The AR37 monoclonal antibody recognizes human and mouse amphiregulin (AREG), a member of the epidermal growth factor (EGF) family. in vivo blocking of amphiregulin (AREG)in vitro blocking of amphiregulin (AREG) Immunofluorescence Western blot ELISA Lindzen et al, Oncog... Read more

Lung cancer patients treated with the blockbuster drug Osimertinib (Tagrisso) eventually develop resistance. We identified a novel MERTK-dependent escape mechanism, that occurs even in the absence of new mutations and is estimated to account for more than 60% of resistance cases. ... Read more