The new technology may help answer outstanding questions about the immune system, cancer, Alzheimer’s, and more.
Invading cells’ private space – prying into their internal functions, decisions and communications – could be a powerful tool that may help researchers develop new immunotherapy treatment for cancer. As reported today in Cell, a research group at the Weizmann Institute of Science has developed a technology that enables them to see inside tens of thousands of individual cells at once in greater details than ever before. The group, headed by Prof. Ido Amit of the Institute’s Immunology Department, applied this method to define the immune cells that infiltrate tumors, identifying a new subset of innate immune cells that “collaborate” with cancer. Blocking these inhibitory immune cells in mice greatly enhanced the anti-tumor immune response, killing the cancer.
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