You are here

Category
Technology Name
Briefcase
Scientist
1267
Description: Monoclonal antibodies specific for cholesterol/ceramide-rich domains (clones 405F, 14F, 499F) and cholesterol micro-domains (clones 36A1, 5881) in cell membranes. Originally raised against an artificial monolayer of lipid mixtures in, and were shown to specifically label the above domains...

Description: Monoclonal antibodies specific for cholesterol/ceramide-rich domains (clones 405F, 14F, 499F) and cholesterol micro-domains (clones 36A1, 5881) in cell membranes. 
Originally raised against an artificial monolayer of lipid mixtures in, and were shown to specifically label the above domains in different cell membranes. 
Reference:  Scheffer L, Futerman AH, Addadi L. 2007. Antibody labeling of cholesterol/ceramide ordered domains in cell membranes. Chembiochem 8(18):2286-94.

M263, M264, M265

+
  • Prof. Lia Addadi
1151
A method to significantly shorten acquisition times of high-quality MRI images. Multidimensional nuclear magnetic resonance (NMR) is used nowadays in many applications (e.g., discovery of new pharmaceutical drugs, characterization of new catalysts, and investigation of the structure and dynamics of...

A method to significantly shorten acquisition times of high-quality MRI images.

Multidimensional nuclear magnetic resonance (NMR) is used nowadays in many applications (e.g., discovery of new pharmaceutical drugs, characterization of new catalysts, and investigation of the structure and dynamics of proteins). One drawback of this technique is that, by contrast to one-dimensional spectroscpic methods, multidimensional NMR requires relatively long measurement times associated with hundreds or thousands of scans. This places certain kinds of rapidly-changing systems in Chemistry outside the scope of the technique. Long acquisition times also make this technique ill-suited for in vivo analyses and for clinical measurements in combination with magnetic resonance imaging (MRI). The current technology allows for the acquisition of multidimentional NMR scans using a single continuous scan, thereby shortening the time needed to acquire high-quality MRI images.

Applications


  • In vivo diagnostics

  • High-throughput proteomics/metabonomics

  • NMR of unstable chemical systems

  • Metabolic dynamics

  • High-resolution NMR in tabletop systems

  • Extensions to non-MR spectroscopies


Advantages


  • Can shorten the acquisition time of any multidimensional spectroscopy experiment by orders of magnitude
  • Compatible with the majority of multidimensional pulse sequences
  • Can be implemented using conventional NMR and MRI hardware

Technology's Essence


The outlined approach, called ultrafast multidimensional NMR, significantly expedites the analysis of the electromagnetic sounds produced, making it possible to acquire complete multidimensional NMR spectra within a fraction of a second. This technology “slices up” the molecular sample into numerous thin layers and then simultaneously performs all the measurements required on every one of these slices. The protocol then integrates these measurements according to their precise location, generating an image that amounts to a full multidimensional spectrum from the entire sample.

+
  • Prof. Lucio Frydman
1507
One-step synthesis of primary amines from alcohols and ammonia under mild conditions.Amines are widely used in the production of numerous products for multiple industries and their use is expected to increase. Global amines market is expected to reach over $14 billion by 2020, with an average annual...

One-step synthesis of primary amines from alcohols and ammonia under mild conditions.
Amines are widely used in the production of numerous products for multiple industries and their use is expected to increase. Global amines market is expected to reach over $14 billion by 2020, with an average annual growth of 3.5%.
Primary amines are most useful in the larger markets of ethanolamines and fatty amines.
Current synthetic methods require harsh reaction conditions, are non-specific and generate toxic waste. The outlined technology utilizes a novel catalyst to synthesize primary amines in a simple single-step fashion directly from alcohols and ammonia.

Applications


• Production of primary amines for numerous industries (agrochemicals, surfactants, personal care, water treatment, fine chemicals, plastics, dyes, pigments, food additives and pharmaceuticals)

Advantages


  • Mild reaction conditions
  • Single step synthesis
  • High yields
  • No solvent required
  • No toxic reagents or by-products
  • Ecologically and economically beneficial

Technology's Essence


Amines are a very important family of compounds used in multiple industries. The presented technology uses selective catalytic synthesis of primary amines from primary alcohols and ammonia. This simple, one-step, easily applicable reaction delivers primary amines in good yields, in addition to valuable environmental and economic advantages.

