Psychiatric disorders, with emphasis on major depressive disorder (MDD), are leading causes of disability and premature death across the globe, with patients showing a heightened risk of self-harm and suicidal ideation. ... Read more

Many newly developed anti-cancer treatments rely on identifying cancer unique signatures that can be used to harness the immune system against the tumor. ... Read more

Multiple myeloma (MM) is an incurable malignancy, and despite novel anti-myeloma drugs that increased survival, up to 30% of patients develop primary resistance, and many patients experience early relapse. ... Read more

Acute liver failure (ALF) is a rapid deterioration of liver function, resulting in a high mortality rate in the absence of liver transplantation. ALF treatment remains highly limited and mostly supportive due to a lack of a comprehensive understanding of the molecular base of ALF. ... Read more

Ewing sarcoma (ES) is a common bone malignancy in children and young adolescents which is usually treated by systemic chemotherapy. In about 25% of the cases, cancer has already spread to other parts of the body at the time of diagnosis. ... Read more

Proteasomal protein degradation is crucial in maintaining cellular integrity and in regulating key cellular processes including cell cycle, proliferation and cell death. ... Read more

Alzheimer's Disease (AD) is an age-associated neurodegenerative disorder characterized clinically by a decline in cognitive function. It is the most common type of dementia, with 5.8 million Americans living with AS in 2020. ... Read more

Defects in neurotransmitters are associated with several neurological diseases such as Parkinson’s disease, epilepsy, and psychiatric disorders. Optogenetics is a technology based on light-sensitive proteins for optical control of cellular processes. ... Read more

delivery and activation of drugs or probes is of great importance in therapeutics, diagnostics, and research. For instance, selective delivery/activation of anti-cancer drugs to tumor cells is crucial for their efficacy and reduced side effects. ... Read more

Pain, particularly in cases of chronic nerve injury and disease, is a critical element of numerous medical conditions and procedures, which is generally managed with opioid analgesics. ... Read more