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5299
LTC4 (6E7) (No. M7-101)
Summary: Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry. Leukotrienes: 101 – Monoclonal antibody to LTC4 Description: Rat monoclonal antibodies raised against Le ... Read more
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5302
An endothelial-adipose cell line derived from a murine bone marrow stroma (14F1.1) (No. M7-103)
Summary: 103 - Bone marrow derived stroma cell line 14F1.1 Description: An endothelial-adipose cell line derived from a murine bone marrow stroma. Reference: Zipori D, Toledo J, von der Mark K. 1985. Phenotypic heterogeneity among stromal cell lines from mouse bone marrow disclosed in their extracellular matrix composition ... Read more
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5305
Anti-Sulfamethazine monoclonal antibody (No. M7-115)
Summary: Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.Leukotrienes: Veterinary drugs: § 115 - Monoclonal antibody to Sulfamethazine (SMZ) Description: Rat mon ... Read more
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5308
Anti-Biotin Antibody (No. M7-116)
Summary: Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry. Biotin: § 116, 142 – Monoclonal antibody to Biotin Description: Monoclonal antibod ... Read more
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5311
Anti-Digoxin monoclonal antibody (No. M7-117)
Summary: Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry. Leukotrienes: Drugs: 117 – Monoclonal antibody to Digoxin - Description: Rat monoclonal antibodies ... Read more
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5314
Anti-Buserelin monoclonal antibody (No. M7-118)
Summary: Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.Leukotrienes: Drugs: § 118 - Monoclonal antibody to Buserelin Description: Rat monoclonal anti ... Read more
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5317
Anti-testosterone 3-(0- carboxymethyl)oxime-BSA monoclonal antibody (No. M7-119)
Summary: Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. Rat monoclonal antibodies raised against testosterone 3-(0- carboxymethyl)oxime-BSA. Available clones: 5F ... Read more
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5320
Anti-Follicle-stimulating hormone (FSH) monoclonal antibody (No. M7-120)
Summary: Monoclonal antibodies raised against bFSH. Available clone: 1G12. Follicle-stimulating hormone (FSH) is synthesized and secreted by gonadotrophs of the anterior pituitary gland. FSH regulates the development, growth, pubertal maturation and reproductive processes of the body.Reference: Somjen D1, Tordjman K, Kohen ... Read more
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5323
Anti-oestradiol-6- carboxymethyl oxime monoclonal antibody (No. M7-127)
Summary: Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. Monoclonal antibodies raised against oestradiol-6- carboxymethyl oxime-BSA. Available clones: 2F9 (Rat, I ... Read more
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5326
Anti-idiotypic antibody against anti-Sulfamethazine (12E12) (No. M7-130)
Summary: Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry. Leukotrienes: Veterinary drugs: 130 - Anti-idiotypic antibody against anti-Sulfamethazine Description: B ... Read more
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5329
Human T3N1M1 prostatic adenocarcinoma tissue for xenograft (No. M7-132)
Summary: WISH-PC frozen tissue samples Description: Neuroendocrine xenograft model of human prostatic small cell carcinoma cancer. Provides a source to study the involvement of neuroendocrine cells in the progression of prostatic adenocarcinoma and can serve as a novel model for the testing of new therapeutic strategies f ... Read more
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5332
Anti-progesterone-7 monoclonal antibody (No. M7-138)
Summary: Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. Monoclonal antibodies raised against progesterone-7- carboxythio thioether-BSA (clone 2H4, Rat IgG1) and ... Read more
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5335
Anti-oestradiol-6-carboxymethyl oxime monoclonal antibody (No. M7-141)
Summary: Monoclonal antibodies for peptide and steroid hormones Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. 127, 274, 141 – Monoclonal antibodies to estra ... Read more
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5338
F4 (No. M7-142)
Summary: Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry. Biotin: 116, 142 – Monoclonal antibody to Biotin - Description: Monoclonal antibodies raised against ... Read more
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5341
Clone 1F5 (No. M7-143)
Summary: Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry. Leukotrienes: Drugs: 143 - Monoclonal antibody to Medroxy-progesterone-acetate - Description: Rat monoclona ... Read more
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5344
Clone 8B6 (No. M7-144)
Summary: Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.Leukotrienes: Drugs: § 144 - Monoclonal antibody to RU-486 Description: Rat monoclonal antibodies raised ... Read more
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5347
Anti-Human chorionic gonadotropin (hCG) monoclonal antibody (No. M7-147)
Summary: Monoclonal antibodies raised against bhCG. Available clones: 1D5 (IgG1), 1E11 (IgG2b).Human chorionic gonadotropin (hCG) is a hormone produced by the syncytiotrophoblast, a component of the fertilized egg, after conception.Monoclonal antibodies for peptide and steroid hormones Due to their high specificity and sen ... Read more
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5350
Clone - 1E11 (No. M7-148)
Summary: Monoclonal antibodies for peptide and steroid hormones Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. Peptide Hormones: 147-148 - Monoclonal antibody t ... Read more
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5353
Anti-7-(O)-carboxymethyl formononetin monoclonal antibody (No. M7-155)
Summary: Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry. Isoflavones: § 155 – Monoclonal antibody to 7-(O)-carboxymethyl formononetin Description: 7-(O)-ca ... Read more
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5356
Anti-Phospho-ERK (PY193 or PT115) Monoclonal Antibodies (No. M7-176)
Summary: 176-177 - Monoclonal antibodies to phospho-ERK/Map Kinase Description: Monoclonal antibodies raised against peptides containing the 11 amino acids, HTGFLTEYVAT, corresponding to the ERK activation loop either Tyr -phosphorylated (ERK-PY193), or Thr-phosphorylated (ERK-PT115). ERK belongs to the family of mitogen-a ... Read more
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5359
ERK-PT115 (No. M7-177)
Summary: 176-177 - Monoclonal antibodies to phospho-ERK/Map Kinase Description: Monoclonal antibodies raised against peptides containing the 11 amino acids, HTGFLTEYVAT, corresponding to the ERK activation loop either Tyr -phosphorylated (ERK-PY193), or Thr-phosphorylated (ERK-PT115). ERK belongs to the family of mitogen-a ... Read more
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5362
Anti-Galactin 8 monoclonal antibody (No. M7-181)
Summary: Description: Monoclonal antibody to Galectin-8 (clone 106.1). Galectin-8 is a secreted, integrin-binding protein, part of a mammalian lectins family. Galectin-8, also known as Prostate Cancer Tumor Antigen-1 (PCTA-1) is highly expressed in human prostate cancer. It was shown to trigger the transcription of a u ... Read more
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5365
Anti-IgE monoclonal antibody (No. M7-185)
Summary: Monoclonal antibodies to IgE Description: Rat monoclonal anti-IgE antibodies that was generated by fusion of plasmacytoma (84.1C) or myeloma (EM953) cells with splenocytes of rat immunized with purified murine IgE mAb. The antibodies react with various IgE mAb of different specificities and not with immunoglobuli ... Read more
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5368
Diastereomer Lytic Peptides for Treatment of Solid Tumors and Metastasis in animal models (No. M7-236)
Summary: 236-237 - Diastereomer Lytic Peptides for Treatment of Solid Tumors and Metastasis Description: 15-mer (Leu-Lys-Dleu- Leu-Lys-Dlys-Leu-Dleu-Dlys-Lys-Leu-Leu-Dlys-Leu-Leu) and 15-mer Histidin (H-Leu-Lys-D-Leu- Leu-His-D-Lys-Leu-D-Leu-D-Lys-His-Leu-Leu-D-Lys-Leu-Leu-NH2) are membrane-active peptides composed of both ... Read more
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5371
15-mer Histidin (No. M7-237)
