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Technology Name
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Scientist
1529
We present an efficient and robust broadband crystal optical conversion device. Various applications of laser optics require tunable laser sources. Currently, most frequency conversion devices rely on a single non-linear crystal, which is either temperature or angle tuned to enhance efficiency. This...

We present an efficient and robust broadband crystal optical conversion device. Various applications of laser optics require tunable laser sources. Currently, most frequency conversion devices rely on a single non-linear crystal, which is either temperature or angle tuned to enhance efficiency. This results only in a narrow efficient spectral band of conversion. Other techniques such as periodic quasi-phase matching result in improved efficiencies but still within a narrow predetermined band. Random quasi-phase matching results in improved bandwidth but in a significant reduction in efficiency. This new device enables ultra-broadband wavelength conversion while maintaining high efficiency.

Applications


  • Laser optics industry
  • Frequency convertor for broadband signals
  • Generation of ultrafast visible radiation
  • Pulse selection.

Advantages


  • 90% efficiency of conversion process.
  • Simple and compact
  • Insensitive to the deviations in alignment, no dependence of the angle incidence beam or of temperature
  • Frequency converter of both broadband signals and ultra-short pulses.

Technology's Essence


This device is based on a new method of adiabatic wavelength conversion. The device works whereby a strong narrow-band pump is introduced into the crystal along with a weaker pulse to be converted. This conversion is realized in a quasi-phase matched nonlinear crystal, where the period is tuned adiabatically from strong negative phase-mismatch to strong positive phase-mismatch (or vice versa). This results in the efficient transformation of the weaker pulse.

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  • Prof. Yaron Silberberg
1121
A method for aligning video images according to sequence. The problem of image alignment has been extensively studied, and successful approaches have been developed for solving this problem. However, these approaches turn out as problematic when there is insufficient overlap between the two images to...

A method for aligning video images according to sequence. The problem of image alignment has been extensively studied, and successful approaches have been developed for solving this problem. However, these approaches turn out as problematic when there is insufficient overlap between the two images to allow extraction of common image properties, i.e., when there is no sufficient similarity (e.g., gray-level, frequencies, statistical) between the two images. Whereas two individual images cannot be aligned when there is no spatial overlap between them, this is not the case when dealing with image sequences. The outlined technology consists of fusion and alignment of discrete, non-overlapping moving images from different sources, by aligning spatio-temporal changes in each sequence rather than in each image.

Applications


  • Multi-sensor image alignment for multi-sensor fusion
  • Alignment of images (sequences) obtained at significantly different zooms (can be useful in surveillance applications)
  • Generation of wide-screen movies from multiple non-overlapping narrow field-of-view movies (such as in IMAX movies) 
  • Alignment and integration of information across video sequences to exceed the physical visual limitations of any individual sensor (e.g., dynamic range, spectral range, spatial resolution, temporal resolution, etc). ~

Advantages


  • Useful for spatially non-overlapping sequences
  • Useful in cases which are inherently difficult for standard image alignment techniques, such as when there is insufficient common spatial information across the two sequences

Technology's Essence


An image sequence contains much more information than any individual image frame does. In particular, temporal changes in a video sequence (e.g., due to camera motion) do not appear in any individual image frame, but are encoded between video frames. When these temporal changes are common to the two sequences, then these sequences can be aligned both in time and in space, even if there is no common spatial information whatsoever. The need for coherent visual appearance, which is a fundamental assumption in image alignment methods, is replaced in this invention with the requirement of coherent temporal behavior. This can be achieved by attaching the two video cameras closely to each other (so that their centers of projections are very close), and moving them jointly in space (e.g., such as when the two cameras are mounted on a moving platform or rig).

 

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  • Prof. Michal Irani
1397
A novel antibody which can be used, for the first time, to recognize ubiquitinated histone 2B. This technology is novel in its ability to recognize proteins and their destinations, and may serve in diagnostics and immunoprecipitation processes.

A novel antibody which can be used, for the first time, to recognize ubiquitinated histone 2B. This technology is novel in its ability to recognize proteins and their destinations, and may serve in diagnostics and immunoprecipitation processes.

Applications


Primary applications in research. Use as a detection tool in western blotting, immunoprecipitation and chromatin immunoprecipitation. Might be used for monitoring processes associated with modulations of ubiquitinated-H2B levels.

