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(yielded 149 results)
  • 5299

    LTC4 (6E7) (No. M7-101)

    Summary: Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry. Leukotrienes:  101 – Monoclonal antibody to LTC4 Description: Rat monoclonal antibodies raised against Le ... Read more

  • 5302

    An endothelial-adipose cell line derived from a murine bone marrow stroma (14F1.1) (No. M7-103)

    Summary: 103 - Bone marrow derived stroma cell line 14F1.1 Description: An endothelial-adipose cell line derived from a murine bone marrow stroma. Reference: Zipori D, Toledo J, von der Mark K. 1985. Phenotypic heterogeneity among stromal cell lines from mouse bone marrow disclosed in their extracellular matrix composition ... Read more

  • 5305

    Anti-Sulfamethazine monoclonal antibody (No. M7-115)

    Summary:  Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.Leukotrienes:   Veterinary drugs: § 115 - Monoclonal antibody to Sulfamethazine (SMZ) Description: Rat mon ... Read more

  • 5308

    Anti-Biotin Antibody (No. M7-116)

    Summary: Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.  Biotin: §  116, 142 – Monoclonal antibody to Biotin           Description: Monoclonal antibod ... Read more

  • 5311

    Anti-Digoxin monoclonal antibody (No. M7-117)

    Summary: Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry. Leukotrienes:   Drugs:  117 – Monoclonal antibody to Digoxin - Description: Rat monoclonal antibodies ... Read more

  • 5314

    Anti-Buserelin monoclonal antibody (No. M7-118)

    Summary:  Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.Leukotrienes:  Drugs: §  118 - Monoclonal antibody to Buserelin      Description: Rat monoclonal anti ... Read more

  • 5317

    Anti-testosterone 3-(0- carboxymethyl)oxime-BSA monoclonal antibody (No. M7-119)

    Summary: Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. Rat monoclonal antibodies raised against testosterone 3-(0- carboxymethyl)oxime-BSA. Available clones: 5F ... Read more

  • 5320

    Anti-Follicle-stimulating hormone (FSH) monoclonal antibody (No. M7-120)

    Summary: Monoclonal antibodies raised against bFSH. Available clone: 1G12. Follicle-stimulating hormone (FSH) is synthesized and secreted by gonadotrophs of the anterior pituitary gland. FSH regulates the development, growth, pubertal maturation and reproductive processes of the body.Reference: Somjen D1, Tordjman K, Kohen ... Read more

  • 5323

    Anti-oestradiol-6- carboxymethyl oxime monoclonal antibody (No. M7-127)

    Summary: Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. Monoclonal antibodies raised against oestradiol-6- carboxymethyl oxime-BSA. Available clones: 2F9 (Rat, I ... Read more

  • 5326

    Anti-idiotypic antibody against anti-Sulfamethazine (12E12) (No. M7-130)

    Summary: Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry. Leukotrienes:   Veterinary drugs: 130 - Anti-idiotypic antibody against anti-Sulfamethazine  Description: B ... Read more

  • 5329

    Human T3N1M1 prostatic adenocarcinoma tissue for xenograft (No. M7-132)

    Summary: WISH-PC frozen tissue samples Description: Neuroendocrine xenograft model of human prostatic small cell carcinoma cancer. Provides a source to study the involvement of neuroendocrine cells in the progression of prostatic adenocarcinoma and can serve as a novel model for the testing of new therapeutic strategies f ... Read more

  • 5332

    Anti-progesterone-7 monoclonal antibody (No. M7-138)

    Summary: Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. Monoclonal antibodies raised against progesterone-7- carboxythio thioether-BSA (clone 2H4, Rat IgG1) and ... Read more

  • 5335

    Anti-oestradiol-6-carboxymethyl oxime monoclonal antibody (No. M7-141)

    Summary: Monoclonal antibodies for peptide and steroid hormones Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.   127, 274, 141 – Monoclonal antibodies to estra ... Read more

  • 5338

    F4 (No. M7-142)

    Summary: Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.   Biotin:  116, 142 – Monoclonal antibody to Biotin - Description: Monoclonal antibodies raised against ... Read more

  • 5341

    Clone 1F5 (No. M7-143)

    Summary: Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry. Leukotrienes: Drugs: 143 - Monoclonal antibody to Medroxy-progesterone-acetate - Description: Rat monoclona ... Read more

  • 5344

    Clone 8B6 (No. M7-144)

    Summary: Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.Leukotrienes:  Drugs: §  144 - Monoclonal antibody to RU-486 Description: Rat monoclonal antibodies raised ... Read more

  • 5347

    Anti-Human chorionic gonadotropin (hCG) monoclonal antibody (No. M7-147)

    Summary: Monoclonal antibodies raised against bhCG. Available clones: 1D5 (IgG1), 1E11 (IgG2b).Human chorionic gonadotropin (hCG) is a hormone produced by the syncytiotrophoblast, a component of the fertilized egg, after conception.Monoclonal antibodies for peptide and steroid hormones Due to their high specificity and sen ... Read more

  • 5350

    Clone - 1E11 (No. M7-148)

    Summary: Monoclonal antibodies for peptide and steroid hormones Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. Peptide Hormones:  147-148 - Monoclonal antibody t ... Read more

  • 5353

    Anti-7-(O)-carboxymethyl formononetin monoclonal antibody (No. M7-155)

    Summary: Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.  Isoflavones: §  155 – Monoclonal antibody to 7-(O)-carboxymethyl formononetin   Description: 7-(O)-ca ... Read more

  • 5356

    Anti-Phospho-ERK (PY193 or PT115) Monoclonal Antibodies (No. M7-176)

    Summary: 176-177 - Monoclonal antibodies to phospho-ERK/Map Kinase Description: Monoclonal antibodies raised against peptides containing the 11 amino acids, HTGFLTEYVAT, corresponding to the ERK activation loop either Tyr -phosphorylated (ERK-PY193), or Thr-phosphorylated (ERK-PT115). ERK belongs to the family of mitogen-a ... Read more

  • 5359

    ERK-PT115 (No. M7-177)

    Summary: 176-177 - Monoclonal antibodies to phospho-ERK/Map Kinase Description: Monoclonal antibodies raised against peptides containing the 11 amino acids, HTGFLTEYVAT, corresponding to the ERK activation loop either Tyr -phosphorylated (ERK-PY193), or Thr-phosphorylated (ERK-PT115). ERK belongs to the family of mitogen-a ... Read more

  • 5362

    Anti-Galactin 8 monoclonal antibody (No. M7-181)

    Summary: Description: Monoclonal antibody to Galectin-8 (clone 106.1). Galectin-8 is a secreted, integrin-binding protein, part of a mammalian lectins family.  Galectin-8, also known as Prostate Cancer Tumor Antigen-1 (PCTA-1) is highly expressed in human prostate cancer.  It was shown to trigger the transcription of a u ... Read more

  • 5365

    Anti-IgE monoclonal antibody (No. M7-185)

