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Scientist
1640
Although early programs targeting MMPs (matrix metalloproteins) were largely unsuccessful due to adverse side effects, they remain a viable and highly desirable therapeutic target. The main obstacle in the attempts to target MMPs is the ability to selectively target individual family members. The...

Although early programs targeting MMPs (matrix metalloproteins) were largely unsuccessful due to adverse side effects, they remain a viable and highly desirable therapeutic target. The main obstacle in the attempts to target MMPs is the ability to selectively target individual family members. The present invention provides highly selective targeted therapy against MMP-7, which is strongly associated with aspects of cancer development such as angiogenesis and metastasis.
The innovative concept leading to this high selectivity is immunization with both a synthetic metal-protein mimicry molecule, previously developed by the present inventors, followed by the metalloenzyme itself (e.g. MMP-7). The resulting antibody exhibits exceptional degree of specificity towards MMP-7 over other MMPs.
The present technology offers an opportunity to re-introduce improved MMP-targeting agents to the cancer therapeutics market, in particular aggressive cancers that face a major unmet medical need. 

Applications


  • Therapy for MMP-7 associated diseases
  • Diagnostic tool for MMP-7 associated diseases

Advantages


  • Highly selective
  • Safe – avoids adverse effects that are associated with broad spectrum MMP inhibitors.
  • Efficient – targeting a physiological active conformation of the enzyme

Technology's Essence


The present technology is based on a previous invention that was developed in Prof. Sagi's lab, of synthetic metal-protein mimicry molecules that mimic the conserved structure of the metalloenzyme catalytic zinc-histidine complex within the active site of each MMP enzyme.
These molecules were shown to be powerful immunogens in the generation of highly selective MMP antibodies since they recognize both electrical and structural determinants residing within the enzyme active site. The potential of this method to successfully generate MMP-targeting therapeutics was shown for MMP-9/2 inhibitory antibodies in mouse models of inflammatory bowel disease.
Prof Sagi and her team now take this invention a step further to achieve even higher specificity. They show that immunizing with the mimicking molecules described above, followed by immunization with the metalloenzyme itself increases selectivity further.   
Implemented for MMP-7-targeting, this approach yielded an antibody with a 5 fold lower Ki towards MMP-7 than towards other MMPs (e.g. MMp-2 and MMP-9).


 

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  • Prof. Irit Sagi
  • Prof. Irit Sagi
1551
A novel set of manganese, ruthenium and related borohydride complexes (Pincer-type) were developed as remarkably efficient and environmentally-benign catalysts for the synthesis of alcohols, amines, amides, imines and esters, which are the basic building blocks for the research, chemicals,...

A novel set of manganese, ruthenium and related borohydride complexes (Pincer-type) were developed as remarkably efficient and environmentally-benign catalysts for the synthesis of alcohols, amines, amides, imines and esters, which are the basic building blocks for the research, chemicals, pharmaceutical and agrochemical industries. In addition, a catalytic carbon-carbon bond formation using non-activated aliphatic nitriles and carbonyl compounds was achieved with the manganese complex. These reactions are conducted under mild and neutral conditions, using low catalyst loading, require no hydrogen acceptors or oxidants, employ no corrosive or toxic reagents and generate no waste. Moreover, manganese is one of the most abundant transition metals on earth crust, making it appealing and biocompatible when considering a system for eventual scale-up and industrial use.

In view of global concerns regarding economy, environment and sustainable energy resources, there is an urgent need for the discovery of new catalytic reactions. These newly developed catalysts address key problems of current traditional synthetic methodologies, both from the economic and the environmental aspects.

Applications


·         Pharmaceuticals

·         Dyes

·         Cosmetics and fragrances

·         Fibers

·         Agrochemicals


Advantages


·         Cost-effective in terms of reagents, reactions conditions (low temperature and pressure) and waste treatment (green reactions).

·         New synthetic pathways that were not possible before, such as the synthesis of amides and imines directly from alcohols and amines, esters synthesis from alcohols and methanol synthesis from CO2 and hydrogen.

·         Broad substrate scope.

·         Excellent yields.