Technology's Essence


The invention involves the generation of antibodies specific to ubiquitinated-H2B which selectively recognize H2B when it is ubiquitinated but not H2B in its unmodified state, or ubiquitin unconjugated to H2B.

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  • Prof. Moshe Oren
1441
New protein as a target to treat B cell-related cancer.Chronic lymphocytic leukemia (CLL), a malignant disease characterized by the accumulation of B lymphocytes in the blood, lymphoid organs, and bone marrow, is the second most common type of leukemia in adults, accounting for about 7,000 new cases of...

New protein as a target to treat B cell-related cancer.
Chronic lymphocytic leukemia (CLL), a malignant disease characterized by the accumulation of B lymphocytes in the blood, lymphoid organs, and bone marrow, is the second most common type of leukemia in adults, accounting for about 7,000 new cases of leukemia each year. Presently, there is no cure for CLL, and the overall goal of leukemia treatment is to bring about a remission. Therefore, identifying new proteins that may serve as a target for inducing cell death in the malignant cells is highly desirable. The present technology identifies a new regulator protein that is essential for the survival of CLL cells.

Applications


• Treatment of CLL, as well as other B cell-related cancers (e.g. gastric cancer and renal cell carcinoma), by blocking CD84 activity
• Diagnosis of CLL

Advantages


• Very specific to malignant B cells
• Diagnosis, and therefore treatment, can be made at early stages of the disease

 


Technology's Essence


B cells taken from CLL patients have a high level of the protein CD84. Stimulation of CD84 upregulates the survival of B-CLL. However, inhibition of CD84 activity with a blocking antibody downregulates the expression of another protein which controls B-CLL survival, thus inducing cell death. Therefore, the present invention reveals CD84 as a regulator of B-CLL survival

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  • Prof. Idit Shachar
1503
Application of Ureides-class compounds protects plants from stress related senescence, effectively extending the shelf-life of vegetables, fruit, leafy greens, cut branches and flowers. Plants suffer damage from factors such as oxidative stress, premature senescence and chlorophyll degradation. All of...

Application of Ureides-class compounds protects plants from stress related senescence, effectively extending the shelf-life of vegetables, fruit, leafy greens, cut branches and flowers.

Plants suffer damage from factors such as oxidative stress, premature senescence and chlorophyll degradation. All of the above can impact the freshness of produce from harvest to end-consumer. Researchers at the Weizmann Institute found that under certain stress conditions model plants produce Ureides, shown to have a protective role. Unexpectedly, this protection can also be achieved by the exogenous application to plants or plant parts post-harvest.

This innovative technique to preserve and prolong the shelf-life of fresh produce is clean, organic and cost-effective. In addition, engineered strains with altered Ureides metabolism can prove more resistant to stress related senescence.

Applications


  • Post-harvest protection of produce via
  • Exogenous application (spray on leaves, add to roots etc.).
  • Incorporation in packaging (e.g. embedded in plastic film).

Advantages


  • Treatment of both aging and light-deprivation in plants
  • Readily available and easily applied, does not require expertise to protect produce
  • Organic, clean, biodegradable materials.

Technology's Essence


Prof. Robert Fluhr and his team found that in wild-type plants conditions of extended darkness or increasing leaf age caused induction of transcripts related to purine catabolism, resulting in marked accumulation of Ureides. In contrast, Arabidopsis mutants of XDH, Atxdh1, accumulated the Ureides precursor (Xanthine) and showed premature senescence symptoms such as enhanced chlorophyll degradation, extensive cell death and upregulation of senescence-related transcripts.

The level of plant reactive oxygen species (ROS) and mortality can be attenuated by the addition of Ureides, suggesting that these metabolites can act as scavengers of ROS. The results highlighted that the regulation of Ureides levels by Atxdh1 has implications for optimal plant survival during nutrient remobilization, such as occurs during normal growth, dark stress and senescence.

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  • Prof. Robert Fluhr
1266
Fast cross-sectioning using multiphoton microscope.  The conventionally used laser-scanning microscopy, confocal and multiphoton microscopy, although being capable of performing optical sectioning, requires a long image acquisition time, tens of milliseconds per section in current commercial systems,...