+
  • Prof. David Milstein
1369
A simple, single-step biochip platform for synthesis of biomolecules. Biochip technology is used today in measuring passive probe-target interactions i.e. measurement of the abundance of specific biomolecules). This technology can now be extended to include complex and cascaded activities on the chip...

A simple, single-step biochip platform for synthesis of biomolecules.

Biochip technology is used today in measuring passive probe-target interactions i.e. measurement of the abundance of specific biomolecules). This technology can now be extended to include complex and cascaded activities on the chip. The present immobilization approaches (based on UV photography) have been essentially limited to short single stranded DNA probes and have not been developed for entire genes or other biochemical functions. Furthermore, most biochips are assembled in a multi-step process that requires expertise in surface chemistry in order to obtain reproducibility and robustness. As a result, light-directed immobilization of molecules on biochips is not widespread and is not easily accessible for research and technology development. The present invention enables, in a simple manner, to immobilize different biomolecules anywhere on the chip to submicron resolution through selective exposure of the monolayer to UV light.

 

Applications


  • Light-directed immobilization of a variety of different biomolecules (e.g. DNA, antibodies, enzymes and peptides)
  • On-chip protein biosynthesis from immobilized genes
  • Design and layout of on-chip traps for proteins from crude cell extract
  • Lab-on-a-chip that provides a general use biochip technology

Advantages


  • Enabling the use of long DNA molecules (whole genes)
  • Robust and simple performance without the need for proficiency in materials science and surface chemistry
  • On-chip protein synthesis with high efficiency, minimal non-specific activity, and a wide dynamic range

 


Technology's Essence


This lab-on-a-chip technology (i.e. a technology that enables to perform laboratory operations on a small scale) is based on a newly synthesized molecule termed daisy that combines three parts all-in-one: a tail and head connected by a backbone. Selective exposure of daisy monolayer to UV light through a mask (photolithography) reveals the surface for chemical binding of a variety of biomolecules. Using this technology it is possible to immobilize different biomolecules anywhere on the chip to submicron resolution. By immobilizing whole genes, thus enabling cell-free biosynthesis of proteins, daisy technology takes the lab-on-a-chip concept to the next level. Daisy biochip technology holds a promise in proteomics, diagnostics and therapeutics.

+
  • Prof. Roy Bar-Ziv
1461
Bidirectional Similarity offers a new approach to summarization of visual data (images and video) based on optimization of well defined similarity measure. Common visual summarization methods (mainly scaling and cropping) suffer from significant deficiencies related to image quality and loss of...

Bidirectional Similarity offers a new approach to summarization of visual data (images and video) based on optimization of well defined similarity measure.

Common visual summarization methods (mainly scaling and cropping) suffer from significant deficiencies related to image quality and loss of important data. Many attempts have been made to overcome these problems, however, success was very limited and neither has become commercially applicable.

Using an optimization problem approach and state-of-the-art algorithms, our method provides superior summarization of visual data as well as a measure to determine similarity, which together provides a basis for a wide range of applications in image and video processing.

Applications


The technology can be utilized in any application where an image size is changed or were similarity of images is important. Sample applications include:

  • Image processing software (as an added-on feature)

  • Resizing software

  • Creation of Thumbnails

  • Adjustment of images to different screen sizes (TV-cellular etc.)

  • Optimization of space-time patches in video processing

  • Image montages

  • Automatic image & video cropping

  • Images synthesis, photo reshuffling and many more


Advantages


While Bidirectional Similarity summarization will not replace existing technologies in all applications, it enjoys significant advantages that will offer better results in many of them. Among its advantages, the Bidirectional Similarity summarization:

  • Provides better resolution and in many cases reduces distortion compared to scaling
  • Reduces (or avoids) loss of important data compared to cropping
  • Allows importance-based summarization even when important information is widespread and hard to define
  • Uses quantitative objective similarity measure
  • Offers a generic tool for different image processing applications (synthesis, montage, reshuffling etc.)