Technology's Essence


Prof. David Milstein’s group has discovered a new mode of action for metal-ligand cooperation, involving aromatization–dearomatization of ligands. Pincer-type, pyridine-based complexes of Mn, Ir, Rh, Ru, Pd, Pt and acridine complexes of Ru have been shown to exhibit such cooperation, leading to facile activation of C-H, C-C, H-H, N-H, O-H bonds, and to novel, environmentally friendly reactions catalyzed by Mn and Ru.

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  • Prof. David Milstein
1604
Novel reporter gene for magnetic resonance imaging applications.The ability to image the duration and location of gene expression in vivo and noninvasively is imperative for the future of biology and clinical medicine. Magnetic Resonance Imaging (MRI) is a widely used noninvasive clinical diagnostic...

Novel reporter gene for magnetic resonance imaging applications.The ability to image the duration and location of gene expression in vivo and noninvasively is imperative for the future of biology and clinical medicine. Magnetic Resonance Imaging (MRI) is a widely used noninvasive clinical diagnostic tool that offers views into deep tissues at exquisite spatial resolution. Recently, MRI has emerged as a valuable tool for monitoring the expression of genes by utilizing metal-complexed MRI agents to display transgene activity in vivo. However, administration of metal complexes into tissues and cells is challenging. Intra-cellular metalloproteins such as Ferritin have been utilized as endogenous MRI contrast agents, but offer relatively low sensitivity. The present technology provides a novel Ferritin-based transgene with enhanced MRI contrast.

 

Applications


  • Non-invasive imaging of gene expression in transgenic mice models.
  • Monitoring target gene expression in pre-clinical studies.
  • Long-term cell labeling and tracking.
  • Visualization of cellular- and gene-based therapeutics.

Advantages


  • Does not require delivery of exogenous substrate.
  • Enhanced MRI contrast over current Ferritin-based reporters.
  • Conversion to magnetite is achieved in physiological conditions and not by synthetic modification or by extreme heating. 

Technology's Essence


Ferritin, the main Iron storage intracellular protein, contains a paramagnetic ferryhydrate core, and thus was proposed as an endogenous MRI reporter gene. However, Ferritin provides relatively low sensitivity. One way to increase sensitivity of Ferritin is to convert the non-crystalline ferrihydrate in its core into crystal magnetite as has been done chemically, to form magneto-ferritin. The current method enhances the magnetic properties of Ferritin by engineering a Ferritin protein fused to a bacteria-derived peptide. This novel recombinant fusion protein facilitates conversion of ferrihydrate into crystal magnetite and by this induces MRI contrast. The new construct can serve for monitoring delivery and differentiation of cells in vivo in cellular based therapy. 

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  • Prof. Michal Neeman
1585
Our scientific team has discovered a method to apply the Gabor Transform to signal processing and data compression. Compared to existing methods that are based on Fourier transform, the new method provides for up to 25% savings in content size for video, audio and images, without any loss in quality...

Our scientific team has discovered a method to apply the Gabor Transform to signal processing and data compression.

Compared to existing methods that are based on Fourier transform, the new method provides for up to 25% savings in content size for video, audio and images, without any loss in quality.

By embracing our method, content providers, ISPs and mobile carriers can achieve major savings in data storage and data transfer costs.

Applications


The method can be used in virtually all applications involving data storage, communication and signal processing. One of the main commercial application is for lossy data compression for video, audio and images. Those types of content constitute the bulk of today’s Internet traffic, and improved compression will generate substantial savings in storage and data transfer costs.

The method also applies to the storage, communication and processing of quantum information and may therefore be expected to have applications in quantum calculations, quantum communication and quantum information processing.


Advantages


Existing data compression methods are based on numerical implementations of the Fourier transform, known as FFT, DCT and similar.

Compared to these methods, Gabor transform method demonstrates a very significant advantage in terms of the size of compressed material.  

The method provides for up to 25% savings in data size, while keeping the same perceived quality of the content.


Technology's Essence


We have discovered the definitive solution to the problem of obtaining accuracy and stability in the Gabor transform.  We realized that there must be an exact informational equivalence between the Gabor transform and the discrete Fourier transform (DFT). The latter is known to provide an exact representation of functions that are band-limited with finite support.  Since the DFT implicitly assumes periodic boundary conditions, to obtain this exact equivalence one needs to modify the Gaussians in the Gabor transform to obey periodic boundary conditions. This leads to Gaussian flexibility with Fourier accuracy --- precisely what has been sought since 1946.

