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Scientist
144
Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry. Leukotrienes:   Drugs: §  144 - Monoclonal antibody to RU-486 Description: Rat monoclonal...

Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs

May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.

Leukotrienes:

 

Drugs:

§  144 - Monoclonal antibody to RU-486

Description: Rat monoclonal antibodies raised against RU-486.

     Available clone: 8B6, IgG1.

  RU-486 (Mifepristone) is a synthetic steroid compound with both antiprogesterone and antiglucocorticoid properties. Functions as a progesterone receptor antagonist and used as an abortifacient in the first months of pregnancy, and in smaller doses as an emergency contraceptive.

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  • Dr. Fortune Kohen
147
Monoclonal antibodies raised against bhCG. Available clones: 1D5 (IgG1), 1E11 (IgG2b).Human chorionic gonadotropin (hCG) is a hormone produced by the syncytiotrophoblast, a component of the fertilized egg, after conception. Monoclonal antibodies for peptide and steroid hormones Due to their high...

Monoclonal antibodies raised against bhCG. Available clones: 1D5 (IgG1), 1E11 (IgG2b).
Human chorionic gonadotropin (hCG) is a hormone produced by the syncytiotrophoblast, a component of the fertilized egg, after conception.

Monoclonal antibodies for peptide and steroid hormones

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.

Peptide Hormones:

§  147-148 - Monoclonal antibody to hCG

Description: Monoclonal antibodies raised against bhCG. Available clones: 1D5 (IgG1), 1E11 (IgG2b).

Human chorionic gonadotropin (hCG) is a hormone produced by the syncytiotrophoblast, a component of the fertilized egg, after conception.

 
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  • Dr. Fortune Kohen
148
Monoclonal antibodies for peptide and steroid hormones Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. Peptide Hormones: §  147-148 -...

Monoclonal antibodies for peptide and steroid hormones

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.

Peptide Hormones:

§  147-148 - Monoclonal antibody to hCG

Description: Monoclonal antibodies raised against bhCG. Available clones: 1D5 (IgG1), 1E11 (IgG2b).

Human chorionic gonadotropin (hCG) is a hormone produced by the syncytiotrophoblast, a component of the fertilized egg, after conception.

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  • Dr. Fortune Kohen
155
Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.   Isoflavones: §  155 – Monoclonal antibody to 7-(O)-carboxymethyl formononetin    Description: 7...

Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs

May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.

 

Isoflavones:

§  155 – Monoclonal antibody to 7-(O)-carboxymethyl formononetin

   Description: 7-(O)-carboxymethyl formononetin is an isoflavone derivative, active as a selective estrogen receptor modulator.

 

 

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  • Dr. Fortune Kohen
169
Monoclonal antibodies for peptide and steroid hormones Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. Steroid Hormones: §  119, 169 –...

Monoclonal antibodies for peptide and steroid hormones

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.

Steroid Hormones:

§  119, 169 – Monoclonal antibodies to Testosterone          

      Description: Rat monoclonal antibodies raised against testosterone 3-(0-   carboxymethyl)oxime-BSA. Available clones: 5F2, 5A4.

Testosterone is the principal male sex hormone and an anabolic steroid. In mammals, testosterone is secreted primarily in the testicles of males and the ovaries of females, although small amounts are also secreted by the adrenal glands.

Reference: Kohen F, Lichter S, Eshhar Z, Lindner HR. 1982. Preparation of monoclonal antibodies able to discriminate between testosterone and 5 alpha-dihydrotestosterone. Steroids. 39(4):453-9.

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  • Dr. Gad Lavie
173
181 - Monoclonal antibody to Galectin-8 Description: Monoclonal antibody to Galectin-8 (clone 106.1). Galectin-8 is a secreted, integrin-binding protein, part of a mammalian lectins family.  Galectin-8, also known as Prostate Cancer Tumor Antigen-1 (PCTA-1) is highly expressed in human prostate cancer...

181 - Monoclonal antibody to Galectin-8

Description: Monoclonal antibody to Galectin-8 (clone 106.1).

