Biotechnology, Pharmaceuticals Immunogenic Compositions For Induction of Anti-Tumor Immunity...
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Project Number: 1156

Principal Investigator:  Prof. Irun R. Cohen

Department : Immunology
Summary

p53 is a tumor-associated antigen which, as a result of mutations, accumulates on tumor cell surfaces. However, p53 is also present, albeit in smaller amounts, on normal cells and, as such, is not recognized by the body's immune system. A new anti-cancer treatment protocol which involves immunization with anti-p53 antibodies can differentiate between cancerous and normal cells, and may be used to direct tumor immunotherapy.

Applications
A. Therapeutic method of preventing or limiting the spread of metastases by treatment of a patient with immunogenic delivery of monoclonal antibody to tumor associated antigens like p53. B. Therapeutic method of eradicating residual tumor cells after resection of the main tumor mass by treatment of a patient with immunogenic delivery of monoclonal antibody to tumor associated antigens like p53.
Advantages
Technology's Essence
Researchers at the Weizmann Institute have observed that activation of the immune system against the p53 protein and subsequent eradication of experimental tumors could be achieved by immunization with anti-p53 antibody, or peptides derived from the variable region of such antibody. Based on these findings, a treatment protocol was developed that utilizes the immunogenic delivery of monoclonal antibody to tumor associated antigens for tumor immunotherapy.
Patent ID
9709
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Biotechnology, Pharmaceuticals

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Immunotherapy
Cell Based Therapy
Cancer
Vaccines
Therapeutics / Pharmaceutical
Peptides / Polypeptides


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Prof. Irun R. Cohen
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