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  • Prof. David J. Tannor
1646
Dedicated and highly efficient EPR analysis of small volume samples in a range of few µl is now made simple with a novel device invented at the Weizmann Institute of Science. This device features a new ejection mechanism and a unique cold trap which enables collection of all time points in a RFQ series...

Dedicated and highly efficient EPR analysis of small volume samples in a range of few µl is now made simple with a novel device invented at the Weizmann Institute of Science. This device features a new ejection mechanism and a unique cold trap which enables collection of all time points in a RFQ series in one continuous experiment.
In order to design and develop inhibitors for therapeutic purposes, the reaction mechanisms of enzymes must be understood. For biological applications, a common methodology of addressing this need is combining Rapid Freeze Quench with Electron Paramagnetic Resonance (RFQ)-EPR, which allows the trapping and analysis of short lived intermediates in chemical reactions. However, commercial RFQ-EPR devices are limited for high field EPR applications due to the demand of large sample volumes for each time point.
Prof. Goldfarb and her team built a new RFQ apparatus based on microfluidic flow and unique ejection and freezing systems, which can be used for collecting small volume samples in capillaries for high field EPR.

Applications


This technology, combined with the variety of W-band high resolution EPR technique (ENDOR, DEER and ESEEM) enables better mechanistic studies of enzymatic reactions, with an emphasis on structural transformations during the reaction, in an efficient and accurate way.


Advantages


  • Collecting all RFQ time points in one continues experiment.
  • Produce small volume samples in the range of a few µl, and handles small capillaries, for high field ERP.
  • An improved dead time of ~5ms, relative to the commercial RFQs with a typical dead-time of 5–10 ms.
  • Ease-of-use and speed.

Technology's Essence


The innovative apparatus consists of two main parts: the microfluidic device and the freeze-quench setup. The microfluidic device comprises a mixer, which mixes the two reacting solutions, a flow path where the reaction occurs, and a sprinkler from which the solution is sprayed out of the device. Prof. Goldfarb and her colleagues improved the common mixing device by adding a fast stream of nitrogen gas which mixes with the ejected reaction solution, and sprays the frozen aerosol out in tiny drops at high speed.
The innovative RFQ device was planned to have a cold solid surface on which the freezing happens rather than the traditional ejection into a cold liquid, in order to minimize the losses of the frozen solution. Moreover the plate rotates at a speed correlated to the flow speed of the solution, thus samples of different reaction times can freeze on a different radius. The frozen samples are then collected into quartz capillaries.

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  • Prof. Daniella Goldfarb
1555
Albumin binding probe for extending the lifetime of drugs. Most polypeptide drugs, in particular non-glycosylated proteins of molecular mass less than 50 kDa, are short-lived species in vivo having circulatory half lives of 5-20 min. Drug association with endogenous albumin may be suitable for...

Albumin binding probe for extending the lifetime of drugs. Most polypeptide drugs, in particular non-glycosylated proteins of molecular mass less than 50 kDa, are short-lived species in vivo having circulatory half lives of 5-20 min. Drug association with endogenous albumin may be suitable for designing an approach to protract the action in vivo of, potentially, any short-lived peptide/protein drug. In doing so two principal obstacles must be overcome: (1) following its conjugation, the probe introduced into a peptide or a protein should have sufficient affinity to albumin to manifest prolonged action in vivo, and (2) in case such covalent introduction results in an inactive product, the latter should be capable to undergo slow reactivation at physiological conditions. The present invention relates to engineering prolonged-acting prodrugs employing an albumin-binding probe that undergoes slow hydrolysis at physiological conditions.

Applications


  • Prolonging half life of short-lined drugs

Advantages


  • Prolonging the action of the drug without effecting its activity 
  • A desirable pharmacokinetic pattern

Technology's Essence


Since albumin is long-lived in vivo, drugs and endogenous substances that tightly associate with it have lower clearance rates than that of the unbound substances, and exhibit prolonged lifetime profiles in vivo. The present invention is based on a concept according to which a long chain fatty acid (LCFA) like albuminbinding compound is covalently linked to a short-lived amino-containing drug to form a non-covalent drug conjugate capable of associating with albumin in vivo, i.e., a long-lived prodrug that gradually releases the pharmacologically active constituent. This approach has been successfully implemented with several drugs (e.g. insulin, exendin and gentamicin).

