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1834
A rapid, label-free biosensor for detecting specific conformation of His-tag labeled proteins, accessible for use in both academic- and commercial-R&D. The fluorescent biosensor detects and labels His-tagged proteins in complex environments, such as living cells, while offering high sensitivity,...

A rapid, label-free biosensor for detecting specific conformation of His-tag labeled proteins, accessible for use in both academic- and commercial-R&D. The fluorescent biosensor detects and labels His-tagged proteins in complex environments, such as living cells, while offering high sensitivity, speed, and cost-effectiveness.

Fluorescent biosensing has become a valuable tool in analytical research, while at the same time the poly-histidine tag (His-tag) has become the most commonly used tag for protein labeling.  However, commercial products for labeling and detecting conformational changes in His-labeled proteins suffer from three main limitations: First is their inability to identify specific changes in the protein conformation. Second, even if such changes are detected, labeling of His-tag proteins is usually very laborious. And third, commercial probes tend to be large and consequently can interfere with the proteins function.  Therefore, there is a need for a small, direct, and non-interfering fluorescent probe for detection of conformational changes.

Dr. Margulies and his team have developed a first of its kind fluorescent molecule that provides detection of changes to the surface of His-labeled proteins. Subsequently, labeling proteins only if they are in a specific conformation. The biosensor exhibits high affinity, excellent signal-to-noise ratio and can be easily applied with no fixation or tedious protocols.

Using the technology, many proteins and specific conformations can now be labeled and studied for the first time (proteins that were already successfully labeled using the biosensor: Calmodulin, B-cell lymphoma 2, G-protein).

Applications


·         Fluorescent detection of specific conformations of His-tag labeled proteins.

·         Direct labeling in both live cell imaging and biochemical assays.

·         Tracking protein-protein interactions in vivo.

·         Localizing proteins and measuring their steady-state concentration in vivo.


Advantages


·         Direct, rapid, and easily applicable.

·         Operate in complex biological environments – live cells or biological media.

·         High affinity and superior signal-to-noise ratio.

·         Small in size - unlikely to interfere with the labeled protein function.      


Technology's Essence


The biosensor presented here is comprised from three main molecular-components: (1) the selective binder (binds to a specific tag, e.g. His-tag); (2) the nonselective binder (binds to the protein surface, as long it is in a specific conformation); and (3) a solvatochromic fluorophore.

The selective binder (1) ensures the sensor will only bind to a tagged protein (in this case, His-tagged protein), regardless of its conformational state. Once the protein folds into the specific conformation, the nonselective binder (2) detects and binds to the modified surface configuration (pre-designed to detect the specific conformation). Now that the local environment of the attached-biosensor and its fluorophore (3) has changed, the fluorophore subsequently emits a distinct and measurable signal.

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  • Dr. David Margulies
1814
Overview Interactions between molecules are the key for many bio-related processes. The ability to characterize these interactions plays a big role in drug development, computer implemented molecular simulations, and research related to biological processes in general. Most of the molecules that...

Overview

Interactions between molecules are the key for many bio-related processes. The ability to characterize these interactions plays a big role in drug development, computer implemented molecular simulations, and research related to biological processes in general. Most of the molecules that participate in biological processes are chiral. Despite the major role of chirality in molecular interactions, especially in various biological and chemical processes, the enantioselectivity of the interaction is not addressed in a proper manner in most of the current calculations. Recently, it was realized that in chiral molecules charge redistribution, which occurs in any biorecognition event, is accompanied by spin polarization, an effect that is not included in the current methods for calculating molecular interactions. Spin polarization is the degree to which the spin, i.e., the intrinsic angular momentum of elementary particles such as electrons, is aligned with a given direction.

 

The Need

Chirality plays an important role in biology. Various techniques are known for simulating and predicting interactions between molecules. However, the current methods often miss the enantioselectivity of biological interactions and do not provide the correct binding energies. This shortcoming suggests that some essential features are not included in our current description of these interactions. There is thus a need for a modification of the current interaction models for better predictions of molecular interactions in various environments.

The Solution

The technique is based on the relation between charge reorganization in a chiral molecule and spin polarization. Thus, charge polarization, occurring in molecular interactions, may both be used to determine the specific chirality of enantiomers of a given molecule and to improve the prediction of interactions between two chiral objects.

