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Technology Name
Briefcase
Scientist
1381

Applications


The new method for detecting irregularities has many applications which include:

  1. Detecting suspicious and/or salient behaviors in video
  2. Attention and saliency in images
  3. Detecting irregular tissue in medical images
  4. Automatic visual inspection for quality assurance (e.g., detecting defects in goods)
  5. Generating a video summary/synopsis
  6. Intelligent fast forward
  7. Non-visual data

    Technology's Essence


    Researchers at the Weizmann Institute have developed a new method for detecting irregularities based only on few regular examples, without any assumed models. In the new method the validity of data is determined as a process of constructing a puzzle: one tries to compose a new observed image region or a new video segment (''the query'') using chunks of data (''pieces of puzzle'') extracted from previous visual examples (''the database''). Regions in the observed data which can be composed using large contiguous chunks of data from the database are considered very likely, whereas regions in the observed data which cannot be composed from the database (or can be composed, but only using small fragmented pieces) are regarded as unlikely/suspicious. The problem is posed as an inference process in a probabilistic graphical model. The invention also includes an efficient algorithm for detecting irregularities. Moreover, the same method can also be used for detecting irregularities/anomalies within data without any prior examples, by learning the notion of regularity/irregularity directly from the query data itself.

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  • Prof. Michal Irani
1250
A robust method of identifying moving or changing objects in a video sequence groups each pixel with other adjacent pixels according to either motion or intensity values. Pixels are then repeatedly regrouped into clusters in a hierarchical manner. As these clusters are regrouped, the motion pattern is...

A robust method of identifying moving or changing objects in a video sequence groups each pixel with other adjacent pixels according to either motion or intensity values. Pixels are then repeatedly regrouped into clusters in a hierarchical manner. As these clusters are regrouped, the motion pattern is refined, until the full pattern is reached.

Applications


These methods for motion-based segmentation may be used in a multitude of applications that need to correctly identify meaningful regions in image sequences and compute their motion. Such applications include:

  1. Surveillance and homeland security - detecting changes, activities, objects.
  2. Medical Imaging - imaging of dynamic tissues.
  3. Quality control in manufacturing, and more.

Technology's Essence


Researchers at the Weizmann Institute of Science have developed a multiscale, motion-based segmentation method which, unlike previous methods, uses the inherent multiple scales of information in images. The method begins by measuring local optical flow at every picture elements (pixels). Then, using algebraic multigrid (AMG) techniques, it assembles together adjacent pixels which are similar in either their motion or intensity values into small aggregates - each pixel being allowed to belong to different aggregates with different weights. These aggregates in turn are assembled into larger aggregates, then still larger, etc., yielding eventually full segments.

As the aggregation process proceeds, the estimation of the motion of each aggregate is refined and ambiguities are resolved. In addition, an adaptive motion model is used to describe the motion of an aggregate, depending on the amount of flow information that is available within each aggregate. In particular, a translation model is used to describe the motion of pixels and small aggregates, switch to an affine model to describe the motion of intermediate sized aggregates, and finally turn to a perspective model to describe aggregates at the coarsest levels of scale. In addition to this, methods for identifying correspondences between aggregates in different images are also being developed. These methods are suitable for image sequences separated by fairly large motion.

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  • Prof. Ronen Ezra Basri
1506
A simple electrochemical method and apparatus for the continues production of CO (carbon monoxide) from CO2 as chemical storage for electrical energy and a basic material for further organic products. Constant progress is made in solar and wind alternative energy production. Unfortunately, these...

A simple electrochemical method and apparatus for the continues production of CO (carbon monoxide) from CO2 as chemical storage for electrical energy and a basic material for further organic products.

Constant progress is made in solar and wind alternative energy production. Unfortunately, these systems are weather and time-dependent. Additionally, most of the geographic areas best suited for harvesting these resources are remote from population centers. Therefore the need for a reliable method to store and transport renewable energy is clear.

CO can be easily converted into methanol, which is one of the major chemical raw materials and can by itself be used as fuel for diesel engines and the energy source for direct methanol fuel cells (DMFC).

At present no reliable method of CO2 to CO reduction is available. Either using low temperatures which leads to low thermodynamic efficiency (<60%), Requires precious metals for electrodes and results in toxic byproducts, or using high temperatures which Requires pure CO2 input and Produces a mixture of CO2 and CO.

The current technology describes an efficient, flexible, continues method for production of CO at high temperatures (900oC) without any byproducts or toxic materials.