Technology's Essence


Bidirectional Similarity Summarization is a patent-pending image and video processing method, which maximizes “completeness” and “coherence” between images and videos, using a measure for quantifying how “good” a visual summary is.

The algorithm uses and iterative process, gradually reducing the image size, while keeping all source patches in the target image, without introducing visual artifacts that are not in the input data. Using a Similarity Index, the algorithm identifies redundant information and compromise the “less important” data while generating the required target image or video.

The Similarity Index, which stands in the heart of the Bidirectional Similarity summarization algorithm, can be utilized by its own, as an objective function within other optimization processes, as well as in comparing the quality of visual summaries generated by different methods

+
  • Prof. Michal Irani
1245

Applications


The novel DNA Aptamer is a promising candidate for therapeutic as well as diagnostic uses: Therapeutic: A novel therapy for Influenza Diagnostics: Detection of Influenza infection in vertebrates such as avian, swine and human

Technology's Essence


Scientists at the Weizmann Institute of Science describe a novel oligonucleotide, also known as an Aptamer, which has been designed to complement the receptor-binding region of the influenza haemagglutinin molecule. It was constructed by screening a DNA library and processing by the SELEX procedure. This DNA Aptamer comprises of a polynucleotide sequence that can bind to a polypeptide within the binding region of the influenza virus to the host cell. The proposed mode of action of this Aptamer is by blocking the binding of influenza virus to target cell receptors and consequently preventing the virus invasion into the host cells. Aptamer is capable of inhibiting the haemagglutinin capacity of the virus and the viral infectivity in vitro. Furthermore, it was shown in an animal model to inhibit viral infection by different influenza strains, as manifested by up to 99% reduction of virus burden in the lungs of treated mice.

+
  • Prof. Ruth Arnon
1522
A method for enhancing the spatial and or temporal resolution (if applicable) of an input signal such as images and videos.   Many imaging devices produce signals of unsatisfactory resolution (e.g. a photo from a cell-phone camera may have low spatial resolution or a video from a web camera may have...

A method for enhancing the spatial and or temporal resolution (if applicable) of an input signal such as images and videos.

 

Many imaging devices produce signals of unsatisfactory resolution (e.g. a photo from a cell-phone camera may have low spatial resolution or a video from a web camera may have both spatial and temporal low resolution). This method applies digital processing to reconstruct more satisfactory high resolution signals.

 

Previous methods for Super-Resolution (SR) require multiple images of the same scene, or else an external database of examples. This method provides the ability to perform SR from a single image (or a single visual source). The algorithm exploits the inherent local data redundancy within visual signals (redundancy both within the same scale, and across different scales).

 

Examples of the methods' capabilities can be found here: http://www.wisdom.weizmann.ac.il/~vision/SingleImageSR.html

 

Applications


  • Enhancing the spatial resolution of images

  • Enhancing the spatial and or temporal resolution of video sequences

  • Enhancing the spatial and or temporal resolution (if applicable) of other signals (e.g., MRI, fMRI, ultrasound, possibly also audio, etc.)

 


Advantages


  • No need for multiple low resolution sources or the use of an external database of examples.

  • Superior results are produced due to exploitation of inherent information in the source signal.


Technology's Essence


The framework combines the power of classical multi image super resolution and example based super resolution. This combined framework can be applied to obtain super resolution from as little as a single low-resolution signal, without any additional external information. The approach is based on an observation that patches in a single natural signal tend to redundantly recur many times inside the signal, both within the same scale, as well as across different scales.

Recurrence of patches within the same scale (at subpixel misalignments) forms the basis for applying the 'classical super resolution' constraints to information from a single signal. Recurrence of patches across different (coarser) scales implicitly provides examples of low-resolution / high-resolution pairs of patches, thus giving rise to 'example-based super-resolution' from a single signal (but without any external database or any prior examples).