    Summary: Monoclonal antibodies to IgE Description: Rat monoclonal anti-IgE antibodies that was generated by fusion of plasmacytoma (84.1C) or myeloma (EM953) cells with splenocytes of rat immunized with purified murine IgE mAb. The antibodies react with various IgE mAb of different specificities and not with immunoglobuli ... Read more

  • 5368

    Diastereomer Lytic Peptides for Treatment of Solid Tumors and Metastasis in animal models (No. M7-236)

    Summary: 236-237 - Diastereomer Lytic Peptides for Treatment of Solid Tumors and Metastasis Description: 15-mer (Leu-Lys-Dleu- Leu-Lys-Dlys-Leu-Dleu-Dlys-Lys-Leu-Leu-Dlys-Leu-Leu) and 15-mer Histidin (H-Leu-Lys-D-Leu- Leu-His-D-Lys-Leu-D-Leu-D-Lys-His-Leu-Leu-D-Lys-Leu-Leu-NH2) are membrane-active peptides composed of both ... Read more

  • 5371

    15-mer Histidin (No. M7-237)

    Summary: 236-237 - Diastereomer Lytic Peptides for Treatment of Solid Tumors and Metastasis Description: 15-mer (Leu-Lys-Dleu- Leu-Lys-Dlys-Leu-Dleu-Dlys-Lys-Leu-Leu-Dlys-Leu-Leu) and 15-mer Histidin (H-Leu-Lys-D-Leu- Leu-His-D-Lys-Leu-D-Leu-D-Lys-His-Leu-Leu-D-Lys-Leu-Leu-NH2) are membrane-active peptides composed of both ... Read more

  • 5374

    Core peptide to inhibit T-Cell mediated inflammation in animal models (No. M7-238)

    Summary: 238 - CP Peptide Description: Core peptide (CP; GLRILLLKV-D-stereoisomer), a synthetic peptide coding for the transmembrane domain of the ?-subunit of the T-cell receptor (TCR), a region that has been identified to be crucial for the assembly and function of the TCR. Was shown to significantly inhibit T-cell-media ... Read more

  • 5377

    Anti-Mono-ubiquitinated H2B monoclonal antibody (No. M7-240)

    Summary: 240 - Monoclonal antibody directed to ubiquitinated-H2B Description: Monoclonal antibodies, specific to ubiquitinated-H2B in its ubiquitinated form but not in its unmodified state, or to ubiquitin un-conjugated to H2B. Monoubiquitylated-H2B takes part in almost every molecular process associated with chromatin bio ... Read more

  • 5380

    Anti-progesterone-7 monoclonal antibody (No. M7-252)

    Summary: Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. Anti-idiotypic antibody raised against anti-progesterone-7- BSA.KLH conjugate (clone 2H4). Available clon ... Read more

  • 5383

    Alpha-Anti Progesterone (2E11) (No. M7-253)

    Summary: Monoclonal antibodies for peptide and steroid hormones Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. Anti-idiotypic antibodies to anti-steroids: 252-253 ... Read more

  • 5386

    Monoclonal Anti-Gliomedin Antibody (Mab#94) (No. M7-257)

    Summary: 257 - Monoclonal antibody to Gliomedin Description: Monoclonal antibody to Gliomedin (MAb 94) raised against a synthetic peptide corresponding to amino acid residues 273–287 (CVIPNDDTLVGRA), present in the extra cellular region of Rat Gliomedin. Gliomedin, a glial ligand for neurofascin and NrCAM, is expressed ... Read more

  • 5389

    Monoclonal Anti-Ermin Antibody (Mab#160) (No. M7-258)

    Summary: 258 - Monoclonal antibody to Ermin Description: Monoclonal antibody to Ermin (MAb160) raised against purified GST–Ermin (residues 1–261). Ermin is a marker of myelinating oligodendroglia, localized to the outer cytoplasmic lip of the myelin sheath and the paranodal loops. It was suggested to play a role in cyt ... Read more

  • 5392

    Monoclonal Anti-Caspr Antibody (Mab#275) (No. M7-259)

    Summary: 259 - Monoclonal antibody to Caspr Description: Monoclonal antibody to Caspr (Mab275), raised against the extracellular domain of Caspr. Caspr is a contactin-associated protein, part of the neurexin family of proteins. It lies in the paranodal section of the myelin sheath and has a role in myelin sheath attachmen ... Read more

  • 5395

    Anti- Glutamate receptor (GluR3B) monoclonal antibody (No. M7-261)

    Summary: 261 - Monoclonal antibody to GluR3B Description: Mouse monoclonal antibody (IgG2a), raised against a synthetic peptide of the Glutamate receptor (GluR3B), corresponding to amino acids 383-395 (NEYERFVPFSDQQISNDSSSSENR) of Leishmania donovani GluR3B. May be used for diagnosis as well as drug development for "autoim ... Read more

  • 5398

    Monoclonal Antibodies Specific to Cholesterol/Ceramide Mixture Clone (No. M7-263)

    Summary: Originally raised against an artificial monolayer of lipid mixtures in, and were shown to specifically label the above domains in different cell membranes. Reference:  Scheffer L, Futerman AH, Addadi L. 2007. Antibody labeling of cholesterol/ceramide ordered domains in cell membranes. Chembiochem 8(18):2286-94. ... Read more

  • 5401

    499F (No. M7-265)

    Summary: Monoclonal antibodies specific to cholesterol/ceramide mixture Description: Monoclonal antibodies specific for cholesterol/ceramide-rich domains (clones 405F, 14F, 499F) and cholesterol micro-domains (clones 36A1, 5881) in cell membranes. Originally raised against an artificial monolayer of lipid mixtures in, and ... Read more

  • 5404

    Anti- estrone-3- glucuronide monoclonal antibody (No. M7-273)

    Summary: Monoclonal antibodies for peptide and steroid hormones Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. 273 - Anti-idiotypic antibody against estrone-3-gl ... Read more

  • 5407

    Anti-Estradiol 15 (No. M7-274)

    Summary: Monoclonal antibodies for peptide and steroid hormones Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.   §  127, 274, 141 – Monoclonal antibodies to ... Read more

  • 5410

    Anti-Estrone-3-Glucuronide monoclonal antibody (No. M7-275)

    Summary: Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. Monoclonal antibodies raised against estrone-3-glucuronide-BSA. Available clones: 8A3 (Rat, IgG2a), 155B3. ... Read more

  • 5413

    Anti-Estrone-3-Glucuronide monoclonal antibody (clones: 155B3, 8A3) (No. M7-276)

    Summary: Monoclonal antibodies for peptide and steroid hormones Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. 275-276 – Monoclonal antibodies to estrone-3-gluc ... Read more

  • 5416

    Anti-Runx-3 monoclonal antibody (No. M7-306)