Summary: 236-237 - Diastereomer Lytic Peptides for Treatment of Solid Tumors and Metastasis Description: 15-mer (Leu-Lys-Dleu- Leu-Lys-Dlys-Leu-Dleu-Dlys-Lys-Leu-Leu-Dlys-Leu-Leu) and 15-mer Histidin (H-Leu-Lys-D-Leu- Leu-His-D-Lys-Leu-D-Leu-D-Lys-His-Leu-Leu-D-Lys-Leu-Leu-NH2) are membrane-active peptides composed of both ... Read more
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5374
Core peptide to inhibit T-Cell mediated inflammation in animal models (No. M7-238)
Summary: 238 - CP Peptide Description: Core peptide (CP; GLRILLLKV-D-stereoisomer), a synthetic peptide coding for the transmembrane domain of the ?-subunit of the T-cell receptor (TCR), a region that has been identified to be crucial for the assembly and function of the TCR. Was shown to significantly inhibit T-cell-media ... Read more
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5377
Anti-Mono-ubiquitinated H2B monoclonal antibody (No. M7-240)
Summary: 240 - Monoclonal antibody directed to ubiquitinated-H2B Description: Monoclonal antibodies, specific to ubiquitinated-H2B in its ubiquitinated form but not in its unmodified state, or to ubiquitin un-conjugated to H2B. Monoubiquitylated-H2B takes part in almost every molecular process associated with chromatin bio ... Read more
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5380
Anti-progesterone-7 monoclonal antibody (No. M7-252)
Summary: Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. Anti-idiotypic antibody raised against anti-progesterone-7- BSA.KLH conjugate (clone 2H4). Available clon ... Read more
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5383
Alpha-Anti Progesterone (2E11) (No. M7-253)
Summary: Monoclonal antibodies for peptide and steroid hormones Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. Anti-idiotypic antibodies to anti-steroids: 252-253 ... Read more
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5386
Monoclonal Anti-Gliomedin Antibody (Mab#94) (No. M7-257)
Summary: 257 - Monoclonal antibody to Gliomedin Description: Monoclonal antibody to Gliomedin (MAb 94) raised against a synthetic peptide corresponding to amino acid residues 273–287 (CVIPNDDTLVGRA), present in the extra cellular region of Rat Gliomedin. Gliomedin, a glial ligand for neurofascin and NrCAM, is expressed ... Read more
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5389
Monoclonal Anti-Ermin Antibody (Mab#160) (No. M7-258)
Summary: 258 - Monoclonal antibody to Ermin Description: Monoclonal antibody to Ermin (MAb160) raised against purified GST–Ermin (residues 1–261). Ermin is a marker of myelinating oligodendroglia, localized to the outer cytoplasmic lip of the myelin sheath and the paranodal loops. It was suggested to play a role in cyt ... Read more
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5392
Monoclonal Anti-Caspr Antibody (Mab#275) (No. M7-259)
Summary: 259 - Monoclonal antibody to Caspr Description: Monoclonal antibody to Caspr (Mab275), raised against the extracellular domain of Caspr. Caspr is a contactin-associated protein, part of the neurexin family of proteins. It lies in the paranodal section of the myelin sheath and has a role in myelin sheath attachmen ... Read more
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5395
Anti- Glutamate receptor (GluR3B) monoclonal antibody (No. M7-261)
Summary: 261 - Monoclonal antibody to GluR3B Description: Mouse monoclonal antibody (IgG2a), raised against a synthetic peptide of the Glutamate receptor (GluR3B), corresponding to amino acids 383-395 (NEYERFVPFSDQQISNDSSSSENR) of Leishmania donovani GluR3B. May be used for diagnosis as well as drug development for "autoim ... Read more
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5398
Monoclonal Antibodies Specific to Cholesterol/Ceramide Mixture Clone (No. M7-263)
Summary: Originally raised against an artificial monolayer of lipid mixtures in, and were shown to specifically label the above domains in different cell membranes. Reference: Scheffer L, Futerman AH, Addadi L. 2007. Antibody labeling of cholesterol/ceramide ordered domains in cell membranes. Chembiochem 8(18):2286-94. ... Read more
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5401
499F (No. M7-265)
Summary: Monoclonal antibodies specific to cholesterol/ceramide mixture Description: Monoclonal antibodies specific for cholesterol/ceramide-rich domains (clones 405F, 14F, 499F) and cholesterol micro-domains (clones 36A1, 5881) in cell membranes. Originally raised against an artificial monolayer of lipid mixtures in, and ... Read more
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5404
Anti- estrone-3- glucuronide monoclonal antibody (No. M7-273)
Summary: Monoclonal antibodies for peptide and steroid hormones Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. 273 - Anti-idiotypic antibody against estrone-3-gl ... Read more
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5407
Anti-Estradiol 15 (No. M7-274)
Summary: Monoclonal antibodies for peptide and steroid hormones Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. § 127, 274, 141 – Monoclonal antibodies to ... Read more
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5410
Anti-Estrone-3-Glucuronide monoclonal antibody (No. M7-275)
Summary: Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. Monoclonal antibodies raised against estrone-3-glucuronide-BSA. Available clones: 8A3 (Rat, IgG2a), 155B3. ... Read more
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5413
Anti-Estrone-3-Glucuronide monoclonal antibody (clones: 155B3, 8A3) (No. M7-276)
Summary: Monoclonal antibodies for peptide and steroid hormones Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. 275-276 – Monoclonal antibodies to estrone-3-gluc ... Read more
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5416
Anti-Runx-3 monoclonal antibody (No. M7-306)
Summary: Monoclonal antibody to Runx-3 Description: Monoclonal antibody to Runx-3 raised against the Runx3 peptide TPSTPSPRGSLSTTSHF. Available clones: 62, H8. Runx-3 (Runt-related transcription factor 3) is a transcription factor, and a master regulator of lineage specific gene expression in several important developmenta ... Read more
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5419
Chromogenic substrate for serum paraoxonase (PONs) activity (No. M7-315)
Summary: 315 - TBBL (5-thiobutyl butyrolactone) Description: TBBL (5-thiobutyl butyrolactone) is a chromogenic lipo-lactone substrate for Serum paraoxonases (PONs), used for sera tests of PONs activity, based on their lactonase activity. The primary enzymatic reaction produces an unstable intermediate that rapidly collap ... Read more
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5422
Anti-Mast cell Function-associated Antigen (MAFA) monoclonal antibody (No. M7-320)
Summary: 320 - Monoclonal antibody G63 Description: Monoclonal antibodies to MAFA (Mast cell Function-associated Antigen), originally raised against intact rat RBL-2H3 cells. MAFA is a type II membrane glycoprotein, which was shown to inhibit the secretory response to the type. Binding of G63 antibody to MAFA was shown to ... Read more
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5425
Escherichia coli UTL2 (No. M7-358)
Summary: Escherichia coli UTL2 Description: A "leaky" strain of E. coli, which is significantly more susceptible to cytotoxic agents. UTL2 holds a mutation in the galU gene causing an impaired outer membrane. Reference: Bibi E. 1996. Functional expression of mouse Mdr1 in an outer membrane permeability mutant of Escheric ... Read more
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5428
MyRepair Blood Test to Identify People at High Risk for Lung Cancer (No. T4-1033)
OverviewA novel diagnostic test to identify individuals with increased risk of lung cancer Background and Unmet NeedLung cancer is the number one killer among cancers, with 160,000 deaths/year in the USA and 1.6 million/year worldwide. Early detection of lung cancer increases 5-year survival rate from 4% to 5 ... Read more
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5434
Acquisition of Multidimensional NMR Spectra in a Single Scan (No. T4-1151)
Summary: A method to significantly shorten acquisition times of high-quality MRI images. Multidimensional nuclear magnetic resonance (NMR) is used nowadays in many applications (e.g., discovery of new pharmaceutical drugs, characterization of new catalysts, and investigation of the structure and dynamics of proteins). One ... Read more