Fast cross-sectioning using multiphoton microscope.  The conventionally used laser-scanning microscopy, confocal and multiphoton microscopy, although being capable of performing optical sectioning, requires a long image acquisition time, tens of milliseconds per section in current commercial systems, due to the scanning process. The field of confocal microscopy relies on the idea of point-by-point illumination of a sample and use mechanical scanning in order to collect an image. Multiphoton microscopes offer a different mechanism for optical sectioning and the need for rejecting out-of-focus scattering is practically eliminated. However, the process is efficient only when the peak intensity of the illuminating light is high. Thus there is a growing need to facilitate the multiphoton microscopy imaging of a sample by providing a novel illumination configuration and method of its operation.

Depth-resolved microscopy has been, for decades, practically synonymous with laser-scanning microscopy. The technique of the present invention provides for full-frame depth-resolved microscopy (or material processing), using an extremely simple setup as well as standard components, aiming at eliminating mechanical scanning across the sample thus making the image acquisition much faster.

 

Applications


  • Optical system for use in a multi-photon microscope.
  • Material processing, e.g. simultaneous depth-resolved modification of a transparent substrate by femtosecond radiation.

Advantages


  • The present invention provides for fast imaging/processing of a sample without scanning.
  • The temporal profile of the pulse remains unchanged as it propagates through the sample.
  • Single-shot depth resolved microscopy is able to capture extremely rapid dynamics, up to the nanosecond regime.
  • The setup enables full-frame video-rate fluorescence lifetime imaging, simply by gating the CCD intensifier.
  • Enables utilization of structure illumination microscopy.
  • Can be used with practically any multiphoton process.

Technology's Essence


The present invention provides the ability for illuminating a region of a sample with dimensions many orders of magnitude larger than a diffraction-limited spot of the imaging lens arrangement used in the microscope. Using this method, full-frame depth-resolved microscopy can be achieved using an extremely simple setup and standard components. the proposed microscope utilizes a pulse manipulator arrangement including a temporal pulse manipulator configured to define a surface, which extends perpendicular to the optical axis of a microscope in the front focal plane of an imaging lens arrangement, and which is patterned to affect trajectories of light components of the input short pulse impinging onto different points of this surface to direct these light components along different optical paths.

This novel invention is not limited to imaging techniques in general and to microscopy in particular and can also be used for material processing.

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  • Prof. Yaron Silberberg
1151
A method to significantly shorten acquisition times of high-quality MRI images. Multidimensional nuclear magnetic resonance (NMR) is used nowadays in many applications (e.g., discovery of new pharmaceutical drugs, characterization of new catalysts, and investigation of the structure and dynamics of...

A method to significantly shorten acquisition times of high-quality MRI images.

Multidimensional nuclear magnetic resonance (NMR) is used nowadays in many applications (e.g., discovery of new pharmaceutical drugs, characterization of new catalysts, and investigation of the structure and dynamics of proteins). One drawback of this technique is that, by contrast to one-dimensional spectroscpic methods, multidimensional NMR requires relatively long measurement times associated with hundreds or thousands of scans. This places certain kinds of rapidly-changing systems in Chemistry outside the scope of the technique. Long acquisition times also make this technique ill-suited for in vivo analyses and for clinical measurements in combination with magnetic resonance imaging (MRI). The current technology allows for the acquisition of multidimentional NMR scans using a single continuous scan, thereby shortening the time needed to acquire high-quality MRI images.

Applications


  • In vivo diagnostics

  • High-throughput proteomics/metabonomics

  • NMR of unstable chemical systems

  • Metabolic dynamics

  • High-resolution NMR in tabletop systems

  • Extensions to non-MR spectroscopies


Advantages


  • Can shorten the acquisition time of any multidimensional spectroscopy experiment by orders of magnitude
  • Compatible with the majority of multidimensional pulse sequences
  • Can be implemented using conventional NMR and MRI hardware

Technology's Essence


The outlined approach, called ultrafast multidimensional NMR, significantly expedites the analysis of the electromagnetic sounds produced, making it possible to acquire complete multidimensional NMR spectra within a fraction of a second. This technology “slices up” the molecular sample into numerous thin layers and then simultaneously performs all the measurements required on every one of these slices. The protocol then integrates these measurements according to their precise location, generating an image that amounts to a full multidimensional spectrum from the entire sample.