Applications


  • Production of CO from CO2
  • Easy conversion into methanol

Advantages


·         No precious (Pt, Ag, Au, Pd) metals required

·         No hazardous chemicals involved, no pollution

·         Continuous operation is possible

·         One can use flue gas as a source

·         Capture of CO2 from air is possible

·         The system is very compact>20 kW/m3

·         Operation conditions are very flexible

·         The process fits existing infrastructure

·         CO can be easily converted into liquid fuel (CH3OH)


Technology's Essence


The outlined technology overcomes the basic problems of CO production by using molten Li2CO3 as the electrolyte, a Ti container (will not undergo corrosion), Ti cathode (does not catalyze decomposition of CO), and a graphite anode (no chemical reaction with Li2CO3). At 900°C and current density of 0.05-2 A/cm2, this unique system enables a thermodynamic efficiency close to 100%, continues production of CO – efficiently separating CO2 to CO and O2.

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  • Prof. Igor Lubomirsky
358
Escherichia coli UTL2 Description: A "leaky" strain of E. coli, which is significantly more susceptible to cytotoxic agents. UTL2 holds a mutation in the galU gene causing an impaired outer membrane. Reference:  B?j? O, Bibi E. 1996. Functional expression of mouse Mdr1 in an outer membrane...

Escherichia coli UTL2

Description: A "leaky" strain of E. coli, which is significantly more susceptible to cytotoxic agents. UTL2 holds a mutation in the galU gene causing an impaired outer membrane.

Reference:  B?j? O, Bibi E. 1996. Functional expression of mouse Mdr1 in an outer membrane permeability mutant of Escherichia coli. Proc Natl Acad Sci U S A 93(12):5969-74.

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  • Prof. Eitan Bibi
1397
A novel antibody which can be used, for the first time, to recognize ubiquitinated histone 2B. This technology is novel in its ability to recognize proteins and their destinations, and may serve in diagnostics and immunoprecipitation processes.

A novel antibody which can be used, for the first time, to recognize ubiquitinated histone 2B. This technology is novel in its ability to recognize proteins and their destinations, and may serve in diagnostics and immunoprecipitation processes.

Applications


Primary applications in research. Use as a detection tool in western blotting, immunoprecipitation and chromatin immunoprecipitation. Might be used for monitoring processes associated with modulations of ubiquitinated-H2B levels.

Technology's Essence


The invention involves the generation of antibodies specific to ubiquitinated-H2B which selectively recognize H2B when it is ubiquitinated but not H2B in its unmodified state, or ubiquitin unconjugated to H2B.

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  • Prof. Moshe Oren
138
Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. Monoclonal antibodies raised against progesterone-7- carboxythio thioether-BSA (clone 2H4, Rat...

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.
Monoclonal antibodies raised against progesterone-7- carboxythio thioether-BSA (clone 2H4, Rat IgG1) and progesterone-11- hemisuccinate-BSA (clone 1E11, IgG1).
Progesterone is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Reference: Jozef G. De Boever, Fotune Kohen, Eugene Bosmans. 1994.  Binding of homologous and heterologous isoluminol- and enzyme-labelled  progesterone conjugates to monoclonal antibodies. Analytica Chimica Acta.  290: 239-245

 

Monoclonal antibodies for peptide and steroid hormones

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.

 

§  138,146 – Monoclonal antibodies to Progesterone          

      Description:  Monoclonal antibodies raised against progesterone-7- carboxythio thioether-BSA (clone 2H4, Rat IgG1) and progesterone-11- hemisuccinate-BSA (clone 1E11, IgG1).

Progesterone is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.

      Reference: Jozef G. De Boever, Fotune Kohen, Eugene Bosmans. 1994.      Binding of homologous and heterologous isoluminol- and enzyme-labelled   progesterone conjugates to monoclonal antibodies. Analytica Chimica Acta.    290: 239-245


 

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  • Dr. Fortune Kohen
186
A DNP-specific murine IgE monoclonal antibody Description: Hybridoma line producing large amounts of reaginic (IgE) anti-DNP monoclonal antibody (clone SPE-7), which was generated by the fusion of splenic lymphocytes from C57BL/6 mice and the NSI plasmacytoma cell line. The monoclonal reaginic antibody...

A DNP-specific murine IgE monoclonal antibody

Description: Hybridoma line producing large amounts of reaginic (IgE) anti-DNP monoclonal antibody (clone SPE-7), which was generated by the fusion of splenic lymphocytes from C57BL/6 mice and the NSI plasmacytoma cell line. The monoclonal reaginic antibody binds to mast cells or rat basophilic leukemia cells and, upon binding of DNP-protein, triggers an anaphylactic reaction.