Applications


  • Drug design

  • Molecular simulations

  • Chirality determination of a given molecule or a molecular structure


Advantages


  • Better understanding of chiral selectivity in biological systems

  • Enhanced prediction accuracy for various processes and material interactions

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  • Prof. Ron Naaman
1658
Rapid, label free assay for glycan identification, accessible for use in medical diagnostics and biomanufacturing quality control. While glycans hold great promise as biomarkers for several diseases including cancer, technologies that enable rapid and sensitive glycan analysis for diagnosis at “point...

Rapid, label free assay for glycan identification, accessible for use in medical diagnostics and biomanufacturing quality control.

While glycans hold great promise as biomarkers for several diseases including cancer, technologies that enable rapid and sensitive glycan analysis for diagnosis at “point of care” settings are not available.

Dr. Margulies and his team from the Weizmann institute of science developed an optical biosensor that is based on combinatorial detection and produces distinct optical “signatures” for even closely related glycan species.

This invention may be implemented into a single device, which will be simple to operate, to identify many types of glycans in high sensitivity for clinical diagnosis and biomanufacturing quality control processes.

Applications


  • Point of care biosensor device for routine detection of glycan biomarkers from clinical samples.

  • Quality control biosensor device for glycans biomanufacturing.


Advantages


  • Label free, rapid, and easy to integrate into a compact self-contained "point of care" system.

  • Highly sensitive due to the combinatorial effect.

  • A single compound identifies many analytes.

  • Ease of miniaturization for future applications.


Technology's Essence


The present invention is based on a multi-sensor array compound which is composed of a non specific receptor (e.g. boronic acid), at least three chromophores and an anchor. The binding event of this compound to an analyte (i.e. carbohydrates, saccharides) is transduced into a measurable optical signature.

The binding of different analytes distinctly affects the emission of each dye, due to direct optical responses of each dye, as well as conformational changes that affect fluorescence resonance energy transfer (FRET) processes among them. Other photochemical processes that further contribute to the discrimination ability of this innovative compound are photo-induced electron transfer (PET) and internal charge transfer (ICT).

The combination of these effects provides a vast number of unique optical signatures. The pattern recognizer evaluates the responses and through predetermined, programmed, or learned patterns, compares the unique pattern or signature of the measurements to stored patterns for known biomarker or chemical species.

Finally, this design is extremely simple to operate and utilizes a single instrumentation, a single excitation wavelength, and a single incubation step, all of which enable straightforward analysis.

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  • Dr. David Margulies
1780
A method based on Fast Neutron Resonance Transmission (FNRT) radiography that enables determining weight percentages of oil and water in thick, intact cores taken from subterranean or underwater geological formations. As part of geological exploitation to find oil and water, cores are extracted and...

A method based on Fast Neutron Resonance Transmission (FNRT) radiography that enables determining weight percentages of oil and water in thick, intact cores taken from subterranean or underwater geological formations. As part of geological exploitation to find oil and water, cores are extracted and tested to determine oil/water content.
This new method allows determining such content rapidly, in non- destructive, specific and quantities analysis of the cores.

Applications


  • Determining the identity and proportions of substances of oil and water content and their distribution in inspected cores

Advantages


  • A non-destructive method which enables to determine the fluid content along the entire length of an intact core or aggregate of cores within their protective sleeves.
  • More comprehensive information and considerable saving of analysis time compared to conventional sampling methods.
    Suitable for all types of rocks including tight-shale rocks.
  • This method enables to measure the weight fraction of oil and water in the core regardless of the core shape, thickness or distribution.
  • The fluid weight fractions in the samples are determined independently, thus the ratio of oil-to-rock weight-ratio is independent of the water content.
  • Due to high penetration of fast neutrons, the method is suitable for screening intact thick rock cores (10-15 cm), for which alternative probes, such as X-rays or slow neutrons suffer limited penetration.

Technology's Essence


In order to map the oil and water content and their distribution, an aggregate of intact cores within their protective sleeves is positioned on a moving conveyor belt and scanned by a broad- energy, fast- neutron beam. The neutrons are detected by a spectroscopic fast neutron imaging detector. The map of neutron-transmission spectra in each pixel provides information of oil/water content and distribution in such cores. 

