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5299
LTC4 (6E7) (No. M7-101)
Summary: Rat monoclonal antibodies raised against Leukotriene C4-KLH. Available clone: 6E7 (IgG1). Cysteinyl leukotrienes are potent lipid mediators in inflammation, inducing smooth muscle contractions and increased capillary permeability. ... Read more
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5302
An endothelial-adipose cell line derived from a murine bone marrow stroma (14F1.1) (No. M7-103)
Summary: 103 - Bone marrow derived stroma cell line 14F1.1 Description: An endothelial-adipose cell line derived from a murine bone marrow stroma. Reference: Zipori D, Toledo J, von der Mark K. 1985. Phenotypic heterogeneity among stromal cell lines from mouse bone marrow disclosed in their extracellular matrix composition ... Read more
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5305
Anti-Sulfamethazine monoclonal antibody (No. M7-115)
Summary: Monoclonal antibody to Sulfamethazine (SMZ) Description: Rat monoclonal antibodies raised against Sulfamethazine-BSA. Available clone: 21C7, IgG1. Sulfamethazine is an antibacterial agents commonly given to food animals (swine, fishetc.) to prevent disease and maximize production. ReferencesPrel ... Read more
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5308
Anti-Biotin Antibody (No. M7-116)
Summary: Monoclonal anti-biotin antibody (clone F1). Very specific for biotin. ReferencesPreparation and properties of anti-biotin antibodies. Kohen F, Bagci H, Barnard G, Bayer EA, Gayer B, Schindler DG, Ainbinder E, Wilchek M.Methods Enzymol. 1997;279:451-63. doi: 10.1016/s0076-6879(97)79049-9.PMID: 9211297 ... Read more
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5317
Anti-testosterone 3-(0- carboxymethyl)oxime-BSA monoclonal antibody (No. M7-119)
Summary: Rat monoclonal antibodies raised against testosterone 3-(0- carboxymethyl)oxime-BSA. Available clones: 5F2, 5A4.Testosterone is the principal male sex hormone and an anabolic steroid. In mammals, testosterone is secreted primarily in the testicles of males and the ovaries of females, although small amounts are als ... Read more
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5326
Anti-idiotypic antibody against anti-Sulfamethazine (12E12) (No. M7-130)
Summary: Betatypic anti-idiotypic antibody raised against anti Sulfamethazine –KLH (clone 21C7). Available clone: 12E12. ReferencesGeneration of an anti-idiotypic antibody as a surrogate ligand for sulfamethazine in immunoassay procedures/ F.Kohen, B.Gayer, Y.Amir-Zaltsman and M.O’Keeffe, Food and Agricultu ... Read more
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5329
Human T3N1M1 prostatic adenocarcinoma tissue for xenograft (No. M7-132)
Summary: WISH-PC frozen tissue samples Description: Neuroendocrine xenograft model of human prostatic small cell carcinoma cancer. Provides a source to study the involvement of neuroendocrine cells in the progression of prostatic adenocarcinoma and can serve as a novel model for the testing of new therapeutic strategies f ... Read more
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5332
Anti-progesterone-7 monoclonal antibody (No. M7-138)
Summary: Monoclonal antibodies raised against position 7 of progesterone (clone 2H4), Rat IgG1. Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. Progesterone is a C ... Read more
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5335
Anti-oestradiol-6-carboxymethyl oxime monoclonal antibody (No. M7-141)
Summary: Monoclonal antibodies to estradiol Description: Monoclonal antibodies raised against oestradiol-6-carboxymethyl oxime-BSA. Available clones: 2F9 (Rat, IgG2a), 15 (IgG2b), 8D9 (IgG2a). Estradiol is a sex hormone, which has not only a critical impact on reproductive and sexual functioning, but also affects other org ... Read more
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5347
Anti-Human chorionic gonadotropin (hCG) monoclonal antibody (No. M7-147)
Summary: Monoclonal antibodies raised against bhCG. Available clones: 1D5 (IgG1) .Human chorionic gonadotropin (hCG) is a hormone produced by the syncytiotrophoblast, a component of the fertilized egg, after conception. ... Read more
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5350
Clone - 1E11 (No. M7-148)
Summary: Monoclonal antibodies for peptide and steroid hormones Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. Peptide Hormones: 147-148 - Monoclonal antibody t ... Read more
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5356
Anti-Phospho-ERK (PY193 or PT115) Monoclonal Antibodies (No. M7-176)
Summary: 176-177 - Monoclonal antibodies to phospho-ERK/Map Kinase Description: Monoclonal antibodies raised against peptides containing the 11 amino acids, HTGFLTEYVAT, corresponding to the ERK activation loop either Tyr -phosphorylated (ERK-PY193), or Thr-phosphorylated (ERK-PT115). ERK belongs to the family of mitogen-a ... Read more
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5359
ERK-PT115 (No. M7-177)
Summary: 176-177 - Monoclonal antibodies to phospho-ERK/Map Kinase Description: Monoclonal antibodies raised against peptides containing the 11 amino acids, HTGFLTEYVAT, corresponding to the ERK activation loop either Tyr -phosphorylated (ERK-PY193), or Thr-phosphorylated (ERK-PT115). ERK belongs to the family of mitogen-a ... Read more
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5362
Anti-Galactin 8 monoclonal antibody (No. M7-181)
Summary: Description: Monoclonal antibody to Galectin-8 (clone 106.1). Galectin-8 is a secreted, integrin-binding protein, part of a mammalian lectins family. Galectin-8, also known as Prostate Cancer Tumor Antigen-1 (PCTA-1) is highly expressed in human prostate cancer. It was shown to trigger the transcription of a u ... Read more
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5365
Anti-IgE monoclonal antibody (No. M7-185)
Summary: Monoclonal antibodies to IgE Description: Rat monoclonal anti-IgE antibodies that was generated by fusion of plasmacytoma (84.1C) or myeloma (EM953) cells with splenocytes of rat immunized with purified murine IgE mAb. The antibodies react with various IgE mAb of different specificities and not with immunoglobuli ... Read more
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5368
Diastereomer Lytic Peptides for Treatment of Solid Tumors and Metastasis in animal models (No. M7-236)
Summary: 236-237 - Diastereomer Lytic Peptides for Treatment of Solid Tumors and Metastasis Description: 15-mer (Leu-Lys-Dleu- Leu-Lys-Dlys-Leu-Dleu-Dlys-Lys-Leu-Leu-Dlys-Leu-Leu) and 15-mer Histidin (H-Leu-Lys-D-Leu- Leu-His-D-Lys-Leu-D-Leu-D-Lys-His-Leu-Leu-D-Lys-Leu-Leu-NH2) are membrane-active peptides composed of both ... Read more
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5371
15-mer Histidin (No. M7-237)
Summary: 236-237 - Diastereomer Lytic Peptides for Treatment of Solid Tumors and Metastasis Description: 15-mer (Leu-Lys-Dleu- Leu-Lys-Dlys-Leu-Dleu-Dlys-Lys-Leu-Leu-Dlys-Leu-Leu) and 15-mer Histidin (H-Leu-Lys-D-Leu- Leu-His-D-Lys-Leu-D-Leu-D-Lys-His-Leu-Leu-D-Lys-Leu-Leu-NH2) are membrane-active peptides composed of both ... Read more
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5374
Core peptide to inhibit T-Cell mediated inflammation in animal models (No. M7-238)
Summary: 238 - CP Peptide Description: Core peptide (CP; GLRILLLKV-D-stereoisomer), a synthetic peptide coding for the transmembrane domain of the ?-subunit of the T-cell receptor (TCR), a region that has been identified to be crucial for the assembly and function of the TCR. Was shown to significantly inhibit T-cell-media ... Read more
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5386
Monoclonal Anti-Gliomedin Antibody (Mab#94) (No. M7-257)
Summary: 257 - Monoclonal antibody to Gliomedin Description: Monoclonal antibody to Gliomedin (MAb 94) raised against a synthetic peptide corresponding to amino acid residues 273–287 (CVIPNDDTLVGRA), present in the extra cellular region of Rat Gliomedin. Gliomedin, a glial ligand for neurofascin and NrCAM, is expressed ... Read more
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5389
Monoclonal Anti-Ermin Antibody (Mab#160) (No. M7-258)