Reference: Eshhar Z, Ofarim M, Waks T. 1980. Generation of hybridomas secreting murine reaginic antibodies of anti-DNP specificity. J Immunol 124(2):775-80.

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  • Prof. Zelig Eshhar
276
Monoclonal antibodies for peptide and steroid hormones Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. §  275-276 – Monoclonal antibodies to...

Monoclonal antibodies for peptide and steroid hormones

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.

§  275-276 – Monoclonal antibodies to estrone-3-glucuronide

Description: Monoclonal antibodies raised against estrone-3-glucuronide-BSA. Available clones: 8A3 (Rat, IgG2a), 155B3.

Estrone-glucuronide is the dominant metabolite of estradiol. Used as one reference method for determining ovulation.

            References: Geoff Barnard, Fortune Kohen. 1998. Monitoring ovarian function by the simultaneous time-resolved fluorescence immunoassay of two urinary steroid metabolites. Clin Chem 44:7 1520–1528.

Barnard G1, Kohen F, Mikola H, L?vgren T. 1989. Measurement of estrone-3-glucuronide in urine by rapid, homogeneous time-resolved fluoroimmunoassay. Clin Chem. 35(4):555-9.

 
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  • Dr. Fortune Kohen
173
181 - Monoclonal antibody to Galectin-8 Description: Monoclonal antibody to Galectin-8 (clone 106.1). Galectin-8 is a secreted, integrin-binding protein, part of a mammalian lectins family.  Galectin-8, also known as Prostate Cancer Tumor Antigen-1 (PCTA-1) is highly expressed in human prostate cancer...

181 - Monoclonal antibody to Galectin-8

Description: Monoclonal antibody to Galectin-8 (clone 106.1).

Galectin-8 is a secreted, integrin-binding protein, part of a mammalian lectins family.  Galectin-8, also known as Prostate Cancer Tumor Antigen-1 (PCTA-1) is highly expressed in human prostate cancer.  It was shown to trigger the transcription of a unique set of genes, some of which are associated with bone remodeling and prostate cancer progression.

Reference: Levy Y, Arbel-Goren R, Hadari YR, Eshhar S, Ronen D, Elhanany E, Geiger B, Zick Y. 2001. Galectin-8 functions as a matricellular modulator of cell adhesion. J Biol Chem. 276(33):31285-95.

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259
259 - Monoclonal antibody to Caspr Description: Monoclonal antibody to Caspr (Mab275), raised against the extracellular domain of Caspr. Caspr is a contactin-associated protein, part of the neurexin family of proteins. It lies in the paranodal section of the myelin sheath and has a role in myelin...

259 - Monoclonal antibody to Caspr

Description: Monoclonal antibody to Caspr (Mab275), raised against the extracellular domain of Caspr.

Caspr is a contactin-associated protein, part of the neurexin family of proteins. It lies in the paranodal section of the myelin sheath and has a role in myelin sheath attachment along with contactin. May be glycosylated.

Reference: Poliak S1, Gollan L, Martinez R, Custer A, Einheber S, Salzer JL, Trimmer JS, Shrager P, Peles E. 1999. Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels. Neuron. 24(4):1037-47.

 

Tech # 1269

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  • Prof. Elior Peles
117
Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry. Leukotrienes:   Drugs: §  117 – Monoclonal antibody to Digoxin         Description: Rat...

Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs

May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.

Leukotrienes:

 

Drugs:

§  117 – Monoclonal antibody to Digoxin

        Description: Rat monoclonal antibodies raised against Digoxin.

        Available clone: 10F10, IgG1.

Digoxin is a purified cardiac glycoside similar to Digitoxin extracted from the foxglove plant, Digitalis lanata. Digoxin is widely used in the treatment of various heart conditions.

 
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  • Dr. Fortune Kohen
288
hVin monoclonal antibody Description: Monoclonal antibodies raised against human Vinculin purified from human uterus. Specifically stains Vinculin at cell-cell and cell-substrate contacts in tissue and cultured cells. Good reactivity is obtained with human, bovine, chicken, dog, rat mouse, turkey and...

hVin monoclonal antibody

Description: Monoclonal antibodies raised against human Vinculin purified from human uterus. Specifically stains Vinculin at cell-cell and cell-substrate contacts in tissue and cultured cells. Good reactivity is obtained with human, bovine, chicken, dog, rat mouse, turkey and xenopus Vinculin.

Vinculin is a cytoskeletal protein associated with the cytoplasmic faces of both cell-cell and cell-extracellular matrix adherens-type junctions. It functions as one of

several interacting proteins involved in anchoring F-actin to the membrane.