    Summary: Monoclonal antibody to Runx-3 Description: Monoclonal antibody to Runx-3 raised against the Runx3 peptide TPSTPSPRGSLSTTSHF. Available clones: 62, H8. Runx-3 (Runt-related transcription factor 3) is a transcription factor, and a master regulator of lineage specific gene expression in several important developmenta ... Read more

  • 5419

    Chromogenic substrate for serum paraoxonase (PONs) activity (No. M7-315)

    Summary: 315 - TBBL (5-thiobutyl butyrolactone) Description: TBBL (5-thiobutyl butyrolactone) is a chromogenic lipo-lactone substrate for Serum paraoxonases (PONs), used for sera tests of PONs activity, based on their lactonase activity.  The primary enzymatic reaction produces an unstable intermediate that rapidly collap ... Read more

  • 5422

    Anti-Mast cell Function-associated Antigen (MAFA) monoclonal antibody (No. M7-320)

    Summary: 320 - Monoclonal antibody G63 Description: Monoclonal antibodies to MAFA (Mast cell Function-associated Antigen), originally raised against intact rat RBL-2H3 cells. MAFA is a type II membrane glycoprotein, which was shown to inhibit the secretory response to the type. Binding of G63 antibody to MAFA was shown to ... Read more

  • 5425

    Escherichia coli UTL2 (No. M7-358)

    Summary: Escherichia coli UTL2 Description: A "leaky" strain of E. coli, which is significantly more susceptible to cytotoxic agents. UTL2 holds a mutation in the galU gene causing an impaired outer membrane. Reference:  Bibi E. 1996. Functional expression of mouse Mdr1 in an outer membrane permeability mutant of Escheric ... Read more

  • 5428

    MyRepair Blood Test to Identify People at High Risk for Lung Cancer (No. T4-1033)

    Summary: A novel diagnostic test to identify individuals with increased risk of lung cancer. Lung cancer is the number one killer among cancers, with 160,000 deaths/year in the USA and 1.6 million/year worldwide. Early detection of lung cancer increases 5-year survival rate from 4% to 54%. Moreover, the National Lung Cance ... Read more

  • 5434

    Acquisition of Multidimensional NMR Spectra in a Single Scan (No. T4-1151)

    Summary: A method to significantly shorten acquisition times of high-quality MRI images. Multidimensional nuclear magnetic resonance (NMR) is used nowadays in many applications (e.g., discovery of new pharmaceutical drugs, characterization of new catalysts, and investigation of the structure and dynamics of proteins). One ... Read more

  • 5437

    Monoclonal Antibodies for Monitoring Hormone and Drug Additives in Food Providing Animals (No. T4-1166)

    Summary: A series of monoclonal antibodies for monitoring hormone and drug additives in animals grown for the food industry. These include mAbs for peptide hormones, steroid hormones, drugs, leukotrienes, isoflavones, and veterinary drugs. ApplicationsMonitoring hormone and drug additives in food providing anim ... Read more

  • 5449

    Cholesterol Antibodies (No. T4-1267)

    Summary: Description: Monoclonal antibodies specific for cholesterol/ceramide-rich domains (clones 405F, 14F, 499F) and cholesterol micro-domains (clones 36A1, 5881) in cell membranes. Originally raised against an artificial monolayer of lipid mixtures in, and were shown to specifically label the above domains in differen ... Read more

  • 5452

    Mouse IgE and Anti-Mouse IgE Monoclonal Antibodies (No. M7-1270)

    Summary: Monoclonal antibodies to IgE Description: Rat monoclonal anti-IgE antibodies that was generated by fusion of plasmacytoma (84.1C) or myeloma (EM953) cells with splenocytes of rat immunized with purified murine IgE mAb. The antibodies react with various IgE mAb of different specificities and not with immunoglobuli ... Read more

  • 5455

    On-Chip Synthesis of Biomolecules (No. T4-1369)

    OverviewCell-free synthetic platforms that enable complex biological activities such as synthesis and self-assembly of biomolecules, can be employed for various applications, including drug discovery and diagnostics. Using synthetic genes, we provide a novel platform for cell-free synthetic biology on a chip which is a c ... Read more

  • 5458

    High-Performance Electrochromic Devices (No. T4-1380)

    Summary: High performance electrochromic materials that exhibit a practical combination of low-voltage operation and efficient color switching as well as long-term stability have been developed by the group of Prof.< size=2 face=Verdana> van der Boom. Electrochromic materials undergo reversible optical changes in res ... Read more

  • 5461

    Detecting Irregularities (such as suspicious movements) in Visual Data (No. T4-1381)

    OverviewWhile image & video processing are rapidly developing fields, most of the recent algorithms must be trained on large and sorted databases to gain adequate performance. Detecting irregularities in previously unknown images or videos is still an unsolved problem. Prof. Michal Irani and her team developed an alg ... Read more

  • 5464

    Monoclonal Anti-Ubiquitinated Histone H2B Antibody (No. T4-1397)

    Summary: A novel antibody which can be used, for the first time, to recognize ubiquitinated histone 2B. This technology is novel in its ability to recognize proteins and their destinations, and may serve in diagnostics and immunoprecipitation processes. ApplicationsPrimary applications in research. Use as a det ... Read more

  • 5467

    Automatic Animation in Video and Still Images (No. T4-1423)

    Summary: Many currently marketed animation tools enable users to define objects and provide them with motion, yet none enable the fast and automatic, animation of a full body captured in a single still photo. A new technology developed by a group of researchers from the Weizmann Institute of Science, enables automatic tran ... Read more

  • 5470

    CD84 - a Novel Regulator of B-CLL Survival (No. T4-1441)

    Summary: Chronic lymphocytic leukemia (CLL), a malignant disease characterized by the accumulation of B lymphocytes in the blood, lymphoid organs, and bone marrow, is the second most common type of leukemia in adults, accounting for about 7,000 new cases of leukemia each year. Presently, there is no cure for CLL, and the o ... Read more

  • 5473

    Inhibition of Nuclear Entry of MAPK Cascade Proteins as a Novel Mechanism for Treating Cancer (No. T4-1446)

    Summary: Peptide sequences for efficient inhibition of nuclear translocation of proteins. The ability to regulate cellular localization of a biological component is important for many functions such as gene therapy, protection from toxic chemicals, transport of anti-cancer agents, and possibly preventing nuclear translocat ... Read more

  • 5479

    Changing an Image Size without Information Loss (No. T4-1461)

    Summary: Bidirectional Similarity offers a new approach to summarization of visual data (images and video) based on optimization of well defined similarity measure. Common visual summarization methods (mainly scaling and cropping) suffer from significant deficiencies related to image quality and loss of important data. Man ... Read more

  • 5482

    Highly Sensitive Nanoscale Scanning Magnetic and Thermal Sensor (No. T4-1481)

    Summary: A new technology developed by a group of researchers from the Weizmann Institute is a nanoscale sensor-on-tip for local magnetic signals and thermal dissipation with state-of-the-art sensitivity and spatial resolution. In light of the rapidly developing scanning-probe based technologies including nanomagnetism, sp ... Read more