Summary: 258 - Monoclonal antibody to Ermin Description: Monoclonal antibody to Ermin (MAb160) raised against purified GST–Ermin (residues 1–261). Ermin is a marker of myelinating oligodendroglia, localized to the outer cytoplasmic lip of the myelin sheath and the paranodal loops. It was suggested to play a role in cyt ... Read more
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5392
Monoclonal Anti-Caspr Antibody (Mab#275) (No. M7-259)
Summary: 259 - Monoclonal antibody to Caspr Description: Monoclonal antibody to Caspr (Mab275), raised against the extracellular domain of Caspr. Caspr is a contactin-associated protein, part of the neurexin family of proteins. It lies in the paranodal section of the myelin sheath and has a role in myelin sheath attachmen ... Read more
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5398
Monoclonal Antibodies Specific to Cholesterol/Ceramide Mixture Clone (No. M7-263)
Summary: Originally raised against an artificial monolayer of lipid mixtures in, and were shown to specifically label the above domains in different cell membranes. Reference: Scheffer L, Futerman AH, Addadi L. 2007. Antibody labeling of cholesterol/ceramide ordered domains in cell membranes. Chembiochem 8(18):2286-94. ... Read more
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5401
499F (No. M7-265)
Summary: Monoclonal antibodies specific to cholesterol/ceramide mixture Description: Monoclonal antibodies specific for cholesterol/ceramide-rich domains (clones 405F, 14F, 499F) and cholesterol micro-domains (clones 36A1, 5881) in cell membranes. Originally raised against an artificial monolayer of lipid mixtures in, and ... Read more
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5404
Anti- estrone-3- glucuronide monoclonal antibody (No. M7-273)
Summary: Betatypic anti-idiotypic antibody raised against anti- estrone-3- glucuronide (clone 8A3). Available clone: 7C1. ReferencesMonitoring ovarian function by the simultaneous time-resolved fluorescence immunoassay of two urinary steroid metabolites. Barnard G, Kohen F.Clin Chem. 1998 Jul;44(7):1520 ... Read more
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5410
Anti-Estrone-3-Glucuronide monoclonal antibody (No. M7-275)
Summary: Monoclonal antibodies raised against estrone-3-glucuronide-BSA. Available clones: 8A3 (Rat, IgG2a). Estrone-glucuronide is the dominant metabolite of estradiol. Used as one reference method for determining ovulation. Due to their high specificity and sensitivity this antibody may be applicable for research, diagno ... Read more
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5413
Anti-Estrone-3-Glucuronide monoclonal antibody (clones: 155B3, 8A3) (No. M7-276)
Summary: Monoclonal antibodies raised against estrone-3-glucuronide-BSA. Available clones: 8A3 (Rat, IgG2a), 155B3. Estrone-glucuronide is the dominant metabolite of estradiol. Used as one reference method for determining ovulation. ReferencesMonitoring ovarian function by the simultaneous time-resolved ... Read more
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5416
Anti-Runx-3 monoclonal antibody (No. M7-306)
Summary: Monoclonal antibody to Runx-3 Description: Monoclonal antibody to Runx-3 raised against the Runx3 peptide TPSTPSPRGSLSTTSHF. Available clones: 62, H8. Runx-3 (Runt-related transcription factor 3) is a transcription factor, and a master regulator of lineage specific gene expression in several important developmenta ... Read more
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5419
Chromogenic substrate for serum paraoxonase (PONs) activity (No. M7-315)
Summary: 315 - TBBL (5-thiobutyl butyrolactone) Description: TBBL (5-thiobutyl butyrolactone) is a chromogenic lipo-lactone substrate for Serum paraoxonases (PONs), used for sera tests of PONs activity, based on their lactonase activity. The primary enzymatic reaction produces an unstable intermediate that rapidly collap ... Read more
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5422
Anti-Mast cell Function-associated Antigen (MAFA) monoclonal antibody (No. M7-320)
Summary: 320 - Monoclonal antibody G63 Description: Monoclonal antibodies to MAFA (Mast cell Function-associated Antigen), originally raised against intact rat RBL-2H3 cells. MAFA is a type II membrane glycoprotein, which was shown to inhibit the secretory response to the type. Binding of G63 antibody to MAFA was shown to ... Read more
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5425
Escherichia coli UTL2 (No. M7-358)
Summary: Escherichia coli UTL2 Description: A "leaky" strain of E. coli, which is significantly more susceptible to cytotoxic agents. UTL2 holds a mutation in the galU gene causing an impaired outer membrane. Reference: Bibi E. 1996. Functional expression of mouse Mdr1 in an outer membrane permeability mutant of Escheric ... Read more
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5428
Blood Test to Identify People at High Risk for Lung Cancer (No. T4-1033)
OverviewA novel diagnostic test to identify individuals with increased risk of lung cancer Background and Unmet NeedLung cancer is the number one killer among cancers, with 160,000 deaths/year in the USA and 1.6 million/year worldwide. Early detection of lung cancer increases 5-year survival rate from 4% to 5 ... Read more
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5434
Acquisition of Multidimensional NMR Spectra in a Single Scan (No. T4-1151)
OverviewMultidimensional nuclear magnetic resonance (NMR) is used nowadays in many applications (e.g., discovering new pharmaceutical drugs, characterization of new catalysts, and investigation of the structure and dynamics of proteins). One drawback of this technique is that multidimensional NMR requires rel ... Read more
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5446
Optical Cross-Sectioning Multiphoton Microscopy Without Scanning (No. T4-1266)
Summary: Fast cross-sectioning using multiphoton microscope. The conventionally used laser-scanning microscopy, confocal and multiphoton microscopy, although being capable of performing optical sectioning, requires a long image acquisition time, tens of milliseconds per section in current commercial systems, due to the s ... Read more
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5449
Cholesterol Antibodies (No. T4-1267)
Summary: Description: Monoclonal antibodies specific for cholesterol/ceramide-rich domains (clones 405F, 14F, 499F) and cholesterol micro-domains (clones 36A1, 5881) in cell membranes. Originally raised against an artificial monolayer of lipid mixtures in, and were shown to specifically label the above domains in differen ... Read more
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5452
Mouse IgE and Anti-Mouse IgE Monoclonal Antibodies (No. M7-1270)
Summary: Monoclonal antibodies to IgE Description: Rat monoclonal anti-IgE antibodies that was generated by fusion of plasmacytoma (84.1C) or myeloma (EM953) cells with splenocytes of rat immunized with purified murine IgE mAb. The antibodies react with various IgE mAb of different specificities and not with immunoglobuli ... Read more
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5455
On-Chip Synthetic Biology Platform for Diagnostics and Therapeutics (No. T4-1369)
OverviewCell-free synthetic platforms that enable complex biological activities such as synthesis and self-assembly of biomolecules, can be employed for various applications, including drug discovery and diagnostics. Using synthetic genes, we provide a novel platform for cell-free synthetic biology on a chip which is a c ... Read more
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5458
High-Performance Electrochromic Devices (No. T4-1380)
OverviewHigh-performance electrochromic materials that exhibit a practical combination of low-voltage operation and efficient color-switching, as well as long-term stability have been developed by the group of Prof. van der Boom. Electrochromic materials that are currently available in the market offer a broad range of c ... Read more
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5461
Software for Detecting Irregularities in Visual Data (No. T4-1381)