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5437
Monoclonal Antibodies for Monitoring Hormone and Drug Additives in Food Providing Animals (No. M7-1166)
Summary: A series of monoclonal antibodies for monitoring hormone and drug additives in animals grown for the food industry. These include mAbs for peptide hormones, steroid hormones, drugs, leukotrienes, isoflavones, and veterinary drugs. ApplicationsMonitoring hormone and drug additives in food providing anim ... Read more
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5449
Cholesterol Antibodies (No. T4-1267)
Summary: Description: Monoclonal antibodies specific for cholesterol/ceramide-rich domains (clones 405F, 14F, 499F) and cholesterol micro-domains (clones 36A1, 5881) in cell membranes. Originally raised against an artificial monolayer of lipid mixtures in, and were shown to specifically label the above domains in differen ... Read more
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5452
Mouse IgE and Anti-Mouse IgE Monoclonal Antibodies (No. M7-1270)
Summary: Monoclonal antibodies to IgE Description: Rat monoclonal anti-IgE antibodies that was generated by fusion of plasmacytoma (84.1C) or myeloma (EM953) cells with splenocytes of rat immunized with purified murine IgE mAb. The antibodies react with various IgE mAb of different specificities and not with immunoglobuli ... Read more
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5455
On-Chip Synthetic Biology Platform for Diagnostics and Therapeutics (No. T4-1369)
OverviewCell-free synthetic platforms that enable complex biological activities such as synthesis and self-assembly of biomolecules, can be employed for various applications, including drug discovery and diagnostics. Using synthetic genes, we provide a novel platform for cell-free synthetic biology on a chip which is a c ... Read more
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5458
High-Performance Electrochromic Devices (No. T4-1380)
OverviewHigh-performance electrochromic materials that exhibit a practical combination of low-voltage operation and efficient color-switching, as well as long-term stability have been developed by the group of Prof. van der Boom. Electrochromic materials that are currently available in the market offer a broad range of c ... Read more
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5461
Detecting Irregularities (such as suspicious movements) in Visual Data (No. T4-1381)
OverviewWhile image & video processing are rapidly developing fields, most of the recent algorithms must be trained on large and sorted databases to gain adequate performance. Detecting irregularities in previously unknown images or videos is still an unsolved problem. Prof. Michal Irani and her team developed an alg ... Read more
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5464
Monoclonal Anti-Ubiquitinated Histone H2B Antibody (No. T4-1397)
Summary: A novel antibody which can be used, for the first time, to recognize ubiquitinated histone 2B. This technology is novel in its ability to recognize proteins and their destinations, and may serve in diagnostics and immunoprecipitation processes. ApplicationsPrimary applications in research. Use as a det ... Read more
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5467
Automatic Animation in Video and Still Images (No. T4-1423)
OverviewMany currently marketed animation tools enable users to define objects and provide them with motion, yet none enable the fast and automatic, animation of a full body captured in a single still photo. A new technology developed by a group of researchers from the Weizmann Institute of Science, enables automatic tra ... Read more
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5470
CD84 - a Novel Regulator of B-CLL Survival (No. T4-1441)
Summary: Chronic lymphocytic leukemia (CLL), a malignant disease characterized by the accumulation of B lymphocytes in the blood, lymphoid organs, and bone marrow, is the second most common type of leukemia in adults, accounting for about 7,000 new cases of leukemia each year. Presently, there is no cure for CLL, and the o ... Read more
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5473
Inhibition of Nuclear Entry of MAPK Cascade Proteins as a Novel Mechanism for Treating Cancer (No. T4-1446)
OverviewInhibition of Nuclear Entry of MAPK Cascade Proteins as a Novel Mechanism for Treating Cancer Background and Unmet NeedERK is a major signaling molecule, which plays a driving role in various pathologies, particularly cancer. When not activated ERK is localized to the cytoplasm. Upon activation ERK bi ... Read more
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5479
Changing an Image Size without Information Loss (No. T4-1461)
OverviewData storage of images and videos became a real issue in the last years when pictures and videos are taken and shared more often, and the memory devices aren’t being minimized fast enough. Prof. Michal Irani and her team have developed an algorithm that can resize images while keeping the important features wit ... Read more
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5482
Highly Sensitive Nanoscale Scanning Magnetic and Thermal Sensor (No. T4-1481)
OverviewA new technology developed by a group of researchers from the Weizmann Institute is a nanoscale sensor-on-tip for local magnetic signals and thermal dissipation with state-of-the-art sensitivity and spatial resolution. Detecting a signal as low as the magnetic moment of a single electron is of key technological i ... Read more
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5485
Conductive Inorganic Fullerenes and Nanotubes (No. T4-1482)
Summary: Modification of the electronic properties of layered-type semiconductors can be accomplished by doping/alloying of the semiconductor. In the present disclosure we show that doping of MoS2 and WS2 nanotubes/nanoparticles can be accomplished by doping with either Re (n-type) or Nb (p-type) foreign atoms. These nanop ... Read more
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5500
Increasing Resolution of an Image (No. T4-1522)
OverviewMany imaging devices produce signals of unsatisfactory resolution (e.g. a photo from a cell-phone camera may have low spatial resolution or a video from a web camera may have both spatial and temporal low resolution). Previous methods for Super-Resolution (SR) require multiple images of the same scene, or else an ... Read more
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5503
Optical Conversion (No. T4-1529)
Summary: We present an efficient and robust broadband crystal optical conversion device. Various applications of laser optics require tunable laser sources. Currently, most frequency conversion devices rely on a single non-linear crystal, which is either temperature or angle tuned to enhance efficiency. This results only i ... Read more
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5512
Green Catalytic Formation of Alcohols, Amines, Amides, Imines and Esters under Mild Conditions (No. T4-1551)
OverviewA team of researchers headed by Prof. David Milstein at the Weizmann Institute of Science (WIS), have developed a novel set of manganese, ruthenium, and related borohydride complexes (Pincer-type). These catalysts are efficient and environmentally-benign for the synthesis of alcohols, amines, amides, imines, and ... Read more
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5515
In Silico Designed Synthetic Carbon Fixation Pathways for Superior Biomass Generation (No. T4-1556)
OverviewModern agriculture faces limited arable land and climate changes. Carbon fixation under these conditions will become a significant growth-limiting factor. Synthetic carbon fixation pathways can allow plants to produce more biomass using the same amount of energy from sunlight. Novel alternative synthetic carbon f ... Read more
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5521
Inorganic Fullerene Coating for Medical Devices (No. T4-1566)
Summary: Novel nanoparticle lubricants can significantly reduce friction of different dental devices and enable reduction of treatment times. Different dental applications suffer from excessive friction, which severely compromise their function. For orthodontic procedures, friction significantly reduces effectiveness and t ... Read more
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5530
A Novel Database to Reduce Unsuccessful Cloning in E. Coli by Detection of Toxic Genes (No. M7-1576)