  • 5485

    Conductive Inorganic Fullerenes and Nanotubes (No. T4-1482)

    Summary: Modification of the electronic properties of layered-type semiconductors can be accomplished by doping/alloying of the semiconductor. In the present disclosure we show that doping of MoS2 and WS2 nanotubes/nanoparticles can be accomplished by doping with either Re (n-type) or Nb (p-type) foreign atoms. These nanop ... Read more

  • 5488

    MicroRNA Differental Profiles as ALS Biomarkers (No. T4-1498)

    Summary: MicroRNAs as potential biomarkers for ALS.Amyotrophic Lateral Sclerosis (ALS) is a devastating disease that progressively destroys motor neurons in the brain and the spinal cord, eventually causing paralysis and death. Currently, there are approximately 25,000 patients with ALS in the USA, with a median age of on ... Read more

  • 5500

    Increasing Resolution of an Image (No. T4-1522)

    OverviewMany imaging devices produce signals of unsatisfactory resolution (e.g. a photo from a cell-phone camera may have low spatial resolution or a video from a web camera may have both spatial and temporal low resolution). Previous methods for Super-Resolution (SR) require multiple images of the same scene, or else an ... Read more

  • 5503

    Optical Conversion (No. T4-1529)

    Summary: We present an efficient and robust broadband crystal optical conversion device. Various applications of laser optics require tunable laser sources. Currently, most frequency conversion devices rely on a single non-linear crystal, which is either temperature or angle tuned to enhance efficiency. This results only i ... Read more

  • 5512

    Green Catalytic Formation of Alcohols, Amines, Amides, Imines and Esters under Mild Conditions (No. T4-1551)

    Summary: A novel set of manganese, ruthenium and related borohydride complexes (Pincer-type) were developed as remarkably efficient and environmentally-benign catalysts for the synthesis of alcohols, amines, amides, imines and esters, which are the basic building blocks for the research, chemicals, pharmaceutical and agroc ... Read more

  • 5515

    In Silico Designed Synthetic Carbon Fixation Pathways for Superior Biomass Generation (No. T4-1556)

    Summary: Synthetic carbon fixation pathways can allow plants to produce more biomass using the same amount of energy from sunlight. Novel carbon fixation cycles discovered at The Weizmann Institute hold potential to greatly increase the capacity of organisms to convert atmospheric carbon into sugars. Modern agriculture fac ... Read more

  • 5521

    Inorganic Fullerene Coating for Medical Devices (No. T4-1566)

    Summary: Novel nanoparticle lubricants can significantly reduce friction of different dental devices and enable reduction of treatment times. Different dental applications suffer from excessive friction, which severely compromise their function. For orthodontic procedures, friction significantly reduces effectiveness and t ... Read more

  • 5530

    A Novel Database to Reduce Unsuccessful Cloning in E. Coli by Detection of Toxic Genes (No. M7-1576)

    Summary: Synthetic genes are commonly used in academic and industrial applications, however in many cases these said genes can be toxic when inserted into the ubiquitously used E. coli. This is problematic as time and money is wasted on attempts to generate genes that will not function in E. coli. The problem is exacerbate ... Read more

  • 5533

    Desulfurization of Flue-Gasses (No. T4-1577)

    Summary: A novel desulfurization system achieves removal of sulfur dioxide (SO2) from industrial exhaust streams at efficiencies that can greatly supersede technologies currently in use. The chemical process is highly selective to SO2, and consumes much less reagents, therefore reducing the cost of desulfurization.Techniqu ... Read more

  • 5536

    A Novel Technique of Thermoelectric Conversion (No. T4-1583)

    Summary: The thermoelectric effect is the direct conversion of temperature differences to electric voltage and vice versa. Thermoelectric effects are used in various applications, where heat energy is saved, that would be otherwise lost. Although the TE conversion efficiency is nowadays low (5-8%), the novel technique deve ... Read more

  • 5545

    Novel MRI Contrast Agent (No. T4-1604)

    Summary: Novel reporter gene for magnetic resonance imaging applications.The ability to image the duration and location of gene expression in vivo and noninvasively is imperative for the future of biology and clinical medicine. Magnetic Resonance Imaging (MRI) is a widely used noninvasive clinical diagnostic tool that offe ... Read more

  • 5548

    SiRNA Proteasome Inhibitors for Cancer Theraphy (No. T4-1619)

    Summary: Triple negative breast cancer (TNBC) is an aggressive type of breast cancer, representing over 10% of all breast cancer cases. TNBC is known for its high risk of relapse, poor survival prospects, and near zero survival rates once TNBC metastasizes. Due to the lack of molecular targets (estrogen, progesterone, and ... Read more

  • 5551

    A TACE Inhibitor (ADAM17) (No. T4-1628)

    Summary: New generation of superior nature-inspired therapeutics for treating inflammation.Inflammation is characterized by elevated levels of TNF-?. Neutralizing TNF-? activity was shown to be beneficial for patients with chronic autoimmune inflammatory diseases such as rheumatoid arthritis (RA) and inflammatory bowel dis ... Read more

  • 5557

    Biological Treatment for Pancreatic Cancer (MMP7 mAb) (No. T4-1640)

    Summary: The innovative concept leading to this high selectivity is immunization with both a synthetic metal-protein mimicry molecule, previously developed by the present inventors, followed by the metalloenzyme itself (e.g. MMP-7). The resulting antibody exhibits exceptional degree of specificity towards MMP-7 over other ... Read more

  • 5560

    Anti-QSOX1 Antibody for Treating Cancer and Metastasis (No. T4-1642)

    OverviewCancer, and especially cancer metastasis, is a leading cause of death worldwide. Research in recent years highlighted the importance of the extracellular matrix (ECM) surrounding the tumor in cancer progression metastasis formation. Therefore, many attempts currently address the unmet need to target enzymes that ... Read more

  • 5566

    Unsupervised Content-Based Image Retrieval (CBIR) and categorization (No. T4-1647)

    Summary: Novel algorithms developed at the Weizmann Institute of Science for Content-Based Image Retrieval (CBIR) can enhance search engines by crowd-sourcing and improved clustering.Discovering visual categories among collection of images is a long standing challenge in computer vision, which limits images-based search en ... Read more

  • 5572

    Affinity Maturated T-Cell Receptor (No. T4-1662)

    Summary: Immunotherapy, that is the use of the immune system to treat cancer, is currently a leading candidate in the combat against cancer. Unlike the toxic effects of both chemotherapy and radiation, immunotherapy is considered to have mild side effects due to its ability to differentiate between healthy and cancerous ce ... Read more

  • 5575

    MRI of Tissue Fibrosis Without Contrast Agent (No. T4-1665)

