON
5416
Anti-Estrone-3-Glucuronide monoclonal antibody (clones: 155B3, 8A3) (No. M7-276)
Monoclonal antibodies raised against estrone-3-glucuronide-BSA. Available clones: 8A3 (Rat, IgG2a), 155B3. Estrone-glucuronide is the dominant metabolite of estradiol. Used as one reference method for determining ovulation.
Monitoring ovarian function by the simultaneous t...
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5413
Anti-Estrone-3-Glucuronide monoclonal antibody (No. M7-275)
Monoclonal antibodies raised against estrone-3-glucuronide-BSA. Available clones: 8A3 (Rat, IgG2a). Estrone-glucuronide is the dominant metabolite of estradiol. Used as one reference method for determining ovulation.
Monitoring ovarian function by the simultaneous time-resolved fl...
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5410
Anti- estrone-3- glucuronide monoclonal antibody (No. M7-273)
Betatypic anti-idiotypic antibody raised against anti- estrone-3- glucuronide (clone 8A3). Available clone: 7C1.
Monitoring ovarian function by the simultaneous time-resolved fluorescence immunoassay of two urinary steroid metabolites.
Barnard G, Kohen F.Clin Chem. 1998 J...
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5404
499F (No. M7-265)
Monoclonal antibodies specific to cholesterol/ceramide mixture
Description: Monoclonal antibodies specific for cholesterol/ceramide-rich domains (clones 405F, 14F, 499F) and cholesterol micro-domains (clones 36A1, 5881) in cell membranes.
...
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Luana Scheffer
Chemistry
5401
Monoclonal Antibodies Specific to Cholesterol/Ceramide Mixture Clone (No. M7-263)
Originally raised against an artificial monolayer of lipid mixtures in, and were shown to specifically label the above domains in different cell membranes. Reference: Scheffer L, Futerman AH, Addadi L. 2007. Antibody labeling of cholesterol/ceramide ordered domains in cell membranes.
...
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Luana Scheffer
Chemistry
5398
Monoclonal Anti-Caspr Antibody (Mab#275) (No. M7-259)
259 - Monoclonal antibody to Caspr Description: Monoclonal antibody to Caspr (Mab275), raised against the extracellular domain of Caspr.
...
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5392
Monoclonal Anti-Ermin Antibody (Mab#160) (No. M7-258)
258 - Monoclonal antibody to Ermin Description: Monoclonal antibody to Ermin (MAb160) raised against purified GST–Ermin (residues 1–261).
...
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Damian Brockschnieder
5389
Monoclonal Anti-Gliomedin Antibody (Mab#94) (No. M7-257)
257 - Monoclonal antibody to Gliomedin Description: Monoclonal antibody to Gliomedin (MAb 94) raised against a synthetic peptide corresponding to amino acid residues 273–287 (CVIPNDDTLVGRA), present in the extra cellular region of Rat Gliomedin.
...
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5386
Core peptide to inhibit T-Cell mediated inflammation in animal models (No. M7-238)
238 - CP Peptide Description: Core peptide (CP; GLRILLLKV-D-stereoisomer), a synthetic peptide coding for the transmembrane domain of the ?-subunit of the T-cell receptor (TCR), a region that has been identified to be crucial for the assembly and
...
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5374
15-mer Histidin (No. M7-237)
236-237 - Diastereomer Lytic Peptides for Treatment of Solid Tumors and Metastasis Description: 15-mer (Leu-Lys-Dleu- Leu-Lys-Dlys-Leu-Dleu-Dlys-Lys-Leu-Leu-Dlys-Leu-Leu) and 15-mer Histidin (H-Leu-Lys-D-Leu-
...
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5371
Diastereomer Lytic Peptides for Treatment of Solid Tumors and Metastasis in animal models (No. M7-236)
236-237 - Diastereomer Lytic Peptides for Treatment of Solid Tumors and Metastasis Description: 15-mer (Leu-Lys-Dleu- Leu-Lys-Dlys-Leu-Dleu-Dlys-Lys-Leu-Leu-Dlys-Leu-Leu) and 15-mer Histidin (H-Leu-Lys-D-Leu-
...
