Scientist: Rony Seger

Peptide sequences for efficient inhibition of nuclear translocation of proteins. The ability to regulate cellular localization of a biological component is important for many functions such as gene therapy, protection from toxic chemicals, transport of anti-cancer agents, and possibly preventing nuclear translocation of ... Read more

Scientist: Irit Sagi

Disruption to the Extra-Cellular Matrix (ECM) is associated with many pathological conditions, such as various cancer types and tissue fibrosis, and also correlates with high tumor malignancy. Therefore, controlling ECM composition and morphology is considered a potential treatment for cancer and other ECM-associated dis ... Read more

Scientist: Zelig Eshhar

Chimeric Antigen Receptor T-Cells (CAR-Ts) are one of the revolutionary technologies of the twenty-first century, invented by Prof. Zelig Eshhar at the Weizmann Institute of Science. The CAR-T technology represents a leap in terms of treating cancer, as the technology programs an individual’s immune system to specifica ... Read more

Scientist: Eran Hornstein

MicroRNAs as potential biomarkers for ALS.Amyotrophic Lateral Sclerosis (ALS) is a devastating disease that progressively destroys motor neurons in the brain and the spinal cord, eventually causing paralysis and death. Currently, there are approximately 25,000 patients with ALS in the USA, with a median age of onset of ... Read more

Scientist: Noam Sobel

HighlightsPseudomonas aeruginosa bacteria are common pathogens that are difficult to treat and are therefore critical to diagnose early when involved in infections. The commonly used method for confirming a P. aeruginosa infection is cultural inoculation, which takes 2-3 days to yield results.   2-Aminoacetophenone (2- ... Read more

Scientist: Ilana Kolodkin-Gal

Biofilm is a complex colony of bacteria, which are attached together by extracellular polymeric substance. This setting provides the bacteria protection against environmental factors, improves their surface attachment, and plays a major role in resistance to treatment. Therefore, biofilms are difficult to eradicate, much ... Read more

Scientist: Yosef Yarden

Improved immunotherapy for breast cancer. Monoclonal antibodies (mAbs) to ErbB-2/HER2 growth factor receptor, or to its sibling, the epidermal growth factor receptor (EGFR), prolong survival of cancer patients, especially when combined with cytotoxic therapies. However, low effectiveness of therapeutic mAbs and the evolu ... Read more

Scientist: Dan Tawfik

Organophosphates are toxic compounds found in chemical warfare agents, such as nerve gases, and insect pesticides.Use of volatile nerve gas agents by terrorist organizations is a key concern of governments around the world. V-type nerve agents (e.g. VX, RVX, and CVX) are particularly toxic nerve gases, with an exceptiona ... Read more

Scientist: Eran Segal

Dietary supplementation with commensal microorganisms, collectively termed probiotics, is a constantly growing market, estimated to exceed 69.3 billion USD by 2023. Probiotics are the third most commonly consumed dietary supplement after vitamin and mineral preparations. Claimed rationales for probiotics consumption by h ... Read more

Scientist: Yosef Yarden

A tailor-made strategy for cancer treatment. The ErbB family of tyrosine kinase receptors and their ligands play important roles in development and tissue remodeling throughout adulthood. ErbB proteins are involved in several types of human cancer. Clinical studies indicate that over-expression of one or more ErbB ligand ... Read more