    Summary: Improved magnetic resonance imaging (MRI) for cardiac fibrosis and other fibrotic diseases.Myocardial fibrosis is associated with worsening ventricular systolic function, abnormal cardiac remodeling, and increased ventricular stiffness, significantly increasing the risk of adverse cardiac outcomes. Hypertension an ... Read more

  • 5584

    Long Chain Sphingoid as Preventing Infection (No. T4-1673)

    Summary: CF is the most common autosomal recessive disorder in western countries, affecting approximately 30,000 people in the US alone. A major risk in CF arises from chronic bacterial lung infections, affecting 80% of CF patients by the age of 25. Bacterial lung infections are also of major clinical importance in patient ... Read more

  • 5587

    Highly Selective Optical Biosensors for Proteins in Biological Samples, with Excellent Signal-to-Noise Ratio (No. T4-1689)

    Summary: Sensing the levels of protein-based biomarkers in biological samples is crucial for diagnosis of various diseases including cancer. Optical biosensors offer sensitivity and cost-effectiveness; however, current commercially available devices fail to provide sufficient selectivity and signal to noise ratios for prot ... Read more

  • 5590

    Production of Syngas from Biomass (No. T4-1716)

    Summary: An efficient and selective decomposition of plant biomass carbohydrates to their basic components, carbon monoxide and hydrogen, for use as syngas.Terrestrial plants contain about 70% hemicellulose and cellulose, which constitute a significant renewable bio-resource with potential as an alternative to petroleum fe ... Read more

  • 5596

    Aerobic Carbon-Carbon Bond Cleavage of Alkenes to Aldehydes and Ketones (No. T4-1722)

    Summary: Our technology provides a new type of oxidative cleavage reaction of organic compounds with highly selective product formation.Polyoxometalate (POM) catalysts have become well-known for their utility and diversity in specific reactions. Through the elucidation of POM catalytic pathways, greater versatility has bee ... Read more

  • 5599

    Biocontrol Enhancers to Promote Root Colonization by Beneficial Bacteria (No. T4-1723)

    Summary: Available chemically based pesticides cause a large number of negative health and environmental effects including the outcome of residual contamination of land, water, and crops. Subsequently there is a need for improved methods of crop protection, preferably the use of environmental friendly alternatives of biolo ... Read more

  • 5602

    Carbon Nanotube Based Transistor Device (No. T4-1730)

    Summary: With the continuous trend of electronic component miniaturization, process control technologies must keep up with component size reduction. Defects that were so far negligible, are now posing critical operation obstacles, and are more difficult to identify as scales are reduced to <10 nm. This new technology de ... Read more

  • 5605

    P38 and JNK Inhibitor as Potential Treatment for Various Pathologies (No. T4-1733)

    OverviewThe development of kinase inhibitors to treat inflammatory diseases was proved beneficial, however, designing specific inhibitors with minimal side effects and prolonged efficacy is challenging as drug resistance often develops. The current technology includes inhibitors that specifically target the nuclear trans ... Read more

  • 5608

    Bioengineered Microorganisms that can "Eat" (Fix) CO2 (No. T4-1736)

    OverviewThe two most pressing challenges facing humanity are the need to feed the growing population with restricted land and water sources and global warming caused due to high atmospheric CO2 levels. Biological systems for CO2 conversion to organic molecules using renewable-energy-harvesting techniques present a promis ... Read more

  • 5611

    A Novel Approach for Treating Cancer and Collagen-Associated Diseases by Using Anti-LOXL-2 Antibody (No. T4-1743)

    Summary: Disruption to the Extra-Cellular Matrix (ECM) is associated with many pathological conditions, such as various cancer types and tissue fibrosis, and also correlates with high tumor malignancy. Therefore, controlling ECM composition and morphology is considered a potential treatment for cancer and other ECM-associa ... Read more

  • 5620

    rPTE with Potent Organophosphate (OPH) Activities (No. T4-1750)

    Summary: Organophosphates are toxic compounds found in chemical warfare agents, such as nerve gases, and insect pesticides.Use of volatile nerve gas agents by terrorist organizations is a key concern of governments around the world. V-type nerve agents (e.g. VX, RVX, and CVX) are particularly toxic nerve gases, with an exc ... Read more

  • 5623

    ERBB2 as a Novel Target to Treat Heart Failure by Inducing Cardiomyocyte Proliferation (No. T4-1752)

    Summary: Existing treatments fail to compensate the irreversible loss of functional cardiomyocytes (CM), thus presenting a major medical unmet need. Inducing native CM replacement is one approach being tested as regenerative treatment, with the advantage of a more straightforward methodology over cell transplantation appro ... Read more

  • 5626

    Spin Controlled Water Electrolysis for Efficient Production of Hydrogen (No. T4-1753)

    Summary: A team of researchers lead by Prof. Naaman have been investigating the CISS effect in different systems. They found that the high efficiency of many natural multiple electron reactions can also be attributed to spin alignment of the electrons involved.The present innovation looks at hydrogen production through wat ... Read more

  • 5629

    Multimodel Transcranial Optical Vascular Assessment (No. T4-1769)

    Summary: Subdural hematoma (SDH) is a collection of blood between the inner layer of the dura and the brain that occurs mostly as a result of trauma.  It is one of the most common neurosurgical conditions in the United States today. SDH monitoring for hematoma expansion would be beneficial to enable expeditious surgical i ... Read more

  • 5635

    A Novel Method for Treating Drug-Resistant Lung Cancer Using a Combination of Antibodies (No. T4-1774)

    Summary: A novel method for treating tyrosine kinase inhibitor (TKI)-resistant cancer, by using a combination of three different antibodies. Lung cancer is known as one of the most fatal forms of cancer. Notably, standard treatments for other cancer types (e.g. TKIs and mAbs), have shown only a limited effect on this speci ... Read more

  • 5647

    A Novel Method of Preventing or Treating Secondary Infections by Inhibition of Membrane Type I Matrix-Metalloproteinase-1 (No. T4-1790)

    Summary: A novel method of preventing secondary infections, by inhibition of membrane type I matrix-metalloproteinase-1 (MT1-MMP), which reduces degradation of the extra-cellular matrix. Pathogens that infect the respiratory system are the cause of some of the most dangerous infections, especially for vulnerable population ... Read more

  • 5653

    A Sensitive and Fast Image Subtrection Technique (No. T4-1801)

    Summary: Image sequences are used in various fields, including medical imaging and satellite/airborne imaging. The comparison between images taken at different conditions (e.g. equipment or configuration, angles, weather and wavelength) can be a highly non-trivial problem, as subtraction artifacts can outnumber real change ... Read more

  • 5656

    Detection of Short Dispered Pulse Signals (No. T4-1802)

    Summary: Pulses are applied in various fields such as oil & gas exploration, detection (e.g. sonar, lidar and radar) and communication. When pulses pass through dispersive media, the arrival times at the detector of different frequency components may differ, and as a result the pulse may become degraded (e.g. transform ... Read more

