Duchenne muscular dystrophy (DMD) is a disease that affects approximately 1 in 3,500 boys with a life expectancy of ~26 years. Duchenne muscular dystrophy (DMD) is a disease that causes progressive muscle weakness, loss of skeletal and heart muscle tissue, degeneration, and eventu... Read more

A novel method of preventing secondary infections, by inhibition of membrane type I matrix-metalloproteinase-1, which reduces degradation of the extra cellular matrix. Pathogens that infect the respiratory system are the cause of some of the most dangerous infections, especially ... Read more

An innovative method for treating diseases associated with dysregulation of collagen fibers in the extracellular matrix (ECM), such as cancer and fibrosis, by targeting LOXL-2. ECM disruption is associated with many pathological conditions, such as various cancer types and tissue... Read more

A novel therapeutic antibody against MMP-7, with exceptional specificity, for the treatment of aggressive cancers. Matrix metalloproteins (MMPs), a family of zinc-dependent endopeptidases, are key enzymes participating in remodeling of the extracellular matrix (ECM), and are thus ... Read more

Targeting TNF-α Converting Enzyme (TACE) to Treat Autoimmune and Inflammatory Diseases Autoimmune and inflammatory mediated disorders encompass a wide range of diseases, including psoriasis, inflammatory bowel disease (IBD), rheumatoid arthritis (RA), systemic sclerosis, systemi... Read more