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  • Prof. Lucio Frydman
1448
A method to produce amides in one step without any unwanted by-products, by coupling of alcohols with amines with the liberation of hydrogen gas, catalyzed by unique ruthenium complexes. Amides are widely used in the industry (e.g. nylon, Kevlar) and have widespread importance in biochemical and...

A method to produce amides in one step without any unwanted by-products, by coupling of alcohols with amines with the liberation of hydrogen gas, catalyzed by unique ruthenium complexes.

Amides are widely used in the industry (e.g. nylon, Kevlar) and have widespread importance in biochemical and chemical systems (e.g. proteins). Synthesis of amides is mostly based on activated acid derivatives or rearrangement reactions induced by an acid or base, which often produce toxic chemical waste and involve tedious procedures. Therefore, an efficient synthesis that avoids wasteful use of coupling reagents or corrosive acidic and basic media is highly desirable. The current technology allows for the clean production of amides from amines and alcohols.

Applications


  • Production of amides for various applications (plastic and rubber industry, paper industry, pharmaceutical intermediates, etc.)

  • Use of the liberated hydrogen (e.g. for the production of ammonia)


Advantages


  • Clean and selective procedure

  • Environment friendly reaction (no base or acid promoters are required, no carboxylic acid derivatives, such as acid chlorides, are needed)

  • Amides and molecular hydrogen are produced in high yields and high turnover numbers directly from alcohols in one step

  • The liberated hydrogen can be used for different applications

  • Formation of a variety of amides


Technology's Essence


Amide formation is a fundamental reaction in chemical synthesis. Amides are commonly formed from the reaction of a carboxylic acid derivative with an amine. Instead of using carboxylic acid derivative, in the present invention the amide motif is generated by direct acylation of amines with alcohols. This is possible through the use of a unique catalyst. This method enables the simple and elegant production of amide polymers and industrially important amides.

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  • Prof. David Milstein
1507
One-step synthesis of primary amines from alcohols and ammonia under mild conditions.Amines are widely used in the production of numerous products for multiple industries and their use is expected to increase. Global amines market is expected to reach over $14 billion by 2020, with an average annual...

One-step synthesis of primary amines from alcohols and ammonia under mild conditions.
Amines are widely used in the production of numerous products for multiple industries and their use is expected to increase. Global amines market is expected to reach over $14 billion by 2020, with an average annual growth of 3.5%.
Primary amines are most useful in the larger markets of ethanolamines and fatty amines.
Current synthetic methods require harsh reaction conditions, are non-specific and generate toxic waste. The outlined technology utilizes a novel catalyst to synthesize primary amines in a simple single-step fashion directly from alcohols and ammonia.

Applications


• Production of primary amines for numerous industries (agrochemicals, surfactants, personal care, water treatment, fine chemicals, plastics, dyes, pigments, food additives and pharmaceuticals)

Advantages


  • Mild reaction conditions
  • Single step synthesis
  • High yields
  • No solvent required
  • No toxic reagents or by-products
  • Ecologically and economically beneficial

Technology's Essence


Amines are a very important family of compounds used in multiple industries. The presented technology uses selective catalytic synthesis of primary amines from primary alcohols and ammonia. This simple, one-step, easily applicable reaction delivers primary amines in good yields, in addition to valuable environmental and economic advantages.

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  • Prof. David Milstein
1270
Monoclonal antibodies to IgE Description: Rat monoclonal anti-IgE antibodies that was generated by fusion of plasmacytoma (84.1C) or myeloma (EM953) cells with splenocytes of rat immunized with purified murine IgE mAb. The antibodies react with various IgE mAb of different specificities and not with...

Monoclonal antibodies to IgE

Description: Rat monoclonal anti-IgE antibodies that was generated by fusion of plasmacytoma (84.1C) or myeloma (EM953) cells with splenocytes of rat immunized with purified murine IgE mAb. The antibodies react with various IgE mAb of different specificities and not with immunoglobulins of other classes, and recognize an epitope on the murine Fc epsilon region.

Were shown to block IgE-Fc?R interactions and inhibit passive cutaneous anaphylaxis. 

Clone 84.1c recognizes a site on IgE, which is identical or very close to the Fc?R binding site. May be used for detection and manipulation of the IgE response in mice.

