Currently available treatments for advanced colorectal cancer (CRC) are primarily inefficient, and the prognosis remains poor, despite the introduction of targeted and immunotherapies. Although many combinations of therapies appear synergistic when tested in vitro, they fail in clinical trials. ... Read more

Ovarian cancer is the fifth leading cause of cancer-related death in women. Due to a lack of early detection methods, it is often diagnosed at a late stage, resulting in negligible changes to cure. ... Read more

Early detection of breast cancer (BC) and monitoring its progression, treatment response, and recurrence are crucial for survival. ... Read more

The constant emergence of new variants threatens the success of the mRNA vaccines developed against SARS-CoV-2. Therefore, there is an urgent need to develop a vaccine that will provide immunity against multiple variants – both existing and potential. Prof. ... Read more

Psychiatric disorders, especially major depressive disorder (MDD), are leading causes of disability and premature death across the globe, with patients showing a heightened risk of self-harm and suicidal ideation. Prof. ... Read more

Of the approximately 30 million adult smokers in the U.S, more than half report attempting to quit smoking every year. However, smoking cessation-associated weight gain (SCWG) constitutes a major obstacle to smoking withdrawal. ... Read more

Acute liver failure (ALF) is a rapid deterioration of liver function, resulting in a high mortality rate in the absence of liver transplantation. ALF treatment remains highly limited and mostly supportive due to a lack of a comprehensive understanding of the molecular base of ALF. ... Read more

Ewing sarcoma (ES) is a common bone malignancy in children and young adolescents which is usually treated by systemic chemotherapy. In about 25% of the cases, cancer has already spread to other parts of the body at the time of diagnosis. ... Read more

Proteasomal protein degradation is crucial in maintaining cellular integrity and in regulating key cellular processes including cell cycle, proliferation and cell death. ... Read more

Immunotherapy has revolutionized cancer treatment by activating the immune system to attack tumor cells. However, notable limitations remain, including differential responses between individuals and cancer types. Dr. ... Read more