Galectin-8 is a secreted, integrin-binding protein, part of a mammalian lectins family.  Galectin-8, also known as Prostate Cancer Tumor Antigen-1 (PCTA-1) is highly expressed in human prostate cancer.  It was shown to trigger the transcription of a unique set of genes, some of which are associated with bone remodeling and prostate cancer progression.

Reference: Levy Y, Arbel-Goren R, Hadari YR, Eshhar S, Ronen D, Elhanany E, Geiger B, Zick Y. 2001. Galectin-8 functions as a matricellular modulator of cell adhesion. J Biol Chem. 276(33):31285-95.

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176
176-177 - Monoclonal antibodies to phospho-ERK/Map Kinase Description: Monoclonal antibodies raised against peptides containing the 11 amino acids, HTGFLTEYVAT, corresponding to the ERK activation loop either Tyr -phosphorylated (ERK-PY193), or Thr-phosphorylated (ERK-PT115). ERK belongs to the...

176-177 - Monoclonal antibodies to phospho-ERK/Map Kinase

Description: Monoclonal antibodies raised against peptides containing the 11 amino acids, HTGFLTEYVAT, corresponding to the ERK activation loop either Tyr -phosphorylated (ERK-PY193), or Thr-phosphorylated (ERK-PT115).

ERK belongs to the family of mitogen-activated protein kinases (MAPKs) and is an important component in many intracellular signaling events. ERK is phosphorylated and activated by the upstream kinases, MEK1 and MEK2 on regulatory Threonin (Thr) and tyrosine (Tyr) residues, which are localized in the activation loop of ERK.

Reference: Yao Z, Dolginov Y, Hanoch T, Yung Y, Ridner G, Lando Z, Zharhary D, Seger R. 2000. Detection of partially phosphorylated forms of ERK by monoclonal antibodies reveals spatial regulation of ERK activity by phosphatases. FEBS Lett. 468(1):37-42.

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  • Prof. Rony Seger
177
176-177 - Monoclonal antibodies to phospho-ERK/Map Kinase Description: Monoclonal antibodies raised against peptides containing the 11 amino acids, HTGFLTEYVAT, corresponding to the ERK activation loop either Tyr -phosphorylated (ERK-PY193), or Thr-phosphorylated (ERK-PT115). ERK belongs to the...

176-177 - Monoclonal antibodies to phospho-ERK/Map Kinase

Description: Monoclonal antibodies raised against peptides containing the 11 amino acids, HTGFLTEYVAT, corresponding to the ERK activation loop either Tyr -phosphorylated (ERK-PY193), or Thr-phosphorylated (ERK-PT115).

ERK belongs to the family of mitogen-activated protein kinases (MAPKs) and is an important component in many intracellular signaling events. ERK is phosphorylated and activated by the upstream kinases, MEK1 and MEK2 on regulatory Threonin (Thr) and tyrosine (Tyr) residues, which are localized in the activation loop of ERK.

Reference: Yao Z, Dolginov Y, Hanoch T, Yung Y, Ridner G, Lando Z, Zharhary D, Seger R. 2000. Detection of partially phosphorylated forms of ERK by monoclonal antibodies reveals spatial regulation of ERK activity by phosphatases. FEBS Lett. 468(1):37-42.

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  • Prof. Rony Seger
179
179 - Allyl-mercapto-captopril (CPSSA - Captosal) Description: Conjugation between allicin (the biologically active molecule in garlic) and captopril, a known antihypertensive drug. Was shown to offer therapeutic benefits for the treatment of the metabolic syndrome, as demonstrated by various animal...

179 - Allyl-mercapto-captopril (CPSSA - Captosal)

Description: Conjugation between allicin (the biologically active molecule in garlic) and captopril, a known antihypertensive drug. Was shown to offer therapeutic benefits for the treatment of the metabolic syndrome, as demonstrated by various animal models. These include improvement of glucose tolerance, preventing weight gain, lowering blood pressure, reducing cardiac hypertrophy and potent antioxidant activities.

Reference: Miron T, Rabinkov A, Peleg E, Rosenthal T, Mirelman D, Wilcheck M. 2004. Allylmercaptocaptopril: a new antihypertensive drug. Am. J. Hypertens. 1:71-73.