Summary: Synthetic genes are commonly used in academic and industrial applications, however in many cases these said genes can be toxic when inserted into the ubiquitously used E. coli. This is problematic as time and money is wasted on attempts to generate genes that will not function in E. coli. The problem is exacerbate ... Read more
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5533
Desulfurization of Flue-Gasses (No. T4-1577)
OverviewA novel flue gas desulfurization (FGD) system achieves removal of sulfur dioxide (SO2) from industrial exhaust streams at efficiencies that can greatly supersede technologies currently in use. The chemical process is highly selective to SO2, and consumes much less reagents, therefore reducing the cost of desulfur ... Read more
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5536
A Novel Technique of Thermoelectric Conversion (No. T4-1583)
Summary: The thermoelectric effect is the direct conversion of temperature differences to electric voltage and vice versa. Thermoelectric effects are used in various applications, where heat energy is saved, that would be otherwise lost. Although the TE conversion efficiency is nowadays low (5-8%), the novel technique deve ... Read more
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5545
Novel MRI Contrast Agent (No. T4-1604)
Summary: Novel reporter gene for magnetic resonance imaging applications.The ability to image the duration and location of gene expression in vivo and noninvasively is imperative for the future of biology and clinical medicine. Magnetic Resonance Imaging (MRI) is a widely used noninvasive clinical diagnostic tool that offe ... Read more
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5551
A TACE Inhibitor (ADAM17) (No. T4-1628)
OverviewTargeting TNF-α Converting Enzyme (TACE) to Treat Autoimmune and Inflammatory Diseases Background and Unmet NeedAutoimmune and inflammatory mediated disorders encompass a wide range of diseases, including psoriasis, inflammatory bowel disease (IBD), rheumatoid arthritis (RA), systemic sclerosis, syst ... Read more
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5557
Biological Treatment for Pancreatic Cancer (MMP7 mAb) (No. T4-1640)
OverviewA novel therapeutic antibody against MMP-7, with exceptional specificity, for the treatment of aggressive cancers. Although early programs targeting MMPs (matrix metalloproteins) were largely unsuccessful due to adverse side effects, they remain a viable and highly desirable therapeutic target. The main obstacle ... Read more
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5560
Anti-QSOX1 Antibody for Treating Cancer and Metastasis (No. T4-1642)
OverviewCancer, and especially cancer metastasis, is a leading cause of death worldwide. Research in recent years highlighted the importance of the extracellular matrix (ECM) surrounding the tumor in cancer progression metastasis formation. Therefore, many attempts currently address the unmet need to target enzymes that ... Read more
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5566
Unsupervised Content-Based Image Retrieval (CBIR) and categorization (No. T4-1647)
OverviewAlthough images search engines are available online, offline networks and databases (in governmental offices, banks, etc.) require an efficient and reliable image search engine. Prof. Michal Irani and her team developed a method for Visual Inference of a collection of images, which builds upon collaboration betwe ... Read more
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5572
Affinity Maturated T-Cell Receptor (No. T4-1662)
OverviewUsing affinity maturated TCRs to generate reactive T cells Background and Unmet NeedImmunotherapy, that is the use of the immune system to treat cancer, is currently a leading candidate in the combat against cancer. Unlike the toxic effects of both chemotherapy and radiation, immunotherapy is consider ... Read more
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5575
MRI of Tissue Fibrosis Without Contrast Agent (No. T4-1665)
Summary: Improved magnetic resonance imaging (MRI) for cardiac fibrosis and other fibrotic diseases.Myocardial fibrosis is associated with worsening ventricular systolic function, abnormal cardiac remodeling, and increased ventricular stiffness, significantly increasing the risk of adverse cardiac outcomes. Hypertension an ... Read more
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5584
Preventing Infections Using Lipid Based Molecules (No. T4-1673)
OverviewSphingosine (SPH), a natural bactericidal agent which acts as a part of the human innate immune system in the skin, was found to be an effective treatment and prophylaxis for bacterial lung infections in cystic fibrosis (CF) mice. CF is the most common autosomal recessive disorder in western countries, affecting ... Read more
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5587
Highly Selective Optical Biosensors for Proteins in Biological Samples, with Excellent Signal-to-Noise Ratio (No. T4-1689)
Summary: Sensing the levels of protein-based biomarkers in biological samples is crucial for diagnosis of various diseases including cancer. Optical biosensors offer sensitivity and cost-effectiveness; however, current commercially available devices fail to provide sufficient selectivity and signal to noise ratios for prot ... Read more
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5590
Production of Syngas from Biomass (No. T4-1716)
Summary: An efficient and selective decomposition of plant biomass carbohydrates to their basic components, carbon monoxide and hydrogen, for use as syngas.Terrestrial plants contain about 70% hemicellulose and cellulose, which constitute a significant renewable bio-resource with potential as an alternative to petroleum fe ... Read more
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5596
Aerobic Carbon-Carbon Bond Cleavage of Alkenes to Aldehydes and Ketones (No. T4-1722)
OverviewOur technology provides a new type of oxidative cleavage reaction of organic compounds with highly selective product formation. Polyoxometalate (POM) catalysts have become well-known for their utility and diversity in specific reactions. Through the elucidation of POM catalytic pathways, greater versatility has b ... Read more
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5602
Carbon Nanotube Based Transistor Device (No. T4-1730)
OverviewWith the continuous trend of electronic component miniaturization, process control technologies must keep up with component size reduction. Defects that were so far negligible, are now posing critical operation obstacles, and are more difficult to identify as scales are reduced to <10 nm. This new technology d ... Read more
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5605
P38 and JNK Inhibitor as Potential Treatment for Various Pathologies (No. T4-1733)
OverviewThe development of kinase inhibitors to treat inflammatory diseases was proved beneficial, however, designing specific inhibitors with minimal side effects and prolonged efficacy is challenging as drug resistance often develops. The current technology includes inhibitors that specifically target the nuclear trans ... Read more
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5608
Bioengineered Microorganisms that can "Eat" (Fix) CO2 (No. T4-1736)
OverviewThe two most pressing challenges facing humanity are the need to feed the growing population with restricted land and water sources and global warming caused due to high atmospheric CO2 levels. Biological systems for CO2 conversion to organic molecules using renewable-energy-harvesting techniques present a promis ... Read more
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5611
A Novel Approach for Treating Cancer and Collagen-Associated Diseases by Using Anti-LOXL-2 Antibody (No. T4-1743)
OverviewAn innovative method for treating diseases associated with dysregulation of collagen fibers in the extracellular matrix (ECM), such as cancer and fibrosis, by targeting LOXL-2. Background and Unmet NeedECM disruption is associated with many pathological conditions, such as various cancer types and tis ... Read more
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5620
rPTE with Potent Organophosphate (OPH) Activities (No. T4-1750)
Summary: Organophosphates are toxic compounds found in chemical warfare agents, such as nerve gases, and insect pesticides.Use of volatile nerve gas agents by terrorist organizations is a key concern of governments around the world. V-type nerve agents (e.g. VX, RVX, and CVX) are particularly toxic nerve gases, with an exc ... Read more