+
  • Prof. Michal Irani
1392
A catalytic based reaction for the treatment of industrial waste water. Millions of tons of organic chemical compounds - including solvents, petrochemicals, agrochemicals, and pharmaceuticals - are produced every year by a wide variety of chemical industries. Two immediate problems arise: 1. Industrial...

A catalytic based reaction for the treatment of industrial waste water. Millions of tons of organic chemical compounds - including solvents, petrochemicals, agrochemicals, and pharmaceuticals - are produced every year by a wide variety of chemical industries. Two immediate problems arise: 1. Industrial production of these chemicals and/or other products leads to effluent streams - highly toxic, contaminated aqueous solutions - from factories. These effluents must be treated prior to release of the water back into the environment. 2. Following use, these chemicals (e.g., agrochemicals, pharmaceuticals) become serious pollutants as they eventually find their way into the soil, sediment, and surface and/or groundwater environments. Current treatment methods are severely limited. Treatment of effluent streams by, e.g., filtration, photocatalysis, or bioreactors is often highly ineffective - the waste compounds not being easily captured, degraded or transformed - and/or prohibitively expensive.

Applications


  • Detoxification of industrial effluents, especially from petrochemical, agrochemical and pharmaceutical industries 
  • Waste water decontamination 
  • In situ and ex situ remediation of water polluted by organic and other contaminants

Advantages


  • Cost efficient
  • Quick

Technology's Essence


Researchers at the Weizmann Institute of Science have developed a new process for degradation and/or treatment of practically any organic contaminant in aqueous solutions under oxidizing (aerobic) conditions. A suite of catalytic materials has been developed which allows both in situ and ex situ remediation of polluted water by oxidative chemical degradation of contaminants. The technology eliminates or reduces a broad range of water pollutants - industrial organic solvents, petrochemicals, agrochemicals and pharmaceuticals (e.g., endocrine disruptors such as antiobiotics and hormones) - and is particularly effective for treating concentrated industrial effluents, under technically convenient conditions. The reaction products consist essentially of benign materials.

+
  • Prof. Brian Berkowitz
1481
In recent years, there has been a growing interest in the development of nanoscale magnetic and thermal characterization tools in order to address rapidly evolving fields, such as nanomagnetism, spintronics and energy-efficient computing. The requirements from these tools include high sensitivity and...

In recent years, there has been a growing interest in the development of nanoscale magnetic and thermal characterization tools in order to address rapidly evolving fields, such as nanomagnetism, spintronics and energy-efficient computing. The requirements from these tools include high sensitivity and high spatial resolution to enable local detection and accurate measurements of extremely low signals. For example, the energy dissipation mechanism in quantum systems is related to preservation of quantum information, which is of particular importance in the field of quantum computing. Available local magnetic imaging methods suffer from low sensitivity and in some cases, low spatial resolution. On the other hand, energy dissipation is not a readily measurable quantity on the nanometer scale and existing thermal imaging methods are not sensitive enough for studying quantum systems and are unsuitable for low temperature operation.

A novel sensor device comprising a nanoscale superconducting quantum interference device (SQUID) was developed by Prof. Zeldov at the Weizmann Institute of Science. The fabrication method enables the miniaturization of the sensor to an effective diameter of below 50 nm and its integration onto the apex of a very sharp tip that is ideally suited for scanning probe microscopy. The extremely small size of the SQUID-on-tip sensor and the ability to approach very close to the sample surface result in nano-metric spatial resolution and a very sensitivity.

Applications


·         Scanning probe microscopy for magnetic and thermal characterization

·         Inspection and probing equipment for quantum computing


Advantages


  • Simple fabrication process

  • High field sensitivity and bandwidth

  • Nanoscale sensors (down to 46 nm in diameter)

  • Tip-sample distance can be as close as a few nanometers


Technology's Essence


A SQUID is a very sensitive magnetometer used to measure extremely subtle magnetic fields, based on superconducting loops. The present invention is a novel sensor device, based on a nanoscale two-junction or multi-junction SQUIDs fabricated on the edge of a sharp tip in a three dimensional geometric configuration. In such a setup, the SQUID can approach the sample to a distance of few nanometers, as opposed to the conventional planar SQUIDs, which results in an extremely high sensitivity.