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  • Prof. David Mirelman
181
Description: Monoclonal antibody to Galectin-8 (clone 106.1). Galectin-8 is a secreted, integrin-binding protein, part of a mammalian lectins family.  Galectin-8, also known as Prostate Cancer Tumor Antigen-1 (PCTA-1) is highly expressed in human prostate cancer.  It was shown to trigger the...

Description: Monoclonal antibody to Galectin-8 (clone 106.1).

Galectin-8 is a secreted, integrin-binding protein, part of a mammalian lectins family.  Galectin-8, also known as Prostate Cancer Tumor Antigen-1 (PCTA-1) is highly expressed in human prostate cancer.  It was shown to trigger the transcription of a unique set of genes, some of which are associated with bone remodeling and prostate cancer progression.

Reference: Levy Y, Arbel-Goren R, Hadari YR, Eshhar S, Ronen D, Elhanany E, Geiger B, Zick Y. 2001. Galectin-8 functions as a matricellular modulator of cell adhesion. J Biol Chem. 276(33):31285-95.

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  • Prof. Yehiel Zick
182
Monoclonal antibodies to IgE Description: Rat monoclonal anti-IgE antibodies that was generated by fusion of plasmacytoma (84.1C) or myeloma (EM953) cells with splenocytes of rat immunized with purified murine IgE mAb. The antibodies react with various IgE mAb of different specificities and not with...

Monoclonal antibodies to IgE

Description: Rat monoclonal anti-IgE antibodies that was generated by fusion of plasmacytoma (84.1C) or myeloma (EM953) cells with splenocytes of rat immunized with purified murine IgE mAb. The antibodies react with various IgE mAb of different specificities and not with immunoglobulins of other classes, and recognize an epitope on the murine Fc epsilon region.

Were shown to block IgE-Fc?R interactions and inhibit passive cutaneous anaphylaxis. 

Clone 84.1c recognizes a site on IgE, which is identical or very close to the Fc?R binding site. May be used for detection and manipulation of the IgE response in mice.

Reference:  Schwarzbaum S, Nissim A, Alkalay I, Ghozi MC, Schindler DG, Bergman Y, Eshhar Z. 1989. Mapping of murine IgE epitopes involved in IgE-Fc epsilon receptor interactions. Eur J Immunol 19(6):1015-23.

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  • Prof. Zelig Eshhar
185
Monoclonal antibodies to IgE Description: Rat monoclonal anti-IgE antibodies that was generated by fusion of plasmacytoma (84.1C) or myeloma (EM953) cells with splenocytes of rat immunized with purified murine IgE mAb. The antibodies react with various IgE mAb of different specificities and not with...

Monoclonal antibodies to IgE

Description: Rat monoclonal anti-IgE antibodies that was generated by fusion of plasmacytoma (84.1C) or myeloma (EM953) cells with splenocytes of rat immunized with purified murine IgE mAb. The antibodies react with various IgE mAb of different specificities and not with immunoglobulins of other classes, and recognize an epitope on the murine Fc epsilon region.

Were shown to block IgE-Fc?R interactions and inhibit passive cutaneous anaphylaxis. 

Clone 84.1c recognizes a site on IgE, which is identical or very close to the Fc?R binding site. May be used for detection and manipulation of the IgE response in mice.

Reference:  Schwarzbaum S, Nissim A, Alkalay I, Ghozi MC, Schindler DG, Bergman Y, Eshhar Z. 1989. Mapping of murine IgE epitopes involved in IgE-Fc epsilon receptor interactions. Eur J Immunol 19(6):1015-23.

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  • Prof. Zelig Eshhar
186
A DNP-specific murine IgE monoclonal antibody Description: Hybridoma line producing large amounts of reaginic (IgE) anti-DNP monoclonal antibody (clone SPE-7), which was generated by the fusion of splenic lymphocytes from C57BL/6 mice and the NSI plasmacytoma cell line. The monoclonal reaginic antibody...

A DNP-specific murine IgE monoclonal antibody

Description: Hybridoma line producing large amounts of reaginic (IgE) anti-DNP monoclonal antibody (clone SPE-7), which was generated by the fusion of splenic lymphocytes from C57BL/6 mice and the NSI plasmacytoma cell line. The monoclonal reaginic antibody binds to mast cells or rat basophilic leukemia cells and, upon binding of DNP-protein, triggers an anaphylactic reaction.