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5623
Treatment of Heart Failure by Inducing Cardiomyocyte Proliferation (No. T4-1752)
OverviewRegulating ErbB2 signaling in cardiomyocytes (CM) as novel treatment for heart diseases by inducing regeneration of cardiac tissue. Background and Unmet NeedIschemic heart disease and heart failure are the leading causes of death in the western world. Although improved medical care reduced early morta ... Read more
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5626
Spin Controlled Water Electrolysis for Efficient Production of Hydrogen (No. T4-1753)
OverviewThe chiral-induced spin selectivity (CISS) effect, discovered in recent years by Prof. Ron Naaman from the Weizmann Institute of Science, implies that electrons transferred through chiral molecules possess a specific spin orientation. Since then, the CISS effect has been investigated in different applicative syst ... Read more
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5629
Multimodel Transcranial Optical Vascular Assessment (No. T4-1769)
OverviewSubdural hematoma (SDH) is a collection of blood between the inner layer of the dura and the brain that occurs mostly as a result of trauma. It is one of the most common neurosurgical conditions in the United States today. SDH monitoring for hematoma expansion would be beneficial to enable expeditious surgical in ... Read more
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5635
A Novel Method for Treating Drug-Resistant Lung Cancer Using a Combination of Antibodies (No. T4-1774)
OverviewA novel method to treat tyrosine kinase inhibitor (TKI) resistant cancer by using a combination of three antibodies that target EGFR (ERBB1), HER2 (ERBB2), and HER3 (ERBB3) receptors. Background and Unmet NeedThe ErbB/HER family of receptor tyrosine kinases includes epidermal growth factor receptor (E ... Read more
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5647
A Novel Method of Preventing or Treating Secondary Infections by Inhibition of Membrane Type I Matrix-Metalloproteinase-1 (No. T4-1790)
OverviewA novel method of preventing secondary infections, by inhibition of membrane type I matrix-metalloproteinase-1, which reduces degradation of the extra cellular matrix. Background and Unmet NeedPathogens that infect the respiratory system are the cause of some of the most dangerous infections, especial ... Read more
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5653
A Sensitive and Fast Image Subtrection Technique (No. T4-1801)
Summary: Image sequences are used in various fields, including medical imaging and satellite/airborne imaging. The comparison between images taken at different conditions (e.g. equipment or configuration, angles, weather and wavelength) can be a highly non-trivial problem, as subtraction artifacts can outnumber real change ... Read more
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5656
Detection of Short Dispered Pulse Signals (No. T4-1802)
Summary: Pulses are applied in various fields such as oil & gas exploration, detection (e.g. sonar, lidar and radar) and communication. When pulses pass through dispersive media, the arrival times at the detector of different frequency components may differ, and as a result the pulse may become degraded (e.g. transform ... Read more
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5659
Novel Method for Diagnosing and Treating Relapsed Obesity (No. T4-1805)
OverviewA novel method for analyzing the likelihood of weight regain following a weight loss program and maintaining target body weight, based on gut microbiome analysis. Background and Unmet NeedThe past century has seen an overwhelming increase in the prevalence of overweight and obese individuals, effectin ... Read more
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5662
Novel CNT Hybrid Films (No. T4-1809)
OverviewBattery and capacitor electrode technologies available in the industry today, are struggling to keep up with rapidly advancing applications that require high power and energy density such as electric vehicles, solar cells and telecommunications systems. One of the leading solutions to this problem are CNT-based f ... Read more
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5665
Platform for Boosting Yield and Activity of Therapeutic T Cells (No. T4-1810)
OverviewProduction of large quantities of T cells is an essential demand for the development of immunotherapies. However, ex-vivo culturing of T-cells is very inefficient, resulting in high cell death rates. The current technology offers unique, optimized conditions that allow increased T-cell proliferation while enhanci ... Read more
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5674
Inertial NEMS for Nanosensor Applications Based on Inorganic Nanotubes (No. T4-1828)
OverviewInertial sensors for motion detection are being incorporated into an increasing number of portable devices, including diverse IoT applications, mobile phones, wearable electronics, automotive systems and medical diagnostic sensors. The current size reduction trend in electronics, requires incorporation of reliabl ... Read more
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5677
Highly Selective Fluorescent Biosensor for Labeling His-Tagged Proteins in a Specific Conformation (No. T4-1834)
OverviewA rapid, label-free biosensor for detecting specific conformation of His-tag labeled proteins, accessible for use in both academic- and commercial-R&D was invented at the Weizmann Institute of Science. This fluorescent biosensor detects and labels His-tagged proteins in complex environments, such as living ce ... Read more
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5680
A Novel Method for Detecting Activation of Necroptosis via Exosome Analysis (No. T4-1839)
Summary: Numerous medical conditions are related to inflammation, such as pancreatitis, psoriasis, inflammatory bowel disease, atherosclerosis, neurodegeneration, and more. However, determination of inflammation in the body, especially at early stages of a pathology is difficult to assess. Therefore, there is a great clini ... Read more
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5683
Secure Search of Encrypted Cloud Data (No. T4-1840)
Summary: Searchable symmetric encryption with practical big-data performance and strong security Highlights Outsourcing data storage to remote servers offers invaluable benefits while introducing many concerns when dealing with sensitive data. In the presence of potentially-vulnerable servers, strong user-side encryption p ... Read more
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5686
Methods for High-Throughput Analysis of Transcriptomes (No. T4-1843)
Summary: Analysis of the transcriptome of cells can inform greatly about the state of said cells, including maturation, activation, transformation, etc. Therefore it would be of great research and clinical value to analyze transcriptomes of different cell populations and to compare gene expression on large scales. A partic ... Read more
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5689
Composite Functional Metasurfaces for Multispectral Achromatic Optics (No. T4-1845)
Summary: A new technology for producing flat optical components based on optical metasurfaces. These components can potentially serve high resolution imaging, spectrometry, light processing and beam shaping devices. The optical metasurfaces that we develop are composed of closely spaced optical nanoantennas which can be ... Read more
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5695
A Novel Synthetic Biology Platform for Controlling Gene Expression (No. T4-1847)
OverviewA method for controlling gene expression using a novel phage-based transcription factor-peptide system. Background and Unmet NeedA fundamental challenge of synthetic biology and its clinical applications is the capability to control gene expression. Presently, gene expression systems for research and ... Read more
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5698
CRISP-Seq: Integrating the Power of Single-Cell RNA Sequencing and CRISPR-Pooled Screens (No. T4-1848)
Summary: Single-cell RNA sequencing (RNA-Seq) is a powerful tool to identify and characterize the transcriptome of single cells. While providing unprecedented resolution in terms of studying cells, single-cell RNA-Seq is functionally a descriptive tool, unless combined with gene manipulation. CRISPR-Cas9 is a genome-editin ... Read more