OverviewWhile image & video processing are rapidly developing fields, most of the recent algorithms must be trained on large and sorted databases to gain adequate performance. Detecting irregularities in previously unknown images or videos is still an unsolved problem. Prof. Michal Irani and her team developed an alg ... Read more
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5467
Automatic Photo Animation in Video and Still Images (No. T4-1423)
OverviewMany currently marketed animation tools enable users to define objects and provide them with motion, yet none enable the fast and automatic, animation of a full body captured in a single still photo. A new technology developed by a group of researchers from the Weizmann Institute of Science, enables automatic tra ... Read more
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5470
Treatment of Autoimmune Diseases by Modulating Bregs (No. T4-1441)
Summary: Chronic lymphocytic leukemia (CLL), a malignant disease characterized by the accumulation of B lymphocytes in the blood, lymphoid organs, and bone marrow, is the second most common type of leukemia in adults, accounting for about 7,000 new cases of leukemia each year. Presently, there is no cure for CLL, and the o ... Read more
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5473
Treating Cancer by Inhibiting Nuclear Entry of MAPK Cascade Proteins (No. T4-1446)
OverviewInhibition of Nuclear Entry of MAPK Cascade Proteins as a Novel Mechanism for Treating Cancer Background and Unmet NeedERK is a major signaling molecule, which plays a driving role in various pathologies, particularly cancer. When not activated ERK is localized to the cytoplasm. Upon activation ERK bi ... Read more
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5479
Smart Resize of Images & Videos (No. T4-1461)
OverviewData storage of images and videos became a real issue in the last years when pictures and videos are taken and shared more often, and the memory devices aren’t being minimized fast enough. Prof. Michal Irani and her team have developed an algorithm that can resize images while keeping the important features wit ... Read more
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5482
Highly Sensitive Nanoscale Scanning Magnetic and Thermal Sensor (No. T4-1481)
OverviewA new technology developed by a group of researchers from the Weizmann Institute is a nanoscale sensor-on-tip for local magnetic signals and thermal dissipation with state-of-the-art sensitivity and spatial resolution. Detecting a signal as low as the magnetic moment of a single electron is of key technological i ... Read more
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5485
Conductive Inorganic Fullerenes and Nanotubes (No. T4-1482)
Summary: Modification of the electronic properties of layered-type semiconductors can be accomplished by doping/alloying of the semiconductor. In the present disclosure we show that doping of MoS2 and WS2 nanotubes/nanoparticles can be accomplished by doping with either Re (n-type) or Nb (p-type) foreign atoms. These nanop ... Read more
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5494
Production of Amines from Alcohol and Ammonia (No. T4-1507)
OverviewA novel, selective, and direct synthesis of primary amines from alcohols and ammonia catalyzed by novel Pincer-type Ruthenium complexes. Amines are widely used in the production of industrially relevant products. Standard commercial methods for synthesis of amines also make use of alcohols and ammonia as reagents ... Read more
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5500
Super resolution from a single visual source (No. T4-1522)
OverviewMany imaging devices produce signals of unsatisfactory resolution (e.g. a photo from a cell-phone camera may have low spatial resolution or a video from a web camera may have both spatial and temporal low resolution). Previous methods for Super-Resolution (SR) require multiple images of the same scene, or else an ... Read more
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5503
Optical Conversion of Ultra-Fast Laser Pulses (No. T4-1529)
OverviewUltra-fast lasers are highly used in both academia (to monitor chemical & biological reactions) and industry (for submicron resolution products). Mainly, the emission source of these lasers is Ti-Sapphire, which produces very short pulses (about ten femtoseconds – 10-14sec) but only in the Near Infrared (NI ... Read more
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5512
Green Catalytic Formation of Alcohols, Amines, Amides, Imines and Esters under Mild Conditions (No. T4-1551)
OverviewA team of researchers headed by Prof. David Milstein at the Weizmann Institute of Science (WIS), have developed a novel set of manganese, ruthenium, and related borohydride complexes (Pincer-type). These catalysts are efficient and environmentally-benign for the synthesis of alcohols, amines, amides, imines, and ... Read more
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5515
Synthetic Carbon Fixation Pathways For Superior Biomass Generation (No. T4-1556)
OverviewModern agriculture faces limited arable land and climate changes. Carbon fixation under these conditions will become a significant growth-limiting factor. Synthetic carbon fixation pathways can allow plants to produce more biomass using the same amount of energy from sunlight. Novel alternative synthetic carbon f ... Read more
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5521
Inorganic Fullerene Coating For Medical Devices (No. T4-1566)
OverviewVarious dental applications suffer from excessive friction, which severely compromises their function. For orthodontic procedures, friction significantly reduces effectiveness and thereby leads to prolonged treatments. In root canal treatments, NiTi (Nickel-Titanium) endodontic files are prone to fatigue-induced ... Read more
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5530
A Novel Database to Reduce Unsuccessful Cloning in E. Coli by Detection of Toxic Genes (No. M7-1576)
Summary: Synthetic genes are commonly used in academic and industrial applications, however in many cases these said genes can be toxic when inserted into the ubiquitously used E. coli. This is problematic as time and money is wasted on attempts to generate genes that will not function in E. coli. The problem is exacerbate ... Read more
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5536
A Novel Technique of Thermoelectric Conversion (No. T4-1583)
Summary: The thermoelectric effect is the direct conversion of temperature differences to electric voltage and vice versa. Thermoelectric effects are used in various applications, where heat energy is saved, that would be otherwise lost. Although the TE conversion efficiency is nowadays low (5-8%), the novel technique deve ... Read more
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5545
Novel MRI Contrast Agent (No. T4-1604)
Summary: Novel reporter gene for magnetic resonance imaging applications.The ability to image the duration and location of gene expression in vivo and noninvasively is imperative for the future of biology and clinical medicine. Magnetic Resonance Imaging (MRI) is a widely used noninvasive clinical diagnostic tool that offe ... Read more
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5557
Antibody Based Therapy to Treat Cancer and GI Related Diseases (No. T4-1640)
OverviewA novel therapeutic antibody against MMP-7, with exceptional specificity, for the treatment of aggressive cancers. Although early programs targeting MMPs (matrix metalloproteins) were largely unsuccessful due to adverse side effects, they remain a viable and highly desirable therapeutic target. The main obstacle ... Read more
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5560
Anti-QSOX1 Antibody for Treating Cancer and Metastasis (No. T4-1642)
OverviewCancer, and especially cancer metastasis, is a leading cause of death worldwide. Research in recent years highlighted the importance of the extracellular matrix (ECM) surrounding the tumor in cancer progression metastasis formation. Therefore, many attempts currently address the unmet need to target enzymes that ... Read more
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5566
An Off-Line Image Search Engine (No. T4-1647)