  • 5659

    Novel Method for Diagnosing and Treating Relapsed Obesity (No. T4-1805)

    Summary: Obesity is the health epidemic of the modern world, with nearly half the global adult population being categorized as obese. The consequences of said mass obesity is that it is overwhelming the medical systems all over the world, as obesity is linked to numerous diseases ranging from diabetes to cancer. The challe ... Read more

  • 5662

    Novel CNT Hybrid Films (No. T4-1809)

    Summary: Battery and capacitor electrode technologies available in the industry today, are struggling to keep up with rapidly advancing applications that require high power and energy density such as electric vehicles, solar cells and telecommunications systems. One of the leading solutions to this problem are CNT-based fi ... Read more

  • 5665

    A Novel Technique to Produce Large Quantities of Therapeutic T cells (No. T4-1810)

    OverviewProduction of large quantities of T cells is an essential demand for the development of immunotherapies. However, ex-vivo culturing of T-cells is very inefficient, resulting in high cell death rates. The current technology offers unique, optimized conditions that allow increased T-cell proliferation while enhanci ... Read more

  • 5668

    Increasing Plant Yield by Inhibiting Attenuating Enzymes (No. T4-1812)

    Summary: A growing global population requires a greater food supply. The agriculture industry and biotechnology sector are trying to overcome the challenge and improve crop efficiency by increasing food production in the same or smaller farming areas, as well as dealing with the threats imposed by climate change. Consequen ... Read more

  • 5671

    Devices and Methods to Measure Small Displacements (No. T4-1815)

    Summary: This novel method utilizes polarized light that in contrast to conventional methods does not interact directly with the material or with the material’s surface. Here the material to be tested is secured underneath a reflective material, such that the polarized light reflected off the reflective material does not ... Read more

  • 5674

    Inertial NEMS for Nanosensor Applications Based on Inorganic Nanotubes (No. T4-1828)

    Summary: Inertial sensors for motion detection are being incorporated into an increasing number of portable devices, including diverse IoT applications, mobile phones, wearable electronics, automotive systems and medical diagnostic sensors. The current size reduction trend in electronics, requires incorporation of reliable ... Read more

  • 5677

    Highly Selective Fluorescent Biosensor for Labeling His-Tagged Proteins in a Specific Conformation (No. T4-1834)

    Summary: A rapid, label-free biosensor for detecting specific conformation of His-tag labeled proteins, accessible for use in both academic- and commercial-R&D. The fluorescent biosensor detects and labels His-tagged proteins in complex environments, such as living cells, while offering high sensitivity, speed, and cos ... Read more

  • 5680

    A Novel Method for Detecting Activation of Necroptosis via Exosome Analysis (No. T4-1839)

    Summary: Numerous medical conditions are related to inflammation, such as pancreatitis, psoriasis, inflammatory bowel disease, atherosclerosis, neurodegeneration, and more. However, determination of inflammation in the body, especially at early stages of a pathology is difficult to assess. Therefore, there is a great clini ... Read more

  • 5683

    Secure Search of Encrypted Cloud Data (No. T4-1840)

    Summary: Searchable symmetric encryption with practical big-data performance and strong security Highlights Outsourcing data storage to remote servers offers invaluable benefits while introducing many concerns when dealing with sensitive data. In the presence of potentially-vulnerable servers, strong user-side encryption p ... Read more

  • 5686

    Methods for High-Throughput Analysis of Transcriptomes (No. T4-1843)

    Summary: Analysis of the transcriptome of cells can inform greatly about the state of said cells, including maturation, activation, transformation, etc. Therefore it would be of great research and clinical value to analyze transcriptomes of different cell populations and to compare gene expression on large scales. A partic ... Read more

  • 5689

    Composite Functional Metasurfaces for Multispectral Achromatic Optics (No. T4-1845)

    Summary: A new technology for producing flat optical components based on optical metasurfaces. These components can potentially serve high resolution imaging, spectrometry, light processing and beam shaping devices. The optical metasurfaces that we develop are composed of closely spaced optical nanoantennas which can be ... Read more

  • 5695

    Arbitrium - A Novel Approach for Controlling Gene Expression (No. T4-1847)

    Summary: One of the challenges in the areas of synthetic biology and its clinical applications, is the capacity to control the induction of different genes, whether for the purpose of activating genetic circuits or inducing the expression of a specific protein. Present approaches are limited to the number of systems availa ... Read more

  • 5698

    CRISP-Seq: Integrating the Power of Single-Cell RNA Sequencing and CRISPR-Pooled Screens (No. T4-1848)

    Summary: Single-cell RNA sequencing (RNA-Seq) is a powerful tool to identify and characterize the transcriptome of single cells. While providing unprecedented resolution in terms of studying cells, single-cell RNA-Seq is functionally a descriptive tool, unless combined with gene manipulation. CRISPR-Cas9 is a genome-editin ... Read more

  • 5701

    Signal Enhancement and Manipulation Using a Signal-Specific Deep Network (No. T4-1850)

    Summary: Optical and dimensional limitations of images can be partially overcome today using signal enhancement technologies which typically rely on supervised, deep-learning methods. However, as existing methods are restricted to specific training images and distortion types, they provide poor results for any practical ca ... Read more

  • 5704

    Optical Bus for a Multi-Core Processor (No. T4-1863)

    Summary: The exponential increase in computational power over the last decades is running into a bottle-neck – the only way of getting more computing power per chip is to integrate multiple-cores, but the problem with multiple-cores is the complex wiring system, used for inter-core communication. This technology, develop ... Read more

  • 5707

    Novel Treatment for Lung Diseases by Allogeneic Cell Transplantation (No. T4-1868)

    Summary: The treatment of respiratory conditions is currently one of the major challenges to health care systems all over the world. The problem is that most therapeutics currently available for treating pulmonary indications are non-curative, and simply improve symptoms. Presently the only cure for late stage pulmonary di ... Read more

  • 5713

    Novel Method for Diagnosis and Treating Cancer by Analyzing the Urea Cycle (No. T4-1872)

    Summary: The urea cycle (UC) is an important metabolic pathway that takes place in the liver. A variety of enzymes, such as argininosuccinate synthase 1 (ASS1) and the trifunctional enzyme CAD, are involved in the UC, which converts excess nitrogen into urea. The UC produces various metabolites based on the balance between ... Read more

  • 5716

    A Method in Improving Survival and Expansion of Hematopoietic Stem Cells (No. T4-1874)

    Summary: hematopoietic cells. HSCs have the capacity to both self-renew and to differentiate, and they migrate from the bone marrow to the blood upon demand. Since HSCs can differentiate to a variety of cell types, including immune system cells, they have a huge therapeutic potential. Indeed, bone marrow transplantation is ... Read more

  • 5719

    Inhibiting Importin to Treat Psychiatric Stress and Other Disorders (No. T4-1875)