+
  • Prof. Eli Zeldov
1263
"Spin-optics", a new method for controlling electric current by manipulating electron spin-orbit interaction, can be used in semiconductors to achieve a wider spectrum of functionality similar to that achieved with polarized light. This method may be used for ultra-fast spin-based transistors.

"Spin-optics", a new method for controlling electric current by manipulating electron spin-orbit interaction, can be used in semiconductors to achieve a wider spectrum of functionality similar to that achieved with polarized light. This method may be used for ultra-fast spin-based transistors.

Applications


  • Ultra-fast spin-based field effect transistor (spin-FET) for communications, computing, and defense applications.
  • Nano- and micro-electronic semiconductor devices for polarizing, filtering, switching, guiding, storing, spin detecting and focusing the current carriers.
  • Devices for signal splitting and wide-angle sparging of electrons.

  • Advantages


    • Use of Nou-magnetic semiconductor materials
    • Creation of spin polarize current

    Technology's Essence


    Researchers at the Weizmann Institute of Science have discovered a novel method for controlling and manipulating the propagation of electrons in semiconductors with spin-orbit interaction by acting on the spin polarization of the electrons. It was found that when the spin-orbit coupling strength in the semiconductor is locally varying, electrons of different spin polarizations deflect by different angles at the region of the spin-orbit inhomogeneity. The spin-orbit coupling can be tuned locally and dynamically by applying bias voltage with gates. With suitable angle of incidence of electrons, one spin polarization either can pass through the region of inhomogeneity or totally reflected, in analogy to the total internal reflection phenomenon in optics. In fact, this new approach to spintronics is similar to manipulating polarized light in optical technologies. With this approach (termed "spin-optics") it is possible to manipulate the current carriers in semiconductors (electrons or holes) to achieve the whole spectrum of functionality used in optics of the polarized light, e.g., spin polarizing, spin filtering, switching, guiding as well as spin-based field effect transistor (spin-FET).

    +
    • Prof. Alexander Finkelstein
    1021
    A method for mapping and correcting optical distortion conferred by live cell specimens in microscopy that cannot be overcome using optical techniques alone can be used both for light microscopy and confocal microscopy. The system determines the 3D refractive index for the samples, and provides a...

    A method for mapping and correcting optical distortion conferred by live cell specimens in microscopy that cannot be overcome using optical techniques alone can be used both for light microscopy and confocal microscopy. The system determines the 3D refractive index for the samples, and provides a method for ray tracing, calculation of 3D space variant point spread, and generalized deconvolution.

    Applications


    Microscopy: The method was developed and applied for light microscopy, and is of critical importance for detection of weak fluorescently labeled molecules (like GFP fusion proteins) in live cells. It may be applicable also to confocal microscopy and other imaging methods like ultrasound, deep ocean sonar imaging, radioactive imaging, non-invasive deep tissue optical probing and photodynamic therapy. Gradient glasses: The determination of the three-dimensional refractive index of samples allows testing and optimization of techniques for production of gradient glasses. Recently continuous refractive index gradient glasses (GRIN, GRADIUM) were introduced, with applications in high quality optics, microlenses, aspherical lenses, plastic molded optics etc. Lenses built from such glasses can be aberration-corrected at a level, which required doublets and triplets using conventional glasses. Optimized performance of such optics requires ray tracing along curved path, as opposed to straight segments between surface borders of homogeneous glass lenses. Curved ray tracing is computation-intensive and dramatically slows down optimization of optical properties. Our algorithm for ray tracing in gradient refractive index eliminates this computational burden.

    Technology's Essence


    A computerized package to process three-dimensional images from live biological cells and tissues was developed in order to computationally correct specimen induced distortions that cannot be achieved by optical technique. The package includes: 1. Three-dimensional (3D) mapping of the refractive index of the specimen. 2. Fast method for ray tracing through gradient refractive index medium. 3. Three-dimensional space variant point spread function calculation. 4. Generalized three-dimensional deconvolution.