Reference:  Schwarzbaum S, Nissim A, Alkalay I, Ghozi MC, Schindler DG, Bergman Y, Eshhar Z. 1989. Mapping of murine IgE epitopes involved in IgE-Fc epsilon receptor interactions. Eur J Immunol 19(6):1015-23.

 

M182, M185, M186

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  • Prof. Zelig Eshhar
1461
Bidirectional Similarity offers a new approach to summarization of visual data (images and video) based on optimization of well defined similarity measure. Common visual summarization methods (mainly scaling and cropping) suffer from significant deficiencies related to image quality and loss of...

Bidirectional Similarity offers a new approach to summarization of visual data (images and video) based on optimization of well defined similarity measure.

Common visual summarization methods (mainly scaling and cropping) suffer from significant deficiencies related to image quality and loss of important data. Many attempts have been made to overcome these problems, however, success was very limited and neither has become commercially applicable.

Using an optimization problem approach and state-of-the-art algorithms, our method provides superior summarization of visual data as well as a measure to determine similarity, which together provides a basis for a wide range of applications in image and video processing.

Applications


The technology can be utilized in any application where an image size is changed or were similarity of images is important. Sample applications include:

  • Image processing software (as an added-on feature)

  • Resizing software

  • Creation of Thumbnails

  • Adjustment of images to different screen sizes (TV-cellular etc.)

  • Optimization of space-time patches in video processing

  • Image montages

  • Automatic image & video cropping

  • Images synthesis, photo reshuffling and many more


Advantages


While Bidirectional Similarity summarization will not replace existing technologies in all applications, it enjoys significant advantages that will offer better results in many of them. Among its advantages, the Bidirectional Similarity summarization:

  • Provides better resolution and in many cases reduces distortion compared to scaling
  • Reduces (or avoids) loss of important data compared to cropping
  • Allows importance-based summarization even when important information is widespread and hard to define
  • Uses quantitative objective similarity measure
  • Offers a generic tool for different image processing applications (synthesis, montage, reshuffling etc.)

Technology's Essence


Bidirectional Similarity Summarization is a patent-pending image and video processing method, which maximizes “completeness” and “coherence” between images and videos, using a measure for quantifying how “good” a visual summary is.

The algorithm uses and iterative process, gradually reducing the image size, while keeping all source patches in the target image, without introducing visual artifacts that are not in the input data. Using a Similarity Index, the algorithm identifies redundant information and compromise the “less important” data while generating the required target image or video.

The Similarity Index, which stands in the heart of the Bidirectional Similarity summarization algorithm, can be utilized by its own, as an objective function within other optimization processes, as well as in comparing the quality of visual summaries generated by different methods

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  • Prof. Michal Irani
1184
Trace chemical or biological elements can be accurately detected and monitored in the field or at the point of care through use of this new quick, cost-effective platform technology based on a hybrid chemical-electronic detector. Analytes can be measured according to the electrical current changes they...

Trace chemical or biological elements can be accurately detected and monitored in the field or at the point of care through use of this new quick, cost-effective platform technology based on a hybrid chemical-electronic detector. Analytes can be measured according to the electrical current changes they induce with high specificity and accuracy at parts-per-billion (ppb) levels.

Applications


Transducer which may be developed to suite: Medical diagnostics: point of care, real time diagnostics of chemical and biological substances. Environmental watch: monitoring air or water pollution, testing for food poisoning. Chemical warfare: detection of chemical agents and explosives. Industry: monitoring industrial processes at real time.

Technology's Essence


Researchers at the Weizmann Institute have developed a platform technology based on novel hybrid chemical-electronic detector MOCSER (MOlecular Controlled SEmiconductor Resistor). The technology is based on a new type of a Gallium Arsenide (GaAs) electronic device covered with a monolayer of sensing molecules. The detection is achieved by measuring the current changes created due to analyte binding. The researchers have succeeded in showing high sensitivity and accuracy of the device down to parts per billion (ppb) levels. They have also demonstrated the possibility for broad applications of this detector by tailoring different sensing molecules on it and measuring various substances.

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  • Prof. Ron Naaman
  • Prof. David Cahen
1518
Improved immunotherapy for breast cancer. Monoclonal antibodies (mAbs) to ErbB-2/HER2 growth factor receptor, or to its sibling, the epidermal growth factor receptor (EGFR), prolong survival of cancer patients, especially when combined with cytotoxic therapies. However, low effectiveness of...