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  • Prof. Amos Breskin
1571
A novel social behavior monitoring system automatically tracks the precise location of each animal at excellent temporal resolution. This innovative technology provides simultaneous identification of complex social and individual behaviors via an integration of RFID and video surveillance. There is a...

A novel social behavior monitoring system automatically tracks the precise location of each animal at excellent temporal resolution. This innovative technology provides simultaneous identification of complex social and individual behaviors via an integration of RFID and video surveillance.

There is a rapidly growing interest in detecting the molecular substrates of social behavior. This interest is driven by the vast implications of such understanding in both research and the pharmaceutical industry, since some prevalent pathological conditions are mainly characterized by a behavioral deficit or abnormality.

It is extremely challenging to quantify social behavior in a reliable manner. Existing methods struggle to find a balance between objectively quantifying behavior on one hand while enabling a natural, stress-free behavioral estimation on the other hand. Currently, researchers work in a strictly controlled and constrained environment that is estranged and stressful to the animals. The outcome is a highly contaminated measurement of natural behavior. This difficultly becomes increasingly complex when more than one animal is involved as often applied in social behavioral studies.

Applications


  • Rigorous characterization of social organizational deficiencies and evaluation of their severity in animal and human models (for example in autism).
  • An optimized system for estimating the efficacy of clinical treatments.

Advantages


  • Long-term tracking of unlimited number of simultaneously studied animals.
  • Machine based, hence objective and automated quantification of behavior.
  • Excellent spatiotemporal resolution in semi natural environment
  • Flexible- the number, size and distribution of the RFID antennas can be adjusted with different enclosure dimensions.
  • Can be applied from Individual behavioral profile or pairs interactions up to collective social organization of groups.
  • Systematic analysis and classification of basic locomotion up to more complex social

Technology's Essence


Researchers at the Weizmann institute developed a method for tightly controlled monitoring of social behavior in a semi-natural environment. They used integrated and synchronized chip reporting and continuous video postage to precisely locate each individual animal. Using this automated monitoring which provides an exceptional temporal resolution they achieved correct identification of numerous basic individual behaviors as well as complex social behaviors. Such complex behavioral profiles set the basis for subsequent analysis which reveals the formation of a social hierarchy.

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  • Dr. Tali Kimchi
1556
Synthetic carbon fixation pathways can allow plants to produce more biomass using the same amount of energy from sunlight. Novel carbon fixation cycles discovered at The Weizmann Institute hold potential to greatly increase the capacity of organisms to convert atmospheric carbon into sugars. Modern...

Synthetic carbon fixation pathways can allow plants to produce more biomass using the same amount of energy from sunlight. Novel carbon fixation cycles discovered at The Weizmann Institute hold potential to greatly increase the capacity of organisms to convert atmospheric carbon into sugars.

Modern agriculture faces limited arable land and climate changes. Carbon fixation under these conditions will become a significant growth limiting factor. The proposed solution provides the ability to enhance crop yields using the same expanse of land.

The novel technology presents alternative synthetic carbon fixation pathways that were discovered by harnessing a systems biology approach. These pathways are predicted to harbor a significant kinetic advantage over their natural counter parts, making them promising candidates for synthetic biology implementation.

Applications


  • Synthetic organisms utilizing this revolutionary technology can offer higher carbon fixation rates as compared to natural alternatives allowing:
  • Superior rate of biomass generation, providing cost effective feedstock for the production of biofuels.
  • Enhanced food production via increased crop yields.

Advantages


  • Minimal thermodynamic bottlenecks and superior kinetics over natural counterparts.

Technology's Essence


The productivity of carbon fixation cycles is limited by the slow rate and lack of substrate specificity of the carboxylating enzyme, RuBisCo. In his discovery Dr. Milo addresses the inefficiency of the carbon fixation process through an alternative cycle that is predicted to be two to three times faster than the Calvin–Benson cycle, employing the most effective carboxylating enzyme, phosphoenolpyruvate carboxylase, using the core of the naturally evolved C4 cycle.

A computational strategy was applied, comparing kinetics, energetic and topology of all the possible pathways that can be assembled from all ~4,000 metabolic enzymes known in nature.

The results suggest a promising new family of synthetic carbon fixation pathways.

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  • Prof. Ron Milo
1593
The study of social behavior in groups of mice may have crucial implications for understanding the social aspects of different disorders.  To be executed correctly, group studies require the ability to track individual’s behavior within the group structure. The main challenge of current research tools...