Reference: Geiger B, Volk T, Volberg T, Bendori R. 1987. Molecular interactions in adherens-type contacts. J Cell Sci Suppl.8:251-72.

Applications


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  • Prof. Benjamin Geiger
142
Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.   Biotin: §  116, 142 – Monoclonal antibody to Biotin            Description: Monoclonal...

Monoclonal antibodies for Isoflavones, leukotrienes, biotin and human and veterinary drugs

May be used for monitoring drug additives in food providing animals for veterinary use and for the food industry.

 

Biotin:

§  116, 142 – Monoclonal antibody to Biotin

           Description: Monoclonal antibodies raised against biotinylated BSA.

           Available clones: F1, F4.

Biotin, also known as vitamin H or coenzyme R, is a water-soluble B-vitamin (vitamin B7). Functions as coenzyme for carboxylase enzymes, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis.

Reference: Bag?i H1, Kohen F, Kus?uoglu U, Bayer EA, Wilchek M. 1993. Monoclonal anti-biotin antibodies simulate avidin in the recognition of biotin. FEBS Lett. 322(1):47-50.

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  • Dr. Fortune Kohen
237
236-237 - Diastereomer Lytic Peptides for Treatment of Solid Tumors and Metastasis Description: 15-mer (Leu-Lys-Dleu- Leu-Lys-Dlys-Leu-Dleu-Dlys-Lys-Leu-Leu-Dlys-Leu-Leu) and 15-mer Histidin (H-Leu-Lys-D-Leu- Leu-His-D-Lys-Leu-D-Leu-D-Lys-His-Leu-Leu-D-Lys-Leu-Leu-NH2) are membrane-active peptides...

236-237 - Diastereomer Lytic Peptides for Treatment of Solid Tumors and Metastasis

Description: 15-mer (Leu-Lys-Dleu- Leu-Lys-Dlys-Leu-Dleu-Dlys-Lys-Leu-Leu-Dlys-Leu-Leu) and 15-mer Histidin (H-Leu-Lys-D-Leu- Leu-His-D-Lys-Leu-D-Leu-D-Lys-His-Leu-Leu-D-Lys-Leu-Leu-NH2) are membrane-active peptides composed of both D- and L amino acids (diastereomers). These peptides have demonstrated potent anti-cancer and anti metastatic activities in several animal models including models for prostate and lung cancer. They were shown to successfully inhibit tumor growth when injected intratumorally or intraveneously. The 15-mer Histidine form shows reduced systemic toxicity.

References: Papo N, Braunstein A, Eshhar Z, Shai Y. 2004. Suppression of human prostate tumor growth in mice by a cytolytic D-, L-amino Acid Peptide: membrane lysis, increased necrosis, and inhibition of prostate-specific antigen secretion. Cancer Res. 64(16):5779-86.

Makovitzki A1, Fink A, Shai Y. 2009. Suppression of human solid tumor growth in mice by intratumor and systemic inoculation of histidine-rich and pH-dependent host defense-like lytic peptides. Cancer Res. 69(8):3458-63.

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  • Prof. Yechiel Shai
119
Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products. Rat monoclonal antibodies raised against testosterone 3-(0- carboxymethyl)oxime-BSA. Available...

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.
Rat monoclonal antibodies raised against testosterone 3-(0- carboxymethyl)oxime-BSA. Available clones: 5F2, 5A4.
Testosterone is the principal male sex hormone and an anabolic steroid. In mammals, testosterone is secreted primarily in the testicles of males and the ovaries of females, although small amounts are also secreted by the adrenal glands.
Reference: Kohen F, Lichter S, Eshhar Z, Lindner HR. 1982. Preparation of monoclonal antibodies able to discriminate between testosterone and 5 alpha-dihydrotestosterone. Steroids. 39(4):453-9.

Monoclonal antibodies for peptide and steroid hormones

Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.

Steroid Hormones:

§  119, 169 – Monoclonal antibodies to Testosterone          

      Description: Rat monoclonal antibodies raised against testosterone 3-(0-   carboxymethyl)oxime-BSA. Available clones: 5F2, 5A4.

Testosterone is the principal male sex hormone and an anabolic steroid. In mammals, testosterone is secreted primarily in the testicles of males and the ovaries of females, although small amounts are also secreted by the adrenal glands.

Reference: Kohen F, Lichter S, Eshhar Z, Lindner HR. 1982. Preparation of monoclonal antibodies able to discriminate between testosterone and 5 alpha-dihydrotestosterone. Steroids. 39(4):453-9.


 

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  • Dr. Fortune Kohen

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