This T-cell line, derived from the BWZ.36/CD8a thymoma of murine origin, was genetically engineered to express CD3 and a codon-optimized Pmel-1 T-cell receptor (TCR) through sequential retroviral transductions. Bassan et al., Int J Cancer, 2019. ... Read more

Spontaneous metastatic spread of melanoma after surgery of the primary tumor. immunization against melanoma metastasis Relevance: A model to study melanoma metastasis in mice. Melanoma metastatic spread, immunization against melanoma metastasis Relevant disease: melanoma Porgador ... Read more

TCR gene therapies show promise in cancer treatment but are hindered by the low natural avidity of TCRs against tumor-associated antigens. MAGE-A1 is a germline antigen expressed in many tumor types, making it a compelling target for TCR-based immunotherapy. Cell therapy for MAGE-... Read more

Hybridoma cell line [clone BUSA14] which generates lacZ inducible CD8+ T -cells capable of recognizing both human and mouse gp100(25-33) melanoma antigens presented on dendritic and tumor cell lines. Cafri G, Sharbi-Yunger A, Tzehoval E, Eisenbach L. Production of LacZ Inducible T... Read more