OverviewAlthough images search engines are available online, offline networks and databases (in governmental offices, banks, etc.) require an efficient and reliable image search engine. Prof. Michal Irani and her team developed a method for Visual Inference of a collection of images, which builds upon collaboration betwe ... Read more
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5572
Optimizing T Cell Receptor Avidity for Adoptive T Cell Therapies (No. T4-1662)
OverviewUsing affinity maturated TCRs to generate reactive T cells Background and Unmet NeedImmunotherapy, that is the use of the immune system to treat cancer, is currently a leading candidate in the combat against cancer. Unlike the toxic effects of both chemotherapy and radiation, immunotherapy is consider ... Read more
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5575
Magnetic resonance imaging (MRI) Of Tissue Fibrosis Without Contrast Agent (No. T4-1665)
OverviewCardiac fibrosis is a scarring event in the cardiac muscle that causes abnormalities in cardiac function and significantly increases the risk of sudden cardiac death. Although a large proportion of the western population is at high risk, early detection is usually not applicable by the currently available imaging ... Read more
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5584
Preventing Infections Using Lipid Based Molecules (No. T4-1673)
OverviewSphingosine (SPH), a natural bactericidal agent which acts as a part of the human innate immune system in the skin, was found to be an effective treatment and prophylaxis for bacterial lung infections in cystic fibrosis (CF) mice. CF is the most common autosomal recessive disorder in western countries, affecting ... Read more
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5587
Highly Selective Optical Biosensors for Proteins in Biological Samples, with Excellent Signal-to-Noise Ratio (No. T4-1689)
Summary: Sensing the levels of protein-based biomarkers in biological samples is crucial for diagnosis of various diseases including cancer. Optical biosensors offer sensitivity and cost-effectiveness; however, current commercially available devices fail to provide sufficient selectivity and signal to noise ratios for prot ... Read more
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5590
Production of Syngas from Biomass (No. T4-1716)
Summary: An efficient and selective decomposition of plant biomass carbohydrates to their basic components, carbon monoxide and hydrogen, for use as syngas.Terrestrial plants contain about 70% hemicellulose and cellulose, which constitute a significant renewable bio-resource with potential as an alternative to petroleum fe ... Read more
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5596
Green Chemistry for Ketones and Aldehydes Production (No. T4-1722)
OverviewOur technology provides a new type of oxidative cleavage reaction of organic compounds with highly selective product formation. Polyoxometalate (POM) catalysts have become well-known for their utility and diversity in specific reactions. Through the elucidation of POM catalytic pathways, greater versatility has b ... Read more
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5602
CNT-Based Structure for High-Resolution Semiconductor Process Control (No. T4-1730)
OverviewWith the continuous trend of electronic component miniaturization, process control technologies must keep up with component size reduction. Defects that were so far negligible, are now posing critical operation obstacles, and are more difficult to identify as scales are reduced to <10 nm. This new technology d ... Read more
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5605
Treatment for Inflammatory Diseases and Cancer (No. T4-1733)
OverviewThe development of kinase inhibitors to treat inflammatory diseases was proved beneficial, however, designing specific inhibitors with minimal side effects and prolonged efficacy is challenging as drug resistance often develops. The current technology includes inhibitors that specifically target the nuclear trans ... Read more
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5608
Carbon fixing bacteria (No. T4-1736)
OverviewThe two most pressing challenges facing humanity are the need to feed the growing population with restricted land and water sources and global warming caused due to high atmospheric CO2 levels. Biological systems for CO2 conversion to organic molecules using renewable-energy-harvesting techniques present a promis ... Read more
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5611
Treating Cancer and Collagen-Associated Diseases by Using Anti-LOXL-2 Antibody (No. T4-1743)
OverviewAn innovative method for treating diseases associated with dysregulation of collagen fibers in the extracellular matrix (ECM), such as cancer and fibrosis, by targeting LOXL-2. Background and Unmet NeedECM disruption is associated with many pathological conditions, such as various cancer types and tis ... Read more
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5620
rPTE with Potent Organophosphate (OPH) Activities (No. T4-1750)
Summary: Organophosphates are toxic compounds found in chemical warfare agents, such as nerve gases, and insect pesticides.Use of volatile nerve gas agents by terrorist organizations is a key concern of governments around the world. V-type nerve agents (e.g. VX, RVX, and CVX) are particularly toxic nerve gases, with an exc ... Read more
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5623
Treatment of Heart Failure by Inducing Cardiomyocyte Proliferation (No. T4-1752)
OverviewRegulating ErbB2 signaling in cardiomyocytes (CM) as novel treatment for heart diseases by inducing regeneration of cardiac tissue. Background and Unmet NeedIschemic heart disease and heart failure are the leading causes of death in the western world. Although improved medical care reduced early morta ... Read more
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5626
Spin Controlled Water Electrolysis for Efficient Production of Hydrogen (No. T4-1753)
OverviewThe chiral-induced spin selectivity (CISS) effect, discovered in recent years by Prof. Ron Naaman from the Weizmann Institute of Science, implies that electrons transferred through chiral molecules possess a specific spin orientation. Since then, the CISS effect has been investigated in different applicative syst ... Read more
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5629
Multimodel Transcranial Optical Vascular Assessment (No. T4-1769)
OverviewSubdural hematoma (SDH) is a collection of blood between the inner layer of the dura and the brain that occurs mostly as a result of trauma. It is one of the most common neurosurgical conditions in the United States today. SDH monitoring for hematoma expansion would be beneficial to enable expeditious surgical in ... Read more
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5635
Treating Drug-Resistant Lung Cancer Using a Combination of Antibodies (No. T4-1774)
OverviewA novel method to treat tyrosine kinase inhibitor (TKI) resistant cancer by using a combination of three antibodies that target EGFR (ERBB1), HER2 (ERBB2), and HER3 (ERBB3) receptors. Background and Unmet NeedThe ErbB/HER family of receptor tyrosine kinases includes epidermal growth factor receptor (E ... Read more
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5647
Antibody for Preventing/Treating Secondary Respiratory Infections (No. T4-1790)
OverviewA novel method of preventing secondary infections, by inhibition of membrane type I matrix-metalloproteinase-1, which reduces degradation of the extra cellular matrix. Background and Unmet NeedPathogens that infect the respiratory system are the cause of some of the most dangerous infections, especial ... Read more
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5659
Method for Microbiome-Based Prediction, Diagnosis, and Treatment of Relapsing Obesity (No. T4-1805)
OverviewA novel method for analyzing the likelihood of weight regain following a weight loss program and maintaining target body weight, based on gut microbiome analysis. Background and Unmet NeedThe past century has seen an overwhelming increase in the prevalence of overweight and obese individuals, effectin ... Read more