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5701
Signal Enhancement and Manipulation Using a Signal-Specific Deep Network (No. T4-1850)
OverviewOptical and dimensional limitations of images can be partially overcome today using signal enhancement technologies which typically rely on supervised, deep-learning methods. However, as existing methods are restricted to specific training images and distortion types, they provide poor results for any practical c ... Read more
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5704
Optical Bus for a Multi-Core Processor (No. T4-1863)
OverviewThe exponential increase in computational power over the last decades is running into a bottle-neck – the only way of getting more computing power per chip is to integrate multiple-cores, but the problem with multiple-cores is the complex wiring system, used for inter-core communication. This technology, develo ... Read more
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5707
Novel Treatment for Lung Diseases by Allogeneic Cell Transplantation (No. T4-1868)
Summary: The treatment of respiratory conditions is currently one of the major challenges to health care systems all over the world. The problem is that most therapeutics currently available for treating pulmonary indications are non-curative, and simply improve symptoms. Presently the only cure for late stage pulmonary di ... Read more
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5713
Cancer Diagnostics by Analyzing Urea Cycle Enzymes (No. T4-1872)
OverviewAn innovative method to diagnose and potentially treat various cancers by analyzing the urea cycle metabolites. Background and Unmet NeedEarly stage diagnosis and treatment of cancer is essential, especially for highly malignant or metastatic tumors. An important stage in cancer progression is cell gr ... Read more
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5716
A Method in Improving Survival and Expansion of Hematopoietic Stem Cells (No. T4-1874)
OverviewA potential method of generating hematopoietic stem cells for transplantation by inhibiting CD74. Summary: Hematopoietic stem cells (HSCs) originate in the bone marrow and are the progenitors of all hematopoietic cells. HSCs have the capacity to both self-renew and to differentiate, and they migrate fro ... Read more
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5719
Treatment of Psychiatric Disorders by Inhibiting Importin Alpha 5 (No. T4-1875)
OverviewAnxiety and stress-related conditions pose a significant health burden on modern healthcare systems. While currently, available anxiolytic drugs can be highly effective for some patients, their long-term use is limited by their potentially severe and debilitating side effects. The group of Prof. Mike Fainzilber d ... Read more
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5722
Universal CAR-Ts (No. T4-1884)
Background and Unmet NeedChimeric Antigen Receptor T-Cells (CAR-Ts) are one of the revolutionary technologies of the twenty-first century, invented by Prof. Zelig Eshhar at the Weizmann Institute of Science. FDA approvals for CAR T cells against B-ALL and DLBCL pave the way for CAR-T cell application against other types ... Read more
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5728
A New Sustainable Process for Hydrocarbons Oxidation (No. T4-1892)
OverviewPhenol is an important industrial commodity used as a precursor to many useful compounds. It is being utilized in huge amounts in a wide range of industry sectors including the pharmaceuticals, plastic-related-products production, paints & coatings, electrical equipment, foams and fuel additives. The current ... Read more
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5731
Preventing Biofilm Formation by Enzyme Inhibitors (No. T4-1893)
Background and Unmet NeedBiofilm is a complex colony of bacteria, which are attached together by extracellular polymeric substance. This setting provides the bacteria protection against environmental factors, improves their surface attachment, and plays a major role in resistance to treatment. Therefore, biofilms are dif ... Read more
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5734
Person-specific Assessment of Probiotics Responsiveness (No. T4-1895)
OverviewProbiotics are a widely consumed dietary supplement, however, their efficacy is controversial and not all individuals benefit from their use. Therefore, a predictive tool that distinguishes between probiotic-permissive and resistant individuals is needed. The current technology provides a method for predicting an ... Read more
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5737
WS2 nanotube-reinforced biodegradable and biocompatible polymer ink for 3d printing (No. T4-1900)
OverviewBiocompatible polymers commonly used in the orthopedic and cosmetic prosthetics, cardiovascular and dental implants and food packaging industries often suffer from poor mechanical properties and thermal stability, limited dimensionality and short shelf-life as compared to their metal comparators. Two research gro ... Read more
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5740
Photovoltaic Devices Based on Guided Nanowire Arrays (No. T4-1906)
Summary: Nanowires are being produced and integrated into various systems today, including solar cells, nano-sensors, nano-electrodes, transparent touch-screen coatings, and LED replacements. Thus far, several challenges have hindered the commercial advancement of nanowire-based technologies. Two major setbacks have been: ... Read more
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5743
Extraction of Gold from Electronic Waste and Ores (No. T4-1910)
OverviewA method for selective extraction of gold has been developed at the Weizmann Institute. This method allows the efficient and environmentally benign recovery of gold that is currently discarded of in large quantities from electronic waste from household appliances, consumer electronic devices and industrial equipm ... Read more
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5746
Imaging Platform for IBD Drug Discovery (No. T4-1925)
OverviewInflammatory bowel disease (IBD) is characterized by chronic inflammation of the gastrointestinal (GI) tract, resulting in its damage and gut barrier dysfunction. These chronic conditions are treatable but not curable, dramatically decrease the patient’s quality of life and affect approximately 1.6 million Amer ... Read more
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5749
Molecular Switches in Solid Media (No. T4-1927)
OverviewMolecular photoswitches are light-responsive molecules with potential applications in a broad range of systems with on-demand functionalities. While molecular photoswitches have been extensively studied in solution, their immobilization to dry, planar surfaces generally renders them photochemically unresponsive. ... Read more
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5752
Artificial Pancreas (No. T4-1942)
OverviewThe alarmingly sharp increase in type 1 diabetes mellitus incidence in recent years has been coupled with a marked rise in the development of closed-loop systems aimed at continuously monitoring blood glucose levels, predicting glucose behavior and delivering adjusted insulin doses. However, to date, these system ... Read more
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5998
Prediction of Gestational Diabetes (No. T4-1962)
Overviewdiabetes mellitus (GDM) is one of the most common complications of pregnancy, increasing the risk for short and long-term adverse events for both mother and offspring. Early intervention can reduce future complications, however, GDM is currently diagnosed only at late pregnancy stages. The group of Prof. Eran Seg ... Read more
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6011
PROMISE search engine for PTMs and Neoantigens (No. T4-2090)
OverviewMany newly developed anti-cancer treatments rely on identifying cancer unique signatures that can be used to harness the immune system against the tumor. The internal state of all cells is constantly represented on their surfaces by unique molecules called Human Leukocyte Antigen (HLA) bound peptides. Consequentl ... Read more
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6012
Recovery of Rare Earth Metals From Ferromagnetic Alloys (No. T4-1936)