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  • Prof. Matityahu Fridkin
  • Prof. Yoram Shechter
1616
Existing treatments against cancer are non-sufficiently selective. Immunotherapy based treatment offers highly selective and efficient solution to this problem. A promising approach in Immunotherapy is adoptive cell therapy (ACT). In ACT, therapeutic lymphocytes are administrated to patients in order...

Existing treatments against cancer are non-sufficiently selective. Immunotherapy based treatment offers highly selective and efficient solution to this problem.
A promising approach in Immunotherapy is adoptive cell therapy (ACT). In ACT, therapeutic lymphocytes are administrated to patients in order to treat a disease. In this process antibody-type cells are generated ex vivo, and then infused to the patient. By this technology the cells can be redirected against specific tumors via genetic engineering, using chimeric receptors.
Currently ACT is logistically and economically challenging since it is limited by the used of the patients’ own cells. Another key concern is safety, due to the danger that the allogeneic cells will be rejected by the patient, or will attack the patient.
In cancer, use of tumor specific, chimeric receptor redirected allogeneic T cells can transform ACT into a standardized, off-the shelf therapy. Overall this method proposes a safe and effective adoptive therapy using allogeneic cells while avoiding the use of bone marrow transplantation (BMT).

Applications


  • Cancer immunotherapy

Advantages


  • Off the shelf, standard treatment
  • Safe
  • Effective
  • No bone marrow transplantation (BMT) is required

Technology's Essence


A novel approach for adoptive immunotherapy using fully MHC-mismatch allogeneic T cells. These cells are redirected with tumor specific non-MHC-restricted antibody-based chimeric antigen receptor (T-bodies) in the absence of Graft-versus-host disease (GVHD). In order to create a standardize treatment, the redirection of T cells can be done through an antibody-based chimeric antigen receptor (CAR), thus creating ‘universal effector T cells’. This is based on a combination of of MHC-mismatched allogeneic T-cells with an MHC unrestricted chimeric antigen receptor. These cells would recognize their target independently of MHC restriction, therefore applied as an ‘off-the shelf’ immunotherapy. Regarding the second challenge of avoiding GVHD, by using a controlled lymphodepletion the researchers were able to create therapeutic window during which the allo-T-body cells could destroy the tumor before being themselves rejected.

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  • Prof. Zelig Eshhar
1518
Improved immunotherapy for breast cancer. Monoclonal antibodies (mAbs) to ErbB-2/HER2 growth factor receptor, or to its sibling, the epidermal growth factor receptor (EGFR), prolong survival of cancer patients, especially when combined with cytotoxic therapies. However, low effectiveness of...

Improved immunotherapy for breast cancer.

Monoclonal antibodies (mAbs) to ErbB-2/HER2 growth factor receptor, or to its sibling, the epidermal growth factor receptor (EGFR), prolong survival of cancer patients, especially when combined with cytotoxic therapies. However, low effectiveness of therapeutic mAbs and the evolution of patient resistance call for improvements. Furthermore, the response to the clinically approved monotherapy of Herceptin (a humanized mAb directed against ErbB-2), is relatively low (~15%) and short lived (median duration, 9 months). Therefore, there is a need to improve the therapeutic treatment against this receptor. The present technology enhances the therapeutic activity of anti-ErB-2 receptor antibodies, by combining two or more epitope-distinct antibodies.

Applications


  • Improved treatment of ErbB-2-overexpressing tumors (e.g. in breast and ovary cancers).


Advantages


  • May enhance patient response and delay acquisition of resistance.
  • Enhancement of therapeutic efficacy and synergy with chemotherapy.

Technology's Essence


Optimal selection of mAbs for cancer immunotherapy may improve its therapeutic potential. The outlined technology addresses an emerging strategy, which enhances the therapeutic activity of anti-receptor antibodies by combining two mAbs engaging distinct epitopes. It was demonstrated that pairs of anti-ErbB-2 mAbs better inhibit ErbB-2-overexpressing tumors than the respective individual mAbs, both in vitro and in vivo.

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  • Prof. Yosef Yarden
1265
A Novel water treatment method capable of handling a wide spectrum of pollutants, both organic and metallic was developed by the group of Prof. Berkowitz and proven in large scale. The combination of ever-growing contamination from various sources (industry, agriculture and domestic uses), the toxicity...