Reference: Eshhar Z, Ofarim M, Waks T. 1980. Generation of hybridomas secreting murine reaginic antibodies of anti-DNP specificity. J Immunol 124(2):775-80.

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  • Prof. Zelig Eshhar
236
236-237 - Diastereomer Lytic Peptides for Treatment of Solid Tumors and Metastasis Description: 15-mer (Leu-Lys-Dleu- Leu-Lys-Dlys-Leu-Dleu-Dlys-Lys-Leu-Leu-Dlys-Leu-Leu) and 15-mer Histidin (H-Leu-Lys-D-Leu- Leu-His-D-Lys-Leu-D-Leu-D-Lys-His-Leu-Leu-D-Lys-Leu-Leu-NH2) are membrane-active peptides...

236-237 - Diastereomer Lytic Peptides for Treatment of Solid Tumors and Metastasis

Description: 15-mer (Leu-Lys-Dleu- Leu-Lys-Dlys-Leu-Dleu-Dlys-Lys-Leu-Leu-Dlys-Leu-Leu) and 15-mer Histidin (H-Leu-Lys-D-Leu- Leu-His-D-Lys-Leu-D-Leu-D-Lys-His-Leu-Leu-D-Lys-Leu-Leu-NH2) are membrane-active peptides composed of both D- and L amino acids (diastereomers). These peptides have demonstrated potent anti-cancer and anti metastatic activities in several animal models including models for prostate and lung cancer. They were shown to successfully inhibit tumor growth when injected intratumorally or intraveneously. The 15-mer Histidine form shows reduced systemic toxicity.

References: Papo N, Braunstein A, Eshhar Z, Shai Y. 2004. Suppression of human prostate tumor growth in mice by a cytolytic D-, L-amino Acid Peptide: membrane lysis, increased necrosis, and inhibition of prostate-specific antigen secretion. Cancer Res. 64(16):5779-86.

Makovitzki A1, Fink A, Shai Y. 2009. Suppression of human solid tumor growth in mice by intratumor and systemic inoculation of histidine-rich and pH-dependent host defense-like lytic peptides. Cancer Res. 69(8):3458-63.

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  • Prof. Yechiel Shai
237
236-237 - Diastereomer Lytic Peptides for Treatment of Solid Tumors and Metastasis Description: 15-mer (Leu-Lys-Dleu- Leu-Lys-Dlys-Leu-Dleu-Dlys-Lys-Leu-Leu-Dlys-Leu-Leu) and 15-mer Histidin (H-Leu-Lys-D-Leu- Leu-His-D-Lys-Leu-D-Leu-D-Lys-His-Leu-Leu-D-Lys-Leu-Leu-NH2) are membrane-active peptides...

236-237 - Diastereomer Lytic Peptides for Treatment of Solid Tumors and Metastasis

Description: 15-mer (Leu-Lys-Dleu- Leu-Lys-Dlys-Leu-Dleu-Dlys-Lys-Leu-Leu-Dlys-Leu-Leu) and 15-mer Histidin (H-Leu-Lys-D-Leu- Leu-His-D-Lys-Leu-D-Leu-D-Lys-His-Leu-Leu-D-Lys-Leu-Leu-NH2) are membrane-active peptides composed of both D- and L amino acids (diastereomers). These peptides have demonstrated potent anti-cancer and anti metastatic activities in several animal models including models for prostate and lung cancer. They were shown to successfully inhibit tumor growth when injected intratumorally or intraveneously. The 15-mer Histidine form shows reduced systemic toxicity.

References: Papo N, Braunstein A, Eshhar Z, Shai Y. 2004. Suppression of human prostate tumor growth in mice by a cytolytic D-, L-amino Acid Peptide: membrane lysis, increased necrosis, and inhibition of prostate-specific antigen secretion. Cancer Res. 64(16):5779-86.

Makovitzki A1, Fink A, Shai Y. 2009. Suppression of human solid tumor growth in mice by intratumor and systemic inoculation of histidine-rich and pH-dependent host defense-like lytic peptides. Cancer Res. 69(8):3458-63.

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  • Prof. Yechiel Shai

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