    +
    • Prof. Zvi Kam
    1441
    New protein as a target to treat B cell-related cancer.Chronic lymphocytic leukemia (CLL), a malignant disease characterized by the accumulation of B lymphocytes in the blood, lymphoid organs, and bone marrow, is the second most common type of leukemia in adults, accounting for about 7,000 new cases of...

    New protein as a target to treat B cell-related cancer.
    Chronic lymphocytic leukemia (CLL), a malignant disease characterized by the accumulation of B lymphocytes in the blood, lymphoid organs, and bone marrow, is the second most common type of leukemia in adults, accounting for about 7,000 new cases of leukemia each year. Presently, there is no cure for CLL, and the overall goal of leukemia treatment is to bring about a remission. Therefore, identifying new proteins that may serve as a target for inducing cell death in the malignant cells is highly desirable. The present technology identifies a new regulator protein that is essential for the survival of CLL cells.

    Applications


    • Treatment of CLL, as well as other B cell-related cancers (e.g. gastric cancer and renal cell carcinoma), by blocking CD84 activity
    • Diagnosis of CLL

    Advantages


    • Very specific to malignant B cells
    • Diagnosis, and therefore treatment, can be made at early stages of the disease

     


    Technology's Essence


    B cells taken from CLL patients have a high level of the protein CD84. Stimulation of CD84 upregulates the survival of B-CLL. However, inhibition of CD84 activity with a blocking antibody downregulates the expression of another protein which controls B-CLL survival, thus inducing cell death. Therefore, the present invention reveals CD84 as a regulator of B-CLL survival

    +
    • Prof. Idit Shachar
    1499
    Bladder cancer is a common malignancy; it is the 4th most common cancer in males and the 9th in females.  The presenting symptom is usually blood in the urine, and diagnosis is currently based on cystoscopy, which is invasive, costly, painful and time consuming.  To date, no biomarker has been...

    Bladder cancer is a common malignancy; it is the 4th most common cancer in males and the 9th in females.  The presenting symptom is usually blood in the urine, and diagnosis is currently based on cystoscopy, which is invasive, costly, painful and time consuming.  To date, no biomarker has been identified in the urine that might be used for screening, staging, prognosis and monitoring treatment.  We now report that the amount of the 60 kDa heat shock protein (HSP60) in a subject’s urine is a biomarker for muscle invasion in patients with bladder cancer – stage T2 and higher.  Moreover, subjects with stage T1 disease can be stratified by their urine levels of HSP60 into a sub-group likely to progress into stage T2 or into a sub-group more likely to respond to conservative treatment with BCG, which does not require removal of the bladder.  The distinction between these two sub-groups of T1 bladder cancer can identify earlier subjects in need of cystectomy, while sparing others unnecessary major surgery.

    Applications


    • Screening subjects with overt hematuria, or at risk of developing bladder cancer (such as heavy smokers)
    • tratifying bladder cancer subjects
    • Prognosis
    • Determining treatment program
    • Monitoring response to therapy.

    Advantages


    • Non-invasive
    • Easy to apply
    • Relatively inexpensive
    • Prognositic.

    Technology's Essence


    Quantitative measurement of HSP60 levels in a subject’s urine by ELISA, radio-immunoassay or other simple assays.

    +
    • Prof. Irun R. Cohen
    1266
    Fast cross-sectioning using multiphoton microscope.  The conventionally used laser-scanning microscopy, confocal and multiphoton microscopy, although being capable of performing optical sectioning, requires a long image acquisition time, tens of milliseconds per section in current commercial systems,...

    Fast cross-sectioning using multiphoton microscope.  The conventionally used laser-scanning microscopy, confocal and multiphoton microscopy, although being capable of performing optical sectioning, requires a long image acquisition time, tens of milliseconds per section in current commercial systems, due to the scanning process. The field of confocal microscopy relies on the idea of point-by-point illumination of a sample and use mechanical scanning in order to collect an image. Multiphoton microscopes offer a different mechanism for optical sectioning and the need for rejecting out-of-focus scattering is practically eliminated. However, the process is efficient only when the peak intensity of the illuminating light is high. Thus there is a growing need to facilitate the multiphoton microscopy imaging of a sample by providing a novel illumination configuration and method of its operation.