A Novel water treatment method capable of handling a wide spectrum of pollutants, both organic and metallic was developed by the group of Prof. Berkowitz and proven in large scale.

The combination of ever-growing contamination from various sources (industry, agriculture and domestic uses), the toxicity of contaminating compounds, and their extreme persistence in the environment, define a complex challenge and serious threat. Feasible technological responses to deal with growing deterioration in water resource quality are difficult to develop, largely because of the wide variety of contaminants having different properties, the stringent environmental standards that must be met, and the inherent heterogeneity of natural aquatic systems. The quest for cost-effective, environmentally-acceptable methods that can target a wide spectrum of contaminants, in situ and ex situ, is urgent and critical today more than ever.

The approach of the technology presented here is to reduce their oxidation state, i.e., to transform them electrochemically. In most cases, complete transformation of contaminants from the oxidized-organic group produces environmentally innocuous compounds, while reduction of heavy metals renders them insoluble and immobile, and therefore much less harmful. These treatment methods can be applied both in situ and ex situ for decontamination of soils, sediments, water, wastewater and gaseous process streams.

Applications


•           Polluted water and wastewater treatment.

•           Soil decontamination.

•           Gaseous process stream treatment.


Advantages


•           Environmentally friendly output.

•           Cost effective.

•           Can be applied in situ as well as ex situ.


Technology's Essence


The treatment method presented here is based on nanosized zerovalent iron (nZVI) particles and cyanocobalamine (vitamin B12) on a diatomite matrix.  Cyanocobalamine is known to be an effective electron mediator, having strong synergistic effects with nZVI for reductive dehalogenation reactions. This composite material also improves the reducing capacity of nZVI by preventing agglomeration of iron nanoparticles, thus increasing their active surface area. The porous structure of the diatomite matrix allows

high hydraulic conductivity, which favors channeling of contaminated water to the reactive surface of the composite material resulting in faster rates of remediation. The composite material rapidly degrades or transforms completely a large spectrum of water contaminants, including halogenated solvents like TCE, PCE, and cis-DCE, pesticides like alachlor, atrazine and bromacyl, and common ions like nitrate, within minutes to hours.

 

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  • Prof. Brian Berkowitz
1033
A novel diagnostic test to identify individuals with increased risk of lung cancer. Lung cancer is the number one killer among cancers, with 160,000 deaths/year in the USA and 1.6 million/year worldwide. Early detection of lung cancer increases 5-year survival rate from 4% to 54%. Moreover, the...

A novel diagnostic test to identify individuals with increased risk of lung cancer.

Lung cancer is the number one killer among cancers, with 160,000 deaths/year in the USA and 1.6 million/year worldwide. Early detection of lung cancer increases 5-year survival rate from 4% to 54%. Moreover, the National Lung Cancer Trial (NLST) showed that early detection of lung cancer by low-dose CT reduces mortality by at least 20%. Despite recommendations for low-dose CT screening for heavy smokers fulfilling the NLST criteria, compliance is low. In addition, 80 million smokers and ex-smokers in the US who do not fulfil NLST risk criteria have no recommended solution.

The MyRepair test fulfils this unmet medical need by providing a quantitative prediction of lung cancer risk using a simple blood test. The test is based on a personalized measurement of the patient’s DNA repair capacity, a mechanism which is highly connected to the onset of cancer. Therefore, the MyRepair technology can potentially increase early detection of lung cancer and thus save lives.

 

Applications


A novel diagnostic test to identify individuals with increased risk of lung cancer


Advantages


·         Simplicity – MyRepair is based on a simple, cost-effective blood test.

·         Accessibility – Compared to low-dose CT which requires specific equipment, the MyRepair test can be easily integrated in general diagnostic labs and therefore may be more accessible to a larger portion of the population.

·         Additional applications – Since the test is based on measuring personalized DNA repair mechanism, it can be adopted in the future for the diagnosis of additional cancer types and DNA repair related diseases.


Technology's Essence


Based on the strong and well documented connection between impaired capacity for DNA repair and onset of cancer, the Livneh lab invented the MyRepair Test, a method for predicting lung cancer risk, based on measuring activity of 3 DNA repair enzymes.

Combining enzyme activities with experimental risk estimates generated MyRepair Score, which measures personalized DNA repair capacity of tested subjects.