OverviewProduction of electric motors for electric vehicles, electric generators for wind turbines, and hard disk drives (HDDs) is highly dependent on the availability of rare earth elements (REE) such as Neodymium, Dysprosium, and Praseodymium to produce permanent magnets (which are also called Neodymium magnets). The a ... Read more
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6014
One-Shot Diagnostic PCR Testing of Pooled Samples (No. T4-2111)
OverviewOne of the main challenges in curbing the spread of coronoavirus disease 2019 (COVID-19) is rooted in the limited technical capacities of current diagnostic testing platforms. Qualitative reverse transcription polymerase chain reaction, the gold standard diagnostic method, requires dedicated machinery and can onl ... Read more
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6016
Increasing Efficiency of Therapeutic A-to-I RNA Editing (No. T4-2028)
OverviewSingle-point mutations can give rise to a wide spectrum of genetic diseases. Recent therapeutic approaches aim at editing the mutated mRNA, providing a safe, reversible and tunable treatment. However, these methods are currently not efficient due to knowledge gaps in the understanding of the rules determining RNA ... Read more
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6018
Methods of diagnosing cancer and predicting responsiveness to therapy (No. T4-2066)
OverviewImmunotherapy was proven very efficient for some patients revolutionizing cancer treatment; however, many patients fail to respond to the treatment. It is currently unknown which patients will respond to immunotherapy. The current technology enables to diagnose cancer and to pre-determine a patient’s likelihood ... Read more
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6019
A Novel Target for Treating and Diagnosing Refractory or Relapsing Multiple Myeloma (No. T4-2075)
OverviewMultiple myeloma (MM) is an incurable malignancy, and despite novel anti-myeloma drugs that increased survival, up to 30% of patients develop primary resistance, and many patients experience early relapse. This innovation deploys single‑cell analytical tools to identify molecular signatures of refractory or rel ... Read more
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6023
Artificial Womb Device for Extended Mammalian Embryogenesis (No. T4-2128)
OverviewMammalian embryos develop inside the uterine environment, making them inaccessible for direct monitoring and perturbations. Therefore, the full in-depth understanding of the developmental process that occurs post embryo implantation in the uterus remains limited. The lab of Prof. Jacob Hanna recently developed a ... Read more
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6024
Higher Efficiency of CRISPR Gene Editing Using Chimeric Cas9 (No. T4-1930)
OverviewCRISPR-Cas9 is a powerful tool for genome editing, widely used for basic research and the development of treatments for genetic diseases. However, its efficiency is currently limited. The current technology is a new chimeric Cas9 fused to a domain that recruits DNA repair factors directly to the genomic site that ... Read more
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6025
Combinatorial Approach to Inhibit Drug-Resistant Lung Cancer Harboring EGFR Mutations (No. T4-1944)
OverviewNon-Small Cell Lung Cancer (NSCLC) is a very common type of cancer, and despite currently available therapies, is one of the deadliest due to the emergence of drug resistance, which results in tumor recurrence. Thus, there is a clear need for novel therapeutic strategies to overcome resistance, especially in the ... Read more
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6026
Anti-Lox antibody Like Compound for Duchenne Muscular Dystrophy (No. T4-1913)
OverviewDuchenne muscular dystrophy (DMD) is a disease that affects approximately 1 in 3,500 boys with a life expectancy of ~26 years. Newly approved FDA treatments are designed to treat specific mutations that account for only 25% of the patients, leaving an unmet need for an effective treatment for the clinical patholo ... Read more
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6027
Ultra tight ACE2 binder for prevention of SARS-Cov-2 infection (No. T4-2024)
Overviewcombat against COVID-19 is still ongoing worldwide. Despite the great advancements in the realm of vaccine development, there is still a great need for efficient medications to treat the disease, especially in vulnerable populations (such as elderly people and subjects with background illnesses). A common strateg ... Read more
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6029
GreenTap - A Novel Method of Inducing and Collecting Plant Exudates (No. T4-1894)
OverviewNumerous plant-originated compounds with unique properties are widely used for diverse applications in the drugs, food, and cosmetics industries. Chemical synthesis of these compounds is not feasible due to their complexity, and harvesting said compounds from plants can be extremely challenging and inefficient. T ... Read more
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6030
A method to identify actively degraded proteins (No. T4-1832)
OverviewThis technology provides a method to identify the full landscape of proteins that are actively being degraded by the proteasome, offering a way to identify novel targets in various biological conditions and contexts. Background and Unmet NeedThe cell's proteome (protein profile) is constantly changing ... Read more
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6082
Frontotemporal Dementia Diagnosis Using Circulating microRNA Biomarkers (No. T4-2037)
OverviewFrontotemporal dementia (FTD) is a heterogeneous neurodegenerative disorder characterized by frontal and temporal lobe atrophy, typically manifesting with behavioral or language impairment. Because of its heterogeneity and lack of available diagnostic laboratory tests, there can be a substantial delay in diagnosi ... Read more
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6085
L-DOPA Production in Plants (No. T4-2048)
OverviewCurrent synthetic pathways of the standard Parkinson’s disease treatment, L-DOPA (levodopa), are complicated, requiring multiple steps, and depend upon the use of either hazardous starting compounds or producing toxic side products. The present technology offers an alternative synthetic method that is greatly s ... Read more
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6088
Treatment Of Bacterial Vaginosis (No. T4-1945)
OverviewTreating bacterial vaginosis by performing vaginal microbial transplants (VMT). Background and Unmet NeedBacterial Vaginosis (BV) is considered the most prevalent form of vaginal infection in women of reproductive age, affecting from one-quarter to one-third of women. Women suffering from BV report di ... Read more
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6091
Novel Targets for Treating Acute Liver Failure (ALF) (No. T4-2071)
OverviewAcute liver failure (ALF) is a rapid deterioration of liver function, resulting in a high mortality rate in the absence of liver transplantation. ALF treatment remains highly limited and mostly supportive due to a lack of a comprehensive understanding of the molecular base of ALF. The group of Profs. Eran Elinav ... Read more
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6097
Repurposed Drug for Amplifying the Anti-Depressant Effects of Ketamine (No. T4-2129)
OverviewPsychiatric disorders, with emphasis on major depressive disorder (MDD), are leading causes of disability and premature death across the globe, with patients showing a heightened risk of self-harm and suicidal ideation. Current pharmaceutical treatment options suffer from significantly prolonged time to response ... Read more
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6100
Electrochemical Reduction Of Carbon Dioxide Catalyzed By Polyoxometalates (No. T4-2133)
OverviewCarbon dioxide (CO2) is the main greenhouse gas that is produced by human activity and has brought the atmospheric CO2 concentration level over the normal outdoor ambient threshold of 400 ppm. This increase is encouraging the search for methods to transform CO2 into more valuable chemicals. Here we provide a new ... Read more
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6106
Covalent Ligand Directed Release (CoLDR) Chemistry – A Versatile Drug Discovery Platform (No. T4-2045)