The study of social behavior in groups of mice may have crucial implications for understanding the social aspects of different disorders. 
To be executed correctly, group studies require the ability to track individual’s behavior within the group structure. The main challenge of current research tools is to allow individuals identification while maintaining sufficient resolution for accurate tracking.
The present technology provides a system that utilizes fluorescent fur dyes to differentially mark and track individuals within a group. Using a sensitive color camera and a newly designed tracking algorithm, behavior of groups may be recorded and analyzed with high temporal and spatial resolution.   
The technology further offers a method for characterizing the group’s interactions using the maximum entropy model.

 

Applications


 


Advantages


  • High spatial and temporal resolution – enabled by sensitive color video tracking.
  • Enables high detailed analysis of individual behavior within the group.
  • Suitable for community study of groups - limited only by available fur dyes.
  • Compatible with long-term analysis.
  • Simple, cost effective.
  • Minimal suffering and improved animal welfare.

  • Technology's Essence


    The present technology takes advantage of the fact that mice are nocturnal (active at night) animals, to mark their fur with different fluorescent dyes. Under ultraviolet light, the mice can be accurately and automatically tracked, over a number of days. As the mice are allowed to move freely in an interesting arena for exploration containing ramps, nest boxes and barriers (Figure 1), their trajectory and behavior are recorded using a sensitive color camera.
    The system further includes an image processing module which analyses the recorded images, calculates a spatiotemporal model and the nature of social interactions between individuals.
    Combining detailed behavioral and genetic analysis ate the level of individuals, in association with group analysis, may enable the identification of genetic and neuronal correlates of complex social interactions. 

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    • Prof. Alon Chen
    358
    Escherichia coli UTL2 Description: A "leaky" strain of E. coli, which is significantly more susceptible to cytotoxic agents. UTL2 holds a mutation in the galU gene causing an impaired outer membrane. Reference:  B?j? O, Bibi E. 1996. Functional expression of mouse Mdr1 in an outer membrane...

    Escherichia coli UTL2

    Description: A "leaky" strain of E. coli, which is significantly more susceptible to cytotoxic agents. UTL2 holds a mutation in the galU gene causing an impaired outer membrane.

    Reference:  B?j? O, Bibi E. 1996. Functional expression of mouse Mdr1 in an outer membrane permeability mutant of Escherichia coli. Proc Natl Acad Sci U S A 93(12):5969-74.

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    • Prof. Eitan Bibi
    1378
    Researchers at the Weizmann Institute developed a novel method to design error-free DNA libraries from error-prone oligonucleotides. The system surpasses existing methods for de novo synthesis of DNA libraries in speed, precision, amenability to automation and ease of combining synthetic with natural...

    Researchers at the Weizmann Institute developed a novel method to design error-free DNA libraries from error-prone oligonucleotides. The system surpasses existing methods for de novo synthesis of DNA libraries in speed, precision, amenability to automation and ease of combining synthetic with natural DNA fragments. 

    All DNA construction protocols struggle with the cumbersome task of cloning and sequencing synthetic DNA fragments, seeking an error-free one. The problem is worsened for longer synthetic DNA which is more prone to errors. Time spent on error correction, clone selection and sequencing is a major bottleneck that prevents de novo DNA synthesis from becoming a routine procedure in labs. 

    This innovative solution significantly decreases the need for labor-intensive time-consuming error correction methods, cloning and sequencing. Furthermore, efficient editing and reassembly of different genes is made possible due to a smart recursive reconstruction process.

     

    Applications


    • Design and construction of synthetic biological molecules and organisms.
    • Construction of designer DNA libraries.

     


    Advantages


    • Applicable in any lab with standard lab equipment. Faster and more precise than existing methods.
    • Amenable to automation, full synthesis in vitro with a modified smPCR protocol.
    • Very simple to combine synthetic and natural DNA fragments.
    • Does not require additional or external methods or reagents for error correction

     


    Technology's Essence


    Divide and Conquer (D&C), the quintessential recursive problem-solving technique, is applied in silico to divide the target DNA sequence into overlapping oligonucleotides short enough to be synthesized directly, albeit with errors; error-prone oligonucleotides are recursively combined in vitro, forming error-prone DNA molecules; error-free fragments of these molecules are then identified, extracted and used as new, typically longer and more accurate, inputs to another iteration of the recursive construction procedure; the entire process repeats until an error-free target molecule is formed.