    OverviewAnxiety and stress-related conditions pose a significant health burden on modern healthcare systems. While currently, available anxiolytic drugs can be highly effective for some patients, their long-term use is limited by their potentially severe and debilitating side effects. The group of Prof. Mike Fainzilber d ... Read more

  • 5722

    Universal CAR-Ts (No. T4-1884)

    Summary: Chimeric Antigen Receptor T-Cells (CAR-Ts) are one of the revolutionary technologies of the twenty-first century, invented by Prof. Zelig Eshhar at the Weizmann Institute of Science. The CAR-T technology represents a leap in terms of treating cancer, as the technology programs an individual’s immune system to sp ... Read more

  • 5728

    A New Sustainable Process for Hydrocarbons Oxidation (No. T4-1892)

    Summary: Phenol is an important industrial commodity used as a precursor to many useful compounds. It is being utilized in huge amounts in a wide range of industry sectors including the pharmaceuticals, plastic-related-products production, paints & coatings, electrical equipment, foams and fuel additives. The global ph ... Read more

  • 5731

    Disrupting or Preventing Formation of Biofilm by Enzyme Inhibitors (No. T4-1893)

    Summary: Biofilm is a complex colony of bacteria, which are attached together by extracellular polymeric substance. This setting provides the bacteria protection against environmental factors, improves their surface attachment, and plays a major role in resistance to treatment. Therefore, biofilms are difficult to eradicat ... Read more

  • 5734

    Person-specific Assessment of Probiotics Responsiveness (No. T4-1895)

    OverviewProbiotics are a widely consumed dietary supplement, however, their efficacy is controversial and not all individuals benefit from their use. Therefore, a predictive tool that distinguishes between probiotic-permissive and resistant individuals is needed. The current technology provides a method for predicting an ... Read more

  • 5737

    WS2 NANOTUBE-REINFORCED BIODEGRADABLE AND BIOCOMPATIBLE POLYMER INK FOR 3D PRINTING (No. T4-1900)

    Summary: Biocompatible polymers commonly used in the orthopedic and cosmetic prosthetics, cardiovascular and dental implants and food packaging industries often suffer from poor mechanical properties and thermal stability, limited dimensionality and short shelf-life as compared to their metal comparators. Two research grou ... Read more

  • 5740

    Photovoltaic Devices Based on Guided Nanowire Arrays (No. T4-1906)

    Summary: Nanowires are being produced and integrated into various systems today, including solar cells, nano-sensors, nano-electrodes, transparent touch-screen coatings, and LED replacements. Thus far, several challenges have hindered the commercial advancement of nanowire-based technologies. Two major setbacks have been: ... Read more

  • 5743

    Extraction of Gold from Electronic Waste and Ores (No. T4-1910)

    Summary: A method for selective extraction of gold has been developed at the Weizmann Institute. This method allows the efficient and environmentally benign recovery of gold that is currently discarded of in large quantities from electronic waste from household appliances, consumer electronic devices and industrial equipme ... Read more

  • 5746

    Methods of Identifying and Using Agents for Treating Diseases Associated with Intestinal Barrier Dysfunction (No. T4-1925)

    OverviewInflammatory bowel disease (IBD) is characterized by chronic inflammation of the gastrointestinal (GI) tract, resulting in its damage and gut barrier dysfunction. These chronic conditions are treatable but not curable, dramatically decrease the patient’s quality of life and affect approximately 1.6 million Amer ... Read more

  • 5749

    Molecular Switches in Solid Media (No. T4-1927)

    Summary: Molecular photoswitches are light-responsive molecules with potential applications in a broad range of systems with on-demand functionalities. While molecular photoswitches have been extensively studied in solution, their immobilization to dry, planar surfaces generally renders them photochemically unresponsive. T ... Read more

  • 5752

    Artificial Pancreas (No. T4-1942)

    Summary: The alarmingly sharp increase in type 1 diabetes mellitus incidence in recent years has been coupled with a marked rise in the development of closed-loop systems aimed at continuously monitoring blood glucose levels, predicting glucose behavior and delivering adjusted insulin doses. However, to date, these systems ... Read more

  • 5827

    A biological drug (PAS- YNS8) for cancer therapy (No. T4-1360)

    BackgroundThe human type I interferons number 12 distinct non-allelic alpha proteins, one beta, and one omega, all sharing the same structure and binding the same two cell surface receptors, IFNAR1 and IFNAR2. Interferons promote a wide range of activities, including antiviral activity, inhibition of cell growth and prol ... Read more

  • 5998

    Prediction of Gestational Diabetes (No. T4-1962)

    Overviewdiabetes mellitus (GDM) is one of the most common complications of pregnancy, increasing the risk for short and long-term adverse events for both mother and offspring. Early intervention can reduce future complications, however, GDM is currently diagnosed only at late pregnancy stages. The group of Prof. Eran Seg ... Read more

  • 6011

    PROMISE search engine for PTMs and Neoantigens (No. T4-2090)

    OverviewMany newly developed anti-cancer treatments rely on identifying cancer unique signatures that can be used to harness the immune system against the tumor. The internal state of all cells is constantly represented on their surfaces by unique molecules called Human Leukocyte Antigen (HLA) bound peptides. Consequentl ... Read more

  • 6012

    Recovery of Rare Earth Metals From Ferromagnetic Alloys (No. T4-1936)

    OverviewProduction of electric motors for electric vehicles, electric generators for wind turbines, and hard disk drives (HDDs) is highly dependent on the availability of rare earth elements (REE) such as Neodymium, Dysprosium, and Praseodymium to produce permanent magnets (which are also called Neodymium magnets). The a ... Read more

  • 6014

    One-Shot Diagnostic PCR Testing of Pooled Samples (No. T4-2111)

    OverviewOne of the main challenges in curbing the spread of coronoavirus disease 2019 (COVID-19) is rooted in the limited technical capacities of current diagnostic testing platforms. Qualitative reverse transcription polymerase chain reaction, the gold standard diagnostic method, requires dedicated machinery and can onl ... Read more

  • 6016

    Increasing Efficiency of Therapeutic A-to-I RNA Editing (No. T4-2028)

    OverviewSingle-point mutations can give rise to a wide spectrum of genetic diseases. Recent therapeutic approaches aim at editing the mutated mRNA, providing a safe, reversible and tunable treatment. However, these methods are currently not efficient due to knowledge gaps in the understanding of the rules determining RNA ... Read more

  • 6018

    Methods of diagnosing cancer and predicting responsiveness to therapy (No. T4-2066)

    OverviewImmunotherapy was proven very efficient for some patients revolutionizing cancer treatment; however, many patients fail to respond to the treatment. It is currently unknown which patients will respond to immunotherapy. The current technology enables to diagnose cancer and to pre-determine a patient’s likelihood ... Read more

  • 6019

    A Novel Target for Treating and Diagnosing Refractory or Relapsing Multiple Myeloma (No. T4-2075)