Overviewdelivery and activation of drugs or probes is of great importance in therapeutics, diagnostics, and research. For instance, selective delivery/activation of anti-cancer drugs to tumor cells is crucial for their efficacy and reduced side effects. However, achieving site-selective delivery/activation is challenging ... Read more
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6109
Covalent Inhibitors for Treatment of Inflammation and Neurodegeneration (No. T4-1880)
OverviewC-Jun NH2-terminal kinase (JNK) plays an integral role in many cellular processes and is associated with the pathophysiology of a number of neurological, inflammatory, and autoimmune diseases. Due to its ubiquity and its extensive activities, direct inhibition is likely and indeed was shown to have toxic effects. ... Read more
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6112
Scarless CRISPR-mediated Genome Editing (No. T4-2036)
OverviewCRISPR-Cas9 is a widely-used tool for genome editing; however, it is very inefficient and often requires the addition of selection markers, forcing the introduction of foreign DNA elements. The current technology offers a strategy for generating an inherent host-derived selection gene by CRISPR technology simulta ... Read more
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6115
Circulating microRNA as a Biomarker for ALS Progression (No. T4-2038)
OverviewAmyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder of the human motor neuron system, for which no effective treatment exists. Variability in the rate of disease progression limits the efficacy of ALS clinical trials, suggesting that developing better biomarkers for prognosis will faci ... Read more
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6118
Treating Chronic Pain by Inhibiting Importin Alpha 3 (No. T4-2040)
OverviewPain, particularly in cases of chronic nerve injury and disease, is a critical element of numerous medical conditions and procedures, which is generally managed with opioid analgesics. While generally highly effective, they are associated with adverse effects, and risk of tolerance, dependence, and abuse. The gro ... Read more
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6124
Safer CAR-T cell platform (No. T4-2033)
OverviewChimeric Antigen Receptor (CAR)-T Cell Therapy is a personalized treatment for cancer in which the patient's T cells are genetically engineered to express a synthetic receptor that binds a tumor antigen. Although this treatment is very successful for treating some hematological cancers, it may cause a severe life ... Read more
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6130
Rapid Phase Retrieval by Lasing (No. T4-1879)
OverviewReconstruction of structures from their scattered intensity distributions is heavily exploited in a range of disciplines, with common methods limited when phase information is lost. Contemporary iterative algorithms depend on a priori knowledge of the object boundaries to solve such inverse scattering problems, b ... Read more
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6139
Inhibitory Proteins for 20S Proteasome Regulation as Cancer Treatment (No. T4-2065)
OverviewProteasomal protein degradation is crucial in maintaining cellular integrity and in regulating key cellular processes including cell cycle, proliferation and cell death. The 20S proteasome can function as an independent degradation machinery and tight regulation must exist to control its proteolytic capacity. Des ... Read more
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6145
WISER – A Holistic Analysis Of Large Scale Electronics Health Records (No. T4-2113)
OverviewIn the current era of big-data medicine, the Electronic Health Records (EHR) analysis is limited due to its disease-oriented approach. We developed WISER (Weizmann Institute of Science Electronic-health-record Research) platform - a suite of algorithms, models, software and workflows that enables the genomics and ... Read more
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6151
Quantum Simulation with Trapped Ions in a Gradient Field (No. T4-1965)
OverviewProgress in a broad range of scientific and technological fields is hampered by the difficulty of understanding and predicting the behavior of highly complex systems. Simulating the behavior of these systems is difficult with classical computers but can be performed efficiently using quantum simulators. Currently ... Read more
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6154
Treatment for Ewing Earcoma Using ETS Proteins (No. T4-2068)
OverviewEwing sarcoma (ES) is a common bone malignancy in children and young adolescents which is usually treated by systemic chemotherapy. In about 25% of the cases, cancer has already spread to other parts of the body at the time of diagnosis. Here, we discover a novel family of ETS proteins that binds the glucocortico ... Read more
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6160
Method of treating Alzheimer's Disease (No. T4-2057)
OverviewAlzheimer's Disease (AD) is an age-associated neurodegenerative disorder characterized clinically by a decline in cognitive function. It is the most common type of dementia, with 5.8 million Americans living with AS in 2020. There are currently no curative or preventive treatments for the disease, which drastical ... Read more
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6166
Gene Panel for Early Detection of AML (No. T4-1896)
Overviewmalignancies such as AML and MDS are usually aggressive and have a low overall survival rate. Recent studies demonstrated that specific mutations in hematopoietic stem cells occur years before the disease is diagnosed in individuals at high risk of developing myeloid malignancies. Therefore, there is a need to pr ... Read more
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6187
AllergenDetect (No. T4-1946)
OverviewAllergies affect a large portion of the population, affecting life quality and can impose life-threatening conditions in some cases. The diagnosis of allergies is currently limited by expensive low throughput methods, presenting a need for high‑throughput methods for allergen detection. Professor Eran Segal and ... Read more
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6193
Small Molecules for Treatment of Huntington's Disease and Related Disorders (No. T4-1947)
OverviewTrinucleotide repeats expansion disorders (TREDs) are a set of diseases in which repetitions of short DNA segments (three nucleotides) occur and accumulate in the genome. This is the cause of several neurological and neuromuscular disorders such as Huntington's disease (HD) and amyptrophic lateral sclerosis (ALS) ... Read more
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6205
Nanoscale Electronic Spin Polarizer and Enhanced Magnetoresistance for Memory Applications (No. T4-1816)
OverviewSpintronics has a large impact on daily life, being the backbone of computing and electronic applications. The reduction in the size of spintronic elements is of central importance for efficient information processing. At the atomic scale, electronic transport is very sensitive to the fine details of the electron ... Read more
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6208
Atomic Magnetometer with Increased Coherence Time for Improved Magnetic Fields Measurements (No. T4-1928)
OverviewAtomic magnetometers are the most precise magnetometers to date and are often used in applications ranging from medical to military uses. The use of atomic magnetometers is often limited in resolution when measuring low frequency signals due to short coherence time (mSec time scale). We have devised a magnetic fi ... Read more
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6220
Predicting Blood Metabolites (No. T4-1941)
OverviewThe serum metabolome contains a plethora of biomarkers and causative agents of various diseases. They are known to be modulated by various genetic and environmental factors such as the gut microbiome, nutrition, and lifestyle. However, most of the serum metabolites and their determinants are still unknown. The gr ... Read more
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6229
A Novel Opto-Genetic Tool for Light Activated Synaptic Silencing (No. T4-2046)
OverviewDefects in neurotransmitters are associated with several neurological diseases such as Parkinson’s disease, epilepsy, and psychiatric disorders. Optogenetics is a technology based on light-sensitive proteins for optical control of cellular processes. It is a powerful research tool for dissecting neuronal circui ... Read more