Bacterial and plant immune systems rely on Toll/Interleukin-1 receptor (TIR) domains to detect pathogens and initiate defense responses through immune signals comprising isomers of cyclic ADP-ribose. Phage therapy: Engineering “super-phages” expressing Tad1 genes to overcome b... Read more

There is a growing need for innovative strategies to selectively target key drivers of immune-mediated diseases. Discovery of highly specific protein inhibitors targeting key human immune molecules, enabling the development of novel biologics for autoimmune and inflammatory diseas... Read more

There is a growing need for effective antiviral therapies, particularly for viruses that currently lack approved treatments. Treatment of viral infections with no currently approved antiviral therapies Development of broad-spectrum antiviral drugs Nucleotide chain term... Read more

Synthetic genes are commonly used in academic and industrial applications, however in many cases these said genes can be toxic when inserted into the ubiquitously used E. coli. This is problematic as time and money is wasted on attempts to generate genes that will not function in E. coli. ... Read more

Bacterial defense systems often block plasmid delivery, limiting strain engineering and biomanufacturing. Enabling efficient transformation of previously untransformable bacterial strains Increasing plasmid delivery and expression efficiency in industrial hosts Expanding the genet... Read more