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5662
Homogeneous Dispersion of CNT Composites for Improved Conductivity (No. T4-1809)
OverviewBattery and capacitor electrode technologies available in the industry today, are struggling to keep up with rapidly advancing applications that require high power and energy density such as electric vehicles, solar cells and telecommunications systems. One of the leading solutions to this problem are CNT-based f ... Read more
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5665
Platform for Boosting Yield and Activity of Therapeutic T Cells (No. T4-1810)
OverviewProduction of large quantities of T cells is an essential demand for the development of immunotherapies. However, ex-vivo culturing of T-cells is very inefficient, resulting in high cell death rates. The current technology offers unique, optimized conditions that allow increased T-cell proliferation while enhanci ... Read more
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5674
Inertial NEMS for Nanosensor Applications Based on Inorganic Nanotubes (No. T4-1828)
OverviewInertial sensors for motion detection are being incorporated into an increasing number of portable devices, including diverse IoT applications, mobile phones, wearable electronics, automotive systems and medical diagnostic sensors. The current size reduction trend in electronics, requires incorporation of reliabl ... Read more
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5677
Highly Selective Fluorescent Biosensor for Labeling His-Tagged Proteins in a Specific Conformation (No. T4-1834)
OverviewA rapid, label-free biosensor for detecting specific conformation of His-tag labeled proteins, accessible for use in both academic- and commercial-R&D was invented at the Weizmann Institute of Science. This fluorescent biosensor detects and labels His-tagged proteins in complex environments, such as living ce ... Read more
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5680
Detecting Necroptosis Activation via Exosome Analysis (No. T4-1839)
Summary: Numerous medical conditions are related to inflammation, such as pancreatitis, psoriasis, inflammatory bowel disease, atherosclerosis, neurodegeneration, and more. However, determination of inflammation in the body, especially at early stages of a pathology is difficult to assess. Therefore, there is a great clini ... Read more
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5683
Secure Search of Encrypted Cloud Data (No. T4-1840)
Summary: Searchable symmetric encryption with practical big-data performance and strong security Highlights Outsourcing data storage to remote servers offers invaluable benefits while introducing many concerns when dealing with sensitive data. In the presence of potentially-vulnerable servers, strong user-side encryption p ... Read more
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5689
Composite Functional Metasurfaces for Multispectral Achromatic Optics (No. T4-1845)
Summary: A new technology for producing flat optical components based on optical metasurfaces. These components can potentially serve high resolution imaging, spectrometry, light processing and beam shaping devices. The optical metasurfaces that we develop are composed of closely spaced optical nanoantennas which can be ... Read more
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5695
A Novel Synthetic Biology Platform for Controlling Gene Expression (No. T4-1847)
OverviewA method for controlling gene expression using a novel phage-based transcription factor-peptide system. Background and Unmet NeedA fundamental challenge of synthetic biology and its clinical applications is the capability to control gene expression. Presently, gene expression systems for research and ... Read more
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5701
Super-Resolution Using Unsupervised Deep Internal Network (No. T4-1850)
OverviewOptical and dimensional limitations of images can be partially overcome today using signal enhancement technologies which typically rely on supervised, deep-learning methods. However, as existing methods are restricted to specific training images and distortion types, they provide poor results for any practical c ... Read more
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5704
Optical Bus for a Multi-Core Processor (No. T4-1863)
OverviewThe exponential increase in computational power over the last decades is running into a bottle-neck – the only way of getting more computing power per chip is to integrate multiple-cores, but the problem with multiple-cores is the complex wiring system, used for inter-core communication. This technology, develo ... Read more
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5707
Allogeneic Cell Transplantation for Treatment for Lung Diseases (No. T4-1868)
Summary: The treatment of respiratory conditions is currently one of the major challenges to health care systems all over the world. The problem is that most therapeutics currently available for treating pulmonary indications are non-curative, and simply improve symptoms. Presently the only cure for late stage pulmonary di ... Read more
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5713
Cancer Diagnostics by Analyzing Urea Cycle Enzymes (No. T4-1872)
OverviewAn innovative method to diagnose and potentially treat various cancers by analyzing the urea cycle metabolites. Background and Unmet NeedEarly stage diagnosis and treatment of cancer is essential, especially for highly malignant or metastatic tumors. An important stage in cancer progression is cell gr ... Read more
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5716
Targeting Novel Regulator for Improved Hematopoietic Stem Cells Generation (No. T4-1874)
OverviewA potential method of generating hematopoietic stem cells for transplantation by inhibiting CD74. Summary: Hematopoietic stem cells (HSCs) originate in the bone marrow and are the progenitors of all hematopoietic cells. HSCs have the capacity to both self-renew and to differentiate, and they migrate fro ... Read more
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5719
Treatment of Psychiatric Disorders by Inhibiting Importin Alpha 5 (No. T4-1875)
OverviewAnxiety and stress-related conditions pose a significant health burden on modern healthcare systems. While currently, available anxiolytic drugs can be highly effective for some patients, their long-term use is limited by their potentially severe and debilitating side effects. The group of Prof. Mike Fainzilber d ... Read more
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5722
Universal CAR-Ts for Treating Cancer (No. T4-1884)
Background and Unmet NeedChimeric Antigen Receptor T-Cells (CAR-Ts) are one of the revolutionary technologies of the twenty-first century, invented by Prof. Zelig Eshhar at the Weizmann Institute of Science. FDA approvals for CAR T cells against B-ALL and DLBCL pave the way for CAR-T cell application against other types ... Read more
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5728
A Sustainable Process for Phenol Production (No. T4-1892)
OverviewPhenol is an important industrial commodity used as a precursor to many useful compounds. It is being utilized in huge amounts in a wide range of industry sectors including the pharmaceuticals, plastic-related-products production, paints & coatings, electrical equipment, foams and fuel additives. The current ... Read more
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5731
Preventing Biofilm Formation by Enzyme Inhibitors (No. T4-1893)
Background and Unmet NeedBiofilm is a complex colony of bacteria, which are attached together by extracellular polymeric substance. This setting provides the bacteria protection against environmental factors, improves their surface attachment, and plays a major role in resistance to treatment. Therefore, biofilms are dif ... Read more
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5734
Person-specific Assessment of Probiotics Responsiveness (No. T4-1895)