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    • Prof. Ehud Y. Shapiro
    1166
    A series of monoclonal antibodies for monitoring hormone and drug additives in animals grown for the food industry. These include mAbs for peptide hormones, steroid hormones, drugs, leukotrienes, isoflavones, and veterinary drugs.

    A series of monoclonal antibodies for monitoring hormone and drug additives in animals grown for the food industry. These include mAbs for peptide hormones, steroid hormones, drugs, leukotrienes, isoflavones, and veterinary drugs.

    Applications


    Monitoring hormone and drug additives in food providing animals for veterinary use and for the food industry.

    Technology's Essence


    Researchers at the Weizmann Institute of Science have developed a series of mAb against peptide and steroid hormones, isoflavones, and human and veterinary drugs. These antibodies are particularly valuable for monitoring hormone and drug additives in food providing animals. The mAb are available for diagnostics, research, and therapeutics.

    The following mAb are available for licensing:

    (Clones marked with * are available for diagnostic and therapeutic use only).

    Peptide Hormones:
    LH: 4F10
    bFSH: 1G12*, 1H9, 1H7
    FSH: 6H6
    bHCG: 1D5
    bHCG+: 1C7 3F11
    HGH: 1C12*, 1C4*, 5E9, 4E12, 5C3, 1C5, 6G3, 5E6, 2C12

    Steroid Hormones:
    progesterone-11a-HS 1E11*
    progesterone-7a-CET 2H4
    Estrone-3-glucuronide 8A3
    Testosterone-3-CMO 5A4
    Testosterone-3-CMO 5F2*
    Estradiol-6-CMO 8D9*

    Anti-idiotypic antibodies to anti-steroids:
    betatypic anti-anti-testosterone 5A4 8G9
    betatypic anti-progesterone 2H4 15F11
    betatypic anti-anti-estrone-3-glucuronide 8A3 7C1
    alphatypic anti-progesterone 2H4 2E11
    betatypic anti-anti-estrone-3-glucuronide 8A3 11C1

    Drugs
    Digoxin 10F10
    RU-486* 8B6*
    Buserelin 8B4
    Medroxy-progesterone-acetate* 1F5*

    Leukotrienes
    LTC4* 6E7

    Biotin
    Biotin-BSA F1

    Isoflavones
    Daidzein 4E4
    Daidzein/daidzin/genistin 2F11
    Estrone-3-glucuronide 8A3
    Genistein/biochanin A 10D8
    Genistein/genistin/daidzin 6E8
    Betatypic anti-anti-genistein 10D8

    Veterinary drugs
    Sulfamethazine (SMZ) 21C7
    Betatypic anti-SMZ 12E12
    4-chloro-androstenedione 14H2
    Virginamycin 486
    Spiramycin 110
    Betatypic anti-anti-spiramycin 133

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    • Dr. Fortune Kohen
    274
    Monoclonal antibodies for peptide and steroid hormones Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.   §  127, 274, 141 – Monoclonal...

    Monoclonal antibodies for peptide and steroid hormones

    Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.

     

    §  127, 274, 141 – Monoclonal antibodies to estradiol         

          Description: Monoclonal antibodies raised against oestradiol-6-     carboxymethyl oxime-BSA. Available clones: 2F9 (Rat, IgG2a), 15 (IgG2b),    8D9 (IgG2a).

    Estradiol is a sex hormone, which has not only a critical impact on reproductive and sexual functioning, but also affects other organs, including the bones. In the female, estradiol acts as a growth hormone for tissues of the reproductive organs.

                References: De Boever J, Kohen F, Usanachitt C, Vandekerckhove D, Leyseele D, Vandewalle L. 1986. Direct chemiluminescence immunoassay for estradiol in serum. Clin Chem. 32(10):1895-900.

                S?mjen D1, Amir-Zaltsman Y, Mor G, Gayer B, Lichter S, Nevo N, Kohen F. 1998. A monoclonal antibody to oestradiol potentiates the stimulation of the specific activity of the brain type creatine kinase by oestrogen in vivo and in vitro. J Steroid Biochem Mol Biol. 64(5-6):297-304.

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    • Dr. Fortune Kohen
    130
    Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry. Leukotrienes:   Veterinary drugs: §  130 - Anti-idiotypic antibody against anti-Sulfamethazine...

    Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs

    May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.

    Leukotrienes:

     

    Veterinary drugs:

    §  130 - Anti-idiotypic antibody against anti-Sulfamethazine

                                  Description: Betetypic anti-idiotypic antibody raised against anti Sulfamethazine –KLH (clone 21C7). Available clone: 12E12.

    Reference: Fortune Kohen , Batya Gayer , Yehudith Amir-Zaltsman &

    Michael O'Keeffe. 2000. Generation of an anti-idiotypic antibody as a surrogateLigand for sulfamethazine in immunoassay procedures, food and agricultural. Immunology 12:3 193-201.

     
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    • Dr. Fortune Kohen
    182
    Monoclonal antibodies to IgE Description: Rat monoclonal anti-IgE antibodies that was generated by fusion of plasmacytoma (84.1C) or myeloma (EM953) cells with splenocytes of rat immunized with purified murine IgE mAb. The antibodies react with various IgE mAb of different specificities and not with...

    Monoclonal antibodies to IgE

    Description: Rat monoclonal anti-IgE antibodies that was generated by fusion of plasmacytoma (84.1C) or myeloma (EM953) cells with splenocytes of rat immunized with purified murine IgE mAb. The antibodies react with various IgE mAb of different specificities and not with immunoglobulins of other classes, and recognize an epitope on the murine Fc epsilon region.

    Were shown to block IgE-Fc?R interactions and inhibit passive cutaneous anaphylaxis. 

    Clone 84.1c recognizes a site on IgE, which is identical or very close to the Fc?R binding site. May be used for detection and manipulation of the IgE response in mice.

    Reference:  Schwarzbaum S, Nissim A, Alkalay I, Ghozi MC, Schindler DG, Bergman Y, Eshhar Z. 1989. Mapping of murine IgE epitopes involved in IgE-Fc epsilon receptor interactions. Eur J Immunol 19(6):1015-23.

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    • Prof. Zelig Eshhar
    257
    257 - Monoclonal antibody to Gliomedin Description: Monoclonal antibody to Gliomedin (MAb 94) raised against a synthetic peptide corresponding to amino acid residues 273–287 (CVIPNDDTLVGRA), present in the extra cellular region of Rat Gliomedin. Gliomedin, a glial ligand for neurofascin and NrCAM, is...

    257 - Monoclonal antibody to Gliomedin

    Description: Monoclonal antibody to Gliomedin (MAb 94) raised against a synthetic peptide corresponding to amino acid residues 273–287 (CVIPNDDTLVGRA), present in the extra cellular region of Rat Gliomedin.

    Gliomedin, a glial ligand for neurofascin and NrCAM, is expressed by myelinating Schwann cells and accumulates at the edges of each myelin segment, aligned with the forming nodes of Ranvier. Gliomedin was shown to induce ion channel organization along the nerve axons, elicit formation of myelin and initiate node formation. Immuno-detection of Gliomedin may be used for diagnostics of neurological pathologies or as a marker for nodes of Ranvier in human and various animal model systems.

    Reference: Eshed Y, Feinberg K, Poliak S, Sabanay H, Sarig-Nadir O, Spiegel I, Bermingham JR Jr, Peles E. 2005. Gliomedin mediates Schwann cell-axon interaction and the molecular assembly of the nodes of Ranvier. Neuron. 47(2):215-29.

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    • Prof. Elior Peles
    115
      Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry. Leukotrienes:   Veterinary drugs: § 115 - Monoclonal antibody to Sulfamethazine (SMZ)...

     

    Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs

    May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.

    Leukotrienes:

     

    Veterinary drugs:

    § 115 - Monoclonal antibody to Sulfamethazine (SMZ)

    Description: Rat monoclonal antibodies raised against Sulfamethazine-BSA.

        Available clone: 21C7, IgG1.

    Sulfamethazine is an antibacterial agents commonly given to food animals (swine, fishetc.) to prevent disease and maximize production.

    Reference: Fortune Kohen , Batya Gayer , Yehudith Amir-Zaltsman &

    Michael O'Keeffe. 2000. Generation of an anti-idiotypic antibody as a surrogateLigand for sulfamethazine in immunoassay procedures, food and agricultural. Immunology 12:3 193-201.

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    • Dr. Fortune Kohen

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