    Depth-resolved microscopy has been, for decades, practically synonymous with laser-scanning microscopy. The technique of the present invention provides for full-frame depth-resolved microscopy (or material processing), using an extremely simple setup as well as standard components, aiming at eliminating mechanical scanning across the sample thus making the image acquisition much faster.

     

    Applications


    • Optical system for use in a multi-photon microscope.
    • Material processing, e.g. simultaneous depth-resolved modification of a transparent substrate by femtosecond radiation.

    Advantages


    • The present invention provides for fast imaging/processing of a sample without scanning.
    • The temporal profile of the pulse remains unchanged as it propagates through the sample.
    • Single-shot depth resolved microscopy is able to capture extremely rapid dynamics, up to the nanosecond regime.
    • The setup enables full-frame video-rate fluorescence lifetime imaging, simply by gating the CCD intensifier.
    • Enables utilization of structure illumination microscopy.
    • Can be used with practically any multiphoton process.

    Technology's Essence


    The present invention provides the ability for illuminating a region of a sample with dimensions many orders of magnitude larger than a diffraction-limited spot of the imaging lens arrangement used in the microscope. Using this method, full-frame depth-resolved microscopy can be achieved using an extremely simple setup and standard components. the proposed microscope utilizes a pulse manipulator arrangement including a temporal pulse manipulator configured to define a surface, which extends perpendicular to the optical axis of a microscope in the front focal plane of an imaging lens arrangement, and which is patterned to affect trajectories of light components of the input short pulse impinging onto different points of this surface to direct these light components along different optical paths.

    This novel invention is not limited to imaging techniques in general and to microscopy in particular and can also be used for material processing.

    +
    • Prof. Yaron Silberberg
    1121
    A method for aligning video images according to sequence. The problem of image alignment has been extensively studied, and successful approaches have been developed for solving this problem. However, these approaches turn out as problematic when there is insufficient overlap between the two images to...

    A method for aligning video images according to sequence. The problem of image alignment has been extensively studied, and successful approaches have been developed for solving this problem. However, these approaches turn out as problematic when there is insufficient overlap between the two images to allow extraction of common image properties, i.e., when there is no sufficient similarity (e.g., gray-level, frequencies, statistical) between the two images. Whereas two individual images cannot be aligned when there is no spatial overlap between them, this is not the case when dealing with image sequences. The outlined technology consists of fusion and alignment of discrete, non-overlapping moving images from different sources, by aligning spatio-temporal changes in each sequence rather than in each image.

    Applications


    • Multi-sensor image alignment for multi-sensor fusion
    • Alignment of images (sequences) obtained at significantly different zooms (can be useful in surveillance applications)
    • Generation of wide-screen movies from multiple non-overlapping narrow field-of-view movies (such as in IMAX movies) 
    • Alignment and integration of information across video sequences to exceed the physical visual limitations of any individual sensor (e.g., dynamic range, spectral range, spatial resolution, temporal resolution, etc). ~

    Advantages


    • Useful for spatially non-overlapping sequences
    • Useful in cases which are inherently difficult for standard image alignment techniques, such as when there is insufficient common spatial information across the two sequences

    Technology's Essence


    An image sequence contains much more information than any individual image frame does. In particular, temporal changes in a video sequence (e.g., due to camera motion) do not appear in any individual image frame, but are encoded between video frames. When these temporal changes are common to the two sequences, then these sequences can be aligned both in time and in space, even if there is no common spatial information whatsoever. The need for coherent visual appearance, which is a fundamental assumption in image alignment methods, is replaced in this invention with the requirement of coherent temporal behavior. This can be achieved by attaching the two video cameras closely to each other (so that their centers of projections are very close), and moving them jointly in space (e.g., such as when the two cameras are mounted on a moving platform or rig).

     

    Click here for additional information
    Click here to visit Prof. Irani`s Homepage

    +
    • Prof. Michal Irani

    Pages