    OverviewMultiple myeloma (MM) is an incurable malignancy, and despite novel anti-myeloma drugs that increased survival, up to 30% of patients develop primary resistance, and many patients experience early relapse. This innovation deploys single‑cell analytical tools to identify molecular signatures of refractory or rel ... Read more

  • 6023

    Artificial Womb Device for Extended Mammalian Embryogenesis (No. T4-2128)

    OverviewMammalian embryos develop inside the uterine environment, making them inaccessible for direct monitoring and perturbations. Therefore, the full in-depth understanding of the developmental process that occurs post embryo implantation in the uterus remains limited. The lab of Prof. Jacob Hanna recently developed a ... Read more

  • 6024

    Modification for Improving the Efficiency of Genome Editing (No. T4-1930)

    OverviewCRISPR-Cas9 is a powerful tool for genome editing, widely used for basic research and the development of treatments for genetic diseases. However, its efficiency is currently limited. The current technology is a new chimeric Cas9 fused to a domain that recruits DNA repair factors directly to the genomic site that ... Read more

  • 6025

    Combinatorial Approach to Inhibit Drug-Resistant Lung Cancer Harboring EGFR Mutations (No. T4-1944)

    OverviewNon-Small Cell Lung Cancer (NSCLC) is a very common type of cancer, and despite currently available therapies, is one of the deadliest due to the emergence of drug resistance, which results in tumor recurrence. Thus, there is a clear need for novel therapeutic strategies to overcome resistance, especially in the ... Read more

  • 6026

    Anti-Lox antibody Like Compound for Duchenne Muscular Dystrophy (No. T4-1913)

    OverviewDuchenne muscular dystrophy (DMD) is a disease that affects approximately 1 in 3,500 boys with a life expectancy of ~26 years. Newly approved FDA treatments are designed to treat specific mutations that account for only 25% of the patients, leaving an unmet need for an effective treatment for the clinical patholo ... Read more

  • 6027

    Ultra tight ACE2 binder for prevention of SARS-Cov-2 infection (No. T4-2024)

    Overviewcombat against COVID-19 is still ongoing worldwide. Despite the great advancements in the realm of vaccine development, there is still a great need for efficient medications to treat the disease, especially in vulnerable populations (such as elderly people and subjects with background illnesses). A common strateg ... Read more

  • 6029

    GreenTap - A Novel Method of Inducing and Collecting Plant Exudates (No. T4-1894)

    OverviewNumerous plant-originated compounds with unique properties are widely used for diverse applications in the drugs, food, and cosmetics industries. Chemical synthesis of these compounds is not feasible due to their complexity, and harvesting said compounds from plants can be extremely challenging and inefficient. T ... Read more

  • 6030
  • 6082

    Cell-Free miRNA Diagnostic Biomarkers for FTD (No. T4-2037)

    OverviewFrontotemporal dementia (FTD) is a heterogeneous neurodegenerative disorder characterized by frontal and temporal lobe atrophy, typically manifesting with behavioral or language impairment. Because of its heterogeneity and lack of available diagnostic laboratory tests, there can be a substantial delay in diagnosi ... Read more

  • 6085

    L-DOPA Production in Plants (No. T4-2048)

    OverviewCurrent synthetic pathways of the standard Parkinson’s disease treatment, L-DOPA (levodopa), are complicated, requiring multiple steps, and depend upon the use of either hazardous starting compounds or producing toxic side products. The present technology offers an alternative synthetic method that is greatly s ... Read more

  • 6088
  • 6091

    Novel Targets for Treating Acute Liver Failure (ALF) (No. T4-2071)

    OverviewAcute liver failure (ALF) is a rapid deterioration of liver function, resulting in a high mortality rate in the absence of liver transplantation. ALF treatment remains highly limited and mostly supportive due to a lack of a comprehensive understanding of the molecular base of ALF. The group of Profs. Eran Elinav ... Read more

  • 6097

    A combination therapy approach to amplify the anti-depressant effects of Ketamine (No. T4-2129)

    OverviewPsychiatric disorders, with emphasis on major depressive disorder (MDD), are leading causes of disability and premature death across the globe, with patients showing a heightened risk of self-harm and suicidal ideation. Current pharmaceutical treatment options suffer from significantly prolonged time to response ... Read more

  • 6100

    Electrochemical Reduction Of Carbon Dioxide Catalyzed By Polyoxometalates (No. T4-2133)

    OverviewCarbon dioxide (CO2) is the main greenhouse gas that is produced by human activity and has brought the atmospheric CO2 concentration level over the normal outdoor ambient threshold of 400 ppm. This increase is encouraging the search for methods to transform CO2 into more valuable chemicals. Here we provide a new ... Read more

  • 6106

    Covalent Ligand Directed Release (CoLDR) Chemistry – A Versatile Drug Discovery Platform (No. T4-2045)

    Overviewdelivery and activation of drugs or probes is of great importance in therapeutics, diagnostics, and research. For instance, selective delivery/activation of anti-cancer drugs to tumor cells is crucial for their efficacy and reduced side effects. However, achieving site-selective delivery/activation is challenging ... Read more

  • 6109
  • 6112

    CRISPR Co-Editing Platform for Scarless Homology-Directed Genome Editing (No. T4-2036)

    OverviewCRISPR-Cas9 is a widely-used tool for genome editing; however, it is very inefficient and often requires the addition of selection markers, forcing the introduction of foreign DNA elements. The current technology offers a strategy for generating an inherent host-derived selection gene by CRISPR technology simulta ... Read more

  • 6115

    Prognostic Cell-Free miRNA biomarker for ALS (No. T4-2038)

    OverviewAmyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder of the human motor neuron system, for which no effective treatment exists. Variability in the rate of disease progression limits the efficacy of ALS clinical trials, suggesting that developing better biomarkers for prognosis will faci ... Read more

  • 6118

    Importin alpha 3 - a novel target for neuropathic pain treatment (No. T4-2040)

    OverviewPain, particularly in cases of chronic nerve injury and disease, is a critical element of numerous medical conditions and procedures, which is generally managed with opioid analgesics. While generally highly effective, they are associated with adverse effects, and risk of tolerance, dependence, and abuse. The gro ... Read more

  • 6124

    Safer CAR-T cell platform (No. T4-2033)

    OverviewChimeric Antigen Receptor (CAR)-T Cell Therapy is a personalized treatment for cancer in which the patient's T cells are genetically engineered to express a synthetic receptor that binds a tumor antigen. Although this treatment is very successful for treating some hematological cancers, it may cause a severe life ... Read more

  • 6130

    Rapid Phase Retrieval by Lasing (No. T4-1879)

    OverviewReconstruction of structures from their scattered intensity distributions is heavily exploited in a range of disciplines, with common methods limited when phase information is lost. Contemporary iterative algorithms depend on a priori knowledge of the object boundaries to solve such inverse scattering problems, b ... Read more