OverviewProbiotics are a widely consumed dietary supplement, however, their efficacy is controversial and not all individuals benefit from their use. Therefore, a predictive tool that distinguishes between probiotic-permissive and resistant individuals is needed. The current technology provides a method for predicting an ... Read more
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5737
Inorganic Nanotubes/Polymer Composites for 3D Printing (No. T4-1900)
OverviewBiocompatible polymers commonly used in the orthopedic and cosmetic prosthetics, cardiovascular and dental implants and food packaging industries often suffer from poor mechanical properties and thermal stability, limited dimensionality and short shelf-life as compared to their metal comparators. Two research gro ... Read more
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5740
Photovoltaic Devices Based on Guided Nanowire Arrays (No. T4-1906)
OverviewNanowires are being produced and integrated into various systems today, including solar cells, nano-sensors, nano-electrodes, transparent touch-screen coatings, and LED replacements. Thus far, two major drawbacks in the advancement of nanowire-based technologies have been: (1) the lack of compatibility with exist ... Read more
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5743
Extraction of Gold from Electronic Waste and Ores (No. T4-1910)
OverviewA method for selective extraction of gold has been developed at the Weizmann Institute. This method allows the efficient and environmentally benign recovery of gold that is currently discarded of in large quantities from electronic waste from household appliances, consumer electronic devices and industrial equipm ... Read more
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5746
Imaging Platform for IBD Drug Discovery (No. T4-1925)
OverviewInflammatory bowel disease (IBD) is characterized by chronic inflammation of the gastrointestinal (GI) tract, resulting in its damage and gut barrier dysfunction. These chronic conditions are treatable but not curable, dramatically decrease the patient’s quality of life and affect approximately 1.6 million Amer ... Read more
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5749
Reversible Operation of Molecular Switches on Solid Surfaces (No. T4-1927)
OverviewMolecular photoswitches are light-responsive molecules with potential applications in a broad range of systems with on-demand functionalities. While molecular photoswitches have been extensively studied in solution, their immobilization to dry, planar surfaces generally renders them photochemically unresponsive. ... Read more
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5752
Artificial Pancreas (No. T4-1942)
OverviewThe alarmingly sharp increase in type 1 diabetes mellitus incidence in recent years has been coupled with a marked rise in the development of closed-loop systems aimed at continuously monitoring blood glucose levels, predicting glucose behavior and delivering adjusted insulin doses. However, to date, these system ... Read more
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5998
Predicting Gestational Diabetes Mellitus (No. T4-1962)
Overviewdiabetes mellitus (GDM) is one of the most common complications of pregnancy, increasing the risk for short and long-term adverse events for both mother and offspring. Early intervention can reduce future complications, however, GDM is currently diagnosed only at late pregnancy stages. The group of Prof. Eran Seg ... Read more
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6011
Search Engine for New Anti-Cancer Targets (No. T4-2090)
OverviewMany newly developed anti-cancer treatments rely on identifying cancer unique signatures that can be used to harness the immune system against the tumor. The internal state of all cells is constantly represented on their surfaces by unique molecules called Human Leukocyte Antigen (HLA) bound peptides. Consequentl ... Read more
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6016
A Platform for Boosting Efficiency of Therapeutic RNA Editing (No. T4-2028)
OverviewSingle-point mutations can give rise to a wide spectrum of genetic diseases. Recent therapeutic approaches aim at editing the mutated mRNA, providing a safe, reversible and tunable treatment. However, these methods are currently not efficient due to knowledge gaps in the understanding of the rules determining RNA ... Read more
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6019
Single-Cell Analysis to Enhance Multiple Myeloma Prognostics (No. T4-2075)
OverviewMultiple myeloma (MM) is an incurable malignancy, and despite novel anti-myeloma drugs that increased survival, up to 30% of patients develop primary resistance, and many patients experience early relapse. This innovation deploys single‑cell analytical tools to identify molecular signatures of refractory or rel ... Read more
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6023
Artificial Womb Device for Extended Mammalian Embryogenesis (No. T4-2128)
OverviewMammalian embryos develop inside the uterine environment, making them inaccessible for direct monitoring and perturbations. Therefore, the full in-depth understanding of the developmental process that occurs post embryo implantation in the uterus remains limited. The lab of Prof. Jacob Hanna recently developed a ... Read more
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6024
Higher Efficiency of CRISPR Gene Editing Using Chimeric Cas9 (No. T4-1930)
OverviewCRISPR-Cas9 is a powerful tool for genome editing, widely used for basic research and the development of treatments for genetic diseases. However, its efficiency is currently limited. The current technology is a new chimeric Cas9 fused to a domain that recruits DNA repair factors directly to the genomic site that ... Read more
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6025
Treatment for Drug-Resistant Non-Small Cell Lung Cancer (No. T4-1944)
OverviewNon-Small Cell Lung Cancer (NSCLC) is a very common type of cancer, and despite currently available therapies, is one of the deadliest due to the emergence of drug resistance, which results in tumor recurrence. Thus, there is a clear need for novel therapeutic strategies to overcome resistance, especially in the ... Read more
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6026
Protein Based Treatment for Duchene Muscular Dystrophy and Cancer (No. T4-1913)
OverviewDuchenne muscular dystrophy (DMD) is a disease that affects approximately 1 in 3,500 boys with a life expectancy of ~26 years. Newly approved FDA treatments are designed to treat specific mutations that account for only 25% of the patients, leaving an unmet need for an effective treatment for the clinical patholo ... Read more
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6027
Biologic Drug for prevention and treatment of COVID-19 (No. T4-2024)
OverviewCombat against COVID-19 is still ongoing worldwide. Despite the great advancements in the realm of vaccine development, there is still a great need for efficient medications to treat the disease, especially in vulnerable populations (such as elderly people and subjects with background illnesses). A common strateg ... Read more
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6029
GreenTap - A Method for Stimulating Production and Extraction of Metabolites in Plantss (No. T4-1894)
OverviewNumerous plant-originated compounds with unique properties are widely used for diverse applications in the drugs, food, and cosmetics industries. Chemical synthesis of these compounds is not feasible due to their complexity, and harvesting said compounds from plants can be extremely challenging and inefficient. T ... Read more
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6030
A method to identify actively degraded proteins (No. T4-1832)
OverviewThis technology provides a method to identify the full landscape of proteins that are actively being degraded by the proteasome, offering a way to identify novel targets in various biological conditions and contexts. Background and Unmet NeedThe cell's proteome (protein profile) is constantly changing ... Read more
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6082
Frontotemporal Dementia Diagnosis Using Circulating microRNA Biomarkers (No. T4-2037)