Improved immunotherapy for breast cancer.

Monoclonal antibodies (mAbs) to ErbB-2/HER2 growth factor receptor, or to its sibling, the epidermal growth factor receptor (EGFR), prolong survival of cancer patients, especially when combined with cytotoxic therapies. However, low effectiveness of therapeutic mAbs and the evolution of patient resistance call for improvements. Furthermore, the response to the clinically approved monotherapy of Herceptin (a humanized mAb directed against ErbB-2), is relatively low (~15%) and short lived (median duration, 9 months). Therefore, there is a need to improve the therapeutic treatment against this receptor. The present technology enhances the therapeutic activity of anti-ErB-2 receptor antibodies, by combining two or more epitope-distinct antibodies.

Applications


  • Improved treatment of ErbB-2-overexpressing tumors (e.g. in breast and ovary cancers).


Advantages


  • May enhance patient response and delay acquisition of resistance.
  • Enhancement of therapeutic efficacy and synergy with chemotherapy.

Technology's Essence


Optimal selection of mAbs for cancer immunotherapy may improve its therapeutic potential. The outlined technology addresses an emerging strategy, which enhances the therapeutic activity of anti-receptor antibodies by combining two mAbs engaging distinct epitopes. It was demonstrated that pairs of anti-ErbB-2 mAbs better inhibit ErbB-2-overexpressing tumors than the respective individual mAbs, both in vitro and in vivo.

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  • Prof. Yosef Yarden
358
Escherichia coli UTL2 Description: A "leaky" strain of E. coli, which is significantly more susceptible to cytotoxic agents. UTL2 holds a mutation in the galU gene causing an impaired outer membrane. Reference:  B?j? O, Bibi E. 1996. Functional expression of mouse Mdr1 in an outer membrane...

Escherichia coli UTL2

Description: A "leaky" strain of E. coli, which is significantly more susceptible to cytotoxic agents. UTL2 holds a mutation in the galU gene causing an impaired outer membrane.

Reference:  B?j? O, Bibi E. 1996. Functional expression of mouse Mdr1 in an outer membrane permeability mutant of Escherichia coli. Proc Natl Acad Sci U S A 93(12):5969-74.

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  • Prof. Eitan Bibi
1378
Researchers at the Weizmann Institute developed a novel method to design error-free DNA libraries from error-prone oligonucleotides. The system surpasses existing methods for de novo synthesis of DNA libraries in speed, precision, amenability to automation and ease of combining synthetic with natural...

Researchers at the Weizmann Institute developed a novel method to design error-free DNA libraries from error-prone oligonucleotides. The system surpasses existing methods for de novo synthesis of DNA libraries in speed, precision, amenability to automation and ease of combining synthetic with natural DNA fragments. 

All DNA construction protocols struggle with the cumbersome task of cloning and sequencing synthetic DNA fragments, seeking an error-free one. The problem is worsened for longer synthetic DNA which is more prone to errors. Time spent on error correction, clone selection and sequencing is a major bottleneck that prevents de novo DNA synthesis from becoming a routine procedure in labs. 

This innovative solution significantly decreases the need for labor-intensive time-consuming error correction methods, cloning and sequencing. Furthermore, efficient editing and reassembly of different genes is made possible due to a smart recursive reconstruction process.

 

Applications


  • Design and construction of synthetic biological molecules and organisms.
  • Construction of designer DNA libraries.

 


Advantages


  • Applicable in any lab with standard lab equipment. Faster and more precise than existing methods.
  • Amenable to automation, full synthesis in vitro with a modified smPCR protocol.
  • Very simple to combine synthetic and natural DNA fragments.
  • Does not require additional or external methods or reagents for error correction

 


Technology's Essence


Divide and Conquer (D&C), the quintessential recursive problem-solving technique, is applied in silico to divide the target DNA sequence into overlapping oligonucleotides short enough to be synthesized directly, albeit with errors; error-prone oligonucleotides are recursively combined in vitro, forming error-prone DNA molecules; error-free fragments of these molecules are then identified, extracted and used as new, typically longer and more accurate, inputs to another iteration of the recursive construction procedure; the entire process repeats until an error-free target molecule is formed.

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  • Prof. Ehud Y. Shapiro

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