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5368
Anti-IgE monoclonal antibody (No. M7-185)
Monoclonal antibodies to IgE Description: Rat monoclonal anti-IgE antibodies that was generated by fusion of plasmacytoma (84.1C) or myeloma (EM953) cells with splenocytes of rat immunized with purified murine IgE mAb.
...
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Michal Baniash
Zelig Eshhar
Faculty of Biology
5365
Anti-Galactin 8 monoclonal antibody (No. M7-181)
Description: Monoclonal antibody to Galectin-8 (clone 106.1).
...
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Sharon Eshhar
5362
Anti-Phospho-ERK (PY193 or PT115) Monoclonal Antibodies (No. M7-176)
176-177 - Monoclonal antibodies to phospho-ERK/Map Kinase Description: Monoclonal antibodies raised against peptides containing the 11 amino acids, HTGFLTEYVAT, corresponding to the ERK activation loop either Tyr -phosphorylated (ERK-PY193), or Thr-phos
...
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5356
Clone - 1E11 (No. M7-148)
Monoclonal antibodies for peptide and steroid hormones Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics.
...
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5350
Anti-Human chorionic gonadotropin (hCG) monoclonal antibody (No. M7-147)
Monoclonal antibodies raised against bhCG. Available clones: 1D5 (IgG1) .Human chorionic gonadotropin (hCG) is a hormone produced by the syncytiotrophoblast, a component of the fertilized egg, after conception.
...
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5347
Clone 1E11 Progesterone (No. M7-146)
Anti-progesterone. Monoclonal antibody raised against position 11 of progesterone (Clone 1E11). It is very specific for progesterone.Progesterone is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
...
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9580
Anti-oestradiol-6-carboxymethyl oxime monoclonal antibody (No. M7-141)
Monoclonal antibodies to estradiol Description: Monoclonal antibodies raised against oestradiol-6-carboxymethyl oxime-BSA. Available clones: 2F9 (Rat, IgG2a), 15 (IgG2b), 8D9 (IgG2a).
Direct chemiluminescence immunoassay for estradiol in serum. De Boever J, Kohen F, Usanachitt C, ...
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5335
Anti-progesterone-7 monoclonal antibody (No. M7-138)
Monoclonal antibodies raised against position 7 of progesterone (clone 2H4), Rat IgG1. Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food produc...
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5332
Human T3N1M1 prostatic adenocarcinoma tissue for xenograft (No. M7-132)
WISH-PC frozen tissue samples
...
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Zelig Eshhar
Faculty of Biology
5329
Anti-idiotypic antibody against anti-Sulfamethazine (12E12) (No. M7-130)
Betatypic anti-idiotypic antibody raised against anti Sulfamethazine –KLH (clone 21C7). Available clone: 12E12.
Generation of an anti-idiotypic antibody as a surrogate ligand for sulfamethazine in immunoassay procedures/
...
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5326
Anti-testosterone 3-(0- carboxymethyl)oxime-BSA monoclonal antibody (No. M7-119)
Rat monoclonal antibodies raised against testosterone 3-(0- carboxymethyl)oxime-BSA. Available clones: 5F2, 5A4.Testosterone is the principal male sex hormone and an anabolic steroid.
Preparation of monoclonal antibodies able to discriminate between testosterone and 5 alpha-dihydr...
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5317
Anti-Biotin Antibody (No. M7-116)
Monoclonal anti-biotin antibody (clone F1). Very specific for biotin.
Preparation and properties of anti-biotin antibodies.
...
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5308
Anti-Sulfamethazine monoclonal antibody (No. M7-115)
Monoclonal antibody to Sulfamethazine (SMZ) Description: Rat monoclonal antibodies raised against Sulfamethazine-BSA. Available clone: 21C7, IgG1. Sulfamethazine is an antibacterial agents commonly given to food animals (swine, fishetc.) to prevent disease and maximize production.
...
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5305
An endothelial-adipose cell line derived from a murine bone marrow stroma (14F1.1) (No. M7-103)
103 - Bone marrow derived stroma cell line 14F1.1
Description: An endothelial-adipose cell line derived from a murine bone marrow stroma.
...
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5302
LTC4 (6E7) (No. M7-101)
Rat monoclonal antibodies raised against Leukotriene C4-KLH. Available clone: 6E7 (IgG1). Cysteinyl leukotrienes are potent lipid mediators in inflammation, inducing smooth muscle contractions and increased capillary permeability.
...
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5299