OverviewFrontotemporal dementia (FTD) is a heterogeneous neurodegenerative disorder characterized by frontal and temporal lobe atrophy, typically manifesting with behavioral or language impairment. Because of its heterogeneity and lack of available diagnostic laboratory tests, there can be a substantial delay in diagnosi ... Read more
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6085
One Step Synthesis of L-DOPA (No. T4-2048)
OverviewCurrent synthetic pathways of the standard Parkinson’s disease treatment, L-DOPA (levodopa), are complicated, requiring multiple steps, and depend upon the use of either hazardous starting compounds or producing toxic side products. The present technology offers an alternative synthetic method that is greatly s ... Read more
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6088
Novel Methods of Treating Bacterial Vaginosis (No. T4-1945)
OverviewTreating bacterial vaginosis by performing vaginal microbial transplants (VMT). Background and Unmet NeedBacterial Vaginosis (BV) is considered the most prevalent form of vaginal infection in women of reproductive age, affecting from one-quarter to one-third of women. Women suffering from BV report di ... Read more
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6091
Treatment for Acute liver failure (ALF) (No. T4-2071)
OverviewAcute liver failure (ALF) is a rapid deterioration of liver function, resulting in a high mortality rate in the absence of liver transplantation. ALF treatment remains highly limited and mostly supportive due to a lack of a comprehensive understanding of the molecular base of ALF. The group of Profs. Eran Elinav ... Read more
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6097
Repurposed Drug for Amplifying the Anti-Depressant Effects of Ketamine (No. T4-2129)
OverviewPsychiatric disorders, with emphasis on major depressive disorder (MDD), are leading causes of disability and premature death across the globe, with patients showing a heightened risk of self-harm and suicidal ideation. Current pharmaceutical treatment options suffer from significantly prolonged time to response ... Read more
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6100
Electrocatalytic Reduction of Carbon Dioxide (CO2) (No. T4-2133)
OverviewCarbon dioxide (CO2) is the main greenhouse gas that is produced by human activity and has brought the atmospheric CO2 concentration level over the normal outdoor ambient threshold of 400 ppm. This increase encourages the search for methods to transform CO2 into more valuable chemicals. Here we provide a new meth ... Read more
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6106
Covalent Chemistry Platform for Diagnostics and Drug Discovery (No. T4-2045)
Overviewdelivery and activation of drugs or probes is of great importance in therapeutics, diagnostics, and research. For instance, selective delivery/activation of anti-cancer drugs to tumor cells is crucial for their efficacy and reduced side effects. However, achieving site-selective delivery/activation is challenging ... Read more
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6109
Covalent Inhibitors for Treatment of Inflammation and Neurodegeneration (No. T4-1880)
OverviewC-Jun NH2-terminal kinase (JNK) plays an integral role in many cellular processes and is associated with the pathophysiology of a number of neurological, inflammatory, and autoimmune diseases. Due to its ubiquity and its extensive activities, direct inhibition is likely and indeed was shown to have toxic effects. ... Read more
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6112
Scarless CRISPR-mediated Genome Editing (No. T4-2036)
OverviewCRISPR-Cas9 is a widely-used tool for genome editing; however, it is very inefficient and often requires the addition of selection markers, forcing the introduction of foreign DNA elements. The current technology offers a strategy for generating an inherent host-derived selection gene by CRISPR technology simulta ... Read more
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6115
Cell-free microRNA as a prognostic biomarker for amyotrophic lateral sclerosis (ALS) (No. T4-2038)
OverviewAmyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder of the human motor neuron system, for which no effective treatment exists. Variability in the rate of disease progression limits the efficacy of ALS clinical trials, suggesting that developing better biomarkers for prognosis will faci ... Read more
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6118
Treating Chronic Pain by Inhibiting Importin Alpha 3 (No. T4-2040)
OverviewPain, particularly in cases of chronic nerve injury and disease, is a critical element of numerous medical conditions and procedures, which is generally managed with opioid analgesics. While generally highly effective, they are associated with adverse effects, and risk of tolerance, dependence, and abuse. The gro ... Read more
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6124
Safer CAR-T cell platform (No. T4-2033)
OverviewChimeric Antigen Receptor (CAR)-T Cell Therapy is a personalized treatment for cancer in which the patient's T cells are genetically engineered to express a synthetic receptor that binds a tumor antigen. Although this treatment is very successful for treating some hematological cancers, it may cause a severe life ... Read more
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6130
Ultra-Rapid Structure Reconstruction Using an All-optical Digital Technology (No. T4-1879)
OverviewReconstruction of structures from their scattered intensity distributions is heavily exploited in a range of disciplines, with common methods limited when phase information is lost. Contemporary iterative algorithms depend on a priori knowledge of the object boundaries to solve such inverse scattering problems, b ... Read more
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6139
Inhibitory Proteins for 20S Proteasome Regulation as Cancer Treatment (No. T4-2065)
OverviewProteasomal protein degradation is crucial in maintaining cellular integrity and in regulating key cellular processes including cell cycle, proliferation and cell death. The 20S proteasome can function as an independent degradation machinery and tight regulation must exist to control its proteolytic capacity. Des ... Read more
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6145
WISER – A Holistic Analysis Of Large Scale Electronics Health Records (No. T4-2113)
OverviewIn the current era of big-data medicine, the Electronic Health Records (EHR) analysis is limited due to its disease-oriented approach. We developed WISER (Weizmann Institute of Science Electronic-health-record Research) platform - a suite of algorithms, models, software and workflows that enables the genomics and ... Read more
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6151
Quantum Simulation with Trapped Ions in a Gradient Field (No. T4-1965)
OverviewProgress in a broad range of scientific and technological fields is hampered by the difficulty of understanding and predicting the behavior of highly complex systems. Simulating the behavior of these systems is difficult with classical computers but can be performed efficiently using quantum simulators. Currently ... Read more
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6154
Treatment for Ewing Sarcoma Using ETS Proteins (No. T4-2068)
OverviewEwing sarcoma (ES) is a common bone malignancy in children and young adolescents which is usually treated by systemic chemotherapy. In about 25% of the cases, cancer has already spread to other parts of the body at the time of diagnosis. Here, we discover a novel family of ETS proteins that binds the glucocortico ... Read more
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6160
Peptides for Treating Alzheimer's Disease (No. T4-2057)
OverviewAlzheimer's Disease (AD) is an age-associated neurodegenerative disorder characterized clinically by a decline in cognitive function. It is the most common type of dementia, with 5.8 million Americans living with AS in 2020. There are currently no curative or preventive treatments for the disease, which drastical ... Read more
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6166