An epidemiological/clinical study performed in Israel, further validated in an independent UK study, demonstrated that lung cancer patients have lower MyRepair Score than healthy people. In addition, subjects who test MyRepair-positive have an 85-fold higher risk to develop lung cancer compared to the general population.

Low MyRepair Score is a risk factor independent of smoking, and of comparable magnitude, indicating that it can be a prognostic tool for smokers, ex-smokers, and non-smokers.

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  • Prof. Zvi Livneh
1447
A cheap and effective solution for protecting RFID tags from power attacks. RFID tags are secure tags present in many applications (e.g. secure passports). They are poised to become the most far-reaching wireless technology since the cell phone, with worldwide revenues expected to reach $2.8 billion in...

A cheap and effective solution for protecting RFID tags from power attacks.

RFID tags are secure tags present in many applications (e.g. secure passports). They are poised to become the most far-reaching wireless technology since the cell phone, with worldwide revenues expected to reach $2.8 billion in 2009. RFID tags were believed to be immune to power analysis attacks since they have no direct connection to an external power supply. However, recent research has shown that they are vulnerable to such attacks, since it is possible to measure their power consumption without actually needing either tag or reader to be physically touched by the attacker. Furthermore, this attack may be carried out even if no data is being transmitted between the tag and the attacker, making the attack very hard to detect. The current invention overcomes these problems by a slight modification of the tag's electronic system, so that it will not be vulnerable to power analysis.

Applications


  • Improved security of RFID tags.

Advantages


  • Simple and cost-effective
  • The design involves changes only to the RF front-end of the tag, making it the quickest to roll-out


Technology's Essence


An RFID system consists of a high-powered reader communicating with a tag using a wireless medium. The reader generates a powerful electromagnetic field around itself and the tag responds to this field. In passive systems, placing a tag inside the reader's field also provides it with the power it needs to operate. According to the inventive concept, the power consumption of the computational element is detached from the power supply of the tag. Thus, the present invention can almost eliminate the power consumption information.

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  • Prof. Adi Shamir
1529
We present an efficient and robust broadband crystal optical conversion device. Various applications of laser optics require tunable laser sources. Currently, most frequency conversion devices rely on a single non-linear crystal, which is either temperature or angle tuned to enhance efficiency. This...

We present an efficient and robust broadband crystal optical conversion device. Various applications of laser optics require tunable laser sources. Currently, most frequency conversion devices rely on a single non-linear crystal, which is either temperature or angle tuned to enhance efficiency. This results only in a narrow efficient spectral band of conversion. Other techniques such as periodic quasi-phase matching result in improved efficiencies but still within a narrow predetermined band. Random quasi-phase matching results in improved bandwidth but in a significant reduction in efficiency. This new device enables ultra-broadband wavelength conversion while maintaining high efficiency.

Applications


  • Laser optics industry
  • Frequency convertor for broadband signals
  • Generation of ultrafast visible radiation
  • Pulse selection.

Advantages


  • 90% efficiency of conversion process.
  • Simple and compact
  • Insensitive to the deviations in alignment, no dependence of the angle incidence beam or of temperature
  • Frequency converter of both broadband signals and ultra-short pulses.

Technology's Essence


This device is based on a new method of adiabatic wavelength conversion. The device works whereby a strong narrow-band pump is introduced into the crystal along with a weaker pulse to be converted. This conversion is realized in a quasi-phase matched nonlinear crystal, where the period is tuned adiabatically from strong negative phase-mismatch to strong positive phase-mismatch (or vice versa). This results in the efficient transformation of the weaker pulse.

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  • Prof. Yaron Silberberg
1267
Description: Monoclonal antibodies specific for cholesterol/ceramide-rich domains (clones 405F, 14F, 499F) and cholesterol micro-domains (clones 36A1, 5881) in cell membranes. Originally raised against an artificial monolayer of lipid mixtures in, and were shown to specifically label the above domains...

Description: Monoclonal antibodies specific for cholesterol/ceramide-rich domains (clones 405F, 14F, 499F) and cholesterol micro-domains (clones 36A1, 5881) in cell membranes. 
Originally raised against an artificial monolayer of lipid mixtures in, and were shown to specifically label the above domains in different cell membranes. 
Reference:  Scheffer L, Futerman AH, Addadi L. 2007. Antibody labeling of cholesterol/ceramide ordered domains in cell membranes. Chembiochem 8(18):2286-94.

