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  • ERBB2 as a Novel Target to Treat Heart Failure by Inducing Cardiomyocyte Proliferation (No. T4-1752)

    Scientist: Eldad Tzahor

    Existing treatments fail to compensate the irreversible loss of functional cardiomyocytes (CM), thus presenting a major medical unmet need. Inducing native CM replacement is one approach being tested as regenerative treatment, with the advantage of a more straightforward methodology over cell transplantation approaches. ... Read more
    5623
  • Inhibiting Importin to Treat Psychiatric Stress and Other Disorders (No. T4-1875)

    Scientist: Michael Fainzilber

    Anxiety and stress-related disorders effect 10-30% of the general population and are therefore considered a major burden on public health. Current medical treatments for anxiety disorders include drugs that target various synaptic mechanisms, such as uptake of neurotransmitters. However, severe side-effects and suboptima ... Read more
    5719
  • Inhibition of Nuclear Entry of MAPK Cascade Proteins as a Novel Mechanism for Treating Cancer (No. T4-1446)

    Scientist: Rony Seger

    Peptide sequences for efficient inhibition of nuclear translocation of proteins. The ability to regulate cellular localization of a biological component is important for many functions such as gene therapy, protection from toxic chemicals, transport of anti-cancer agents, and possibly preventing nuclear translocation of ... Read more
    5473
  • Long Chain Sphingoid as Preventing Infection (No. T4-1673)

    Scientist: Anthony H. Futerman

    CF is the most common autosomal recessive disorder in western countries, affecting approximately 30,000 people in the US alone. A major risk in CF arises from chronic bacterial lung infections, affecting 80% of CF patients by the age of 25. Bacterial lung infections are also of major clinical importance in patients with ... Read more
    5584
  • Methods for High-Throughput Analysis of Transcriptomes (No. T4-1843)

    Scientist: Ido Amit

    Analysis of the transcriptome of cells can inform greatly about the state of said cells, including maturation, activation, transformation, etc. Therefore it would be of great research and clinical value to analyze transcriptomes of different cell populations and to compare gene expression on large scales. A particularly ... Read more
    5686
  • Methods of Identifying and Using Agents for Treating Diseases Associated with Intestinal Barrier Dysfunction (No. T4-1925)

    Scientist: Benjamin Geiger

    The obesity pandemic has reached alarming magnitudes, affecting more than 2 billion people worldwide and accounting for more than 3 million deaths per year. A poorly understood feature of the ‘metabolic syndrome’ is its association with dysfunctions of the intestinal barrier, leading to enhanced permeability and tran ... Read more
    5746
  • Monoclonal Anti-Ubiquitinated Histone H2B Antibody (No. T4-1397)

    Scientist: Moshe Oren

    A novel antibody which can be used, for the first time, to recognize ubiquitinated histone 2B. This technology is novel in its ability to recognize proteins and their destinations, and may serve in diagnostics and immunoprecipitation processes. ... Read more
    5464
  • Mouse IgE and Anti-Mouse IgE Monoclonal Antibodies (No. T4-1270)

    Scientist: Zelig Eshhar

    Monoclonal antibodies to IgE Description: Rat monoclonal anti-IgE antibodies that was generated by fusion of plasmacytoma (84.1C) or myeloma (EM953) cells with splenocytes of rat immunized with purified murine IgE mAb. The antibodies react with various IgE mAb of different specificities and not with immunoglobulins of o ... Read more
    5452
  • MRI of Tissue Fibrosis Without Contrast Agent (No. T4-1665)

    Scientist: Michal Neeman

    Improved magnetic resonance imaging (MRI) for cardiac fibrosis and other fibrotic diseases.Myocardial fibrosis is associated with worsening ventricular systolic function, abnormal cardiac remodeling, and increased ventricular stiffness, significantly increasing the risk of adverse cardiac outcomes. Hypertension and diabe ... Read more
    5575
  • MyRepair Blood Test to Identify People at High Risk for Lung Cancer (No. T4-1033)

    Scientist: Zvi Livneh

    A novel diagnostic test to identify individuals with increased risk of lung cancer. Lung cancer is the number one killer among cancers, with 160,000 deaths/year in the USA and 1.6 million/year worldwide. Early detection of lung cancer increases 5-year survival rate from 4% to 54%. Moreover, the National Lung Cancer Trial ... Read more
    5428

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