Early Detection and Treatment of Myeloid Leukemia (No. T4-1896)
Overviewmalignancies such as AML and MDS are usually aggressive and have a low overall survival rate. Recent studies demonstrated that specific mutations in hematopoietic stem cells occur years before the disease is diagnosed in individuals at high risk of developing myeloid malignancies. Therefore, there is a need to pr ... Read more
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6187
A high-throughput method for detecting allergens and viral infections (No. T4-1946)
OverviewAllergies affect a large portion of the population, affecting life quality and can impose life-threatening conditions in some cases. The diagnosis of allergies is currently limited by expensive low throughput methods, presenting a need for high‑throughput methods for allergen detection. Professor Eran Segal and ... Read more
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6193
Small Molecules for Treatment of Huntington's Disease and Related Disorders (No. T4-1947)
OverviewTrinucleotide repeats expansion disorders (TREDs) are a set of diseases in which repetitions of short DNA segments (three nucleotides) occur and accumulate in the genome. This is the cause of several neurological and neuromuscular disorders such as Huntington's disease (HD) and amyptrophic lateral sclerosis (ALS) ... Read more
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6205
Nanoscale Electronic Spin Polarizer and Enhanced Magnetoresistance for Memory Applications (No. T4-1816)
OverviewSpintronics has a large impact on daily life, being the backbone of computing and electronic applications. The reduction in the size of spintronic elements is of central importance for efficient information processing. At the atomic scale, electronic transport is very sensitive to the fine details of the electron ... Read more
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6208
Atomic Magnetometer with Increased Coherence Time for Improved Magnetic Fields Measurements (No. T4-1928)
OverviewAtomic magnetometers are the most precise magnetometers to date and are often used in applications ranging from medical to military uses. The use of atomic magnetometers is often limited in resolution when measuring low frequency signals due to short coherence time (mSec time scale). We have devised a magnetic fi ... Read more
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6220
Predicting Blood Metabolites (No. T4-1941)
OverviewThe serum metabolome contains a plethora of biomarkers and causative agents of various diseases. They are known to be modulated by various genetic and environmental factors such as the gut microbiome, nutrition, and lifestyle. However, most of the serum metabolites and their determinants are still unknown. The gr ... Read more
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6232
Improved Treatment for Glaucoma (No. T4-1433)
OverviewGlaucoma is one of the leading causes of irreversible blindness worldwide, affecting over 60 million people. It is usually caused due to raised intraocular pressure (IOP). Although several drug classes which lower IOP are available, they all cause local and systemic side effects, and improved treatments are great ... Read more
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6862
Protein coupling using cystein-free inteins (No. T4-2039)
OverviewTraceless covalent modification of proteins, including joining peptides or adding chemical groups, is extremely useful for numerous applications in chemical biology, protein chemistry, and biotechnology. A powerful tool currently used rely on Inteins, protein domains that auto-catalyze peptide bond formation. How ... Read more
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6961
Predicting Childhood Obesity (No. T4-2076)
OverviewChildhood obesity is a global health crisis, which holds extended complex health and psychological problems. Although an early diagnosis of children at risk for obesity could allow intervention and prevention, healthcare professionals have little guidance to identify individuals at risk. The current technology pr ... Read more
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7108
Sensitizing Non-Small Cell Lung Cancer (NSCLC) to Immunotherapy (No. T4-2082)
Overviewnon-small cell lung cancer (NSCLC) has a poor prognosis and low survival rates. Recently developed immunotherapy has revolutionized the therapy for NSCLC, significantly prolonging the overall survival of advanced‑stage patients. However, only 15-20% of the patients respond to immunotherapy and benefit from it. ... Read more
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7150
Cell Surface Modification with Synthetic Receptors (No. T4-1961)
OverviewTechnologies that target cells or modify their behavior are of great interest to improve diagnostic, therapeutic, and imaging platforms. However, methods for modifying cells' surfaces with synthetic agents are still limited by the complexity of synthesis procedures and restricted dynamic control of the newly acqu ... Read more
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9580
Clone 1E11 Progesterone (No. M7-146)
OverviewAnti-progesterone. Monoclonal antibody raised against position 11 of progesterone (Clone 1E11). It is very specific for progesterone.Progesterone is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species. Binding of homologous and heterologous isol ... Read more
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12511
Diagnosis and prognosis of inflammatory bowel diseases using host RNA sequencing of fecal samples (No. T4-2175)
OverviewInflammatory bowel disease (IBD) patients suffer from chronic inflammation of the gastrointestinal (GI) tract. The disease course varies, and patients often experience relapses and remission, despite the availability of several medications types. Currently, the disease stage is only assessed by histological analy ... Read more
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12514
New Antiviral Drugs from Bacterial Natural Products (No. T4-1934)
OverviewThe increasing incidence of viral infections across the globe is driving the demand for antiviral drugs. Prof. Rotem Sorek and his team identified a new family of bacterial enzymes that produce various nucleotide analogs with antiviral properties (Bernheim, Nature 2021). With further chemical modifications, these ... Read more
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12950
Reusable Gold Nanostars Substrates for Signal Amplification for Diagnostics (No. T4-2127)
OverviewNumerous spectroscopic techniques utilize signal enhancement from surfaces of nanoparticles linked to analyte molecules. However, existing surface-enhanced spectroscopies (SES) are based on solution-based nanoparticles dispersion and are unsuitable for solid substrates. Dr. Shimanovich and her team (led by Dr. So ... Read more
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13571
A Marker for Consciousness State Following Brain Injury (No. T4-1959)
OverviewImprovements in emergency medicine have increased survival rates after brain injury but, paradoxically, have resulted in an increasing number of survivors living with disorders of consciousness. The limitations of current consciousness assessment tools result in a high rate of misdiagnosis, which has numerous the ... Read more
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13574
Recycling of Platinum Group Metals (No. T4-1670)
OverviewA method for selective extraction of precious and rare metals has been developed at the Weizmann Institute. This method allows the efficient and environmentally benign recovery of precious materials that are currently discarded of in large quantities from spent catalysts (automotive and industrial) from industria ... Read more
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14060
Prosody Based Speech Analysis (No. T4-1856)
OverviewA major part of human communication is conveyed through intonation, or prosody – the music of speech. It is the least conscious, most instinctive activity of speech conveying all non-verbal linguistic information including sentiment, emphasis, conversation action and a large variety of signals: whether we are h ... Read more