M263, M264, M265

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  • Prof. Lia Addadi
1151
A method to significantly shorten acquisition times of high-quality MRI images. Multidimensional nuclear magnetic resonance (NMR) is used nowadays in many applications (e.g., discovery of new pharmaceutical drugs, characterization of new catalysts, and investigation of the structure and dynamics of...

A method to significantly shorten acquisition times of high-quality MRI images.

Multidimensional nuclear magnetic resonance (NMR) is used nowadays in many applications (e.g., discovery of new pharmaceutical drugs, characterization of new catalysts, and investigation of the structure and dynamics of proteins). One drawback of this technique is that, by contrast to one-dimensional spectroscpic methods, multidimensional NMR requires relatively long measurement times associated with hundreds or thousands of scans. This places certain kinds of rapidly-changing systems in Chemistry outside the scope of the technique. Long acquisition times also make this technique ill-suited for in vivo analyses and for clinical measurements in combination with magnetic resonance imaging (MRI). The current technology allows for the acquisition of multidimentional NMR scans using a single continuous scan, thereby shortening the time needed to acquire high-quality MRI images.

Applications


  • In vivo diagnostics

  • High-throughput proteomics/metabonomics

  • NMR of unstable chemical systems

  • Metabolic dynamics

  • High-resolution NMR in tabletop systems

  • Extensions to non-MR spectroscopies


Advantages


  • Can shorten the acquisition time of any multidimensional spectroscopy experiment by orders of magnitude
  • Compatible with the majority of multidimensional pulse sequences
  • Can be implemented using conventional NMR and MRI hardware

Technology's Essence


The outlined approach, called ultrafast multidimensional NMR, significantly expedites the analysis of the electromagnetic sounds produced, making it possible to acquire complete multidimensional NMR spectra within a fraction of a second. This technology “slices up” the molecular sample into numerous thin layers and then simultaneously performs all the measurements required on every one of these slices. The protocol then integrates these measurements according to their precise location, generating an image that amounts to a full multidimensional spectrum from the entire sample.

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  • Prof. Lucio Frydman
1481
In recent years, there has been a growing interest in the development of nanoscale magnetic and thermal characterization tools in order to address rapidly evolving fields, such as nanomagnetism, spintronics and energy-efficient computing. The requirements from these tools include high sensitivity and...

In recent years, there has been a growing interest in the development of nanoscale magnetic and thermal characterization tools in order to address rapidly evolving fields, such as nanomagnetism, spintronics and energy-efficient computing. The requirements from these tools include high sensitivity and high spatial resolution to enable local detection and accurate measurements of extremely low signals. For example, the energy dissipation mechanism in quantum systems is related to preservation of quantum information, which is of particular importance in the field of quantum computing. Available local magnetic imaging methods suffer from low sensitivity and in some cases, low spatial resolution. On the other hand, energy dissipation is not a readily measurable quantity on the nanometer scale and existing thermal imaging methods are not sensitive enough for studying quantum systems and are unsuitable for low temperature operation.

A novel sensor device comprising a nanoscale superconducting quantum interference device (SQUID) was developed by Prof. Zeldov at the Weizmann Institute of Science. The fabrication method enables the miniaturization of the sensor to an effective diameter of below 50 nm and its integration onto the apex of a very sharp tip that is ideally suited for scanning probe microscopy. The extremely small size of the SQUID-on-tip sensor and the ability to approach very close to the sample surface result in nano-metric spatial resolution and a very sensitivity.

Applications


·         Scanning probe microscopy for magnetic and thermal characterization

·         Inspection and probing equipment for quantum computing


Advantages


  • Simple fabrication process

  • High field sensitivity and bandwidth

  • Nanoscale sensors (down to 46 nm in diameter)

  • Tip-sample distance can be as close as a few nanometers


Technology's Essence


A SQUID is a very sensitive magnetometer used to measure extremely subtle magnetic fields, based on superconducting loops. The present invention is a novel sensor device, based on a nanoscale two-junction or multi-junction SQUIDs fabricated on the edge of a sharp tip in a three dimensional geometric configuration. In such a setup, the SQUID can approach the sample to a distance of few nanometers, as opposed to the conventional planar SQUIDs, which results in an extremely high sensitivity.

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  • Prof. Eli Zeldov

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